Cited by 383Neuroscience and Neuropharmacology ResearchCellular transport and secretionNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

Short-term forms of presynaptic plasticity

Open access

Fioravante, Diasynou, Regehr, Wade G·2011·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2011.02.003PMC PMC3599780

Open this paper in CoChat — free account

Abstract

Synapses exhibit several forms of short-term plasticity that play a multitude of computational roles. Short-term depression suppresses neurotransmitter release for hundreds of milliseconds to tens of seconds; facilitation and post-tetanic potentiation lead to synaptic enhancement lasting hundreds of milliseconds to minutes. Recent advances have provided insight into the mechanisms underlying these forms of plasticity. Vesicle depletion, as well as inactivation of both release sites and calcium channels, contribute to synaptic depression. Mechanisms of short-term enhancement include calcium channel facilitation, local depletion of calcium buffers, increases in the probability of release downstream of calcium influx, altered vesicle pool properties, and increases in quantal size. Moreover, there is a growing appreciation of the heterogeneity of vesicles and release sites and how they can contribute to use-dependent plasticity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.conb.2011.02.003

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Self-citation
The role of calcium in neuromuscular facilitation
Katz, B., & Miledi, R. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008469 · Cited by 1,347
Vesicle Pools and Ca2+ Microdomains: New Tools for Understanding Their Roles in Neurotransmitter Release
Neher, E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80983-6 · Cited by 1,010
Synaptic vesicle pools
Rizzoli, S. O., & Betz, W. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1583 · Cited by 975
Multiple Roles of Calcium Ions in the Regulation of Neurotransmitter Release
Neher, E., & Sakaba, T. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.019 · Cited by 966
Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions
Newton, A. C. (2001) · Chemical Reviews · doi:10.1021/cr0002801 · Cited by 963
The synapsins: Key actors of synapse function and plasticity
Cesca, F., Baldelli, P., Valtorta, F., & Benfenati, F. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.006 · Cited by 654
Calcium Channel Regulation and Presynaptic Plasticity
Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
Kaeser, P. S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo, J., & Südhof, T. C. (2011) · Cell · doi:10.1016/j.cell.2010.12.029 · Cited by 607
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C., & Südhof, T. C. (2002) · Nature · doi:10.1038/415321a · Cited by 579
Distinct pools of synaptic vesicles in neurotransmitter release
Pieribone, V. A., Shupliakov, O., Brodin, L., Hilfiker, S., Czernik, A. J., & Greengard, P. (1995) · Nature · doi:10.1038/375493a0 · Cited by 532
Determinants of the Time Course of Facilitation at the Granule Cell to Purkinje Cell Synapse
Atluri, P. P., & Regehr, W. G. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05661.1996 · Cited by 513
Self-citation
Calcium Dependence and Recovery Kinetics of Presynaptic Depression at the Climbing Fiber to Purkinje Cell Synapse
Dittman, J. S., & Regehr, W. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06147.1998 · Cited by 410
Self-citation
Short-term plasticity at the calyx of held
von Gersdorff, H., & Borst, J. G. G. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn705 · Cited by 388
Calmodulin Mediates Rapid Recruitment of Fast-Releasing Synaptic Vesicles at a Calyx-Type Synapse
Sakaba, T., & Neher, E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00543-8 · Cited by 363
Vesicle pools and short-term synaptic depression: lessons from a large synapse
Schneggenburger, R., Sakaba, T., & Neher, E. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02139-2 · Cited by 361
Inactivation of Presynaptic Calcium Current Contributes to Synaptic Depression at a Fast Central Synapse
Forsythe, I. D., Tsujimoto, T., Barnes‐Davies, M., Cuttle, M. F., & Takahashi, T. (1998) · Neuron · doi:10.1016/s0896-6273(00)81017-x · Cited by 356
RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone
Han, Y., Kaeser, P. S., Südhof, T. C., & Schneggenburger, R. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.014 · Cited by 354
Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity
Junge, H. J., Rhee, J.-S., Jahn, O., Varoqueaux, F., Spiess, J., Waxham, M. N., Rosenmund, C., & Brose, N. (2004) · Cell · doi:10.1016/j.cell.2004.06.029 · Cited by 290
RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13
Deng, L., Kaeser, P. S., Xu, W., & Südhof, T. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.005 · Cited by 287
