Cited by 123interferon and immune responsesImmune Response and InflammationDNA and Nucleic Acid Chemistry

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Cytosolic sensing of immuno-stimulatory DNA, the enemy within

Open access

Dhanwani, Rekha, Takahashi, Mariko, Sharma, Sonia·2018·Current Opinion in Immunology

DOI 10.1016/j.coi.2017.11.004PMC PMC5916810

Open this paper in CoChat — free account

Abstract

In the cytoplasm, DNA is sensed as a universal danger signal by the innate immune system. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor/enzyme that catalyzes formation of 2'-5'-cGAMP, an atypical cyclic di-nucleotide second messenger that binds and activates the Stimulator of Interferon Genes (STING), resulting in recruitment of Tank Binding Kinase 1 (TBK1), activation of the transcription factor Interferon Regulatory Factor 3 (IRF3), and trans-activation of innate immune response genes, including type I Interferon cytokines (IFN-I). Activation of the pro-inflammatory cGAS-STING-IRF3 response is triggered by direct recognition of the DNA genomes of bacteria and viruses, but also during RNA virus infection, neoplastic transformation, tumor immunotherapy and systemic auto-inflammatory diseases. In these circumstances, the source of immuno-stimulatory DNA has often represented a fundamental yet poorly understood aspect of the response. This review focuses on recent findings related to cGAS activation by an array of self-derived DNA substrates, including endogenous retroviral elements, mitochondrial DNA (mtDNA) and micronuclei generated as a result of genotoxic stress and DNA damage. These findings emphasize the role of the cGAS axis as a cell-intrinsic innate immune response to a wide variety of genomic insults.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.coi.2017.11.004

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182
Mitochondrial DNA stress primes the antiviral innate immune response
West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Woo, S.-R., Fuertes, M. B., Corrales, L., Spranger, S., Furdyna, M. J., Leung, M. Y. K., Duggan, R., Wang, Y., Barber, G. N., Fitzgerald, K. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.017 · Cited by 1,917
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
Vanpouille-Box, C., Alard, A., Aryankalayil, M. J., Sarfraz, Y., Diamond, J. M., Schneider, R. J., Inghirami, G., Coleman, C. N., Formenti, S. C., & Demaria, S. (2017) · Nature Communications · doi:10.1038/ncomms15618 · Cited by 1,834
cGAS surveillance of micronuclei links genome instability to innate immunity
Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature · doi:10.1038/nature23449 · Cited by 1,752
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Corrales, L., Glickman, L. H., McWhirter, S. M., Kanne, D. B., Sivick, K. E., Katibah, G. E., Woo, S.-R., Lemmens, E., Banda, T., Leong, J. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.031 · Cited by 1,560
Mitotic progression following DNA damage enables pattern recognition within micronuclei
Harding, S. M., Benci, J. L., Irianto, J., Discher, D. E., Minn, A. J., & Greenberg, R. A. (2017) · Nature · doi:10.1038/nature23470 · Cited by 1,508

