The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Autophagy and the immune function in aging
Open accessAbstract
Just when you thought that you had heard it all about autophagy-the conserved cellular process that mediates turnover of cellular constituents in the lysosomes - studies keep coming out highlighting new types of autophagy, new functions for autophagy or even new autophagy-independent roles for the proteins associated with this process. The field of immunology has been riding the autophagic wave since the beginning of its revival; first due to its role in the host defense against pathogens, and more recently through the better understanding of the unique characteristics and functions of different autophagic pathways in immune cells. Here, we describe some of these new functions that are tightening the connection between autophagy and acquired or innate immunity and their malfunctioning with age.
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“The accumulation of oxidative damage could be due to a decline in lysosomal and autophagy function [104].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [104]
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“The second characteristic of aged cells is increased mitochondrial dysfunction and ensuing oxidative damage to proteins and DNA.”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [104]
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Citations
Cites
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Self-citationAutophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Mammalian autophagy: core molecular machinery and signaling regulation
Yang, Z., & Klionsky, D. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.014 · Cited by 1,956
Autophagy in infection, inflammation and immunity
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A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
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Items 101–112 of 112
Wong, E. S. P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00078-6
Age-Related Changes in Immune Regulation by Noncoding RNAs
Wang, W., Qian, F., & Montgomery, R. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_109-1
Macián, F. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_112
Zvarych, L., & Bаzyка, D. (2024) · Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology · doi:10.33145/2304-8336-2024-29-327-358
“…regulation of autophagy alters the innate immune response by affecting inflammasome activity, cyto(cid:15) kine secretion, antigen presentation, and lympho(cid:15) cyte function [7, 8], which underlies cognitive decline, development of malignancy, and autoim(cid:15) munity in elderly people [9].”
Reverse aging through immune driven signaling
Kumar, U., Simran, Tyagi, L., Mishra, S., Gupta, M., & Sohal, J. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33159-6.00016-3
Anti-Aging the Immune System: Hype or Hope? A Mechanistic Review
Ilyas, A. (2026) · Premier Journal of Immunology · doi:10.70389/pji.100011
McCormick, J. J., McCormick, K. E., Goulet, N., Hutchins, K. P., & Kenny, G. P. (2026) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00115.2026
Genetic associations in sepsis and ARDS
Moroniti, J. J., Rameshchandran, P. M., Guo, M., Labuda, V., Chandy, M., & Leligdowicz, A. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1864880
“Impaired autophagy has been associated with mitochondrial dysfunction, exaggerated inflammatory responses, and organ injury in critical illness (Cuervo and Macian, 2014; Schneider and Cuervo, 2014).”
Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
Šimončičová, E., & Tremblay, M. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1884230
“…have been connected to this detrimental polarization, highlighting the relevance of this pathway for therapeutic targeting (Figure 1; Barrella et al., 2026; Carmona-Gutierrez et al., 2016; Cuervo and Macian, 2014; Guerrero-Navarro et al., 2022; Tan and Finkel, 2023; Tsap and Shcherbata, 2025).”
The Senescence-Malignancy Axis: An Inflammaging Perspective
Patrono, I., Sonnessa, M., Trerotola, M., Giudetti, A. M., Summa, S. D., Zito, F. A., Saponaro, C., & Vergara, D. (2026) · Antioxidants · doi:10.3390/antiox15101357
“Alterations in autophagy regulation have significant consequences for the innate immune response, as well as for aging and age-related diseases, by modifying inflammasome activation, cytokine release, antigen presentation, and lymphocyte activity [43].”
Metadata
- Authors
- Cuervo, A. M., & Macian, F.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 29
- Pages
- 97-104
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC4119564
- OpenAlex
- W2036701722
- Cited by
- 112
- References
- 63
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 18 · 2018: 12 · 2017: 14 · 2016: 12 · 2015: 6 · 2014: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Glenn Foundation for Medical Research
- National Institutes of Health (UL1TR001073)
- National Institute on Aging (R01AG021904, R37AG021904, P01AG031782)
- National Institute of Allergy and Infectious Diseases (R01AI059738)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK041296)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- autophagy, aging, immune function, innate immunity, adaptive immunity, host defense against infection, autophagy-independent function, immune cell function, lysosomes
- MeSH terms
- Aging, Animals, Autophagy, Humans, Immunity, Innate, Lymphocytes, Antigen Presentation, Adaptive Immunity
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