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Prefrontal control of fear: more than just extinction

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Sotres-Bayon, Francisco, Quirk, Gregory J·2010·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2010.02.005PMC PMC2878722

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Abstract

Although fear research has largely focused on the amygdala, recent findings highlight cortical control of the amygdala in the service of fear regulation. In rodent models, it is becoming well established that the infralimbic (IL) prefrontal cortex plays a key role in extinction learning, and recent findings are uncovering molecular mechanisms involved in extinction-related plasticity. Furthermore, mounting evidence implicates the prelimbic (PL) prefrontal cortex in the production of fear responses. Both IL and PL integrate inputs from the amygdala, as well as other structures to gate the expression of fear via projections to inhibitory or excitatory circuits within the amygdala. We suggest that dual control of the amygdala by separate prefrontal modules increases the flexibility of an organism's response to danger cues.

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An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · cited 1×
“com In addition to diverse inputs, mPFC also has divergent outputs capable of coordinating different and sometimes competing brain systems [48,49 ].”
Background
The expression of the emotions in man and animals.
Darwin, C. D. (1872) · J. Murray eBooks · doi:10.1037/10001-000 · Cited by 12,120
Effects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear
Rowe, M. K., & Craske, M. G. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10016-x · Cited by 1,782
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · cited 2×
“IL-mediated inhibition of fear after extinction Although previous recording and lesion studies have implicated IL in extinction [9], recent findings have identified specific molecular cascades in IL involved in extinction learning.”
BackgroundResultSelf-citation
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428 · cited 1×
“However, unlike neurons in lateral amygdala whose conditioned responses last only a few hundred milliseconds [32], PL neurons show sustained increases in activity that mirror the time course of freezing responses, lasting tens of seconds [31 ].”
BackgroundSelf-citation
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365 · cited 1×
“Another key input is the ventral hippocampus (Hipp), which unlike the dorsal hippocampus, projects monosynaptically to PL, IL, and BA [44].”
Background
The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction
Scheel-Krüger, J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90037-5 · Cited by 1,281
The Expression of the Emotions in Man and Animals
Darwin, C. R., & Lorenz, K. Z. (1965) · University of Chicago Press eBooks · doi:10.7208/chicago/9780226220802.001.0001 · Cited by 1,271
Switching on and off fear by distinct neuronal circuits
Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950 · cited 3×
“Focal inactivation of BA prevented not only renewal of fear after extinction, but also expression of extinction, depending on the time point of inactivation [38 ].”
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References
Ebenezer, I. S. (2015) · Wiley eBooks · doi:10.1002/9781118385777.refs
MotivationWe thank A. E. Fink for producing the Predatory Imminence Continuum artwork in Figure . We would like to thank M. Tinsley for his contribution to the first edition of this chapter. We would like to thank Polar Bears Alive, Baton Rouge, Louisiana, for the use of the polar bear photo, M. Domjan for the quail photo, K. Hollis for the pictures of the fish, and S. Crowley for the pictures of the rats.
Godsil, B. P., & Fanselow, M. S. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop204002
Spectrum of Neurodegeneration in Autism Spectrum Disorder
Rani, K. (2022) · IGI Global eBooks · doi:10.4018/978-1-6684-5360-5.ch019
Faculty Opinions recommendation of Corticolimbic Mechanisms of Behavioral Inhibition under Threat of Punishment.
Floresco, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735386554.793566197
Emotional memory
Ehlers, M. R., & Todd, R. M. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780198793014.003.0012
Faculty Opinions recommendation of Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes.
Schultz, W. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734425892.793565160
Faculty Opinions recommendation of Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation.
Rajbhandari, A. K. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.740088798.793585671
Investigação de correlatos neurais de estratégias de enfrentamento ao estresse na atividade oscilatória da rede mesolímbica-hipocampo-frontocortical
Marques, D. B. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-06052022-163630
Integrating the Complementary Therapies of Energy Psychology and Dreamwork – the Dream to Freedom Method
Hoss, R. J., Hoss, L. M., & Church, D. (2022) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.2203024 · Cited by 1
Plataforma de computação neurocognitiva:protótipo na reabilitação do zumbido através da regulação da emoção concomitante com a estimulação transcraniana por corrente diret
Ghodratitoostani, I. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.55.2022.tde-03032023-100207
Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial forebrain domainsPreprint
Bearer, E. L., Medina, C. S., Uselman, T. W., & Jacobs, R. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.10.557059
“…has been hypothesized to play a role in drug use (Du et al., 2018, Frankin TR et al., 2002, Volkow et al., 1996) and in post-traumatic stress and anxiety disorders (Kesner and Churchwell, 2011, Laine et al., 2017, Padilla-Coreano et al., 2019, Sotres-Bayon and Quirk, 2010, Vertes, 2006).”
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Singh, R. K. (2024) · Qeios · doi:10.32388/1kc9th
“Net effect of the active states of agents in modules in M on rest of the processing system, S, is to select speciﬁc processing and action that are aligned with the suitability conditions [37, 38, 39].”
Background
The Emergence of Consciousness in a Physical UniversePreprint
Singh, R. K. (2024) · Qeios · doi:10.32388/1kc9th.2
Individual differences and relationship contexts in the perception and response to criticism: an emotion and family systems perspective
Neoh, M. J. Y. (2024) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/174933
The Emergence of Consciousness in a Physical UniversePreprint
Singh, R. K. (2024) · Qeios · doi:10.32388/1kc9th.3
The Neuroanatomy and Neurophysiology of the Dog
Masson, S., Bleuer‐Elsner, S., Muller, G., Médam, T., Chevallier, J., & Gaultier, E. (2024) · Springer eBooks · doi:10.1007/978-3-031-53012-8_2
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Successful Emotional Priming in Virtual Reality was Not Modulated by tDCS and Did Not Affect Time PerceptionPreprint
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Authors: Sotres-Bayon, F., & Quirk, G. J.
Affiliations: University of Puerto Rico, Medical Sciences Campus (PR)
ORCID: Quirk, Gregory J
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2010-04
Volume: 20
Issue: 2
Pages: 231-235
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2010.02.005
PMC: PMC2878722
OpenAlex: W2141747781
Cited by: 625
References: 57
Citations by year: 2026: 32 · 2025: 24 · 2024: 39 · 2023: 27 · 2022: 25 · 2021: 45 · 2020: 32 · 2019: 33 · 2018: 42 · 2017: 38 · 2016: 49 · 2015: 54 · 2014: 48 · 2013: 62 · 2012: 35
FWCI: 3.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5p50mh086400-05, 5r01mh081975-05)
National Institute of Mental Health (P-50-MH-086400, R01-MH081975, R01MH058883)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: fear extinction, prefrontal cortex, infralimbic cortex, prelimbic cortex, amygdala, fear regulation, fear expression
MeSH terms: Affect, Amygdala, Animals, Association Learning, Behavior, Extinction, Psychological, Fear, Humans, Neural Pathways, Neuronal Plasticity, Prefrontal Cortex

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Prefrontal control of fear: more than just extinction

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