The role of acetylcholine in learning and memory

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A proposed function for hippocampal theta rhythm: separate phases of encoding and retrieval enhance reversal of prior learning

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Neuromodulation: acetylcholine and memory consolidation

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Bidirectional synaptic plasticity induced by a single burst during cholinergic theta oscillation in CA1 in vitro

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High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation

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Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology

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Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in rat hippocampal region CA3

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The Brain Cholinergic System in Neurodegenerative Diseases

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Learning to ignore: A modeling study of a decremental cholinergic pathway and its influence on attention and learningPreprint

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Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer’s Disease Pathophysiology

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ATP-Citrate Lyase (ACLY): An Extensive Investigation from Molecular Insight to Therapeutic implications

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Eyes on Memory: Pupillometry in Encoding and Retrieval

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Protective effect of menthol against thioacetamide-induced hepatic encephalopathy by suppressing oxidative stress and inflammation, augmenting expression of BDNF and α7-nACh receptor, and improving spatial memory

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Betahistine’s Neuroprotective Actions against Lipopolysaccharide-Induced Neurotoxicity: Insights from Experimental and Computational Studies

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Medial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training

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Cholinergic regulation of dendritic Ca 2+ spikes controls firing mode of hippocampal CA3 pyramidal neurons

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IUPHAR review: Moving beyond dopamine-based therapeutic strategies for schizophrenia

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Nerve growth factor retrieves neuropeptide Y and cholinergic immunoreactivity in the nucleus accumbens of old rats

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Salvia officinalis induces antidepressant-like effect, anxiolytic activity and learning improvement in hippocampal lesioned and intact adult rats

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Model of theta frequency perturbations and contextual fear memory

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Standardized Extract (HemoHIM) Protects against Scopolamine-Induced Amnesia in a Murine Model

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Tactile stimulation improves cognition, motor, and anxiety‐like behaviors and attenuates the Alzheimer's disease pathology in adult APP NL‐G‐F/NL‐G‐F mice

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Sub-pocket-focused designing of tacrine derivatives as potential acetylcholinesterase inhibitors

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Cognitive Enhancer Donepezil Attenuates Heroin-Seeking Behavior Induced by Cues in Rats

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Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing

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Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum : in vitro assessments by molecular docking and molecular dynamics simulations

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Extracts of Sideritis scardica and Clinopodium vulgare Alleviate Cognitive Impairments in Scopolamine-Induced Rat Dementia

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Rubus coreanus Miquel Ameliorates Scopolamine-Induced Memory Impairments in ICR Mice

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Estrogen levels modify scopolamine-induced amnesia in gonadally intact rats

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Layer-specific processing of excitatory signals in CA1 interneurons depends on postsynaptic M2 muscarinic receptors

Zheng, F., Seeger, T., Nixdorf-Bergweiler, B., & Alzheimer, C. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.016 · Cited by 11

Intra-dorsal hippocampal microinjections of lithium and scopolamine induce a cross state-dependent learning in mice.

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Transcriptional control of synaptic components by the clock machinery

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Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus Gallus domesticus)

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In Vivo Attenuation of M-Current Suppression Impairs Consolidation of Object Recognition Memory

Kosenko, A., Moftakhar, S., Wood, M. A., & Hoshi, N. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0348-20.2020 · Cited by 11

Fucoidan ameliorates scopolamine-induced neuronal impairment and memory dysfunction in rats via activation of cholinergic system and regulation of cAMP-response element-binding protein and brain-derived neurotrophic factor expressions

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Structural and Functional Properties of Hippocampal Neurons

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The Effect of Ethanol Extract from Mesua ferrea Linn Flower on Alzheimer’s Disease and Its Underlying Mechanism

Plekratoke, K., Boonyarat, C., Monthakantirat, O., Nualkaew, N., Wangboonskul, J., Awale, S., Chulikhit, Y., Daodee, S., Khamphukdee, C., Chaiwiwatrakul, S., et al. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45050259 · Cited by 10

Cholinergic modulation of rearing in rats performing a spatial memory task

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Daidzein’s potential in halting neurodegeneration: unveiling mechanistic insights

Singh, L. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03356-5 · Cited by 12

Anti-Amnesic Effect of Agastache rugosa on Scopolamine-Induced Memory Impairment in Mice

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Recurrent connectivity shapes spatial coding in hippocampal CA3 subregions

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Phytomedicine Potential of Oroxylum indicum Root and Its Constituents: Targeting Alzheimer’s Disease

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Auditory Neuroscience: How to Stop Tinnitus by Buzzing the Vagus

Schnupp, J. W. H. (2011) · Current Biology · doi:10.1016/j.cub.2011.02.021 · Cited by 10

Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease

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Cholinergic and purinergic systems: A key to multiple sclerosis?

