Aging and Immune Function: Molecular Mechanisms to Interventions

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · see citing works

Lipid rafts and signal transduction

Simons, K., & Toomre, D. K. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 6,252 · see citing works

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Development by Self-Digestion

Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,671 · see citing works

Reactive oxygen species, cellular redox systems, and apoptosis

Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340 · see citing works

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · cited 1× · see citing works

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

Nguyen, T., Nioi, P., & Pickett, C. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r900010200 · Cited by 2,655 · see citing works

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works

Adapting Proteostasis for Disease Intervention

Balch, W. E., Morimoto, R. I., Dillin, A., & Kelly, J. W. (2008) · Science · doi:10.1126/science.1141448 · Cited by 2,495 · see citing works

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J. I., Scott, L. J., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 2,217 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works

Human natural killer cells

Caligiuri, M. A. (2008) · Blood · doi:10.1182/blood-2007-09-077438 · Cited by 1,910 · see citing works

Changes in thymic function with age and during the treatment of HIV infection

Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893 · see citing works

MicroRNA-155 is induced during the macrophage inflammatory response

O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866 · see citing works

The epigenetic progenitor origin of human cancer

Feinberg, A. P., OHLSSON, R. I., & Henikoff, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1748 · Cited by 1,851 · see citing works

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725 · see citing works

Induction of autophagy by spermidine promotes longevity

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680 · see citing works

mTOR regulates memory CD8 T-cell differentiation

Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575 · see citing works

FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562 · see citing works

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Rushmore, T. H., Morton, M. R., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99004-6 · Cited by 1,464 · see citing works

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works

Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282 · see citing works

Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

Nguyen, T., Sherratt, P. J., & Pickett, C. B. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140229 · Cited by 1,232 · see citing works

Molecular inflammation: Underpinnings of aging and age-related diseases

Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203 · see citing works

Proteolysis: from the lysosome to ubiquitin and the proteasome

Ciechanover, A. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1552 · Cited by 1,133 · see citing works

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115 · see citing works

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090 · see citing works

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene

Radjendirane, V., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,034 · see citing works

Calorie restriction, SIRT1 and metabolism: understanding longevity

Bordone, L., & Guarente, L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1616 · Cited by 1,021 · see citing works

MicroRNA Control in the Immune System: Basic Principles

Xiao, C., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2008.12.027 · Cited by 1,008 · see citing works

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

Cuervo, A. M., & Dice, J. F. (1996) · Science · doi:10.1126/science.273.5274.501 · Cited by 979 · see citing works

DNA Repair, Genome Stability, and Aging

Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works

The molecular machinery of autophagy: unanswered questions

Klionsky, D. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01620 · Cited by 935 · see citing works

The Free Radical Theory of Aging

Harman, D. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310202 · Cited by 926 · see citing works

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

Rock, K. L., & Goldberg, A. L. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.739 · Cited by 923 · see citing works

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923 · see citing works

Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

Brunk, U. T., & Terman, A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00959-0 · Cited by 919 · see citing works

The aging of the immune system

Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908 · see citing works

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., KOTSUJI, T., Otsuka, F., Roop, D. R., et al. (2003) · Nature Genetics · doi:10.1038/ng1248 · Cited by 881 · see citing works

Immunosenescence: emerging challenges for an ageing population

Aw, D., Silva, A. B., & Palmer, D. B. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02555.x · Cited by 880 · see citing works

Calcium and oxidative stress: from cell signaling to cell death

Ermak, G., & Davies, K. J. A. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(01)00108-0 · Cited by 874 · see citing works

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

Morimoto, R. I. (2008) · Genes & Development · doi:10.1101/gad.1657108 · Cited by 872 · see citing works

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

Lithgow, G. J., White, T. M., Melov, S., & Johnson, T. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7540 · Cited by 862 · see citing works

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

Sauer, S., Bruno, L., Hertweck, A., Finlay, D. K., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D. A., O’Connor, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800928105 · Cited by 861 · see citing works

Foxo3a is essential for maintenance of the hematopoietic stem cell pool

Miyamoto, K., Kazuhito, N., & Atsushi, H. (2009) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 858 · see citing works

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

Morley, J. F., Brignull, H. R., Weyers, J. J., & Morimoto, R. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152161099 · Cited by 811 · see citing works

The Influence of Age on T Cell Generation and TCR Diversity

Naylor, K., Li, G., Vallejo, A. N., Lee, W.-W., Koetz, K., Bryl, E., Witkowski, J., Fulbright, J., Weyand, C. M., & Goronzy, J. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7446 · Cited by 802 · see citing works

Autophagy and aging: The importance of maintaining "clean" cells

Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792 · see citing works

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., & Barrett, J. C. (2004) · Nature Cell Biology · doi:10.1038/ncb1095 · Cited by 790 · see citing works

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

Haxhinasto, S., Mathis, D., & Benoist, C. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20071477 · Cited by 775 · see citing works

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

Suh, J. H., Shenvi, S. V., Dixon, B. M., Liu, H., Jaiswal, A. K., Liu, R.-M., & Hagen, T. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400282101 · Cited by 774 · see citing works

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

Dice, J. F. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90019-8 · Cited by 755 · see citing works

Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals

Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754 · see citing works

Telomere length, stem cells and aging

Blasco, M. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.38 · Cited by 747 · see citing works

Genetic determination of telomere size in humans: a twin study of three age groups.

Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 741 · see citing works

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

de Magalhães, J. P., Curado, J., & Church, G. M. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp073 · Cited by 737 · see citing works

Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

Schmid, D., Pypaert, M., & Münz, C. (2007) · Immunity · doi:10.1016/j.immuni.2006.10.018 · Cited by 732 · see citing works

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724 · see citing works

Autophagy promotes MHC class II presentation of peptides from intracellular source proteins

Dengjel, J., Schoor, O., Fischer, R., Reich, M. R., Kraus, M., Müller, M., Kreymborg, K., Altenberend, F., Brandenburg, J., Kalbacher, H., et al. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0501190102 · Cited by 680 · see citing works

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

Sykiotis, G. P., & Bohmann, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.002 · Cited by 675 · see citing works

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature · doi:10.1038/nature05456 · Cited by 669 · see citing works

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00218-5 · Cited by 666 · see citing works

Age-related decline in chaperone-mediated autophagy

Cuervo, A. M., & Dice, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002102200 · Cited by 665 · see citing works

Genomic instability in laminopathy-based premature aging

Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J.-D., Li, K. M., Chau, P. Y., Chen, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1266 · Cited by 650 · see citing works

Collapse of proteostasis represents an early molecular event in <i>Caenorhabditis elegans</i> aging

Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902882106 · Cited by 649 · see citing works

Lifespan of human lymphocyte subsets defined by CD45 isoforms

Michie, C. A., McLean, A. R., Alcock, C. J., & Beverley, P. C. L. (1992) · Nature · doi:10.1038/360264a0 · Cited by 635 · see citing works

A critical role for the autophagy gene Atg5 in T cell survival and proliferation

Pua, H. H., Dzhagalov, I., Chuck, M., Mizushima, N., & He, Y.-W. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061303 · Cited by 622 · cited 1× · see citing works

