Genetic approaches for understanding the role of serotonin receptors in mood and behavior
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Serotonin (5-hydroxytryptamine; 5-HT) is an ancient signaling molecule that has a conserved role in modulating mood and behavior. Integral to its pleiotropic actions is the existence of multiple receptors, expressed in distinct but often overlapping patterns within the brain and the periphery. The existence of ∼14 mammalian receptor subtypes, many of which possess similar pharmacological profiles, has made assigning functional roles for these receptors challenging. This challenge has been further compounded by the revelation that a single receptor can have several different functions depending upon where and when it is expressed and activated, that is, in brain versus periphery, or at different developmental time points. This review highlights the contribution of genetic techniques to dissect the specific function of distinct serotonin receptor populations across the life course, with an emphasis on the contribution of different serotonin 1A receptor populations to mood and behavior. Similar approaches hold the promise to elucidate the functional roles of other receptors, as well as the interaction of serotonin with other neuroendocrine modulators of mood and behavior.
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Transgenic technology allows investigators to upregulate or downregulate genes of interest in specific brain regions at particular developmental timepoints with temporal and spatial precision not previously achievable.
“These strategies allow investigators to upregulate or downregulate genes of interest in specific brain regions at particular developmental timepoints, with temporal and spatial precision that has not previously been achievable 88.”
From DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS: Review: Dissecting OCD Circuits: Animals to Treatments (2015) · cites this paper as [88]
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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Self-citationA review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,150 · see citing works
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985 · see citing works
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · see citing works
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855 · see citing works
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428 · see citing works
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works
The spectrum of behaviors influenced by serotonin
Lucki, I. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00139-5 · Cited by 1,154 · see citing works
Psychopharmacology: The Fourth Generation of Progress
Green, A. I. (1996) · Psychiatric Services · doi:10.1176/ps.47.3.312 · Cited by 1,151 · see citing works
Regulation of serotonin-2C receptor G-protein coupling by RNA editing
Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., & Emeson, R. B. (1997) · Nature · doi:10.1038/387303a0 · Cited by 1,010 · cited 1× · see citing works
“There are 14 known human 5-HT receptors, more than in any other neuromodulatory system; receptor diversity is further amplified by alternative splicing, RNA editing, and heterodimerization [1,2].”
BackgroundDentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
McHugh, T. J., Jones, M. W., Quinn, J. J., Balthasar, N., Coppari, R., Elmquist, J. K., Lowell, B. B., Fanselow, M. S., Wilson, M. A., & Tonegawa, S. (2007) · Science · doi:10.1126/science.1140263 · Cited by 958 · see citing works
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works
Self-citationNichols, D. E., & Nichols, C. D. (2008) · Chemical Reviews · doi:10.1021/cr078224o · Cited by 895 · cited 2× · see citing works
“Multiple different receptors can be expressed in the same brain regions, and even within the same cells [2].”
