Frasca, Daniela

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology

Immune responses and vaccinationsImmune Response and Inflammation

Cited by 439

Aging, obesity, and inflammatory age-related diseases

Frasca, D., Blomberg, B. B., & Paganelli, R. (2017) · Frontiers in Immunology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 371

Inflammaging decreases adaptive and innate immune responses in mice and humans

Frasca, D., & Blomberg, B. B. (2016) · Biogerontology

Genetics, Aging, and Longevity in Model OrganismsImmune Response and Inflammation

Cited by 357

Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures

Nakaya, H. I., Hagan, T., Duraisingham, S. S., Lee, E. K., Kwissa, M., Rouphael, N., Frasca, D., Gersten, M., Mehta, A. K., Gaujoux, R., et al. (2015) · Immunity

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 337

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 333

Obesity decreases B cell responses in young and elderly individuals

Frasca, D., Ferracci, F., Diaz, A., Romero, M., Lechner, S., & Blomberg, B. B. (2016) · Obesity

Adipokines, Inflammation, and Metabolic DiseasesImmune responses and vaccinations

Cited by 228

B cells and aging: molecules and mechanisms

Cancro, M. P., Hao, Y., Scholz, J. L., Riley, R. L., Frasca, D., Dunn-Walters, D. K., & Blomberg, B. B. (2009) · Trends in Immunology

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 198

Effects of aging on B cell function

Frasca, D., & Blomberg, B. B. (2009) · Current Opinion in Immunology

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 161

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

Frasca, D., Diaz, A., Romero, M., & Blomberg, B. B. (2017) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 160

New advances in CMV and immunosenescence

Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y.-L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., et al. (2014) · Experimental Gerontology

Cytomegalovirus and herpesvirus researchImmune responses and vaccinations

Cited by 150

Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase

Frasca, D., Van der Put, E., Riley, R. L., & Blomberg, B. B. (2004) · The Journal of Immunology

T-cell and B-cell ImmunologyDNA Repair Mechanisms

Cited by 150

The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations

Frasca, D., Diaz, A., Romero, M., & Blomberg, B. B. (2016) · Vaccine

Influenza Virus Research StudiesT-cell and B-cell Immunology

Cited by 144

Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans

Frasca, D., Diaz, A., Romero, M., Landin, A. M., Phillips, M., Lechner, S. C., Ryan, J. G., & Blomberg, B. B. (2010) · Vaccine

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 143

Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination

Frasca, D., & Blomberg, B. B. (2020) · Immunity & Ageing

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 130

Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine

Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2015) · Vaccine

Cytomegalovirus and herpesvirus researchInfluenza Virus Research Studies

Cited by 116

High TNF-α levels in resting B cells negatively correlate with their response

Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2014) · Experimental Gerontology

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 115

Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

Frasca, D., Landin, A. M., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders

Cited by 97

Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine

Frasca, D., Diaz, A., Romero, M., Phillips, M., Mendez, N. V., Landin, A. M., & Blomberg, B. B. (2012) · International Immunology

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 86

AID Activity in B Cells Strongly Correlates with Polyclonal Antibody Affinity Maturation in-vivo Following Pandemic 2009-H1N1 Vaccination in Humans

Khurana, S., Frasca, D., Blomberg, B., & Golding, H. (2012) · PLoS Pathogens

Influenza Virus Research StudiesT-cell and B-cell Immunology

Cited by 85

Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses

Frasca, D. (2018) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 82

Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011–2012 influenza vaccine season

Frasca, D., Diaz, A., Romero, M., Mendez, N. V., Landin, A. M., & Blomberg, B. B. (2013) · Immunity & Ageing

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 77

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

Aiello, A. E., Chiu, Y.-L., & Frasca, D. (2017) · GeroScience

Cytomegalovirus and herpesvirus researchImmune responses and vaccinations

Cited by 73

MicroRNAs miR-155 and miR-16 decrease AID and E47 in B cells from elderly individuals

Frasca, D., Diaz, A., Romero, M., Ferracci, F., & Blomberg, B. B. (2015) · The Journal of Immunology

T-cell and B-cell ImmunologyMicroRNA in disease regulation

Cited by 69

Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging

Frasca, D., & Blomberg, B. B. (2017) · Frontiers in Immunology

Adipokines, Inflammation, and Metabolic DiseasesT-cell and B-cell Immunology

Cited by 66