Aberrant T cell differentiation in the absence of Dicer

Muljo, S. A., Ansel, K. M., Kanellopoulou, C., Livingston, D. M., Rao, A., & Rajewsky, K. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050678 · Cited by 621 · see citing works

DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

Robert, M., Morin, S., Beaulieu, N., Gauthier, F., Chute, I. C., Barsalou, A., & MacLeod, A. R. (2002) · Nature Genetics · doi:10.1038/ng1068 · Cited by 615 · see citing works

Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

Nguyen, T., Sherratt, P. J., Huang, H.-C., Yang, C. S., & Pickett, C. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207293200 · Cited by 615 · see citing works

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

Sokol, C. L., Chu, N.-Q. T., Yu, S., Nish, S. A., Laufer, T. M., & Medzhitov, R. M. (2009) · Nature Immunology · doi:10.1038/ni.1738 · Cited by 612 · see citing works

The Nrf2–ARE Pathway

Johnson, J. A., Johnson, D. A., Kraft, A. D., Calkins, M. J., Jakel, R. J., Vargas, M. R., & Chen, P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.036 · Cited by 588 · see citing works

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

Tal, M. C., Sasai, M., Lee, H. K., Yordy, B., Shadel, G. S., & Iwasaki, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807694106 · Cited by 573 · see citing works

Premature Aging in Mice Deficient in DNA Repair and Transcription

de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J., Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T. J., van Leeuwen, W., Themmen, A. P. N., et al. (2002) · Science · doi:10.1126/science.1070174 · Cited by 545 · see citing works

The immunology of exceptional individuals: the lesson of centenarians

Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 531 · see citing works

Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works

Thymic involution and immune reconstitution.

Lynch, H. E., Goldberg, G. L., Chidgey, A., Van den Brink, M. R. M., Boyd, R., & Sempowski, G. D. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.003 · Cited by 522 · see citing works

Genomic 5-methyldeoxycytidine decreases with age.

Wilson, V. L., Smith, R. A., Ma, S., & Cutler, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61057-9 · Cited by 521 · see citing works

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

Zhang, C., & Cuervo, A. M. (2008) · Nature Medicine · doi:10.1038/nm.1851 · Cited by 520 · see citing works

DNA repair is limiting for haematopoietic stem cells during ageing

Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., et al. (2007) · Nature · doi:10.1038/nature05875 · Cited by 518 · see citing works

The Role of the Thymus in Immune Reconstitution in Aging, Bone Marrow Transplantation, and HIV-1 Infection

Haynes, B. F., Markert, M. L., Sempowski, G. D., Patel, D. D., & Hale, L. P. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.529 · Cited by 502 · see citing works

Human innate immunosenescence: causes and consequences for immunity in old age

Panda, A., Arjona, A., Sapey, E., Bai, F., Fikrig, E., Montgomery, R. R., Lord, J. M., & Shaw, A. C. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.004 · Cited by 502 · see citing works

Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines

Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5893 · Cited by 499 · see citing works

Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

Kwak, M.-K., Wakabayashi, N., Greenlaw, J. L., Yamamoto, M. P., & Kensler, T. W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8786-8794.2003 · Cited by 498 · see citing works

Redox Regulation in Cancer: A Double‐edged Sword with Therapeutic Potential

Acharya, A., Das, I., Chandhok, D., & Saha, T. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.1.10095 · Cited by 487 · see citing works

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

Paulsen, C. E., & Carroll, K. S. (2009) · ACS Chemical Biology · doi:10.1021/cb900258z · Cited by 478 · see citing works

Aging of the Immune System: How Much Can the Adaptive Immune System Adapt?

Weng, N. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.001 · Cited by 476 · see citing works

The Role of Ubiquitin in NF-κB Regulatory Pathways

Skaug, B. A., Jiang, X., & Chen, Z. J. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.070907.102750 · Cited by 471 · see citing works

Motif module map reveals enforcement of aging by continual NF-κB activity

Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007) · Genes &amp; Development · doi:10.1101/gad.1588507 · Cited by 466 · see citing works

Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.

Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463 · see citing works

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

Stewart, D., Killeen, E., Naquin, R., Alam, S., & Alam, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209195200 · Cited by 463 · see citing works

The Involution of the Ageing Human Thymic Epithelium is Independent of Puberty

Steinmann, G. G., KLAUS, B. M., & Müller-Hermelink, H. K. (1985) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1985.tb01916.x · Cited by 455 · see citing works

Innate immunity and inflammation in ageing: a key for understanding age-related diseases

Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity &amp; Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453 · see citing works

A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans

Boehm, M., & Slack, F. J. (2005) · Science · doi:10.1126/science.1115596 · Cited by 449 · see citing works

The ageing immune system: is it ever too old to become young again?

Dorshkind, K., Montecino-Rodriguez, E., & Signer, R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2471 · Cited by 445 · see citing works

The immune system in extreme longevity

Sansoni, P., Vescovini, R., Fagnoni, F. F., Biasini, C., Zanni, F., Zanlari, L., Telera, A. R., Lucchini, G., Passeri, G., Monti, D., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.008 · Cited by 442 · see citing works

The molecular inflammatory process in aging

Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P. (2006) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2006.8.572 · Cited by 437 · see citing works

Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway

Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works

Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening

Oikawa, S., & Kawanishi, S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00748-6 · Cited by 435 · see citing works

B‐cell diversity decreases in old age and is correlated with poor health status

Gibson, K. L., Wu, Y., Barnett, Y., Duggan, O., Vaughan, R., Kondeatis, E., Nilsson, B., Wikby, A., Kipling, D., & Dunn‐Walters, D. K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00443.x · Cited by 433 · see citing works

Innate immunity in aging: impact on macrophage function

Plowden, J., Renshaw‐Hoelscher, M., Engleman, C., Katz, J. M., & Sambhara, S. R. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00102.x · Cited by 430 · see citing works

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

Petersen, S., Saretzki, G., & Zglinicki, T. V. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3893 · Cited by 427 · see citing works

Analyses and comparisons of telomerase activity and telomere length in human T and B cells: Insights for epidemiology of telomere maintenance

Lin, J., Epel, E., Cheon, J., Kroenke, C., Sinclair, E., Bigos, M., Wolkowitz, O., Mellon, S., & Blackburn, E. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.09.012 · Cited by 426 · see citing works

Impact of aging on DNA methylation

Richardson, B. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00010-2 · Cited by 420 · see citing works

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8+T Lymphocytes in Healthy Seropositive Donors

Gillespie, G. M. A., Wills, M. R., Appay, V., O’Callaghan, C. A., Murphy, M., Smith, N. T., Sissons, P., Rowland‐Jones, S., Bell, J. I., & Moss, P. A. H. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.8140-8150.2000 · Cited by 419 · see citing works

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

Pérez, V. I., Buffenstein, R., Masamsetti, V., Leonard, S., Salmon, A. B., Mele, J., Andziak, B., Yang, T., Edrey, Y., Friguet, B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809620106 · Cited by 418 · see citing works

Regulated expression of telomerase activity in human T lymphocyte development and activation.

