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The role of acetylcholine in learning and memory
Open accessAbstract
Pharmacological data clearly indicate that both muscarinic and nicotinic acetylcholine receptors have a role in the encoding of new memories. Localized lesions and antagonist infusions demonstrate the anatomical locus of these cholinergic effects, and computational modeling links the function of cholinergic modulation to specific cellular effects within these regions. Acetylcholine has been shown to increase the strength of afferent input relative to feedback, to contribute to theta rhythm oscillations, activate intrinsic mechanisms for persistent spiking, and increase the modification of synapses. These effects might enhance different types of encoding in different cortical structures. In particular, the effects in entorhinal and perirhinal cortex and hippocampus might be important for encoding new episodic memories.
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“Functionally, these receptors play a role in learning and memory (Hasselmo 2006).”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Hasselmo 2006
In the citing paper
“DA and ACh neurotransmission play critical roles in the regulation of memory via the ventral tegmental area and MSDB projections to the PFC-hippocampus-associated circuits”
In the citing paper
“An increase of acetylcholine concentration (ACh) at the synapse by inhibiting the acetylcholinesterase (AChE) is one of the approaches to slow down the progression of AD [18,19,20,21,22,23,24,25,26].”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [18]
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Cites
Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
Klausberger, T., Magill, P. J., Márton, L. F., Roberts, J. D. B., Cobden, P. M., Buzsáki, G., & Somogyi, P. (2003) · Nature · doi:10.1038/nature01374 · Cited by 1,345
Hasselmo, M. E., Bodelón, C., & Wyble, B. P. (2002) · Neural Computation · doi:10.1162/089976602317318965 · Cited by 875
Self-citationLevin, E. D., McClernon, F. J., & Rezvani, A. H. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0164-7 · Cited by 820
Neuromodulation: acetylcholine and memory consolidation
Hasselmo, M. E. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01365-0 · Cited by 809
Self-citationHuerta, P. T., & Lisman, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90094-2 · Cited by 673
Differential regulation of neocortical synapses by neuromodulators and activity
Gil, Z., Connors, B. W., & Amitai, Y. (1997) · Neuron · doi:10.1016/s0896-6273(00)80380-3 · Cited by 553
Hasselmo, M. E., & McGaughy, J. (2004) · Progress in Brain Research · doi:10.1016/s0079-6123(03)45015-2 · Cited by 525
Self-citationBland, B. H., & Oddie, S. D. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00358-8 · Cited by 520
Hasselmo, M., & Schnell, E. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03898.1994 · Cited by 466
Self-citationHasselmo, M. E., Schnell, E., & Barkai, E. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05249.1995 · Cited by 463
Self-citationLow acetylcholine during slow-wave sleep is critical for declarative memory consolidation
Gais, S., & Born, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305404101 · Cited by 412
Object and Place Memory in the Macaque Entorhinal Cortex
SUZUKI, W. A., Miller, E. K., & Desimone, R. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.2.1062 · Cited by 388
Memory Representation within the Parahippocampal Region
Young, B. J., Otto, T., Fox, G. D., & Eichenbaum, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05183.1997 · Cited by 372
Chrobak, J. J., & Buzsáki, G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06160.1994 · Cited by 360
Hasselmo, M. E., & Bower, J. M. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.5.1222 · Cited by 358
Self-citationCholinergic excitation of GABAergic interneurons in the rat hippocampal slice.
Pitler, T. A., & Alger, B. E. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019119 · Cited by 288
Mechanism of Graded Persistent Cellular Activity of Entorhinal Cortex Layer V Neurons
Fransén, E., Tahvildari, B., Egorov, A. V., Hasselmo, M. E., & Alonso, A. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.036 · Cited by 279
Self-citationAlkondon, M., & Albuquerque, E. X. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.3043 · Cited by 238
Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm
Yoder, R. M., & Pang, K. C. H. (2005) · Hippocampus · doi:10.1002/hipo.20062 · Cited by 237
Visual Working Memory Is Impaired when the Medial Temporal Lobe Is Damaged
Olson, I. R., Moore, K. S., Stark, M., & Chatterjee, A. K. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.7.1087 · Cited by 233
Klink, R., & Alonso, A. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.4.1813 · Cited by 228
Nicotinic Modulation of Glutamate and GABA Synaptic Transmission in Hippocampal Neurons
RADCLIFFE, K. A., FISHER, J. L., GRAY, R., & DANI, J. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11332.x · Cited by 205
Gioanni, Y., Rougeot, C., Clarke, P. B. S., Lepousé, C., Thierry, A. M., & Vidal, C. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00403.x · Cited by 191
Atri, A., Sherman, S. J., Norman, K. A., Kirchhoff, B. A., Nicolas, M. M., Greicius, M. D., Cramer, S. C., Breiter, H. C., Hasselmo, M. E., & Stern, C. E. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.1.223 · Cited by 168
Self-citationWeinberger, N. M. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00072-8 · Cited by 165
Buccafusco, J. J., Letchworth, S. R., Bencherif, M., & Lippiello, P. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.05.007 · Cited by 154
Ovsepian, S. V., Anwyl, R., & Rowan, M. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03582.x · Cited by 154
Winters, B. D., & Bussey, T. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04055.x · Cited by 149
Cholinergic modulation of excitatory synaptic transmission in the CA3 area of the hippocampus
Vogt, K. E., & Regehr, W. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00075.2001 · Cited by 149