The role of presynaptic calcium in short-term enhancement at the hippocampal mossy fiber synapse
Regehr, W. G., Delaney, K., & Tank, D. W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00523.1994 · Cited by 269
Self-citation
Ca2+ Buffer Saturation Underlies Paired Pulse Facilitation in Calbindin-D28k-Containing Terminals
Blatow, M., Caputi, A., Burnashev, N., Monyer, H., & Rozov, A. V. (2003) · Neuron · doi:10.1016/s0896-6273(03)00196-x · Cited by 267
Calcium Dependence of Exo- and Endocytotic Coupling at a Glutamatergic Synapse
Hosoi, N., Holt, M., & Sakaba, T. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.010 · Cited by 256
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
Shin, O.-H., Lu, J., Rhee, J.-S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., Machius, M., Rizo, J., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1758 · Cited by 243
The Decrease in the Presynaptic Calcium Current Is a Major Cause of Short-Term Depression at a Calyx-Type Synapse
Xu, J., & Wu, L. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.024 · Cited by 241
Interdependence of PKC-Dependent and PKC-Independent Pathways for Presynaptic Plasticity
Wierda, K. D. B., Toonen, R. F. G., de Wit, H., Brussaard, A. B., & Verhage, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.001 · Cited by 225
Bassoon speeds vesicle reloading at a central excitatory synapse
Hallermann, S., Fejtova, A., Schmidt, H., Weyhersmüller, A., Silver, R. A., Gundelfinger, E. D., & Eilers, J. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.026 · Cited by 223
Quantitative Relationship between Transmitter Release and Calcium Current at the Calyx of Held Synapse
Sakaba, T., & Neher, E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00462.2001 · Cited by 216
Probing the Intracellular Calcium Sensitivity of Transmitter Release during Synaptic Facilitation
Felmy, F., Neher, E., & Schneggenburger, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00085-0 · Cited by 185
Regulation of Presynaptic CaV2.1 Channels by Ca2+ Sensor Proteins Mediates Short-Term Synaptic Plasticity
Mochida, S., Few, A. P., Scheuer, T., & Catterall, W. A. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.036 · Cited by 174
PTP and LTP at a hippocampal mossy fiber-interneuron synapse
Alle, H., Jonas, P., & Geiger, J. R. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251610898 · Cited by 158
Multiple Roles for the Active Zone Protein RIM1α in Late Stages of Neurotransmitter Release
Calakos, N., Schoch, S., Südhof, T. C., & Malenka, R. C. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.014 · Cited by 155
Quantitative Analysis of Calcium-Dependent Vesicle Recruitment and Its Functional Role at the Calyx of Held Synapse
Hosoi, N., Sakaba, T., & Neher, E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4122-07.2007 · Cited by 154
Phorbol Esters Modulate Spontaneous and Ca2+-Evoked Transmitter Release via Acting on Both Munc13 and Protein Kinase C
Lou, X., Korogod, N., Brose, N., & Schneggenburger, R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0550-08.2008 · Cited by 140
Functional Compensation of P/Q by N-Type Channels Blocks Short-Term Plasticity at the Calyx of Held Presynaptic Terminal
Inchauspe, C. G., Martini, F. J., Forsythe, I. D., & Uchitel, O. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2104-04.2004 · Cited by 140
Roles of the Fast-Releasing and the Slowly Releasing Vesicles in Synaptic Transmission at the Calyx of Held
Sakaba, T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0182-06.2006 · Cited by 134
Compound vesicle fusion increases quantal size and potentiates synaptic transmission
He, L., Xue, L., Xu, J., McNeil, B. D., Bai, L., Melicoff, E., Adachi, R., & Wu, L. (2009) · Nature · doi:10.1038/nature07860 · Cited by 132
Presynaptic N‐type and P/Q‐type Ca 2+ channels mediating synaptic transmission at the calyx of Held of mice
Ishikawa, T., Kaneko, M., Shin, H., & Takahashi, T. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.089912 · Cited by 131
Post‐tetanic potentiation in the rat calyx of Held synapse
Habets, R. L. P., & Borst, J. G. G. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.079160 · Cited by 111
Properties and Plasticity of Paired-Pulse Depression at a Central Synapse
Waldeck, R. F., Pereda, A. E., & Faber, D. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05312.2000 · Cited by 110
Facilitation through Buffer Saturation: Constraints on Endogenous Buffering Properties
Matveev, V., Zucker, R. S., & Sherman, A. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74324-6 · Cited by 108
Short-Term Synaptic Depression and Recovery at the Mature Mammalian Endbulb of Held Synapse in Mice
Wang, Y., & Manis, P. B. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90715.2008 · Cited by 106
Two Ca2+-Dependent Steps Controlling Synaptic Vesicle Fusion and Replenishment at the Cerebellar Basket Cell Terminal