Weng, N., Levine, B. L., June, C. H., & Hodes, R. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2471 · Cited by 403 · see citing works

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

Lages, C. S., Suffia, I., Velilla, P. A., Huang, B., Warshaw, G., Hildeman, D. A., Belkaid, Y., & Chougnet, C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1835 · Cited by 399 · see citing works

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

Cao, W., Manicassamy, S., Tang, H., Kasturi, S. P., Pirani, A. M., Murthy, N., & Pulendran, B. (2008) · Nature Immunology · doi:10.1038/ni.1645 · Cited by 399 · see citing works

Age-Related Alterations in the Inflammatory Response to Dermal Injury

Swift, M. E., Burns, A. L., Gray, K. L., & DiPietro, L. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01539.x · Cited by 398 · see citing works

Biology of Immune Responses to Vaccines in Elderly Persons

Weinberger, B., Herndler‐Brandstetter, D., Schwanninger, A., Weiskopf, D., & Grubeck‐Loebenstein, B. (2008) · Clinical Infectious Diseases · doi:10.1086/529197 · Cited by 392 · see citing works

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Sinclair, L. V., Finlay, D. K., Feijóo, C. G., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H., & Cantrell, D. A. (2008) · Nature Immunology · doi:10.1038/ni.1603 · Cited by 391 · see citing works

The proteasomal system

Jung, T., Catalgol, B., & Grune, T. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.001 · Cited by 389 · see citing works

Molecular mechanisms of aging-associated inflammation.

Sarkar, D., & Fisher, P. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.04.009 · Cited by 379 · see citing works

Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.

Finke, J. H., Zea, A. H., Stanley, J., Longo, D., Mizoguchi, H., Tubbs, R. R., Wiltrout, R. H., O’Shea, J. J., Kudoh, S., & Klein, E. A. (1993) · PubMed · Cited by 379 · see citing works

Altered cytokine production in the elderly

Rink, L., Cakman, I., & Kirchner, H. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00153-x · Cited by 378 · see citing works

Aging: ROS or TOR

Blagosklonny, M. V. (2008) · Cell Cycle · doi:10.4161/cc.7.21.6965 · Cited by 375 · see citing works

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregatesPreprint

Boyault, C., Zhang, Y., Fritah, S., Caron, C., Gilquin, B., Kwon, S. H., Garrido, C., Yao, T., Vourc’h, C., Matthias, P., et al. (2007) · Genes & Development · doi:10.1101/gad.436407 · Cited by 370 · see citing works

The nuclear signaling of NF-κB: current knowledge, new insights, and future perspectives

Wan, F., & Lenardo, M. J. (2009) · Cell Research · doi:10.1038/cr.2009.137 · Cited by 370 · see citing works

Generation of Functional Thymocytes in the Human Adult

Jamieson, B. D., Douek, D. C., Killian, S., Hultin, L. E., Scripture-Adams, D. D., Giorgi, J. V., Marelli, D., Koup, R. A., & Zack, J. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80056-4 · Cited by 367 · see citing works

DNA damage and ageing: new-age ideas for an age-old problem

Garinis, G. A., van der Horst, G. T. J., Vijg, J., & H.J. Hoeijmakers, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1108-1241 · Cited by 366 · see citing works

microRNAs and the immune response

Tsitsiou, E., & Lindsay, M. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.05.003 · Cited by 358 · see citing works

miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging

Hackl, M., Brunner, S. M., Fortschegger, K., Schreiner, C., Mičutková, L., Mück, C., Laschober, G. T., Lepperdinger, G., Sampson, N., Berger, P., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00549.x · Cited by 356 · see citing works

Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8+T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly Persons

Almanzar, G., Schwaiger, S., Jenewein, B., Keller, M., Herndler‐Brandstetter, D., Würzner, R., Schönitzer, D., & Grubeck‐Loebenstein, B. (2005) · Journal of Virology · doi:10.1128/jvi.79.6.3675-3683.2005 · Cited by 356 · see citing works

Age-Associated Defect in Human TLR-1/2 Function

van Duin, D., Mohanty, S., Thomas, V., Ginter, S., Montgomery, R. R., Fikrig, E., Allore, H. G., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.970 · Cited by 352 · see citing works

Proteasomes in immune cells: more than peptide producers?

Groettrup, M., Kirk, C. J., & Basler, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2687 · Cited by 345 · see citing works

The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging – A Mini-Review

Calderwood, S. K., Murshid, A., & Prince, T. L. (2009) · Gerontology · doi:10.1159/000225957 · Cited by 343 · see citing works

Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1

Nguyen, T., Sherratt, P. J., Nioi, P., Yang, C. S., & Pickett, C. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503074200 · Cited by 341 · see citing works

Inflammation markers predicting frailty and mortality in the elderly

Martinis, M. D., Franceschi, C., Monti, D., & Ginaldi, L. (2006) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.11.004 · Cited by 341 · see citing works

Immunosenescence: what does it mean to health outcomes in older adults?

McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.023 · Cited by 340 · see citing works

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

Otsuji, M., Kimura, Y., Aoe, T., Okamoto, Y., & Saito, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13119 · Cited by 338 · see citing works

Requirement for theXrcc1DNA Base Excision Repair Gene during Early Mouse Development

Tebbs, R. S., Flannery, M. L., Meneses, J. J., Hartmann, A., Tucker, J. D., Thompson, L. H., Cleaver, J. E., & Pedersen, R. A. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9232 · Cited by 337 · see citing works

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333 · see citing works

Signal transduction and functional changes in neutrophils with aging

Fülöp, T., Larbi, A., Douziech, N., Fortin, C. F., Guérard, K., Lesur, O., Khalil, A., & Dupuis, G. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00110.x · Cited by 331 · see citing works

Elevated levels of tumor necrosis factor alpha and mortality in centenarians

Bruunsgaard, H., Andersen-Ranberg, K., Hjelmborg, J. V. B., Pedersen, B. K., & Jeune, B. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00329-2 · Cited by 325 · see citing works

Thymic output in aged mice

Hale, J. S., Boursalian, T. E., Turk, G. L., & Fink, P. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601040103 · Cited by 322 · see citing works

The aging innate immune system

Gómez, C. R., Boehmer, E. D., & Kovacs, E. J. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.07.013 · Cited by 317 · see citing works

Syndromes of Telomere Shortening

Armanios, M. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082908-150046 · Cited by 317 · see citing works

Aging of the Immune System as a Prognostic Factor for Human Longevity

Larbi, A., Franceschi, C., Mazzatti, D. J., Solana, R., Wikby, A., & Pawelec, G. (2008) · Physiology · doi:10.1152/physiol.00040.2007 · Cited by 316 · see citing works

Aging and Innate Immunity

Solana, R., Pawelec, G., & Tarazona, R. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.003 · Cited by 313 · see citing works

IL‐2 gene expression and NF‐kappa B activation through CD28 requires reactive oxygen production by 5‐lipoxygenase.

