Cited by 1Artificial Intelligence in Healthcare and EducationBiomedical Text Mining and OntologiesArtificial Intelligence in Healthcare

Med-KGMA: A novel AI-driven medical support system leveraging knowledge graphs and medical advisors

Varshney, Sona, Jain, Bhawna, Singh, Prerna, Rani, Drishti, Mehra, Saumya·2025·Computers in Biology and Medicine

Abstract

Healthcare systems worldwide face a growing burden, struggling to provide timely diagnosis and personalized care due to resource constraints. The increasing demand for medical expertise often results in delayed interventions, making automated decision support crucial. However, existing medical question-answering (QnA) systems struggle with hallucinations, limited contextual understanding, and difficulty handling complex queries, which often results in unreliable responses. To address these challenges, this study proposes Med-KGMA, an artificial intelligence-driven medical QnA system that leverages the proposed SequentialRotatE, a knowledge graph embedding model, along with the Mixture-of-Medical-Advisors (MoMA) framework to enhance diagnostic accuracy and treatment recommendations. Unlike conventional methods, SequentialRotatE effectively captures contextual relationships between medical entities, improving the system's reasoning capabilities. Additionally, the MoMA framework, which dynamically routes queries to specialized advisors based on complexity and relevance, ensures more precise recommendations. Experimental results demonstrate that Med-KGMA achieves 91.32% accuracy, outperforming state-of-the-art baselines. This approach advances medical knowledge representation through optimized query processing, tailored knowledge graphs, and intelligent advisor selection, providing an efficient, scalable solution. By addressing initial symptom analysis and reducing healthcare loa…

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Crossref · 10.1016/j.compbiomed.2025.110929

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Authors
Varshney, S., Jain, B., Singh, P., Rani, D., & Mehra, S.
Affiliations
Indira Gandhi Delhi Technical University for Women (IN)
Corresponding author
Jain, Bhawna
Venue
Computers in Biology and Medicine
Publisher
Elsevier BV
Published
2025-10
Volume
197
Issue
Pt A
Pages
110929
ISSN
0010-4825 (ISSN-L)
OpenAlex
W4413502878
Cited by
0
References
59
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Computers in Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
  • Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
Keywords
medical question answering, knowledge graphs, knowledge graph embedding, query routing, clinical decision support, hallucination mitigation, symptom analysis, treatment guidelines, individualized care
MeSH terms
Artificial Intelligence, Humans, Decision Support Systems, Clinical

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