Cited by 112Autophagy in Disease and TherapyPhagocytosis and Immune RegulationT-cell and B-cell Immunology

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Autophagy and the immune function in aging

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Cuervo, Ana Maria, Macian, Fernando·2014·Current Opinion in Immunology

DOI 10.1016/j.coi.2014.05.006PMC PMC4119564

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Abstract

Just when you thought that you had heard it all about autophagy-the conserved cellular process that mediates turnover of cellular constituents in the lysosomes - studies keep coming out highlighting new types of autophagy, new functions for autophagy or even new autophagy-independent roles for the proteins associated with this process. The field of immunology has been riding the autophagic wave since the beginning of its revival; first due to its role in the host defense against pathogens, and more recently through the better understanding of the unique characteristics and functions of different autophagic pathways in immune cells. Here, we describe some of these new functions that are tightening the connection between autophagy and acquired or innate immunity and their malfunctioning with age.

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“Research demonstrates that declining autophagy during cellular aging leads to diminished cell performance and potential death, as cells struggle to maintain healthy proteins and organelles (Cuervo and Macian, 2014; Rubinsztein et al., 2011).”
A Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19
Su, W., Wu, C., Wu, S. V., Lee, M., Liao, M.-T., Lu, K., & Lu, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.865321 · Cited by 18
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McCormick, J. J., McManus, M. K., King, K. E., Goulet, N., & Kenny, G. P. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00163.2023 · Cited by 16
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Autophagy and Glycative Stress: A Bittersweet Relationship in Neurodegeneration
Gómez, O., Perini-Villanueva, G., Yuste, A., Rodríguez‐Navarro, J. A., Poch, E., & Bejarano, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.790479 · Cited by 14
“For instance, agedependent failure has been associated with transcriptional changes of ATG proteins that are required for trapping of the cargo, biogenesis of the autophagosomes, and maturation of lysosomal proteases (Cuervo and Macian, 2014).”
Background
Early-onset dietary restriction maintains mitochondrial health, autophagy and ER function in the left ventricle during aging
Li, S., Lin, Y., Chiang, C.-H., Wang, P., & Chen, C. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108944 · Cited by 13
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Potential of nanoparticles and nanopolymers in treatment of age-associated diseases
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Authors: Cuervo, A. M., & Macian, F.
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2014-08
Volume: 29
Pages: 97-104
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2014.05.006
PMC: PMC4119564
OpenAlex: W2036701722
Cited by: 112
References: 63
Citations by year: 2026: 6 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 18 · 2018: 12 · 2017: 14 · 2016: 12 · 2015: 6 · 2014: 1
FWCI: 1.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Glenn Foundation for Medical Research
National Institutes of Health (UL1TR001073)
National Institute on Aging (R01AG021904, R37AG021904, P01AG031782)
National Institute of Allergy and Infectious Diseases (R01AI059738)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK041296)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: autophagy, aging, immune function, innate immunity, adaptive immunity, host defense against infection, autophagy-independent function, immune cell function, lysosomes
MeSH terms: Aging, Animals, Autophagy, Humans, Immunity, Innate, Lymphocytes, Antigen Presentation, Adaptive Immunity

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