Łoś, M., Schenk, H., Hexel, K., Baeuerle, P. A., Dröge, W., & Schulze‐Osthoff, K. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00043.x · Cited by 304 · see citing works

Caloric restriction in humans

Holloszy, J. O., & Fontana, L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.009 · Cited by 304 · see citing works

Efficient Cross-presentation Depends on Autophagy in Tumor Cells

Li, Y.-H., Wang, L.-X., Yang, G., Hao, F., Urba, W., & Hu, H.-M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0161 · Cited by 303 · see citing works

Calorie Restriction in Biosphere 2: Alterations in Physiologic, Hematologic, Hormonal, and Biochemical Parameters in Humans Restricted for a 2-Year Period

Walford, R. L., Mock, D., Verdery, R. B., & MacCallum, T. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.6.b211 · Cited by 302 · see citing works

The cellular response to general and programmed DNA double strand breaks

Bassing, C. H., & Alt, F. W. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.001 · Cited by 301 · see citing works

The Thymus Is a Common Target Organ in Infectious Diseases

Savino, W. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020062 · Cited by 298 · see citing works

Leukemia Inhibitory Factor, Oncostatin M, IL-6, and Stem Cell Factor mRNA Expression in Human Thymus Increases with Age and Is Associated with Thymic Atrophy

Sempowski, G. D., Hale, L. P., Sundy, J. S., Massey, J. M., Koup, R. A., Douek, D. C., Patel, D. D., & Haynes, B. F. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.2180 · Cited by 298 · see citing works

Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction

Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10203 · Cited by 297 · see citing works

An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes

Curtale, G., Citarella, F., Carissimi, C., Goldoni, M., Carucci, N., Fulci, V., Franceschini, D., Meloni, F., Barnaba, V., & Macino, G. (2009) · Blood · doi:10.1182/blood-2009-06-225987 · Cited by 297 · see citing works

Ageing-related chromatin defects through loss of the NURD complex

Pegoraro, G., Kubben, N., Wickert, U., Goehler, H., Hoffmann, K., & Misteli, T. (2009) · Nature Cell Biology · doi:10.1038/ncb1971 · Cited by 293 · see citing works

Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study

Aviv, A., Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., & Berenson, G. S. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn338 · Cited by 290 · see citing works

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

Tonoki, A., Kuranaga, E., Tomioka, T., Hamazaki, J., Murata, S., Tanaka, K., & Miura, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01227-08 · Cited by 288 · see citing works

Autophagy, organelles and ageing

Terman, A., Gustafsson, B., & Brunk, U. T. (2007) · The Journal of Pathology · doi:10.1002/path.2094 · Cited by 287 · see citing works

Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis

Palombella, V. J., Conner, E. M., Fuseler, J. W., Destree, A. T., Davis, J. M., Laroux, F. S., Wolf, R. E., Huang, J., Brand, S., Elliott, P. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15671 · Cited by 286 · see citing works

Peripheral blood dendritic cells and monocytes are differently regulated in the elderly

Bella, S. D., Bierti, L., Presicce, P., Arienti, R., Valenti, M., Saresella, M., Vergani, C., & Villa, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.09.012 · Cited by 280 · see citing works

Evidence of premature immune aging in patients thymectomized during early childhood

Sauce, D., Larsen, M., Fastenackels, S., Duperrier, A., Keller, M., Grubeck-Loebenstein, B., Ferrand, C., Debré, P., Sidi, D., & Appay, V. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39269 · Cited by 278 · cited 2× · see citing works

Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death

Li, C., Capan, E., Zhao, Y., Zhao, J., Stolz, D. B., Watkins, S. C., Jin, S., & Lu, B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5163 · Cited by 278 · see citing works

Regulation of the aging process by autophagy.

Salminen, A., & Kaarniranta, K. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.004 · Cited by 270 · see citing works

Enhancing Immunity Through Autophagy

Münz, C. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132537 · Cited by 262 · see citing works

Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.

Nagel, J. E., Chopra, R. K., Chrest, F. J., McCoy, M. T., Schneider, E. L., Holbrook, N. J., & Adler, W. H. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113422 · Cited by 259 · see citing works

Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging

Armanios, M., Alder, J. K., Parry, E. M., Karim, B., Strong, M. A., & Greider, C. W. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.10.028 · Cited by 257 · see citing works

Degradation of Promoter-bound p65/RelA Is Essential for the Prompt Termination of the Nuclear Factor κB Response

Saccani, S., Marazzi, I., Beg, A. A., & Natoli, G. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040196 · Cited by 253 · see citing works

Postsynthetic Trimethylation of Histone H4 at Lysine 20 in Mammalian Tissues Is Associated with Aging

Sarg, B., Koutzamani, E., Helliger, W., Rundquist, I., & Lindner, H. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205166200 · Cited by 252 · see citing works

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

Csiszár, A., Labinskyy, N., Jiménez, R., Pinto, J. T., Ballabh, P., Losonczy, G., Pearson, K. J., de Cabo, R., & Ungvari, Z. I. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.004 · Cited by 248 · see citing works

Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice

Haynes, L., Linton, P., Eaton, S. M., Tonkonogy, S. L., & Swain, S. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.1013 · Cited by 248 · see citing works

Aging: Central role for autophagy and the lysosomal degradative system

Rajawat, Y. S., Hilioti, Z., & Bossis, I. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.001 · Cited by 247 · see citing works

Analysis of the human thymic perivascular space during aging

Flores, K. G., Li, J., Sempowski, G. D., Haynes, B. F., & Hale, L. P. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7558 · Cited by 247 · see citing works

Role of Cytomegalovirus in the T Cell Changes Seen in Elderly Individuals

Looney, R. J., Falsey, A. R., Campbell, D., Torres, A., Kolassa, J. E., Brower, C. A., McCann, R. M., Menegus, M. A., McCormick, K., Frampton, M. W., et al. (1999) · Clinical Immunology · doi:10.1006/clim.1998.4638 · Cited by 246 · see citing works

Protein degradation and aging

Martínez‐Vicente, M., Sovak, G., & Cuervo, A. M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.07.005 · Cited by 245 · see citing works

T cell surface redox levels determine T cell reactivity and arthritis susceptibility

Gelderman, K. A., Hultqvist, M. H., Holmberg, J., Olofsson, P., & Holmdahl, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604571103 · Cited by 244 · see citing works

Effects of aging on T cell function

Haynes, L., & Maue, A. C. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.009 · Cited by 244 · see citing works

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

Pearson, K. J., Lewis, K. N., Price, N. L., Chang, J. W., Perez, E., Cascajo, M. V., Tamashiro, K. L., Poosala, S., Csiszár, A., Ungvari, Z. I., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712162105 · Cited by 238 · see citing works

Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)

Ouyang, Q., Wagner, W. M., Voehringer, D., Wikby, A., Klatt, T., Walter, S., Müller, C. A., Pircher, H., & Pawelec, G. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00134-7 · Cited by 238 · see citing works

Lymphokines and aging: interleukin-2 production and activity in aged animals.