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Amyloid Peptide Scaffolds Coordinate with Alzheimer’s Disease Drugs

Jonnalagadda, S. V. R., Gerace, A. J., Thai, K., Johnson, J., Tsimenidis, K., Jakubowski, J. M., Shen, C., Henderson, K. J., Tamamis, P., & Gkikas, M. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.9b10368 · Cited by 9

Dopamine plays a critical role in the olfactory adaptive learning pathway in Caenorhabditis elegans

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Recent Developments in Tacrine-based Hybrids as a Therapeutic Option for Alzheimer’s Disease

Yamalı, C., & Dönmez, Ş. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666221201145141 · Cited by 10

31st Annual Computational Neuroscience Meeting: CNS*2022

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Evidence for a specific role for muscarinic receptors in crossmodal object recognition in rats

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α7-Nicotinic Acetylcholine Receptors: New Therapeutic Avenues in Alzheimer’s Disease

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Is doping of cognitive performance an anti‐herbivore adaptation? Alkaloids inhibiting acetylcholinesterase as a case

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Cholinergic modulation of hippocampal long-term potentiation in chronic cerebral hypoperfused rats

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Biperiden Selectively Impairs Verbal Episodic Memory in a Dose- and Time-Dependent Manner in Healthy Subjects

Borghans, L. G. J. M., Sambeth, A., & Blokland, A. (2019) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001157 · Cited by 10

The Unexplored Territory of Neural Models: Potential Guides for Exploring the Function of Metabotropic Neuromodulation

Hasselmo, M. E., Alexander, A. S., Hoyland, A., Robinson, J. C., Bezaire, M. J., Chapman, G. W., Saudargienė, A., Carstensen, L. C., & Dannenberg, H. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.048 · Cited by 11

Acetylcholine and Spontaneous Recognition Memory in Rodents and Primates

Easton, A., Barros, M., & Lever, C. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_132 · Cited by 10

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts

Gao, X., Bender, F., Soh, H., Chen, C., Altafi, M., Schütze, S., Heidenreich, M., Gorbati, M., Corbu, M.-A., Carús-Cadavieco, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24805-2 · Cited by 11

Tong Luo Jiu Nao ameliorates Aβ1–40-induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus

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A Context-Sensitive Mechanism in Hippocampal CA1 Networks

Tsukada, M., & Fukushima, Y. (2010) · Bulletin of Mathematical Biology · doi:10.1007/s11538-010-9566-8 · Cited by 10

Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model

Brown, K. A., Carpenter, J. M., Preston, C. J., Ludwig, H. D., Clay, K. B., Harn, D. A., Norberg, T., Wagner, J. J., & Filipov, N. M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119707 · Cited by 10

Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia

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A disinhibitory circuit mechanism explains a general principle of peak performance during mid-level arousalPreprint

Beerendonk, L., Mejías, J. F., Nuiten, S. A., de Gee, J. W., Fahrenfort, J. J., & van Gaal, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.28.550956 · Cited by 10

Accelerating maturation of spatial memory systems by experience - evidence from sleep oscillation signatures of memory processing

Contreras, M. P., Fechner, J., Born, J., & Inostroza, M. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.1967-22.2023 · Cited by 9

Analysing the effect caused by increasing the molecular volume in M1-AChR receptor agonists and antagonists: a structural and computational study

Montejo-López, W., Sampieri-Cabrera, R., Nicolás‐Vázquez, M. I., Aceves-Hernández, J. M., & Razo‐Hernández, R. S. (2024) · RSC Advances · doi:10.1039/d3ra07380g · Cited by 10

Modeling the contribution of theta-gamma coupling to sequential memory, imagination, and dreaming

Pirazzini, G., & Ursino, M. (2024) · Frontiers in Neural Circuits · doi:10.3389/fncir.2024.1326609 · Cited by 10

Standardized extract of Ginkgo biloba induced memory consolidation in female mice with hypofunction of vesicular acetylcholine transporter

Muratori, B. G., da Veiga, I. E. T., Medeiros, G. N., da Silva, S. S., Soliani, A. G., Prado, C. M., & Cerutti, S. M. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115455 · Cited by 9

Effects of wakeful rest on memory consolidation: A systematic review and meta-analysis