Show all 62 references

Sorted by citations

L1 drives IFN in senescent cells and promotes age-associated inflammation
De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255
“The absolute average retrotransposition frequency (percentage of GFP-positive cells) was 4.1, which matches the published values for the reporter used (pLD143) 53 . l, Knockdowns of cGAS and STING were performed in senescent or 3X cells as with the other shRNAs (Fig.”
Influential
Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signaling after nuclear DNA damage
Dunphy, G., Flannery, S. M., Almine, J. F., Connolly, D. J., Paulus, C., Jønsson, K. L., Jakobsen, M. R., Nevels, M. M., Bowie, A. G., & Unterholzner, L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.034 · Cited by 648
cGAS-STING, an important pathway in cancer immunotherapy
Jiang, M., Chen, P., Wang, L., Li, W., Chen, B., Liu, Y., Wang, H., Zhao, S., Ye, L., He, Y., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00916-z · Cited by 647
A Genetic Map of the Response to DNA Damage in Human Cells
Olivieri, M., Cho, T., Álvarez-Quilón, A., Li, K., Schellenberg, M. J., Zimmermann, M., Hustedt, N., Rossi, S. E., Adam, S., Melo, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.040 · Cited by 551
Biomolecular Condensates and Cancer
Boija, A., Klein, I. A., & Young, R. A. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.12.003 · Cited by 338
Type I Interferons in Autoimmune Disease
Crow, M. K., Olferiev, M., & Kirou, K. A. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043952 · Cited by 320
Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair
Audu, C. O., Melvin, W. J., Joshi, A., Wolf, S., Moon, J. Y., Davis, F. M., Barrett, E. C., Mangum, K. D., Deng, H., Xing, X., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00919-5 · Cited by 163
Self-citation
Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression
Zhong, F., Liang, S., & Zhong, Z. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.10.008 · Cited by 135
Role of microglia in stroke
Planas, A. M. (2024) · Glia · doi:10.1002/glia.24501 · Cited by 144
DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells
Li, C., Liu, W., Wang, F., Hayashi, T., Mizuno, K., Hattori, S., Fujisaki, H., & Ikejima, T. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.037 · Cited by 106
Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication
Wang, H., Wang, T., Yan, S., Tang, J., Zhang, Y., Wang, L., Xu, H., & Tu, C. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02183-9 · Cited by 122
African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity
Ran, Y., Li, D., Xiong, M.-G., Liu, H., Feng, T., Shi, Z., Li, Y., Wu, H.-N., Wang, S., Zheng, H., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010270 · Cited by 91
Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches
Kudryashova, K. S., Burka, K., Kulaga, A. Y., Vorobyeva, N. S., & Kennedy, B. K. (2020) · PROTEOMICS · doi:10.1002/pmic.201900408 · Cited by 95
Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity
Cunningham, C. M., Dunne, A., & López-Rodríguez, A. B. (2018) · The Neuroscientist · doi:10.1177/1073858418809941 · Cited by 80
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy
Ye, Z., Shi, Y., Lees‐Miller, S. P., & Tainer, J. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.797880 · Cited by 85
Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
Durand, J. K., Zhang, Q. H., & Baldwin, A. S. (2018) · Cells · doi:10.3390/cells7090139 · Cited by 73
PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers
Lee, E. K., & Konstantinopoulos, P. A. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920944116 · Cited by 72
Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair
Kellner, V., & Luke, B. (2019) · The EMBO Journal · doi:10.15252/embj.2019102309 · Cited by 67
SAMHD1 and the innate immune response to cytosolic DNA during DNA replication
Coquel, F., Neumayer, C., Lin, Y., & Pasero, P. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.017 · Cited by 62
Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling
Emam, A., Wu, X. Y., Xu, S., Wang, L., Liu, S., & Wang, B. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00950-8 · Cited by 55
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response
Dhanwani, R., Takahashi, M., Mathews, I. T., Lenzi, C., Romanov, A., Watrous, J. D., Pieters, B. C. H., Hedrick, C. C., Benedict, C. A., Linden, J. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba3688 · Cited by 48
Self-citation
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis
Paul, S., Kaplan, M. H., Khanna, D., McCourt, P. M., Saha, A. K., Tsou, P., Anand, M., Radecki, A. A., Mourad, M., Sawalha, A. H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34775-8 · Cited by 47
Poor mitochondrial health and systemic inflammation? Test of a classic hypothesis in the Baltimore Longitudinal Study of Aging
Zampino, M., Brennan, N. A., Kuo, P.-L., Spencer, R. G., Fishbein, K. W., Simonsick, E. M., & Ferrucci, L. (2020) · GeroScience · doi:10.1007/s11357-020-00208-x · Cited by 43
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P
Luteijn, R. D., van Terwisga, S. R., Eecke, J. E. V., Onia, L., Zaver, S. A., Woodward, J. J., Wubbolts, R., Raulet, D. H., & van Kuppeveld, F. J. M. (2024) · Science Signaling · doi:10.1126/scisignal.ade3643 · Cited by 40
MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer
Yamashita, N., Morimoto, Y., Fushimi, A., Ahmad, R., Bhattacharya, A., Daimon, T., Haratake, N., Inoue, Y., Ishikawa, S., Yamamoto, M., et al. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0772 · Cited by 39
The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek
Tremblay, N., Freppel, W., Sow, A. A., & Chatel‐Chaix, L. (2019) · Vaccines · doi:10.3390/vaccines7040145 · Cited by 44
Mitochondrial Dysfunction-Associated Mechanisms in the Development of Chronic Liver Diseases
Arumugam, M. K., Gopal, T., Kandy, R. R. K., Boopathy, L. K., Perumal, S. K., Ganesan, M., Rasineni, K., Donohue, T. M., Osna, N. A., & Kharbanda, K. K. (2023) · Biology · doi:10.3390/biology12101311 · Cited by 40
Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection
Patrick, K. L., & Watson, R. O. (2021) · Infection and Immunity · doi:10.1128/iai.00687-20 · Cited by 38
Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation
García-Nicolás, O., Godel, A., Zimmer, G., & Summerfield, A. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01039-4 · Cited by 37
Nucleic Acid Sensing in Mammals and Plants: Facts and Caveats
Heil, M., & Vega-Muñoz, I. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.10.003 · Cited by 35
Cationic Nanostructures for Vaccines Design
Carmona‐Ribeiro, A. M., & Pérez-Betancourt, Y. (2020) · Biomimetics · doi:10.3390/biomimetics5030032 · Cited by 33
Activation of Innate Immunity by Therapeutic Nucleic Acids
Bishani, A., & Chernolovskaya, E. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413360 · Cited by 35
Mitochondrial Contribution to Inflammation in Diabetic Kidney Disease
Mitrofanova, A. V., Fontanella, A. M., Burke, G. W., Merscher, S., & Fornoni, A. (2022) · Cells · doi:10.3390/cells11223635 · Cited by 35
A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis
Wing, P. A. C., Davenne, T., Wettengel, J. M., Lai, A. G., Zhuang, X., Chakraborty, A., D’Arienzo, V., Kramer, C., Ko, C., Harris, J. M., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900355 · Cited by 29
Targeting activation of cGAS-STING signaling pathway by engineered biomaterials for enhancing cancer immunotherapy
Liang, J., Jin, X., Deng, X., Huang, Q., Zhang, S., Chen, W., & Zhang, X. (2024) · Materials Today · doi:10.1016/j.mattod.2024.07.004 · Cited by 30
Consequences of Genomic Diversification Induced by Segregation Errors
Soto, M., Raaijmakers, J. A., & Medema, R. H. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.01.003 · Cited by 28
Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense
Kufer, T. A., Creagh, E. M., & Bryant, C. E. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.08.001 · Cited by 29
DNA‐Based Biomaterials for Immunoengineering
Maeda, M., Kojima, T., Song, Y., & Takayama, S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801243 · Cited by 27
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens
Wang, J., Ba, G., Han, Y.-Q., Ming, S., Wang, M.-D., Fu, P.-F., Zhao, Q., Zhang, S., Wu, Y., Yang, G., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.01.015 · Cited by 26
The Mystery of Cancer Resistance: A Revelation Within Nature
Trivedi, D. D., Dalai, S. K., & Bakshi, S. R. (2023) · Journal of Molecular Evolution · doi:10.1007/s00239-023-10092-6 · Cited by 29
Retroelement-derived RNA and its role in the brain
Evans, T. A., & Erwin, J. A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.11.001 · Cited by 25
Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer
Yamashita, N., Fushimi, A., Morimoto, Y., Bhattacharya, A., Hagiwara, M., Yamamoto, M., Hata, T., Shapiro, G. I., Long, M. D., Liu, S., et al. (2022) · Cancers · doi:10.3390/cancers14112580 · Cited by 24
Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach
Goyal, F., Chattopadhyay, A., Navik, U., Jain, A., Reddy, P. H., Bhatti, G. K., & Bhatti, J. S. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300255 · Cited by 25