Thoman, M. L., & Weigle, W. O. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.5.2102 · Cited by 232 · see citing works

Effect of voluntary exercise on longevity of rats

Holloszy, J. O., Smith, E. K., Vining, M., & Adams, S. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.3.826 · Cited by 231 · see citing works

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates

Messaoudi, I., Warner, J., Fischer, M. B., Park, B., Hill, B. J., Mattison, J. A., Lane, M. A., Roth, G. S., Ingram, D. K., Picker, L. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606661103 · Cited by 225 · see citing works

Cytokines, leptin, and stress‐induced thymic atrophy

Gruver, A. L., & Sempowski, G. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108025 · Cited by 225 · see citing works

Overexpression of Proteasome β5 Assembled Subunit Increases the Amount of Proteasome and Confers Ameliorated Response to Oxidative Stress and Higher Survival Rates

Chondrogianni, N., Tzavelas, C., Pemberton, A. J., Nezis, I. P., Rivett, A. J., & Gonos, E. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413007200 · Cited by 224 · see citing works

The loss of telomerase activity in highly differentiated CD8+CD28−CD27− T cells is associated with decreased Akt (Ser473) phosphorylation

Plunkett, F. J., Franzese, O., Finney, H. M., Fletcher, J. M., Belaramani, L. L., Salmon, M., Dokal, I., Webster, D., Lawson, A. D. G., & Akbar, A. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7710 · Cited by 222 · see citing works

Inhibition of NF-κB and Oxidative Pathways in Human Dendritic Cells by Antioxidative Vitamins Generates Regulatory T Cells

Tan, P., Sagoo, P., Chan, C. C. W., Yates, J., Campbell, J., Beutelspacher, S. C., Foxwell, B. M. J., Lombardi, G., & George, A. J. T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7633 · Cited by 220 · see citing works

CD4+CD25+Foxp3+ T Cells and CD4+CD25−Foxp3+ T Cells in Aged Mice

Nishioka, T., Shimizu, J., Iida, R., Yamazaki, S., & Sakaguchi, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6586 · Cited by 220 · see citing works

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration.

Alpdogan, O., Hubbard, V. M., Smith, O. M., Patel, N., Lu, S., Goldberg, G. L., Gray, D. H., Feinman, J., Kochman, A. A., Eng, J. M., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2831 · Cited by 220 · see citing works

Neutrophil ageing and immunesenescence

Lord, J. M., Butcher, S. K., Killampalli, V. V., Lascelles, D., & Salmon, M. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00285-8 · Cited by 218 · see citing works

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

Rossi, S. W., Jeker, L. T., Ueno, T., Kuse, S., Keller, M. P., Zuklys, S., Gudkov, A. V., Takahama, Y., Krenger, W., Blazar, B. R., et al. (2007) · Blood · doi:10.1182/blood-2006-10-049767 · Cited by 215 · see citing works

The 26 S Proteasome: From Basic Mechanisms to Drug Targeting

Navon, A., & Ciechanover, A. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.018481 · Cited by 214 · see citing works

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

Min, D., Panoskaltsis-Mortari, A., Kuro-o, M., Holländer, G. A., Blazar, B. R., & Weinberg, K. I. (2007) · Blood · doi:10.1182/blood-2006-08-043794 · Cited by 214 · see citing works

Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age

Kiffin, R., Kaushik, S., Zeng, M., Bandyopadhyay, U., Zhang, C., Massey, A. C., Martinez-Vicente, M., & Cuervo, A. M. (2007) · Journal of Cell Science · doi:10.1242/jcs.001073 · Cited by 213 · see citing works

Redox Signals and NF-κB Activation in T Cells

Ginn‐Pease, M. E., & Whisler, R. L. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00067-7 · Cited by 206 · see citing works

T cell receptor excision circle assessment of thymopoiesis in aging mice

Sempowski, G. D., Gooding, M. E., Liao, H. X., Le, P. T., & Haynes, B. F. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(01)00122-5 · Cited by 206 · see citing works

Immunosenescence: molecular mechanisms and diseases

Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,023 · see citing works

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works

Immunosenescence: a key player in cancer development

Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works

Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Bajaj, V., Gadi, N., Spihlman, A. P., Wu, S. C., Choi, C. H., & Moulton, V. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.571416 · Cited by 476 · see citing works

Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept

Chung, H. Y., Kim, D. H., Lee, E. K., Chung, K. W., Chung, S., Lee, B., Seo, A. Y., Chung, J. H., Jung, Y. S., Im, E., et al. (2018) · Aging and Disease · doi:10.14336/ad.2018.0324 · Cited by 495 · see citing works

Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

Puzianowska-Kuźnicka, M., Owczarz, M., Wieczorowska-Tobis, K., Nadrowski, P., Chudek, J., Slusarczyk, P., Skalska, A., Jonas, M., Franek, E., & Mossakowska, M. (2016) · Immunity &amp; Ageing · doi:10.1186/s12979-016-0076-x · Cited by 445 · see citing works

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

Fisicaro, P., Barili, V., Montanini, B., Acerbi, G., Ferracin, M., Guerrieri, F., Salerno, D., Boni, C., Massari, M., Cavallo, M. C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4275 · Cited by 344 · see citing works

Aging, melatonin, and the pro- and anti-inflammatory networks

Hardeland, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051223 · Cited by 337 · see citing works

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

Santa‐María, C., López-Enríquez, S., la Paz, S. M., Geniz, I., Reyes-Quiróz, M. E., Santamaría, M. M., Palomares, F., Sobrino, F., & Álba, G. (2023) · Nutrients · doi:10.3390/nu15010224 · Cited by 324 · see citing works

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

Meftahi, G. H., Jangravi, Z., Sahraei, H., & Bahari, Z. (2020) · Inflammation Research · doi:10.1007/s00011-020-01372-8 · Cited by 289 · see citing works

Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

Hardeland, R. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12090 · Cited by 285 · see citing works

Human T cell immunosenescence and inflammation in aging

Bektas, A., Schurman, S. H., Sen, R., & Ferrucci, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0716-335r · Cited by 270 · see citing works

Blood Epigenetic Age may Predict Cancer Incidence and Mortality

Zheng, Y., Joyce, B. T., Colicino, E., Liu, L., Zhang, W., Dai, Q., Shrubsole, M. J., Kibbe, W. A., Gao, T., Zhang, Z., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.008 · Cited by 219 · see citing works

Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection

Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 189 · see citing works

Melatonin and brain inflammaging

Hardeland, R., Cardinali, D. P., Brown, G. M., & Pandi-Perumal, S. R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.02.001 · Cited by 186 · see citing works

From hepatitis A to E: A critical review of viral hepatitis

Castañeda, D., Gonzalez, A. J., Alomari, M., Tandon, K. S., & Zervos, X. B. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i16.1691 · Cited by 179 · see citing works

Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis

Han, Z., Wang, K., Ding, S., & Zhang, M. (2024) · Bone Research · doi:10.1038/s41413-024-00375-z · Cited by 189 · see citing works

Natural Killer Cell Dysfunction and Its Role in COVID-19

van Eeden, C., Khan, L., Osman, M. S., & Tervaert, J. W. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176351 · Cited by 172 · see citing works

Resveratrol-enriched rice attenuates UVB-ROS-induced skin aging via downregulation of inflammatory cascades

Subedi, L., Lee, T. H., Wahedi, H. M., Baek, S.-H., & Kim, S. Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8379539 · Cited by 174 · see citing works

Bullous Pemphigoid: Trigger and Predisposing Factors

Moro, F., Fania, L., Sinagra, J. L., Salemme, A., & Zenzo, G. D. (2020) · Biomolecules · doi:10.3390/biom10101432 · Cited by 179 · see citing works

Physical Activity and Nutritional Influence on Immune Function: An Important Strategy to Improve Immunity and Health Status

Shao, T., Verma, H. K., Pande, B., Costanzo, V., Ye, W., Cai, Y., & Bhaskar, L. V. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.751374 · Cited by 170 · see citing works

T cell ageing: effects of age on development, survival & function.

