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Immunoaging induced by hematopoietic stem cell aging
Abstract
Hematopoietic stem cells (HSCs) generate all known hematopoietic lineages and self-renew, but the function of HSCs declines during aging, which is characterized as impairments of lymphopoiesis and enhanced myelopoiesis. These aging-associated changes correlate with an increasing risk of myelo-proliferative diseases and impairments in immune function. Recent studies showed that only a subpopulation of HSCs contains a high capacity to undergo lymphoid differentiation but this subpopulation is lost during aging, which contributes to age-related impairments in lymphopoiesis. On the basis of the observations that DNA damage and telomere dysfunction can impair stem cell function, it is possible that accumulation of DNA damage results in the loss of subpopulations of HSCs that are required for the maintenance of lymphopoiesis and immune functions during aging.
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“The proportion of CD56bright NK cells appears to be reduced in the elderly, which is likely the consequence of an impaired production of new NK cells with advanced age, due to a lower output from the bone marrow [98].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [98]
In the citing paper
“The innate immune response also declines with age.”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [94]
In the citing paper
“There are changes in innate cell numbers, with skewing of haematopoiesis towards the myeloid lineages [93,94].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [94]
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Guo, Z., Wu, F., Chen, Y., Xu, J. M., & Chen, Z. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00534-8 · Cited by 9
“Decreased levels of CD56 bright NK cells in the elderly could be due to age-associated changes in both the quantity and functionality of hematopoietic stem cells, alongside a diminished capacity for generating new NK cells [20, 31].”
The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype
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“The absence of any changes in the myeloid/lymphoid ratio in the current study may be explained by the fact that the retired breeders were only 6 months old, with the age asscociated increases in myelopoieisis typically only arising in mice at a much older 1–2 years of age [16, 17].”
BackgroundResultInfluentialMolecular Determinants of Atherosclerosis
Marı́n-Garcı́a, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00006-8 · Cited by 6
Regulation of Myelopoiesis by CD137L Signaling
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“Hematopoiesis has been known to be skewed towards myelopoiesis during aging resulting in a much compromised lymphopoiesis [51].”
BackgroundLoss of GADD34 induces early age‐dependent deviation to the myeloid lineage
Nishio, N., Ito, S., & Isobe, K. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.78 · Cited by 7
Common marmoset CD117 + hematopoietic cells possess multipotency
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Sirtuins and the prevention of immunosenescence
Lasigliè, D. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.011 · Cited by 5
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Effect of Biomodulina-T® and VA-MENGOC-BC® on lymphocyte subpopulations in older adults
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“Another important event related to changes in immune system during ageing is the declined function of hematopoietic stem cells which is characterized by impaired lymphopoiesis and enhanced myelopoiesis [19-23].”
BackgroundTelomere Biology in Senescence and Aging
Zhu, H., & van der Harst, P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00007-1 · Cited by 5
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Myeloid-Derived Suppressor Cells in Aged Humans
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Targeting Senescent Cells to Improve Human Health
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“The function of hematopoietic stem cells declines with aging, resulting in decreased lymphopoiesis and increased myelopoiesis, an consequently impaired immune function (Wang et al. 2011).”
BackgroundSearching for Clinically Relevant Biomarkers in Geriatric Oncology
Κάτσιλα, Θ., Patrinos, G. P., & Kardamakis, D. M. (2018) · BioMed Research International · doi:10.1155/2018/3793154 · Cited by 3
“To name a few, the ageing of the hematopoietic system, which is one of the most studied and best characterized systems due to tissue accessibility by peripheral blood sampling, is marked by decrease in lymphopoiesis (often referred to by “immunosenescence” [11]) and a relative increase of myelopoiesis, possibly becaus…”
BackgroundMultitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity
Mangerich, A., & Bürkle, A. (2015) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-14151-0_6 · Cited by 2
“, an age-related decline in the capacity of adaptive immunity, consisting of more specific responses carried out by B and T-cells [313].”
BackgroundMechanisms of Hematopoietic Stem Cell Ageing and Targets for Hematopoietic Tumour Prevention
Liao, M., & Wang, J. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_8 · Cited by 2
Self-citationInterconnection Between Cellular Senescence, Regeneration and Ageing in Salamanders
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Natural Killer Cells and Health Status: Age, CMV Infection, and Obesity
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Natural Killer Cells and Health Status: Age, CMV Infection, and Obesity
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Jankowski, C. S. R., & Weichhart, T. (2024) · Immunometabolism · doi:10.1097/in9.0000000000000048 · Cited by 1
“Several mechanisms contribute to HSC aging, including DNA damage, senescence, epigenetic reprogramming, and impaired mitochondrial activity [3,4,6] .”
Closing the Circle: Stem Cell Rejuvenation and Longevity
Florian, M. C., & Geiger, H. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_16
Self-citationAppay, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.03854-x
Natural Killer Cells and Health Status: Age, CMV Infection, and Obesity
Pera, A., Pita‐López, M. L., Campos, C., Hassouneh, F., López-Sejas, N., Sánchez-Correa, B., Tarazona, R., & Solana, R. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_127-1 · Cited by 1
Myeloid-Derived Suppressor Cells in Aged Humans
Rauh, M. J., Cook, E. K., & Bowdish, D. M. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_96-1
Investigating senescence in cellular plasticity and tissue regeneration
Ritschka, B. (2017) · Repositori digital de la UPF (Universitat Pompeu Fabra)
Lymphohematopoietic Stem Cells and Their Aging
Leins, H., & Geiger, H. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_30-1
Self-citation
Metadata
- Authors
- Wang, J., Geiger, H., & Rudolph, K. L.
- Affiliations
- Universität Ulm (DE)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Rudolph, K Lenhard
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 23
- Issue
- 4
- Pages
- 532-536
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2170352596
- Semantic Scholar
- 8b3a2c42088c6d10f70fd28be811af503753cada
- Cited by
- 107
- References
- 51
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 12 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 12 · 2012: 10
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cell aging, immunosenescence, lymphocyte development, myelopoiesis, myeloproliferative neoplasms, DNA damage, telomere dysfunction, lymphoid differentiation, immune function decline
- MeSH terms
- Signaling Lymphocytic Activation Molecule Family Member 1, Aging, Animals, Cell Division, Clone Cells, DNA Damage, Hematopoietic Stem Cells, Humans, Myeloproliferative Disorders, Receptors, Cell Surface, Thymus Gland, Antigens, CD, Lymphocyte Subsets, Telomere, Reactive Oxygen Species, Cell Lineage, Lymphopoiesis, Myelopoiesis, Mice, Immunity, Humoral
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