Cytosolic DNA Sensors and CNS Responses to Viral Pathogens
Jeffries, A. M., & Marriott, I. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.576263 · Cited by 22
Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases
Feng, Y., Huang, W. C., Paul, C., Liu, X., Sadayappan, S., Wang, Y., & Pauklin, S. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00889-1 · Cited by 22
Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity
Kim, J. C., Liu, X., Fitzgerald, K., Eng, J. S., Orf, J., O’Brien, S. A., Belmontes, B., Casbon, A.-J., Novitskiy, S. V., Tarbell, K. V., et al. (2023) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-022-03327-w · Cited by 22
Host-pathogen protein-nucleic acid interactions: A comprehensive review
Jain, A., Mittal, S., Tripathi, L. P., Nussinov, R., & Ahmad, S. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.001 · Cited by 23
Significance of base excision repair to human health
Zhao, S., Tadesse, S., & Kidane, D. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.05.002 · Cited by 22
The importance of type I interferon in orchestrating the cytotoxic T-cell response to cancer
Busselaar, J., Sijbranda, M., & Borst, J. G. (2024) · Immunology Letters · doi:10.1016/j.imlet.2024.106938 · Cited by 21
The cGAS-STING pathway promotes endometriosis by up-regulating autophagy
Zhu, S., Chen, Q., Sun, J., Du, W., Chen, Z., Yu, M., Tao, J., Zhou, Y., Zhao, Y., & Zhang, Q. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109644 · Cited by 18
Innate Immune DNA Sensing of Flaviviruses
Zhu, T., & Fernández-Sesma, A. (2020) · Viruses · doi:10.3390/v12090979 · Cited by 19
A Link between Replicative Stress, Lamin Proteins, and Inflammation
Willaume, S., Rass, E., Fontanilla-Ramirez, P., Moussa, A., Wanschoor, P., & Bertrand, P. (2021) · Genes · doi:10.3390/genes12040552 · Cited by 28
Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis
Kirsch‐Volders, M., & Fenech, M. F. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108395 · Cited by 20
Knockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis
Xie, W., Zhang, L., Shen, J., Lai, F., Han, W., & Liu, X. (2024) · BMC Cancer · doi:10.1186/s12885-024-12296-5 · Cited by 18
Immune Checkpoint Inhibitors, Small-Molecule Immunotherapies and the Emerging Role of Neutrophil Extracellular Traps in Therapeutic Strategies for Head and Neck Cancer
O’Meara, C. H., Jafri, Z., & Khachigian, L. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411695 · Cited by 18
Self-DNA Sensing Fuels HIV-1-Associated Inflammation
Heil, M., & Brockmeyer, N. H. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.06.004 · Cited by 16
Grouper cGAS is a negative regulator of STING-mediated interferon response
Zhang, L., Zhang, X., Liao, J., Xu, L., Kang, S., Chen, H., Sun, M., Wu, S., Xu, Z., Wei, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1092824 · Cited by 16
Operation of mitochondrial machinery in viral infection-induced immune responses
Lai, J., Luo, S., & Ho, L. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.044 · Cited by 16
G3BP1 enhances cytoplasmic DNA pattern recognition
Wiser, C. L., Kim, B., & Ascano, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0279-8 · Cited by 15
Mechanisms by Which Genotoxins Cause Micronuclei and Other Nuclear Anomalies
Fenech, M. F. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013604-00008 · Cited by 16
Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy
Zhao, S., Habib, S. L., Senejani, A. G., Sebastian, M. M., & Kidane, D. (2022) · Biomedicines · doi:10.3390/biomedicines10030557 · Cited by 14
Cell type- and region-specific translatomes in an MPTP mouse model of Parkinson's disease
Huang, Q., Chen, C., Chen, W., Cai, C., Xing, H., Li, J., Li, M., & Ma, S. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106105 · Cited by 14
Micronuclei and Their Association with Infertility, Pregnancy Complications, Developmental Defects, Anaemias, Inflammation, Diabetes, Chronic Kidney Disease, Obesity, Cardiovascular Disease, Neurodegenerative Diseases and Cancer
Bonassi, S., & Fenech, M. F. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013604-00038 · Cited by 15
cGAS-dependent proinflammatory and immune homeostatic effects of the microtubule-targeting agent paclitaxel
Serpico, A. F., Pisauro, C., & Grieco, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127623 · Cited by 14
Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes
Issa, W., Njeim, R., Carrazco, A., Burke, G. W., & Mitrofanova, A. V. (2024) · Cells · doi:10.3390/cells13131157 · Cited by 13
Aneuploidy, inflammation and diseases
Kirsch‐Volders, M., & Fenech, M. F. (2022) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2022.111777 · Cited by 12
Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process
Pancione, M., Cerulo, L., Remo, A., Giordano, G., Gutiérrez-Uzquiza, Á., Bragado, P., & Porrás, A. (2021) · Biomolecules · doi:10.3390/biom11050629 · Cited by 12
The role of the adaptor molecule STING during Schistosoma mansoni infection
Souza, C. D. L. R., Sanches, R. C. O., Assis, N. R. G., Marinho, F. V., Mambelli, F., Morais, S. B., Gimenez, E. G. T., Guimarães, E. S., Castro, T. B. R., & Oliveira, S. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-64788-6 · Cited by 11
Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans
Williams, A. B., Heider, F., Messling, J.-E., Rieckher, M., Bloch, W., & Schumacher, B. (2019) · Genetics · doi:10.1534/genetics.119.302422 · Cited by 10
LC3B labeling of the parasitophorous vacuole membrane of Plasmodium berghei liver stage parasites depends on the V‐ATPase and ATG16L1
Bindschedler, A., Schmuckli‐Maurer, J., Buchser, S., Fischer, T. D., Wacker, R., Davalan, T., Brunner, J., & Heussler, V. T. (2024) · Molecular Microbiology · doi:10.1111/mmi.15259 · Cited by 11
TBK1 is paradoxical in tumor development: a focus on the pathway mediating IFN-I expression
Wang, B., Zhang, F., Wu, X., & Ji, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1433321 · Cited by 9
Inhibiting DNA Sensing Pathway Controls Steroid Hyporesponsive Lung Inflammation
Mdkhana, B., Sharif‐Askari, N. S., Cagliani, R., Al-Sheakly, B. K. S., Ramakrishnan, R. K., Sharif‐Askari, F. S., Hachim, I. Y., Hamid, Q. A., Rawas‐Qalaji, M., & Halwani, R. (2024) · Advanced Biology · doi:10.1002/adbi.202400230 · Cited by 9
Like a Rolling Stone: Sting-Cgas Pathway and Cell-Free DNA as Biomarkers for Combinatorial Immunotherapy
Sicard, G., Fina, F., Fanciullino, R., Barlési, F., & Ciccolini, J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080758 · Cited by 12
Development of a risk model to predict prognosis in breast cancer based on cGAS-STING-related genes
Chen, C., Wang, J., Dong, C., LIM, D. J., & Feng, Z. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1121018 · Cited by 8
Activation of APOBEC3 cytidine deaminases and endogenous retroviruses is integrated by MUC1-C in NSCLC cells
Haratake, N., Takamori, S., Isozaki, H., Shigeta, K., Kikutake, C., Ozawa, H., Bhattacharya, A., Nakashoji, A., Suyama, M., Takenaka, T., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02673-9 · Cited by 7
GNB4 Silencing Promotes Pyroptosis to Inhibit the Development of Glioma by Activating cGAS–STING Pathway
Gao, Z., & Yang, J. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01194-7 · Cited by 7
Emerging areas for therapeutic discovery in SLE
Maria, N. I., & Davidson, A. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.004 · Cited by 8
Selective Inhibition of Cysteine-Dependent Enzymes by Bioorthogonal Tethering
Spear, L. A., Huang, Y., Chen, J., Nödling, A. R., Virdee, S., & Tsai, Y. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167524 · Cited by 7
Age‐Dependent Pathogenesis of Influenza A Virus H7N9 Mediated Through PB1‐F2‐Induced Mitochondrial DNA Release and Activation of cGAS‐STING‐NF‐κB Signaling
Cheung, P. H., Yuen, T., Tang, T., Leung, H., Lee, T. T., Chan, P., Cheng, Y., Fung, S., Ye, Z., Chan, C., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.70062 · Cited by 6
The STING-IRF3 pathway contributes to paraquat-induced acute lung injury
Wang, N., Wang, X., Li, Y., Shen, H., Liu, Z., Ma, Z., Li, Q., & Zhao, M. (2021) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2021.1974133 · Cited by 6
LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition
Mehmood, A., Xue, Y., Yassin, H. M., Zubair, M. A., Rahmat, S. A., & Ahmad, A. (2025) · Współczesna Onkologia · doi:10.5114/wo.2025.152369 · Cited by 5
Mitochondrial DNA may act as a biomarker to predict donor‐kidney quality
Hao, C., Zhang, J., Zhang, F., Wu, J., Cao, H., & Wang, W. (2021) · Clinical Transplantation · doi:10.1111/ctr.14469 · Cited by 5
The immunostimulator Victrio activates chicken toll-like receptor 21
Ilg, T. (2019) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2019.109977 · Cited by 5
Single cell transcriptomics of bone marrow derived macrophages reveals Ccl5 as a biomarker of direct IFNAR-independent responses to DNA sensing
McCarty, E., Yu, J. D., Ninh, V. K., Calcagno, D. M., Lee, J., & King, K. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1199730 · Cited by 4
Modulation of Immune Reaction in Hydrodynamic Gene Therapy for Hemophilia A
