The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Immunoaging induced by hematopoietic stem cell aging
Abstract
Hematopoietic stem cells (HSCs) generate all known hematopoietic lineages and self-renew, but the function of HSCs declines during aging, which is characterized as impairments of lymphopoiesis and enhanced myelopoiesis. These aging-associated changes correlate with an increasing risk of myelo-proliferative diseases and impairments in immune function. Recent studies showed that only a subpopulation of HSCs contains a high capacity to undergo lymphoid differentiation but this subpopulation is lost during aging, which contributes to age-related impairments in lymphopoiesis. On the basis of the observations that DNA damage and telomere dysfunction can impair stem cell function, it is possible that accumulation of DNA damage results in the loss of subpopulations of HSCs that are required for the maintenance of lymphopoiesis and immune functions during aging.
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“The proportion of CD56bright NK cells appears to be reduced in the elderly, which is likely the consequence of an impaired production of new NK cells with advanced age, due to a lower output from the bone marrow [98].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [98]
In the citing paper
“The innate immune response also declines with age.”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [94]
In the citing paper
“There are changes in innate cell numbers, with skewing of haematopoiesis towards the myeloid lineages [93,94].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [94]
Citations
Cites
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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
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Cell intrinsic alterations underlie hematopoietic stem cell aging
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Lymphohematopoietic Stem Cells and Their Aging
Leins, H., & Geiger, H. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_30
Self-citationSeptin7 is essential in early hematopoiesis, but redundant at later stages
Ronkina, N., Verheyden, N. A., Gambhir, P., Laaß, K., Yakovleva, T., Doerrie, A., Abbey, M., Menon, M., Selich, A., Galla, M., et al. (2026) · Life Science Alliance · doi:10.26508/lsa.202603637
“…changes in HSCs and hematopoiesis result from both intrinsic alterations within HSCs and extrinsic influences from the bone marrow (BM) niche (Kamminga & de Haan, 2006; Geiger et al, 2007; Wang et al, 2011; Guidi et al, 2017; Florian et al, 2018; Saçma et al, 2019; Mejia-Ramirez et al, 2020).”
Ferdousi, L. V. (2014) · theses.fr (ABES) · doi:10.70675/9d73199ez7949z4602zadcfz6763e4bdd1b0
Breaking barriers in pulmonary health of patients with metabolic diseases: senolytics and beyond
Rennerova, M., Žaloudíková, M., Haluzík, M., & Hubáčková, S. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1812724
“This process contributes to inflammaging, progressive tissue damage, and the development of age-related diseases (Wang et al., 2011).”
ANGPTL8 induces the aging of hematopoietic stem/progenitor cells
Chen, M., Zhang, M., Mei, H., Bai, X., Wang, X., Tang, Y., Jiang, H., Zhang, L., Zhou, C., & Yuan, Y. (2026) · Biogerontology · doi:10.1007/s10522-026-10517-x
“Increasing evidence suggests that the aging process begins at the highest levels of the hematopoietic hierarchy [Geiger et al. 2013; Wang et al. 2011].”
Metadata
- Authors
- Wang, J., Geiger, H., & Rudolph, K. L.
- Affiliations
- Universität Ulm (DE)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Rudolph, K Lenhard
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 23
- Issue
- 4
- Pages
- 532-536
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2170352596
- Semantic Scholar
- 8b3a2c42088c6d10f70fd28be811af503753cada
- Cited by
- 107
- References
- 51
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 12 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 12 · 2012: 10
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cell aging, immunosenescence, lymphocyte development, myelopoiesis, myeloproliferative neoplasms, DNA damage, telomere dysfunction, lymphoid differentiation, immune function decline
- MeSH terms
- Signaling Lymphocytic Activation Molecule Family Member 1, Aging, Animals, Cell Division, Clone Cells, DNA Damage, Hematopoietic Stem Cells, Humans, Myeloproliferative Disorders, Receptors, Cell Surface, Thymus Gland, Antigens, CD, Lymphocyte Subsets, Telomere, Reactive Oxygen Species, Cell Lineage, Lymphopoiesis, Myelopoiesis, Mice, Immunity, Humoral
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