Quercetin Prevents Body Weight Loss Due to the Using of Superparamagnetic Iron Oxide Nanoparticles in Rat
Open accessAbstract
BACKGROUND: Superparamagnetic iron oxide nanoparticles (SPION) have been largely considered for numerous applications in biomedicine such as magnetic resonance imaging, hyperthermia, cell tracking, anticancer treatment, and targeted delivery of drugs or genes. However, they may have side effects such body weight loss. Quercetin (QT), a strong antioxidant and free radical scavenger and a natural flavonoid, has a wide range of biological and therapeutic effects. In this study, the effect of QT on prevention of weight loss due to the using of SPION has been investigated. MATERIALS AND METHODS: SPION and QT-SPION were administered orally at 50 and 100 mg/kg for 7 days. Then, the body weight was measured at the beginning and the end of the study. RESULTS: Rats fed with 50 and 100 mg/kg SPION showed a significant weight loss, whereas those that fed with 50 mg/kg QT-SPION did not. A weight loss was observed in rats treated with 100 mg/kg of QT-SPION. CONCLUSIONS: The results of this study showed that quercetin could prevent weight loss due to the SPION.
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Nanotechnology may significantly improve brain delivery of quercetin and enhance its bioavailability.
“several studies using multiple nanoparticles formulations have shown that the use of nanotechnology may significantly improve the brain delivery of quercetin and enhance its bioavailability (Kumari et al., 2010; Bagad and Khan, 2015; Najafabadi et al., 2018)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Najafabadi et al., 2018
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- Authors
- Najafabadi, R. E., Kazemipour, N., Esmaeili, A., Beheshti, S., & Nazifi, S.
- Affiliations
- Shiraz University (IR)
- University of Isfahan (IR)
- Department of Clinical Science, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
- Corresponding author
- Esmaeili, Abolghasem
- Venue
- Advanced Biomedical Research
- Published
- 2018-01
- Volume
- 7
- Issue
- 1
- Pages
- 8-8
- ISSN
- 2277-9175 (ISSN-L)
- PMC
- PMC5812102
- OpenAlex
- W2792304370
- Cited by
- 18
- References
- 42
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Advanced Biomedical Research (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- quercetin, superparamagnetic iron oxide nanoparticles, weight loss, nanoparticle toxicity, flavonoids, antioxidants
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