Salam, N., Rane, S., Das, R., Faulkner, M. F., Gund, R., Kandpal, U., Lewis, V., Mattoo, H., Prabhu, S. B., Ranganathan, V., et al. (2013) · Europe PMC (PubMed Central) · Cited by 138 · see citing works

Autoimmunity in the Elderly: Insights from Basic Science and Clinics - A Mini-Review

Watad, ‬., Bragazzi, N. L., Adawi, M., Amital, H., Toubi, E., Katz, B.-S. P., & Shoenfeld, Y. (2017) · Gerontology · doi:10.1159/000478012 · Cited by 137 · see citing works

Implication of ferroptosis in aging

Mazhar, M., Din, A. U., Ali, H., Yang, G., Ren, W., Wang, L., Fan, X., & Yang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00553-6 · Cited by 133 · see citing works

The Role of Immunosenescence in Neurodegenerative Diseases

Costantini, E., D’Angelo, C., & Reale, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/6039171 · Cited by 133 · see citing works

Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies

Cardinali, D. P., & Hardeland, R. (2016) · Neuroendocrinology · doi:10.1159/000446543 · Cited by 131 · see citing works

The role of melatonin, a multitasking molecule, in retarding the processes of ageing

Majidinia, M., Reiter, R. J., Shakouri, S. K., & Yousefi, B. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.010 · Cited by 123 · see citing works

Late-onset asthma: current perspectives

Hirano, T., & Matsunaga, K. (2018) · Journal of Asthma and Allergy · doi:10.2147/jaa.s125948 · Cited by 105 · see citing works

Merkel Cell Carcinoma in Immunosuppressed Patients

Ma, J., & Brewer, J. D. (2014) · Cancers · doi:10.3390/cancers6031328 · Cited by 102 · see citing works

Age and the risks of high-efficacy disease modifying drugs in multiple sclerosis

Schweitzer, F., Laurent, S. A., Fink, G. R., Barnett, M. H., Reddel, S., Hartung, H., & Warnke, C. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000701 · Cited by 100 · see citing works

The Confounders of Cancer Immunotherapy: Roles of Lifestyle, Metabolic Disorders and Sociological Factors

Deshpande, R. P., Sharma, S., & Watabe, K. (2020) · Cancers · doi:10.3390/cancers12102983 · Cited by 101 · see citing works

The Relationship between Reactive Oxygen Species and the cGAS/STING Signaling Pathway in the Inflammaging Process

Andrade, B., Jara‐Gutiérrez, C., Paz-Araos, M., Vázquez, M. C., Díaz, P., & Murgas, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315182 · Cited by 92 · see citing works

Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis

Opitz, E., Koch, A., Klingel, K., Schmidt, F., Prokop, S., Rahnefeld, A., Sauter, M., Heppner, F. L., Völker, U., Kandolf, R., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002233 · Cited by 90 · see citing works

Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging

Ariffin, H., Azanan, M. S., Abd Ghafar, S. S., Oh, L., Lau, K. H., Thirunavakarasu, T., Sedan, A., Ibrahim, K., Chan, A., Chin, T. F., et al. (2017) · Cancer · doi:10.1002/cncr.30857 · Cited by 99 · see citing works

Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients

Jordan, A., Yang, J., Fisher, C., Racke, M. K., & Mao‐Draayer, Y. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458520949158 · Cited by 86 · see citing works

Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction

Halade, G. V., Kain, V., Black, L. M., Prabhu, S. D., & Ingle, K. A. (2016) · Aging · doi:10.18632/aging.101077 · Cited by 83 · see citing works

Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice

Menees, K. B., Earls, R. H., Chung, J., Jernigan, J. E., Filipov, N. M., Carpenter, J. M., & Lee, J. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00214-3 · Cited by 85 · see citing works

CCL19 as a Chemokine Risk Factor for Posttreatment Lyme Disease Syndrome: a Prospective Clinical Cohort Study

Aucott, J. N., Soloski, M. J., Rebman, A. W., Crowder, L. A., Lahey, L. J., Wagner, C. A., Robinson, W. H., & Bechtold, K. T. (2016) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00071-16 · Cited by 83 · see citing works

Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases

Sonninen, T.-M., Goldsteins, G., Laham-Karam, N., Koıstınaho, J., & Lehtonen, Š. (2020) · Cells · doi:10.3390/cells9102183 · Cited by 84 · see citing works

Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

Barbouti, A., Vasileiou, P. V. S., Evangelou, K., Vlasis, K. G., Papoudou‐Bai, A., Gorgoulis, V. G., & Kanavaros, P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7986071 · Cited by 83 · see citing works

Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives

Pinto, R. D., & Ferri, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123701 · Cited by 75 · see citing works

Comprehensive assessment of cellular senescence in the tumor microenvironment

Wang, X., Ma, L., Pei, X., Wang, H., Tang, X., Pei, J.-F., Ding, Y.-N., Qu, S., Wei, Z.-Y., Wang, H.-Y., et al. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac118 · Cited by 76 · see citing works

The influence of the microbiota on immune development, chronic inflammation, and cancer in the context of aging

Tibbs, T., Lopez, L. R., & Arthur, J. C. (2019) · Microbial Cell · doi:10.15698/mic2019.08.685 · Cited by 70 · see citing works

Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophi:lymphocyte ratio, leading to inflamed milieu in acute heart failure

Kain, V., Pol, W. V. D., Mariappan, N., Ahmad, A. M., Eipers, P. G., Gibson, D. L., Gladine, C., Vigor, C., Durand, T., Morrow, C. D., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802477r · Cited by 68 · see citing works

Inflammatory biomarkers of frailty: A review

Zhang, L., Zeng, X., He, F., & Huang, X. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112253 · Cited by 67 · see citing works

Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF

Rotondo, J. C., Bononi, I., Puozzo, A., Govoni, M., Foschi, V., Lanza, G., Gafà, R., Gaboriaud, P., Touzé, A., Selvatici, R., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2899 · Cited by 66 · see citing works

