The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Short-term forms of presynaptic plasticity
Open accessAbstract
Synapses exhibit several forms of short-term plasticity that play a multitude of computational roles. Short-term depression suppresses neurotransmitter release for hundreds of milliseconds to tens of seconds; facilitation and post-tetanic potentiation lead to synaptic enhancement lasting hundreds of milliseconds to minutes. Recent advances have provided insight into the mechanisms underlying these forms of plasticity. Vesicle depletion, as well as inactivation of both release sites and calcium channels, contribute to synaptic depression. Mechanisms of short-term enhancement include calcium channel facilitation, local depletion of calcium buffers, increases in the probability of release downstream of calcium influx, altered vesicle pool properties, and increases in quantal size. Moreover, there is a growing appreciation of the heterogeneity of vesicles and release sites and how they can contribute to use-dependent plasticity.
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“Short-term synaptic plasticity can increase or decrease the strength of a synaptic signal several-fold (Fioravante and Regehr, 2011).”
From The Presynaptic Active Zone (2012) · cites this paper as Fioravante and Regehr, 2011
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Citations
Cites
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Self-citationThe role of calcium in neuromuscular facilitation
Katz, B., & Miledi, R. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008469 · Cited by 1,347
Neher, E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80983-6 · Cited by 1,010
Rizzoli, S. O., & Betz, W. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1583 · Cited by 975
Multiple Roles of Calcium Ions in the Regulation of Neurotransmitter Release
Neher, E., & Sakaba, T. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.019 · Cited by 966
Newton, A. C. (2001) · Chemical Reviews · doi:10.1021/cr0002801 · Cited by 963
The synapsins: Key actors of synapse function and plasticity
Cesca, F., Baldelli, P., Valtorta, F., & Benfenati, F. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.006 · Cited by 654
Calcium Channel Regulation and Presynaptic Plasticity
Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
Kaeser, P. S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo, J., & Südhof, T. C. (2011) · Cell · doi:10.1016/j.cell.2010.12.029 · Cited by 607
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C., & Südhof, T. C. (2002) · Nature · doi:10.1038/415321a · Cited by 579
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Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062
Artificial synapse network on inorganic proton conductor for neuromorphic systems
Zhu, L. Q., Wan, C., Guo, L. Q., Shi, Y., & Wan, Q. C. (2014) · Nature Communications · doi:10.1038/ncomms4158 · Cited by 863
Neuromorphic Functions in PEDOT:PSS Organic Electrochemical Transistors
Gkoupidenis, P., Schaefer, N., Garlan, B., & Malliaras, G. G. (2015) · Advanced Materials · doi:10.1002/adma.201503674 · Cited by 593
Short-Term Presynaptic Plasticity
Regehr, W. G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005702 · Cited by 482
Self-citationElectric-double-layer transistors for synaptic devices and neuromorphic systems
He, Y., Yang, Y., Nie, S., Liu, R., & Wan, Q. C. (2018) · Journal of Materials Chemistry C · doi:10.1039/c8tc00530c · Cited by 244
Metadata
- Authors
- Fioravante, D., & Regehr, W. G.
- Affiliations
- Harvard University (US)
- Corresponding author
- Regehr, Wade G
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 21
- Issue
- 2
- Pages
- 269-274
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC3599780
- OpenAlex
- W1975727393
- Cited by
- 375
- References
- 64
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 22 · 2023: 16 · 2022: 26 · 2021: 26 · 2020: 23 · 2019: 37 · 2018: 34 · 2017: 25 · 2016: 26 · 2015: 29 · 2014: 28 · 2013: 22 · 2012: 24
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R37 NS032405)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- short-term plasticity, short-term depression, short-term facilitation, post-tetanic potentiation, neurotransmitter release, vesicle depletion, calcium buffers, quantal size, release sites, vesicle heterogeneity, use-dependent plasticity
- MeSH terms
- Animals, Humans, Neuronal Plasticity, Synaptic Vesicles, Calcium Channels, Presynaptic Terminals
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