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Autophagy and the immune function in aging
Open accessAbstract
Just when you thought that you had heard it all about autophagy-the conserved cellular process that mediates turnover of cellular constituents in the lysosomes - studies keep coming out highlighting new types of autophagy, new functions for autophagy or even new autophagy-independent roles for the proteins associated with this process. The field of immunology has been riding the autophagic wave since the beginning of its revival; first due to its role in the host defense against pathogens, and more recently through the better understanding of the unique characteristics and functions of different autophagic pathways in immune cells. Here, we describe some of these new functions that are tightening the connection between autophagy and acquired or innate immunity and their malfunctioning with age.
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“The accumulation of oxidative damage could be due to a decline in lysosomal and autophagy function [104].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [104]
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“The second characteristic of aged cells is increased mitochondrial dysfunction and ensuing oxidative damage to proteins and DNA.”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [104]
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Cited by
Sorted by citations
Evolution of the immune system in humans from infancy to old age
Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796
“The accumulation of oxidative damage could be due to a decline in lysosomal and autophagy function[104].”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
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“The dysregulation in autophagy has important effects in the innate immune response, in aging and age-related diseases by influencing inflammasome activity, cytokine secretion, antigen presentation, and lymphocyte function (73, 74).”
BackgroundMeasuring biological aging in humans: a quest
Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781
“Beyond hereditary disease, evidence is emerging that autophagy becomes defective with aging and contributes to immunosenescence (Cuervo & Macian, 2014; Zhang, Puleston, & Simon, 2016).”
BackgroundZhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 425
Autophagy in liver diseases: Time for translation?
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Metadata
- Authors
- Cuervo, A. M., & Macian, F.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 29
- Pages
- 97-104
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC4119564
- OpenAlex
- W2036701722
- Cited by
- 112
- References
- 63
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 18 · 2018: 12 · 2017: 14 · 2016: 12 · 2015: 6 · 2014: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Glenn Foundation for Medical Research
- National Institutes of Health (UL1TR001073)
- National Institute on Aging (R01AG021904, R37AG021904, P01AG031782)
- National Institute of Allergy and Infectious Diseases (R01AI059738)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK041296)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- autophagy, aging, immune function, innate immunity, adaptive immunity, host defense against infection, autophagy-independent function, immune cell function, lysosomes
- MeSH terms
- Aging, Animals, Autophagy, Humans, Immunity, Innate, Lymphocytes, Antigen Presentation, Adaptive Immunity
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