Cited by 166T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunotherapy and Immune Responses

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Effects of aging on B cell function

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Frasca, Daniela, Blomberg, Bonnie B·2009·Current Opinion in Immunology

DOI 10.1016/j.coi.2009.06.001PMC PMC2853364

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Abstract

Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (AID), and E47 transcription factor. Effects on somatic hypermutation (SHM) have been varied depending on the system studied. Increase of AID in mice has shown improved CSR but not SHM. The reported microarray analysis of human B cell subsets may now be used to delineate B cell defects with aging and all the advances presented should lead to selecting agents for improved immune response in the elderly.

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Self-citation
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Authors: Frasca, D., & Blomberg, B. B.
Affiliations: University of Miami (US)
Corresponding author: Blomberg, Bonnie B
ORCID: Frasca, Daniela
Blomberg, Bonnie B
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2009-08
Volume: 21
Issue: 4
Pages: 425-430
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2009.06.001
PMC: PMC2853364
OpenAlex: W1989321304
Cited by: 161
References: 59
Citations by year: 2026: 8 · 2025: 6 · 2024: 2 · 2023: 8 · 2022: 17 · 2021: 9 · 2020: 21 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 14 · 2012: 13
FWCI: 0.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AG-23717, AG28586)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: B cell aging, immunosenescence, activation-induced cytidine deaminase, somatic hypermutation, B cell defect, vaccine response in the elderly, aged mice
MeSH terms: AICDA (Activation-Induced Cytidine Deaminase), Aging, Animals, B-Lymphocytes, Cytidine Deaminase, Gene Expression Regulation, Humans, Immune Tolerance, Immunoglobulin Class Switching, Somatic Hypermutation, Immunoglobulin, Mice, TCF Transcription Factors, Transcription Factor 7-Like 1 Protein

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