Sakaba, T. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.029 · Cited by 103
Relative Roles of Different Mechanisms of Depression at the Mouse Endbulb of Held
Yang, H., & Xu‐Friedman, M. A. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01293.2007 · Cited by 101
Naked Dense Bodies Provoke Depression
Hallermann, S., Kittel, R. J., Wichmann, C., Rings, A., Fouquet, W., Mertel, S., Owald, D., Eimer, S., Depner, H., Schwärzel, M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2495-10.2010 · Cited by 97
Effects of Mobile Buffers on Facilitation: Experimental and Computational Studies
Tang, Y.-G., Schlumpberger, T., Kim, T., Lueker, M., & Zucker, R. S. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76819-6 · Cited by 97
Activity-dependent activation of presynaptic protein kinase C mediates post-tetanic potentiation
Brager, D. H., Cai, X., & Thompson, S. M. (2003) · Nature Neuroscience · doi:10.1038/nn1067 · Cited by 95
Posttetanic potentiation critically depends on an enhanced Ca 2+ sensitivity of vesicle fusion mediated by presynaptic PKC
Korogod, N., Lou, X., & Schneggenburger, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704603104 · Cited by 94
Role of Ca2+ channels in short-term synaptic plasticity
Xu, J., He, L., & Wu, L. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.005 · Cited by 86
Target Cell-Specific Involvement of Presynaptic Mitochondria in Post-Tetanic Potentiation at Hippocampal Mossy Fiber Synapses
Lee, D., Lee, K.-H., Ho, W., & Lee, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3985-07.2007 · Cited by 85
RIM proteins and their role in synapse function
Mittelstaedt, T., Álvarez‐Barón, E., & Schoch, S. (2010) · Biological Chemistry · doi:10.1515/bc.2010.064 · Cited by 82
Presynaptic Release Probability and Readily Releasable Pool Size Are Regulated by Two Independent Mechanisms during Posttetanic Potentiation at the Calyx of Held Synapse
Lee, J. S., Kim, M., Ho, W., & Lee, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2165-08.2008 · Cited by 80
Differential Expression of Posttetanic Potentiation and Retrograde Signaling Mediate Target-Dependent Short-Term Synaptic Plasticity
Beierlein, M., Fioravante, D., & Regehr, W. G. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.002 · Cited by 78
Self-citation
Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short‐term synaptic plasticity
Rodríguez-Castañeda, F., Maestre-Martínez, M., Coudevylle, N., Dimova, K. P., Junge, H. J., Lipstein, N., Lee, D., Becker, S., Brose, N., Jahn, O., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.373 · Cited by 77
Frequency-Independent Synaptic Transmission Supports a Linear Vestibular Behavior
Bagnall, M. W., McElvain, L. E., Faulstich, M., & du Lac, S. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.002 · Cited by 76
Interaction between Facilitation and Depression at a Large CNS Synapse Reveals Mechanisms of Short-Term Plasticity
Müller, M., Goutman, J., Kochubey, O., & Schneggenburger, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4378-09.2010 · Cited by 67
Post-tetanic increase in the fast-releasing synaptic vesicle pool at the expense of the slowly releasing pool
Lee, J. S., Ho, W., & Lee, S. (2010) · The Journal of General Physiology · doi:10.1085/jgp.201010437 · Cited by 61
An Increase in Calcium Influx Contributes to Post-Tetanic Potentiation at the Rat Calyx of Held Synapse
Habets, R. L. P., & Borst, J. G. G. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00427.2006 · Cited by 60
Release‐independent depression at pyramidal inputs onto specific cell targets: dual recordings in slices of rat cortex
Thomson, A. M., & Bannister, A. P. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0057o.x · Cited by 56
Gene targeting of presynaptic proteins in synaptic plasticity and memory: Across the great divide
Powell, C. M. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.08.014 · Cited by 47
Phosphorylation of synapsin domain A is required for post-tetanic potentiation
Fiumara, F., Milanese, C., Corradi, A. M., Giovedì, S., Leitinger, G., Menegon, A., Montarolo, P. G., Benfenati, F., & Ghirardi, M. (2007) · Journal of Cell Science · doi:10.1242/jcs.012005 · Cited by 46
Activity-dependent calpain activation plays a critical role in synaptic facilitation and post-tetanic potentiationPreprint
Khoutorsky, A., & Spira, M. E. (2009) · Learning & Memory · doi:10.1101/lm.1275709 · Cited by 24
Endocytosis and synaptic plasticity: might the tail wag the dog?
Wilkinson, R. S., & Lin, M. Y. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.01.011 · Cited by 15
Fluctuation Analysis of Tetanic Rundown (Short-Term Depression) at a Corticothalamic Synapse
Ran, I., Quastel, D. M. J., Mathers, D. A., & Puil, E. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.3891 · Cited by 6

