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Effects of aging on T cell function
Open accessAbstract
Immunosenescence influences many components of the immune system. Most importantly, profound changes in T cell function are evident in older individuals. The impact of aging on specific T cell subsets has been difficult to examine, but recent advances in murine model systems and new insights into T cell function have allowed for the more precise examination of how T cell responses change with aging. Importantly, recent studies have shown that age-related enhancement of both Th17 generation and regulatory T cell function may contribute to significant changes in immune function. In this review, we summarize the current views on how aging influences the factors that impact T cell function and how this can affect the immune response to infections, vaccinations, and tumors.
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“Furthermore, regulatory T cells (Tregs) appear to accumulate with age and further contribute to reduced responsiveness of effector T cells (11, 12).”
From Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes (2019) · cites this paper as [12]
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Metadata
- Authors
- Haynes, L., & Maue, A. C.
- Affiliations
- Trudeau Institute (US)
- SUNY Upstate Medical University (US)
- Corresponding author
- Haynes, Laura
- Maue, Alexander C
- ORCID
- Haynes, Laura
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 21
- Issue
- 4
- Pages
- 414-417
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC3800142
- OpenAlex
- W2048088192
- Cited by
- 244
- References
- 32
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 12 · 2023: 10 · 2022: 13 · 2021: 17 · 2020: 18 · 2019: 13 · 2018: 14 · 2017: 2 · 2016: 13 · 2015: 13 · 2014: 23 · 2013: 22 · 2012: 24
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Immunology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG021600)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- immunosenescence, T cell function, aging, Th17 cells, regulatory T cells, T cell response, infection immunity, vaccination, antitumor immunity
- MeSH terms
- Aging, Animals, Bacterial Infections, Humans, Immune Tolerance, Neoplasms, Vaccination, Virus Diseases, T-Lymphocyte Subsets, Interleukin-17, T-Lymphocytes, Regulatory, Mice
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