Reactive Oxygen Species in Skin Repair, Regeneration, Aging, and Inflammation

Xu, H., Zheng, Y., Liu, Q., Liu, L., Luo, F.-L., Zhou, H.-C., Isoda, H., Ohkohchi, N., & Li, Y.-M. (2018) · InTech eBooks · doi:10.5772/intechopen.72747 · Cited by 65 · see citing works

Immunosenescence, Aging, and Systemic Lupus Erythematous

Montoya-Ortiz, G. (2013) · Autoimmune Diseases · doi:10.1155/2013/267078 · Cited by 65 · see citing works

Glutathione and glutathione derivatives in immunotherapy

Fraternale, A., Brundu, S., & Magnani, M. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0202 · Cited by 64 · see citing works

T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis

Chen, G., Lustig, A., & Weng, N. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00121 · Cited by 60 · see citing works

IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19

Luporini, R. L., Rodolpho, J. M. D. A., Kubota, L. T., Martin, A. C. B. M., Cominetti, M. R., Aníbal, F. D. F., & Pott, H. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155507 · Cited by 59 · see citing works

Outbreak of SARS-CoV2: Pathogenesis of infection and cardiovascular involvement

Amirfakhryan, H., & Safari, F. (2020) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2020.05.007 · Cited by 57 · see citing works

Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination

Li, W., Zhang, Z., Kumar, S., Botey-Bataller, J., Zoodsma, M., Ehsani, A., Zhan, Q., Alaswad, A., Zhou, L., Grondman, I., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00819-z · Cited by 66 · see citing works

CNS Ageing in Health and Neurodegenerative Disorders

Kesidou, E., Theotokis, P., Damianidou, O., Boziki, M. K., Konstantinidou, N., Taloumtzis, C., Sintila, S.-A., Grigoriadis, P., Evangelopoulos, M., Bakirtzis, C., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062255 · Cited by 57 · see citing works

Aging and chronic kidney disease: epidemiology, therapy, management and the role of immunity

Tang, Y., Jiang, J., Zhao, Y., & Du, D. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae235 · Cited by 65 · see citing works

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity

Amoah, A., Keller, A., Emini, R., Hoenicka, M., Liebold, A., Vollmer, A., Eiwen, K., Soller, K., Sakk, V., Zheng, Y., et al. (2021) · Haematologica · doi:10.3324/haematol.2020.269670 · Cited by 56 · see citing works

miR-34a and miR-9 are overexpressed and SIRT genes are downregulated in peripheral blood mononuclear cells of aging humans

Owczarz, M., Budzińska, M., Domaszewska-Szostek, A., Borkowska, J., Połosak, J., Gewartowska, M., Ślusarczyk, P., & Puzianowska‐Kuźnicka, M. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217720884 · Cited by 54 · see citing works

An immunologist’s guide to immunosenescence and its treatment

Caruso, C., Ligotti, M. E., Accardi, G., Aiello, A., & Candore, G. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2106217 · Cited by 53 · see citing works

Viral Hepatitis in the Elderly

Carrion, A. F., & Martin, P. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.7 · Cited by 53 · see citing works

The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity

Petrone, A. B., O’Connell, G. C., Regier, M., Chantler, P. D., Simpkins, J. W., & Barr, T. L. (2015) · Translational Stroke Research · doi:10.1007/s12975-015-0431-9 · Cited by 52 · see citing works

Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus

Malloy, A. M. W., Falsey, A. R., & Ruckwardt, T. J. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-38919-1_11 · Cited by 51 · see citing works

Clinical predictors of descending necrotizing mediastinitis after deep neck infections

Kimura, A., Miyamoto, S., & Yamashita, T. (2019) · The Laryngoscope · doi:10.1002/lary.28406 · Cited by 51 · see citing works

T-cell regulation of fibroblasts and cardiac fibrosis

Bradshaw, A. D., & DeLeon‐Pennell, K. Y. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.04.001 · Cited by 51 · see citing works

Effects of exogenous vitamins A, C, and E and NADH supplementation on proliferation, cytokines release, and cell redox status of lymphocytes from healthy aged subjects

Bouamama, S., Merzouk, H., Medjdoub, A., Merzouk, A. S., & Merzouk, S. A. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0201 · Cited by 48 · see citing works

Immune surveillance of senescence: potential application to age-related diseases

Wang, T., & Nakanishi, M. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.06.007 · Cited by 47 · see citing works

Understanding respiratory syncytial virus (RSV) vaccine development and aspects of disease pathogenesis

Jorquera, P. A., Anderson, L. J., & Tripp, R. A. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2016.1115353 · Cited by 45 · see citing works

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

Barbouti, A., Evangelou, K., Pateras, I. S., Papoudou-Bai, A., Patereli, A., Stefanaki, K., Rontogianni, D., Muñoz-Espín, D., Kanavaros, P., & Gorgoulis, V. G. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.02.005 · Cited by 44 · see citing works

Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques

Okoye, A. A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A. W., Sammader, P., Legasse, A. W., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500609 · Cited by 44 · see citing works

Inflammaging, immunosenescence, and cardiovascular aging: insights into long COVID implications

Müller, L., & Benedetto, S. D. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1384996 · Cited by 43 · see citing works

Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients

Liao, M.-T., Wu, C., Wu, S. V., Lee, M., Hu, W., Tsai, K., Yang, C., Lu, C., Chiu, S.-K., & Lu, K. (2021) · Antioxidants · doi:10.3390/antiox10091440 · Cited by 43 · see citing works

Immunosenescence and Aging: Neuroinflammation Is a Prominent Feature of Alzheimer’s Disease and Is a Likely Contributor to Neurodegenerative Disease Pathogenesis

Bowirrat, A. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12111817 · Cited by 45 · see citing works

Persistence of immune responses to the HPV ‐16/18 AS 04‐adjuvanted vaccine in women aged 15–55 years and first‐time modelling of antibody responses in mature women: results from an open‐label 6–year follow‐up study

Schwarz, T. F., Spaczyński, M., Kaufmann, A. M., Wysocki, J., Gałaj, A., Schulze, K., Suryakiran, P. V., Thomas, F., & Descamps, D. (2014) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13070 · Cited by 42 · see citing works

Mechanisms of skin aging

de Antioquia, U., Mesa-Arango, A., Flórez-Muñoz, S., de Antioquia, U., Sanclemente, G., & de Antioquia, U. (2017) · IATREIA · doi:10.17533/udea.iatreia.v30n2a05 · Cited by 41 · see citing works

Evidence of immunomodulatory effects of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486

You, J., & Yaqoob, P. (2012) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2012.01014.x · Cited by 41 · see citing works

The diseased kidney: aging and senescent immunology

Chi, M., Tian, Z., Ma, K., Li, Y., Wang, L., Nasser, M. I., & Liu, C. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00313-9 · Cited by 41 · see citing works

Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells

Løhr, M., Jensen, A., Eriksen, L., Grønbæk, M., Loft, S. H., & Möller, P. (2014) · Oncotarget · doi:10.18632/oncotarget.3202 · Cited by 40 · see citing works