Flagged first, then by citations

Sorted by citations

The Presynaptic Active Zone
Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062
Artificial synapse network on inorganic proton conductor for neuromorphic systems
Zhu, L. Q., Wan, C., Guo, L. Q., Shi, Y., & Wan, Q. C. (2014) · Nature Communications · doi:10.1038/ncomms4158 · Cited by 863
Neuromorphic Functions in PEDOT:PSS Organic Electrochemical Transistors
Gkoupidenis, P., Schaefer, N., Garlan, B., & Malliaras, G. G. (2015) · Advanced Materials · doi:10.1002/adma.201503674 · Cited by 593
Short-Term Presynaptic Plasticity
Regehr, W. G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005702 · Cited by 482
Self-citation
Electric-double-layer transistors for synaptic devices and neuromorphic systems
He, Y., Yang, Y., Nie, S., Liu, R., & Wan, Q. C. (2018) · Journal of Materials Chemistry C · doi:10.1039/c8tc00530c · Cited by 244

See all 383

Authors: Fioravante, D., & Regehr, W. G.
Affiliations: Harvard University (US)
Corresponding author: Regehr, Wade G
ORCID: Fioravante, Diasynou
Regehr, Wade G
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2011-04
Volume: 21
Issue: 2
Pages: 269-274
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2011.02.003
PMC: PMC3599780
OpenAlex: W1975727393
Cited by: 375
References: 64
Citations by year: 2026: 12 · 2025: 22 · 2024: 22 · 2023: 16 · 2022: 26 · 2021: 26 · 2020: 23 · 2019: 37 · 2018: 34 · 2017: 25 · 2016: 26 · 2015: 29 · 2014: 28 · 2013: 22 · 2012: 24
FWCI: 2.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R37 NS032405)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: short-term plasticity, short-term depression, short-term facilitation, post-tetanic potentiation, neurotransmitter release, vesicle depletion, calcium buffers, quantal size, release sites, vesicle heterogeneity, use-dependent plasticity
MeSH terms: Animals, Humans, Neuronal Plasticity, Synaptic Vesicles, Calcium Channels, Presynaptic Terminals

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Short-term forms of presynaptic plasticity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks