CD47-targeted bismuth selenide nanoparticles actualize improved photothermal therapy by increasing macrophage phagocytosis of cancer cells
Abstract
CD47, a transmembrane protein overexpressed in most tumors, limits macrophage phagocytosis by interacting with macrophage signal-regulated protein α (SIRPα). In this study, we have developed CD47-targeted bismuth selenide nanoparticles (Ab-PEG-Bi 2 Se 3) that increase phagocytosis of cancer cells by macrophages to actualize improved photothermal therapy (PTT). The functionalized nanoparticles were constructed by conjugating anti-CD47 antibody (Ab) to PEGylated bismuth selenide nanoparticles (PEG-Bi 2 Se 3). The anti-CD47 antibody modified on the nanoparticles enhanced the phagocytic activity of macrophages toward tumor cells by specifically blocking the crosstalk between CD47 and SIRPα. Meanwhile, Ab-PEG-Bi 2 Se 3 showed excellent photothermal performance including strong near infrared (NIR) absorbance, high photothermal conversion efficiency and photostability, and exhibited outstanding in vitro PTT effect under NIR laser irradiation. In vivo therapeutic experiments revealed that this CD47-targeted PTT nanoagent, with the assistance of enhanced macrophage phagocytosis, achieved the goal of tumor eradication. Besides, toxicity studies confirmed that Ab-PEG-Bi 2 Se 3 had good biocompatibility. In conclusion, Ab-PEG-Bi 2 Se 3 may serve as an efficient PTT platform in combination with macrophage-mediated immunotherapy to improve antitumor efficacy.
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A variety of tumor cell surface markers such as CD44, CD47, CD20, CD147, CD31 have been identified as effective targets for specific and selective anti-tumor therapy.
“In addition to the above specific ligand modifications, a variety of tumor cell surface markers such as CD44, CD47, CD20, CD147, CD31 have been identified as effective targets for specific and selective anti-tumor therapy.214–216”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [216]
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- Authors
- Guo, Z., Liu, Y., Zhou, H., Zheng, K., Wang, D., Jia, M., Xu, P., Ma, K., Cui, C., & Wang, L.
- Affiliations
- Dalian University of Technology (CN)
- Inner Mongolia Medical University (CN)
- Corresponding author
- Guo, Zhaoming
- Wang, Li
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 184
- Pages
- 110546
- ISSN
- 0927-7765 (ISSN-L)
- OpenAlex
- W2977354137
- Cited by
- 48
- References
- 36
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 2 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 5
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Liaoning Province
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- CD47, photothermal therapy, macrophage phagocytosis, SIRPα, anti-CD47 antibody, PEGylation, near-infrared absorption, tumor targeting, antitumor efficacy, nanoparticle toxicity
- MeSH terms
- A549 Cells, Animals, Antineoplastic Agents, Bismuth, Drug Screening Assays, Antitumor, Female, Humans, Infrared Rays, Macrophages, Mammary Neoplasms, Experimental, Mice, Inbred BALB C, Particle Size, Phagocytosis, Photochemotherapy, Surface Properties, Tumor Cells, Cultured, Molecular Structure, Organoselenium Compounds, Selenium Compounds, Cell Proliferation, Mice, CD47 Antigen, Nanoparticles
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