Chapman, C. A., & Lacaille, J.-C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08637.1999 · Cited by 144
Cholinergic modulation of the hippocampus during encoding and retrieval
Rogers, J. L., & Kesner, R. P. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00063-7 · Cited by 141
Fransén, E., Alonso, A. A., & Hasselmo, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01081.2002 · Cited by 137
Self-citationSchon, K., Atri, A., Hasselmo, M. E., Tricarico, M. D., LoPresti, M. L., & Stern, C. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1982-05.2005 · Cited by 132
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Leung, L.-W. S., Bixia Shen, A., Rajakumar, N., & Ma, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09297.2003 · Cited by 130
Muscarinic and nicotinic receptor modulation of object and spatial -back working memory in humans
GREEN, A., Ellis, K. A., Ellis, J. R., Bartholomeusz, C., ILIC, S., Croft, R. J., LUANPHAN, K., & NATHAN, P. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.04.010 · Cited by 127
Haj-Dahmane, S., & Andrade, R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.3.1197 · Cited by 126
Effects of muscarinic blockade in perirhinal cortex during visual recognition
Tang, Y., Mishkin, M., & Aigner, T. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12667 · Cited by 125
Griffin, A. L., Asaka, Y., Darling, R. D., & Berry, S. D. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.2.403 · Cited by 117
McQuiston, A. R., & Madison, D. V. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05693.1999 · Cited by 114
Lawrence, J. J., Statland, J. M., Grinspan, Z. M., & McBain, C. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.100875 · Cited by 109
McGaughy, J. A., Koene, R. A., Eichenbaum, H., & Hasselmo, M. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2386-05.2005 · Cited by 105
Self-citationAction potentials and relations to the theta rhythm of medial septal neurons in vivo
Brazhnik, E. S., & Fox, S. E. (1999) · Experimental Brain Research · doi:10.1007/s002210050794 · Cited by 102
de Sevilla, D. F., Cabezas, C., de Prada, A. N. O., Sánchez‐Jiménez, A., & Buño, W. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.029165 · Cited by 101
Kimura, F. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00151-6 · Cited by 92
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Patil, M. M., Linster, C., Lubenov, E., & Hasselmo, M. E. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.5.2467 · Cited by 91
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Elvander-Tottie, E., Schött, P. A., Sandin, J., Bjelke, B., Kehr, J., Yoshitake, T., & Ögren, S. O. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.058 · Cited by 88
Blokland, A., Honig, W., & Raaijmakers, W. G. M. (1992) · Psychopharmacology · doi:10.1007/bf02245886 · Cited by 85
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Brazhnik, E. S., Muller, R. U., & Fox, S. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00611.2003 · Cited by 78
Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys
Turchi, J. N., Saunders, R. C., & Mishkin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409708102 · Cited by 71
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Patil, M. M., & Hasselmo, M. E. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.5.2103 · Cited by 69
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Siok, C. J., Rogers, J. A., Kocsis, B., & Hajós, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04560.x · Cited by 68
Hasselmo, M. E., & Cekic, M. M. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00010-1 · Cited by 63
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de Sevilla, D. F., & Buño, W. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02490.x · Cited by 57
Pang, K. C. H., & Nocera, R. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.2.265 · Cited by 57
Linster, C., Maloney, M. E., Patil, M. M., & Hasselmo, M. E. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00078-9 · Cited by 56
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Giocomo, L. M., & Hasselmo, M. E. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04316.x · Cited by 52
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Bunce, J. G., Sabolek, H. R., & Chrobak, J. J. (2004) · Hippocampus · doi:10.1002/hipo.10200 · Cited by 38
Synaptic mechanisms and cholinergic regulation in auditory cortex
Metherate, R., & Hsieh, C. Y. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45010-3 · Cited by 35
Cholinergic modulation of synaptic physiology in deep layer entorhinal cortex of the rat
Cheong, M. Y., Yun, S. H., Mook‐Jung, I., Joo, I.-S., Huh, K., & Jung, M. W. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1203 · Cited by 32
Kunitake, A., Kunitake, T., & Stewart, M. (2004) · Hippocampus · doi:10.1002/hipo.20016 · Cited by 27
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Metadata
- Authors
- Hasselmo, M. E.
- Affiliations
- Boston University (US)
- Corresponding author
- Hasselmo, Michael E
- ORCID
- Hasselmo, Michael E
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 16
- Issue
- 6
- Pages
- 710-715
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC2659740
- OpenAlex
- W2053696585
- Cited by
- 1,693
- References
- 62
- Citations by year
- 2026: 77 · 2025: 122 · 2024: 154 · 2023: 126 · 2022: 128 · 2021: 98 · 2020: 104 · 2019: 102 · 2018: 99 · 2017: 90 · 2016: 75 · 2015: 73 · 2014: 63 · 2013: 69 · 2012: 75
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH 60013, MH61492, R01MH060013, R01MH061492)
- National Institute on Drug Abuse (DA 16454, R01DA016454)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- acetylcholine, muscarinic receptors, nicotinic acetylcholine receptors, memory encoding, learning, cholinergic modulation, theta oscillations, synaptic plasticity, entorhinal cortex, perirhinal cortex, hippocampus, episodic memory, afferent feedback
- MeSH terms
- Acetylcholine, Action Potentials, Afferent Pathways, Animals, Brain, Feedback, Humans, Learning, Memory, Neural Inhibition, Synaptic Transmission, Theta Rhythm
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