Weng, L., Yu, J., Lv, Z., Yang, S., Jülich, S. T., & Lei, X. (2025) · Psychonomic Bulletin & Review · doi:10.3758/s13423-025-02665-x · Cited by 13

The Ties That Bind: Aberrant Plasticity and Networks Dysfunction in Movement Disorders—Implications for Rehabilitation

Ferrazzoli, D., Ortelli, P., Volpe, D., Cucca, A., Versace, V., Nardone, R., Saltuari, L. L., & Sebastianelli, L. (2021) · Brain Connectivity · doi:10.1089/brain.2020.0971 · Cited by 9

Estradiol treatment in young postmenopausal women with self‐reported cognitive complaints: Effects on cholinergic‐mediated cognitive performance

Conley, A. C., Albert, K. M., McDonald, B. C., Saykin, A. J., Dumas, J. A., & NEWHOUSE, P. A. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2838 · Cited by 9

Reduced Ca2+ transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway

Debnath, A., Williams, P., & Bamber, B. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.931328 · Cited by 11

Motion Learning and Generalization of Musculoskeletal Robot Using Gain Primitives

Zhong, S., & Wu, W. L. (2023) · IEEE Transactions on Automation Science and Engineering · doi:10.1109/tase.2023.3249228 · Cited by 9

The many enigmas of nicotine

Papke, R. L. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.08.001 · Cited by 9

Sunset Yellow induced biochemical and histopathological alterations in rat brain sub-regions

Bhatt, D., Vyas, K., Singh, S. A., John, P. J., & Soni, I. (2024) · Acta Histochemica · doi:10.1016/j.acthis.2024.152155 · Cited by 9

Comparison of Malondialdehyde, Acetylcholinesterase, and Apoptosis-Related Markers in the Cortex and Hippocampus of Cognitively Dysfunctional Mice Induced by Scopolamine

Park, H., Nam, M.-H., Park, J.-H., Lee, J., Hong, H.-S., Kim, T., Lee, I.-H., Shin, C.-H., Lee, S., & Seo, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12112475 · Cited by 10

Network burst dynamics under heterogeneous cholinergic modulation of neural firing properties and heterogeneous synaptic connectivity

Knudstrup, S. G., Żochowski, M., & Booth, V. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13210 · Cited by 9

Carbachol-Induced theta-like oscillations in the rodent brain limbic system: Underlying mechanisms and significance

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Role of nicotinic acetylcholine receptors for modulation of microcircuits in the agranular insular cortex

Toyoda, H. (2018) · Journal of Oral Biosciences · doi:10.1016/j.job.2018.12.001 · Cited by 9

Nicotinic acetylcholine receptors in a songbird brain

Asogwa, N., Toji, N., He, Z.-W., Shao, C.-R., Shibata, Y., Tatsumoto, S., Ishikawa, H., Go, Y., & Wada, K. (2022) · The Journal of comparative neurology · doi:10.1002/cne.25314 · Cited by 6

An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention

Kandeda, A. K., Nodeina, S., & Mabou, S. T. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01052-y · Cited by 9

Contribution of Ih to the relative facilitation of synaptic responses induced by carbachol in the entorhinal cortex during repetitive stimulation of the parasubiculum

Sparks, D. W., & Chapman, C. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.005 · Cited by 9

Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells

Edelstein, J., Hao, T., Cao, Q. C., Morales, L., & Rockwell, P. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.09.008 · Cited by 9

Effects of Selective M1 Muscarinic Receptor Activation on Hippocampal Spatial Representations and Neuronal Oscillations

Lebois, E. P., Trimper, J. B., Hu, C., Levey, A. I., & Manns, J. R. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00160 · Cited by 9

2,4-Bis(1,1-dimethylethyl)phenol from Cinnamomum loureirii Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice

Kim, C. R., Choi, S. J., Kim, J. K., Park, C., Gim, M. C., Kim, Y., Park, G. G., & Shin, D.-H. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00997 · Cited by 9

Cholinergic input to the hippocampus is not required for a model of episodic memory in the rat, even with multiple consecutive events

Seel, S. V., Eacott, M. J., Langston, R. F., & Easton, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.001 · Cited by 9

Dorsoventral-Specific Effects of Nerve Agent Surrogate Diisopropylfluorophosphate on Synaptic Transmission in the Mouse Hippocampus

Brown, K. A., Filipov, N. M., & Wagner, J. J. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.263053 · Cited by 9

Kinetics of Chemical Processes in the Human Brain. The Cholinergic Synapse—Mechanisms of Functioning and Control Methods

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