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation

Weiland, D., Brachvogel, B., Hornig‐Do, H., Neuhaus, J., Holzer, T., Tobin, D. J., Niessen, C. M., Wiesner, R. J., & Baris, O. R. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.08.019 · Cited by 39 · see citing works

Aging Immune System and Its Correlation With Liability to Severe Lung Complications

Li, Y., Wang, C., & Peng, M. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.735151 · Cited by 40 · see citing works

Telomerase deficiency reflects age-associated changes in CD4+ T cells

Matthe, D. M., Thoma, O., Sperka, T., Neurath, M. F., & Waldner, M. J. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00273-0 · Cited by 38 · see citing works

Structural and Functional Changes in Aged Skin Lymphatic Vessels

Kataru, R. P., Park, H. J., Shin, J., Baik, J. E., Sarker, A., Brown, S., & Mehrara, B. J. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.864860 · Cited by 39 · see citing works

Challenges for the human immune system after leaving Earth

Marchal, S., Choukèr, A., Bereiter‐Hahn, J., Kraus, A., Grimm, D. G., & Krüger, M. (2024) · npj Microgravity · doi:10.1038/s41526-024-00446-9 · Cited by 41 · see citing works

Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain

Bonanno, M., Papa, D., Cerasa, A., Maggio, M. G., & Calabrò, R. S. (2024) · Medicina · doi:10.3390/medicina60020285 · Cited by 40 · see citing works

Interleukin‐37 improves T‐cell‐mediated immunity and chimeric antigen receptor T‐cell therapy in aged backgrounds

Hamilton, J. A. G., Lee, M., Hunter, R., Ank, R. S., Story, J. Y., Talekar, G. R., Sisroe, T., Ballak, D. B., Fedanov, A., Porter, C. C., et al. (2021) · Aging Cell · doi:10.1111/acel.13309 · Cited by 36 · see citing works

Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing

Rezzani, R., Franco, C., Hardeland, R., & Rodella, L. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228806 · Cited by 37 · see citing works

Sirtuins, aging, and cardiovascular risks

Favero, G., Franceschetti, L., Rodella, L. F., & Rezzani, R. (2015) · AGE · doi:10.1007/s11357-015-9804-y · Cited by 36 · see citing works

miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans

Budzińska, M., Owczarz, M., Pawlik-Pachucka, E., Roszkowska-Gancarz, M., Ślusarczyk, P., & Puzianowska‐Kuźnicka, M. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0379-y · Cited by 35 · see citing works

The Aging of γδ T Cells

Xu, W., Lau, Z. W. X., Fülöp, T., & Larbi, A. (2020) · Cells · doi:10.3390/cells9051181 · Cited by 35 · see citing works

Designing the Next Generation of Vaccines: Relevance for Future Pandemics

Domínguez‐Andrés, J., van Crevel, R., Divangahi, M., & Netea, M. G. (2020) · mBio · doi:10.1128/mbio.02616-20 · Cited by 36 · see citing works

Continued root maturation despite persistent apical periodontitis of immature permanent teeth after failed regenerative endodontic therapy

Lin, L. M., Kim, S. G., Martín, G., & Kahler, B. (2018) · Australian Endodontic Journal · doi:10.1111/aej.12252 · Cited by 34 · see citing works

Updates on Old and Weary Haematopoiesis

Konieczny, J., & Arranz, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092567 · Cited by 33 · see citing works

Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes

Ravikrishnan, A., Wijaya, I., Png, E., Chng, K. R., Ho, E. X. P., Ng, A. H. Q., Naim, A. N. M., Gounot, J.-S., Guan, S. P., Lee, J. H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52097-9 · Cited by 39 · see citing works

Art therapy and music reminiscence activity in the prevention of cognitive decline: study protocol for a randomized controlled trial

Mahendran, R., Rawtaer, I., Fam, J., Wong, J., Kumar, A. P., Gandhi, M., Jing, K. X., Feng, L., & Kua, E. H. (2017) · Trials · doi:10.1186/s13063-017-2080-7 · Cited by 33 · see citing works

Altered regulation of CXCR4 expression during aging contributes to increased CXCL12‐dependent chemotactic migration of CD4+ T cells

Canè, S., Ponnappan, S., & Ponnappan, U. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00830.x · Cited by 32 · see citing works

Melatonin as a promising modulator of aging related neurodegenerative disorders: Role of microRNAs

Fathalizadeh, A., Rahnemayan, S., Rajabi, H., Vahed, N., Kashani, H. R. K., Rezabakhsh, A., & Sanaie, S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105839 · Cited by 33 · see citing works

Accelerated immune aging was correlated with lupus‐associated brain fog in reproductive‐age systemic lupus erythematosus patients

Kalim, H., Pratama, M. Z., Mahardini, E., Winoto, E. S., Krisna, P. A., & Handono, K. (2020) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13816 · Cited by 31 · see citing works

Down syndrome: is it really characterized by precocious immunosenescence?

Kusters, M., Verstegen, R. H. J., & de Vries, E. (2011) · Europe PMC (PubMed Central) · Cited by 30 · see citing works

Gut microbiome, Vitamin D, ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection

Shenoy, S. (2021) · Inflammation Research · doi:10.1007/s00011-021-01510-w · Cited by 31 · see citing works

Growth hormone-mediated reprogramming of macrophage transcriptome and effector functions

Schneider, A., Wood, H. N., Geden, S. E., Greene, C. J., Yates, R. M., Masternak, M. M., & Rohde, K. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-56017-6 · Cited by 29 · see citing works

Overview of Epstein–Barr-Virus-Associated Gastric Cancer Correlated with Prognostic Classification and Development of Therapeutic Options

Re, V. D., Brisotto, G., Repetto, O., Zorzi, M. D., Caggiari, L., Zanussi, S., Alessandrini, L., Canzonieri, V., Miolo, G., Puglisi, F., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249400 · Cited by 27 · see citing works

An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly

Bell, M. R., & Kutzler, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114175 · Cited by 29 · see citing works

Immune system modulation in aging: Molecular mechanisms and therapeutic targets

Cisneros, B., García‐Aguirre, I., Unzueta, J., Arrieta‐Cruz, I., González-Morales, O., Domínguez-Larrieta, J. M., Tamez-González, A., Leyva‐Gómez, G., & Magaña, J. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1059173 · Cited by 88 · see citing works

The ageing immune system as a driver of systemic ageing

Jang, I. H., Niedernhofer, L. J., Robbins, P. D., & Camell, C. D. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01269-3 · Cited by 33 · see citing works

Immunosenescence and the Geriatric Giants: Molecular Insights into Aging and Healthspan

Fetarayani, D., Kahdina, M., Waitupu, A., Pratiwi, L., Ningtyas, M. C., Adytia, G. J., & Sutanto, H. (2025) · Medical Sciences · doi:10.3390/medsci13030100 · Cited by 14 · see citing works

Role of the immune system in aging

la Fuente, M. D. (2008) · Inmunología · doi:10.1016/s0213-9626(08)70066-0 · Cited by 12 · see citing works

Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases

Upadhyay, P., Suhail, A., Khanal, P., & Kumar, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1637191 · Cited by 24 · see citing works