BackgroundEnhanced Aggressive Behavior in Mice Lacking 5-HT 1B Receptor
Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Ségu, L., Buhot, M.-C., & Hen, R. (1994) · Science · doi:10.1126/science.8091214 · Cited by 839 · see citing works
Self-citationPazos, Á., Cortés, R., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90857-1 · Cited by 824 · see citing works
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works
Self-citationSerotonin receptor 1A knockout: An animal model of anxiety-related disorder
Ramboz, S., Oosting, R. S., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M. M., Mann, J. J., Brunner, D., & Hen, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14476 · Cited by 813 · see citing works
Self-citationElevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice
Heisler, L. K., Chu, H.-M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., & Tecott, L. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15049 · Cited by 704 · see citing works
Increased anxiety of mice lacking the serotonin 1A receptor
Parks, C. L., Robinson, P. S., Sibille, E. L., Shenk, T. E., & Tóth, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10734 · Cited by 691 · see citing works
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T. L., Kobilka, T. S., Francke, U., Lefkowitz, R. J., & Caron, M. G. (1987) · Nature · doi:10.1038/329075a0 · Cited by 515 · see citing works
Peyron, C., Petit, J.-M., Rampon, C., Jouvet, M., & Luppi, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00268-6 · Cited by 509 · see citing works
Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders
Kheirbek, M. A., Klemenhagen, K. C., Sahay, A., & Hen, R. (2012) · Nature Neuroscience · doi:10.1038/nn.3262 · Cited by 509 · see citing works
Self-citation5-HT1A receptor agonists: recent developments and controversial issues
Vry, J. D. (1995) · Psychopharmacology · doi:10.1007/bf02245588 · Cited by 455 · see citing works
5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
Richardson-Jones, J. W., Craige, C. P., Guiard, B. P., Stephen, A., Metzger, K. L., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Beck, S. G., et al. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.003 · Cited by 450 · see citing works
Self-citationVeenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112345109 · Cited by 333 · see citing works
Serotonergic Modulation of Neurotransmission in the Rat Basolateral Amygdala
Rainnie, D. G. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.1.69 · Cited by 310 · see citing works
Serotonin, the periaqueductal gray and panic
Graeff, F. G. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.12.004 · Cited by 285 · see citing works
5-HT1A Receptors, Gene Repression, and Depression: Guilt by Association
Albert, P. R., & Lemonde, S. (2004) · The Neuroscientist · doi:10.1177/1073858404267382 · Cited by 275 · see citing works
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
Holmes, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.006 · Cited by 264 · see citing works
Role of Somatodendritic 5‐HT Autoreceptors in Modulating 5‐HT Neurotransmission a
Blier, P., Piñeyro, G., Mansari, M. E., Bergeron, R., & de Montigny, C. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10192.x · Cited by 262 · see citing works
The neuropsychology of anxiety: reprise.
Gray, J. A., & McNaughton, N. (1996) · PubMed · Cited by 230 · see citing works
Hale, M. W., Shekhar, A., & Lowry, C. A. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9827-1 · Cited by 210 · see citing works
Gardier, A. M., Malagié, I., Trillat, A., Jacquot, C., & Artigas, F. (1996) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1996.tb00145.x · Cited by 198 · see citing works
Richardson-Jones, J. W., Craige, C. P., Nguyen, T. H., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Guiard, B. P., Beck, S. G., Hen, R., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5836-10.2011 · Cited by 192 · see citing works
Self-citationCapacity for 5-HT1A–mediated autoregulation predicts amygdala reactivity
Fisher, P. M., Meltzer, C. C., Ziolko, S. K., Price, J. C., Moses-Kolko, E. L., Berga, S. L., & Hariri, A. R. (2006) · Nature Neuroscience · doi:10.1038/nn1780 · Cited by 156 · see citing works
Transcriptional regulation of the 5-HT 1A receptor: implications for mental illness
Albert, P. R. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0376 · Cited by 137 · see citing works
Cai, X., Gu, Z., Zhong, P., Ren, Y., & Yan, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203752200 · Cited by 130 · see citing works
Ceci, A., Baschirotto, A., & Borsini, F. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90177-5 · Cited by 126 · see citing works
The use of antidepressant drugs in patients with heart disease.
Glassman, A. H., Rodríguez, A. I. E., & Shapiro, P. A. (1998) · PubMed · Cited by 125 · see citing works
Laaris, N., Haj‐Dahmane, S., Hamon, M., & Lanfumey, L. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00095-n · Cited by 124 · see citing works
Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex
Casanovas, J. M., Hervás, I., & Artigas, F. (1999) · Neuroreport · doi:10.1097/00001756-199905140-00010 · Cited by 118 · see citing works
Ashby, C. R., Edwards, E., & Wang, R. Y. (1994) · Synapse · doi:10.1002/syn.890170306 · Cited by 116 · see citing works
5-HT1A autoreceptor desensitization by chronic ultramild stress in mice
Lanfumey, L., Pardon, M., Laaris, N., Joubert, C., Hanoun, N., Hamon, M., & Cohen‐Salmon, C. (1999) · Neuroreport · doi:10.1097/00001756-199911080-00021 · Cited by 107 · see citing works
Serotonin transporter gene polymorphism and affective disorder.
Kunugi, H., Tatsumi, M., Sakai, T., Hattori, M., & Nanko, S. (1996) · PubMed · Cited by 96 · see citing works
Tanaka, K. F., Ahmari, S. E., Leonardo, E. D., Richardson-Jones, J. W., Budreck, E. C., Scheiffele, P., Sugio, S., Inamura, N., Ikenaka, K., & Hen, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.020 · Cited by 96 · see citing works
Self-citationThe Main Features of Central 5-HT1A Receptors
Hamon, M. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60921-3_9 · Cited by 95 · see citing works
Parsons, L. H., Kerr, T. M., & Tecott, L. H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00254.x · Cited by 92 · see citing works
Haddjeri, N., Lavoie, N., & Blier, P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300489 · Cited by 91 · see citing works
Kung, M. P., Frederick, D., Mu, M., Zhuang, Z. P., & Kung, H. F. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24352-x · Cited by 89 · see citing works
Early life adversity programs changes in central 5‐HT neuronal function in adulthood
Gartside, S. E., Johnson, D. A., Leitch, M. M., Troakes, C., & Ingram, C. D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02668.x · Cited by 88 · see citing works
Iacono, L. L., & Gross, C. T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5219-07.2008 · Cited by 82 · see citing works
Serotonin transporter gene polymorphism and affective disorder
Kunugi, H., Tatsumi, M., Sakai, T., Hattori, M., Nanko, S., Stöber, G., Heils, A., & Lesch, K. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90993-9 · Cited by 82 · see citing works
Spinelli, S., Chefer, S. I., Carson, R. E., Jagoda, E. M., Lang, L., Heilig, M. A., Barr, C. S., Suomi, S. J., Higley, J. D., & Stein, E. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.030 · Cited by 77 · see citing works
Modification of serotonin neuron properties in mice lacking 5-HT1A receptors
Richer, M., Hen, R., & Blier, P. U. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01607-7 · Cited by 67 · see citing works
Self-citationThe main features of central 5-HT1 receptors.
Hamon, M., Lanfumey, L., Mestikawy, S. E., Boni, C., Miquel, M. C., Bolaños, F. J., Schechter, L. E., & GOZLAN, H. (1989) · HAL · Cited by 65 · see citing works
Laaris, N., Poul, E. L., Hamon, M., & Lanfumey, L. (1997) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1997.tb00187.x · Cited by 61 · see citing works
Early-Life Blockade of 5-HT1A Receptors Alters Adult Anxiety Behavior and Benzodiazepine Sensitivity
Vinkers, C. H., Oosting, R. S., van Bogaert, M. J. V., Olivier, B., & Groenink, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.013 · Cited by 59 · see citing works
He, M. L., Sibille, E. L., Benjamin, D., Tóth, M., & Shippenberg, T. S. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02271-5 · Cited by 59 · see citing works
Raymond, J. R., Kim, J., Beach, R. E., & Tisher, C. C. (1993) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1993.264.1.f9 · Cited by 57 · see citing works
Fisher, P. M., Price, J. C., MELTZER, C. C., Moses‐Kolko, E. L., Becker, C. R., Berga, S. L., & Hariri, A. R. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-2 · Cited by 50 · see citing works
Wang, S., Zhang, Z., Guo, Y., Teng, G., & Chen, B. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.07.006 · Cited by 44 · see citing works
Altered Function of the Serotonin 1A Autoreceptor and the Antidepressant Response
Blier, P. U. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.028 · Cited by 41 · see citing works
Barone, P. R., Jordan, D., Atger, F., Kopp, N., & Fillion, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)90636-x · Cited by 36 · see citing works
Effects of stereoselective 5-HT1A agonists on male rat sexual behavior
Ahlénius, S., Larsson, K., & Arvidsson, L. E. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90408-5 · Cited by 34 · see citing works
Iyo, A. H., Kieran, N., Chandran, A., Albert, P. R., Wicks, I., Bissette, G., & Austin, M. C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.053 · Cited by 30 · see citing works
Role of 5-HT1A receptors in fluoxetine-induced lordosis inhibition
Guptarak, J., Sarkar, J., Hiegel, C., & Uphouse, L. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.003 · Cited by 28 · see citing works
Raymond, J. R., Fargin, A., Lohse, M. J., Regan, J. W., Senogles, S. E., Lefkowitz, R. J., & Caron, M. G. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09091-1 · Cited by 27 · see citing works
Mouse Models of the 5-HTTLPR × Stress Risk Factor for Depression
Carola, V., & Gross, C. T. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_190 · Cited by 23 · see citing works
New antidepressant strategy based on acute siRNA silencing of 5-HT1A autoreceptors
Bortolozzi, A. A., Castañé, A., Semakova, J., Santana, N., Alvarado, G., Cortés, R., Ferrés‐Coy, A., Fernández, G., Carmona, M. C., Tóth, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.52 · Cited by 15 · see citing works
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1 of the 71 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [25]Blier P Bergeron R The use of pindolol to potentiate antidepressant medication The Journal of clinical psychiatry 1998 59 Suppl 5 16 23 discussion 24–15 9635544
Cited by
Sorted by citations
50 years of hurdles and hope in anxiolytic drug discovery
Griebel, G., & Holmes, A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4075 · Cited by 414 · see citing works
Serotonergic neurons signal reward and punishment on multiple timescales
Cohen, J. Y., Amoroso, M. W., & Uchida, N. (2015) · eLife · doi:10.7554/elife.06346 · Cited by 388 · see citing works
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior
Crews, F. T., Vetreno, R. P., Broadwater, M., & Robinson, D. L. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012138 · Cited by 332 · see citing works
Albert, P. R., Vahid-Ansari, F., & Luckhart, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00199 · Cited by 321 · see citing works
Optogenetic pharmacology for control of native neuronal signaling proteins
Krämer, R., Mourot, A., & Adesnik, H. (2013) · Nature Neuroscience · doi:10.1038/nn.3424 · Cited by 240 · see citing works
Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use
Taylor, C. P., Traynelis, S. F., Siffert, J. O., Pope, L. E., & Matsumoto, R. R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.010 · Cited by 188 · see citing works
Ahmari, S. E., & Dougherty, D. D. (2015) · Depression and Anxiety · doi:10.1002/da.22367 · Cited by 128 · see citing works
Self-citationMood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms
Pla, P., Orvoën, S., Saudou, F., David, D. J. P., & Humbert, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00135 · Cited by 91 · see citing works
Shadmehr, R., & Ahmed, A. A. (2020) · The MIT Press eBooks · doi:10.7551/mitpress/12940.001.0001 · Cited by 103 · see citing works
Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale
Dag, U., Nwabudike, I., Kang, D., Gomes, M. A., Kim, J. S., Atanas, A. A., Bueno, E., Estrem, C., Pugliese, S. M., Wang, Z., et al. (2023) · Cell · doi:10.1016/j.cell.2023.04.023 · Cited by 93 · see citing works
Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans
Koelle, M. R. (2016) · WormBook · doi:10.1895/wormbook.1.75.2 · Cited by 57 · see citing works
Donaldson, Z. R., François, B. L., Santos, T. L., Almli, L. M., Boldrini, M., Champagne, F. A., Arango, V., Mann, J. J., Stockmeier, C. A., Galfalvy, H., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.226 · Cited by 58 · see citing works
