Effects of aging on B cell function

Germinal centres: role in B-cell physiology and malignancy

Klein, U., & Dalla‐Favera, R. (2007) · Nature reviews. Immunology · doi:10.1038/nri2217 · Cited by 899

Lifetime of plasma cells in the bone marrow

Manz, R. A., Thiel, A., & Radbruch, A. (1997) · Nature · doi:10.1038/40540 · Cited by 866

The regulation of IgA class switching

Cerutti, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2322 · Cited by 777

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

Ahmad‐Nejad, P., Häcker, H., Rutz, M., Bauer, S., Vabulas, R. M., & Wagner, H. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200207)32:7 · Cited by 728

Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

Rada, C. A., Williams, G. T., Nilsen, H. L., Barnes, D. E., Lindahl, T. L., & Neuberger, M. S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01215-0 · Cited by 712

B-cell responses to vaccination at the extremes of age

Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659

The immunology of exceptional individuals: the lesson of centenarians

Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535

MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

Teng, G., Hakimpour, P., Landgraf, P., Rice, A., Tuschl, T., Casellas, R. C., & Papavasiliou, F. N. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.015 · Cited by 457

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

Dorsett, Y., McBride, K. M., Janković, M., Gazumyan, A., Thai, T., Robbiani, D. F., Virgilio, M. D., Reina‐San‐Martin, B., Heidkamp, G. F., Schwickert, T. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.002 · Cited by 456

B‐cell diversity decreases in old age and is correlated with poor health status

Gibson, K. L., Wu, Y., Barnett, Y., Duggan, O., Vaughan, R., Kondeatis, E., Nilsson, B., Wikby, A., Kipling, D., & Dunn‐Walters, D. K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00443.x · Cited by 433

Immunosuppression strategies in elderly renal transplant recipients

Camilleri, B., Pararajasingam, R., Buttigieg, J., & Halawa, A. M. (2020) · Transplantation Reviews · doi:10.1016/j.trre.2020.100529 · Cited by 5

Immunosenescence, Inflammaging, and Their Implications for Cancer and Anemia

Paudel, S., Sharma, P., & Puri, N. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_14 · Cited by 6

Young age at diagnosis is associated with better prognosis in stage IV breast cancer

Liu, W., Xiong, X., Mo, Y., Chen, W., Li, M., Liang, R., Zhang, Z.-B., & Zhang, Z. (2019) · Aging · doi:10.18632/aging.102536 · Cited by 5

Nutraceuticals in immunosenescence

Magrone, T., & Jirillo, E. (2015) · Anti‐ageing nutrients · doi:10.1002/9781118823408.ch5 · Cited by 4

Aging and vaccines: impact of immunosenescence and inflammaging in vaccine response

Albaloshi, J., Alnakhli, A., & Cham, L. B. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1797166 · Cited by 4

Human B Cell Senescence in Pulmonary Infections

Blomberg, B. B. (2012) · Open Longevity Science · doi:10.2174/1876326x01206010047 · Cited by 3

The relationship between premature ageing and immune responses in the oral cavity of Down syndrome

Tanaka, Y., Abiko, Y., & Mega, J. (2009) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2009.10.002 · Cited by 3

Over-distension of the airways by mechanical ventilation in the elderly: adding insult to injury

Pop-Vicas, A. E., & Opal, S. M. (2013) · Critical Care · doi:10.1186/cc12754 · Cited by 3

Femoral fracture leads to moderate pulmonary organ damage in aged mice and induces immune alterations

Bülow, J. M., Rinderknecht, H., Wagner, A., Haffner‐Luntzer, M., Bundkirchen, K., Neunaber, C., Relja, B., & Becker, N. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1763857 · Cited by 2

Integrative analysis of the mouse cecal microbiome across diet, age, and weight in the diverse BXD population

Zhou, Z., Lamanna, A., Halder, R., Pansart, E., Narayanasamy, S., Boussoufa, B., Kerkour, T., Wilmes, P., & Williams, E. G. (2026) · Microbiome · doi:10.1186/s40168-026-02369-x · Cited by 2

Epidemiological investigation of emergency infusion adverse drug reactions in Nanjing, China: a prospective cross-sectional study

Cao, Y., Hao, W., Wu, Y., Qiao, J., Xie, M., Jin, H., Zhang, J., Sun, G., & Sun, H. (2023) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2023.2223945 · Cited by 2

The interplay between aging and inflammation and its role in chronic disease development

Guan, J. (2024) · Theoretical and Natural Science · doi:10.54254/2753-8818/48/2024pj0121 · Cited by 2

Immune accentuations as a prognostic factor for adaptation in Antarctic conditions