Zhao, M., Sun, Y., Yin, M., Zhao, J.-J., Li, S.-A., Li, G., Zhang, F., Xu, J., Meng, F., Zhang, B., et al. (2021) · Human Gene Therapy · doi:10.1089/hum.2021.145 · Cited by 4
The Third Man: DNA sensing as espionage in pulmonary vascular health and disease
Bryant, A. J., Pham, A. T., Gogoi, H., Mitchell, C. R., Pais, F. M., & Jin, L. (2021) · Pulmonary Circulation · doi:10.1177/2045894021996574 · Cited by 3
The Fate of Micronuclei and Micronucleated Cells
Stopper, H., & Hintzsche, H. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013604-00024 · Cited by 4
Non‐canonical PKG1 regulation in cardiovascular health and disease
Su, J., & Burgoyne, J. R. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70148 · Cited by 3
Cytosolic DNA in radiotherapy: relevance, mechanisms, and detection
Poulton, E., Desjardins, A., Harding, S. M., Malbeteau, L., & Koritzinsky, M. (2025) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2025.111220 · Cited by 4
Human functional genomics reveals toxicological mechanism underlying genotoxicants-induced inflammatory responses under low doses exposure
Tian, M., Xia, P., Yan, L., Gou, X., Yu, H., & Zhang, X. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137658 · Cited by 3
Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis
Le, A. C., Oudin, V., Dick, J., Alikhan, M. A., Gottschalk, T. A., Lu, L., Lawlor, K. E., Cheong, D. K. Y., Mandwie, M., Alexander, I. E., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.188951 · Cited by 3
Hepatit B Virüsüne (HBV) Karşı Doğal Bağışık, Kronik HBV Enfeksiyonu Olan ve HBV ile Karşılaşmamış Bireylerdeki “Stimulator of Interferon Genes (STING)” mRNA Düzeylerinin Karşılaştırılması
Kasap, B., Buruk, C. K., Kaklıkkaya, N., Özkaya, E., Kasap, Z. A., & Aydın, F. (2020) · Mikrobiyoloji Bulteni · doi:10.5578/mb.68787 · Cited by 3
Overcoming photodynamic therapy resistance via DNA repair inhibitors: Advanced review
Moloudi, K., Abrahamse, H., & George, B. P. A. (2025) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2025.104724 · Cited by 2
Selective Inhibition of Kinase Activity in Mammalian Cells by Bioorthogonal Ligand Tethering
Chen, J., Huang, Y., Gan, W., & Tsai, Y. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3251-2_16 · Cited by 2
Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma
Lv, Z., Gao, W., Du, Z., Zheng, Y., Liu, T., Hao, C., & Xue, D. (2023) · Epigenetics · doi:10.1080/15592294.2023.2276371 · Cited by 2
Ataxia Telengectesia Protein Influences Bleomycin-Induced DNA Damage in Human Fibroblast Cells
Gnanasekaran, T. S., & Venkatachalam, P. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01275-z · Cited by 2
Unexpected link between mitochondrial DNA and T cell help in systemic lupus erythematosus
Pisetsky, D. S. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215597 · Cited by 2
ISG15 fast-tracks DNA replication
Meroni, A., & Vindigni, A. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202007028 · Cited by 2
Pathophysiology of glomerulonephritis in autoimmune diseases
Maeda, K. (2025) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000001134 · Cited by 1
Deoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes 2309176
Corey, M., Rayadurgam, M., Vatanmakanian, M., Gibbons, A., Altbaum, C., Jung, J., Reddy, N., Saminathan, P., Kakugawa, K., & Sharma, S. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag141.1506 · Cited by 1
Self-citation

Authors: Dhanwani, R., Takahashi, M., & Sharma, S.
Affiliations: La Jolla Institute for Immunology (US)
Corresponding author: Sharma, Sonia
ORCID: Dhanwani, Rekha
Takahashi, Mariko
Sharma, Sonia
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2018-02
Volume: 50
Pages: 82-87
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2017.11.004
PMC: PMC5916810
OpenAlex: W2771759088
Cited by: 123
References: 62
Citations by year: 2026: 6 · 2025: 9 · 2024: 17 · 2023: 15 · 2022: 16 · 2021: 15 · 2020: 17 · 2019: 17 · 2018: 11
FWCI: 1.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA199376)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: cGAS-STING pathway, cytosolic DNA sensing, STING, IRF3, type I interferon, innate immunity, endogenous retroviruses, mitochondrial DNA, micronuclei, genotoxic stress, DNA damage, cancer immunotherapy, autoinflammatory disease, RNA virus infection, oncogenic transformation
MeSH terms: Animals, Antigens, Cytosol, DNA, DNA Damage, Humans, Immunity, Immunity, Innate, Infections, Inflammation, Neoplasms, Host-Pathogen Interactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cytosolic sensing of immuno-stimulatory DNA, the enemy within

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks