The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation
Open accessAbstract
Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell death. Along with IL-4, IL-7, IL-9, IL-15, and IL-21, IL-2 shares the common cytokine receptor γ chain, γc, which is mutated in humans with X-linked severe combined immunodeficiency. Herein, we primarily focus on the recently discovered complex roles of IL-2 in broadly modulating T cells for T helper cell differentiation. IL-2 does not specify the type of Th differentiation that occurs; instead, IL-2 modulates expression of receptors for other cytokines and transcription factors, thereby either promoting or inhibiting cytokine cascades that correlate with each Th differentiation state. In this fashion, IL-2 can prime and potentially maintain Th1 and Th2 differentiation as well as expand such populations of cells, whereas it inhibits Th17 differentiation but also can expand Th17 cells.
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Metadata
- Authors
- Liao, W., Lin, J.-X., & Leonard, W. J.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 23
- Issue
- 5
- Pages
- 598-604
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2083054031
- Cited by
- 745
- References
- 57
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Liao, W., Lin, J.-X., & Leonard, W. J. (2011). IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2011.08.003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