Dubrovskyi, I., Zabara, D., Anoshko, Y., Kozeretska, I. A., Deyneka, I., Khytryi, A., Matkovskyi, V., Martynenko, D., & Dons’koi, B. V. (2025) · Polar Biology · doi:10.1007/s00300-025-03359-9 · Cited by 2

Identification of Donor–recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study

Choisy, C., Foucher, Y., Masset, C., Maanaoui, M., Lenain, R., Rostaing, L. P. E., Jouvé, T., Quintrec, M. L., Serre, J., Morélon, E., et al. (2025) · Transplantation · doi:10.1097/tp.0000000000005464 · Cited by 2

Aging and Quantitative Amounts of Immunoglobulin G and its Subclasses in Patients with Chronic Rhinosinusitis

Hashemi, S. A., & Madani, S. A. (2013) · Research in Endocrinology · doi:10.5171/2013.401901 · Cited by 1

Bone Marrow Hematopoietic Niches

Wu, J. Y., & Kronenberg, H. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00007-4 · Cited by 2

Characteristics of B Cells and B Cell Responses in Aged Individuals

Mei, H. E., & Radbruch, A. (2011) · Springer eBooks · doi:10.1007/978-3-0346-0219-8_4 · Cited by 2

When wrinkles appear on the immune system can it be reversed?

Sibaii, H., El-Zayat, S. R., & Khalil, M. (2020) · European Cytokine Network · doi:10.1684/ecn.2020.0441 · Cited by 4

Analysis of immune cell remodeling and functional alterations induced by aging and obesity in mice

Sim, H. B., Choi, Y.-J., Mun, S., Ramos, S., Park, D.-H., Lee, J.-B., Jeong, S., & Kim, J.-J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115735 · Cited by 1

Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics

Bartolucci, M., Utyro, O., Muraglia, A., Repetto, A., Agostini, V. W., Pizzonia, M., Ottaviani, S., Tripodi, G., Filaci, G., Cancedda, R., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1695213 · Cited by 1

Progeroid syndromes: models for stem cell aging?

Bellantuono, I., Sanguinetti, G., & Keith, W. N. (2011) · Biogerontology · doi:10.1007/s10522-011-9347-2 · Cited by 1

Immune aging and pulmonary diseases

Guo, L., Xu, Y., Liu, X., Yang, Y. P., Xu, Z. Z., & Bai, L. (2023) · Clinical eHealth · doi:10.1016/j.ceh.2023.06.001 · Cited by 1

Immunogenicity of the 23-valent polysaccharide pneumococcal vaccine in children with steroid sensitive nephrotic syndrome

Ulu, E., & Çalışkan, S. (2025) · Pediatric Nephrology · doi:10.1007/s00467-025-07026-3 · Cited by 1

Indoxyl Sulfate Alters the Humoral Response of the ChAdOx1 COVID-19 Vaccine in Hemodialysis Patients

Hou, Y., Wu, C., Lu, K., & Kuo, K. (2022) · Vaccines · doi:10.3390/vaccines10091378 · Cited by 1

Combination nanoadjuvant-based vaccine against influenza virus for older adults

Senapati, S. (2020) · doi:10.31274/etd-20210114-134 · Cited by 1

The Aging Lymphocyte

Valenzuela, H., & Effros, R. B. (2012) · Springer eBooks · doi:10.1007/978-1-4471-4174-7_2

Promoting Thymopoiesis with Age: Potential Role of the Transcription Factor Foxn1

Zook, E. C. (2012) · Loyola eCommons (Loyola University of Chicago)

Influence of Stress and Cytokinic Profiles on Cognitive Performance in Older Adults

Rawson, K. S. (2012) · Digital Commons - University of South Florida (University of South Florida)

Senescence of Adaptive Immunity: Key Points for the General Physician

Lee, F. J., & Katelaris, C. H. (2010) · Aging Health · doi:10.2217/ahe.10.33

New Cells in Old Mice: The ABCs of Humoral Immunosenescence

Hao, Y. (2012) · Open Longevity Science · doi:10.2174/1876326x01206010112

Effects of Aging on B Cells

Nicknam, M. H., & Rezaiemanesh, A. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_14

Using TIRF microscopy to analyze stimulated and basal state B-cell MHC II clustering in response to ageing and dietary fish oil

Melton, M. (2013) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)

AID in Aging and in Autoimmune Disease

Diaz, M., Frasca, D., & Blomberg, B. B. (2010) · Modecular medicine and medicinal · doi:10.1142/9781848165939_0009

Aging of Immune System Organs

Parker, G. A. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-47377-2_5

The Immunosenescence of �? & ?� T cells in human blood and skin

Xu, W. (2019) · doi:10.32657/10220/47613

Kidney Transplant in Elderly

Petraglia, L., & Heldal, K. (2019) · Springer eBooks · doi:10.1007/978-3-030-18711-8_13

Association of B cell profile and receptor repertoire with the progression of Alzheimer’s diseasePreprint

Mook‐Jung, I., Park, J., Noh, J., Jang, S. S., Kim, K. H., Choi, H., Lee, D., Chung, J., Lee, D. Y., Lee, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-312269/v1

Ageing and vaccination in transplant patients

Wang, L. (2021) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.160954435

Machine learning in the context of better healthcare in aging

Henriques, J. M. O., Ribeiro, C., Rocha, T., Paredes, S., Carvalho, P., Duarte, A. I., Freitas, A. A., Cunha‐Oliveira, T., & Pereira, F. B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00015-x

Overview of S-RBD Antibody Levels After Covid-19 Vaccination in Premenopausal and Menopausal Women

Saimin, J., Irawaty, I., Purnamasari, N. I., Purnamasari, Y., & Mulyawati, S. A. (2023) · Indonesian Journal of Obstetrics and Gynecology · doi:10.32771/inajog.v11i1.1666

Additional file 11 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D. S., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059533

Additional file 10 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D. S., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059530

Additional file 9 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D. S., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059572

Additional file 12 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D. S., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059536

Additional file 13 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D. S., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059539

Additional file 6 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059563

Additional file 1 of Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation

Wang, L., Rondaan, C., de Joode, A. A. E., Raveling‐Eelsing, E., Bos, N. A., & Westra, J. (2021) · Figshare · doi:10.6084/m9.figshare.16960328

Additional file 5 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059560

Additional file 15 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059545

Additional file 2 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059551

Additional file 1 of Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons

Verschoor, C., Belsky, D. W., Andrew, M. K., Haynes, L., Loeb, M., Pawelec, G., McElhaney, J. E., & Kuchel, G. A. (2022) · Figshare · doi:10.6084/m9.figshare.20579731

Additional file 4 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059557

Additional file 1 of The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China

Liu, W., Xu, J., Pu, Q., Lan, M., Zhang, X., Gu, Y., Wang, Y., Zheng, F., Qian, J., Fan, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21220382

Additional file 3 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059554

Additional file 8 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059569

Additional file 7 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059566

Additional file 2 of The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells

Sugiyama, Y., Fujiwara, M., Sakamoto, A., Tsushima, H., Nishikimi, A., & Maruyama, M. (2022) · Figshare · doi:10.6084/m9.figshare.17798543

Additional file 1 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059548

Additional file 14 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059542

Additional file 1 of The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells

Sugiyama, Y., Fujiwara, M., Sakamoto, A., Tsushima, H., Nishikimi, A., & Maruyama, M. (2022) · Figshare · doi:10.6084/m9.figshare.17798537

Impact du microbiote intestinal sur les surinfections bactériennes post-grippales

Sencio, V. (2020) · theses.fr (ABES) · doi:10.70675/15f9ad6cz34d4z4d8azac75zece70c0fd094

Diagnostic workflow for X‐linked agammaglobulinemia integrating BTK expression and B‐cell maturation analysis by flow cytometry

Mariia, I., Malakhova, E. A., Fadeeva, M., Vedmedskaia, V., Shlyapnikov, Y. M., Musaeva, E. Y., Киева, А. М., Raykina, E. V., Lodoeva, O., Sozonova, T., et al. (2026) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.70038

Hypergammaglobulinemia in treated and untreated people with HIV

Vigmo, I., Nilsson, S., Yilmaz, A., Gisslén, M., Robertson, J., & Karlsson, J. (2026) · PLoS ONE · doi:10.1371/journal.pone.0349405

Rescuing age-associated vaccine hyporesponsiveness in murine and nonhuman primate models with an immunostimulatory vaccine adjuvant

Maxwell, J., Joyner, J. A., Norton, J. E., Knapp, W., Wang, I., Swaminathan, G., Monslow, M. A., & Citron, M. P. (2026) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2026.2689208

Immunoglobulin G in aging and cancer

Bu, M., Li, Z., Jones, E., Lubaba, U., Liu, X., & Li, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1854902

Synergistic effects of physical and psychological distress on immunesenescence

Duggal, N. A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)

Age effects on B cells and humoral immunity in humans

Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.004 · Cited by 271

Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans

Frasca, D., Riley, R. L., & Blomberg, B. B. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.005 · Cited by 136

Decreases in E2A, AID, and Ig class switch show intrinsic defects in human B cells with age (85.14)

Blomberg, B. B., Landin, A. M., Riley, R. L., Lechner, S. C., Ryan, J., Schwartz, R. J., & Frasca, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.supp.85.14 · Cited by 1

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333

Effect of Age on the Immunoglobulin Class Switch

Frasca, D., Riley, R. L., & Blomberg, B. B. (2004) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v24.i5.10 · Cited by 41