Self-citationEfimova, E. V., Kozlova, A. A., Razenkova, V. A., Katolikova, N. V., Antonova, K. A., Sotnikova, T. D., Merkulyeva, N. S., Veshchitskii, A. S., Kalinina, D. S., Korzhevsky, D. E., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108373 · Cited by 55 · see citing works
The role of serotonin in depression—A historical roundup and future directions
Bremshey, S., Groß, J., Renken, K., & Masseck, O. A. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16097 · Cited by 60 · see citing works
Gwynne, W. D., Hallett, R. M., Girgis-Gabardo, A., Bojović, B., Dvorkin‐Gheva, A., Aarts, C. W., Dias, K., Bane, A. L., & Hassell, J. A. (2017) · Oncotarget · doi:10.18632/oncotarget.16646 · Cited by 54 · see citing works
Sun, S., Yang, S., Mao, Y., Jia, X., & Zhang, Z. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0020-7 · Cited by 49 · see citing works
Weinersmith, K. L., & Earley, R. L. (2016) · Animal Behaviour · doi:10.1016/j.anbehav.2016.06.004 · Cited by 48 · see citing works
Liu, Y., Shan, L., Liu, T., Li, J., Chen, Y., Sun, C., Yang, C., Bian, X., Niu, Y., Zhang, C., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.02.010 · Cited by 45 · see citing works
Peterson, M. P., Rosvall, K. A., Taylor, C. A., Lopez, J. A., Choi, J.-H., Ziegenfus, C., Tang, H., Colbourne, J. K., & Ketterson, E. D. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.089813 · Cited by 33 · see citing works
Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis
Song, N., Huang, Y., Yu, X., Lang, B., Ding, Y., & Zhang, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00185 · Cited by 32 · see citing works
Behavioral Effects of Exposure to Phthalates in Female Rodents: Evidence for Endocrine Disruption?
Adam, N., & Mhaouty‐Kodja, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052559 · Cited by 27 · see citing works
Antidepressants for neuroprotection in Huntington's disease: A review
Jamwal, S., & Kumar, P. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.033 · Cited by 27 · see citing works
Spatial memory in Huntington’s disease: A comparative review of human and animal data
Glikmann‐Johnston, Y., Fink, K. D., Deng, P., Torrest, A., & Stout, J. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.015 · Cited by 27 · see citing works
Luckhart, C., Philippe, T. J., François, B. L., Vahid-Ansari, F., Geddes, S. D., Béïque, J.-C., Lagace, D. C., Daigle, M., & Albert, P. R. (2016) · Molecular Brain · doi:10.1186/s13041-016-0254-y · Cited by 24 · see citing works
Harkin, E. F., Lynn, M. B., Payeur, A., Boucher, J.-F., Caya-Bissonnette, L., Cyr, D., Stewart, C. A., Longtin, A., Naud, R., & Béïque, J.-C. (2023) · eLife · doi:10.7554/elife.72951 · Cited by 21 · see citing works
Assessing neurocognitive function in psychiatric disorders: A roadmap for enhancing consensus
Ahmari, S. E., Eich, T. S., Cebenoyan, D., Smith, E. E., & Simpson, H. B. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.06.011 · Cited by 20 · see citing works
Self-citationTsuji, M., Miyagawa, K., & Takeda, H. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14r07cp · Cited by 19 · see citing works
Kim, M., Hwang, I., Pagire, H. S., Pagire, S. H., Choi, W., Choi, W. G., Yoon, J., Lee, W. M., Song, J. S., Yoo, E. K., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00002 · Cited by 17 · see citing works
Eriksson, O., Wall, A. E., Olsson, U., Marteinsdóttir, Í., Holstad, M., Ågren, H., Hartvig, P., Långström, B., & Naessén, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159538 · Cited by 13 · see citing works
Curtin, A. C., & Johnston, C. S. (2022) · Journal of Dietary Supplements · doi:10.1080/19390211.2022.2030843 · Cited by 8 · see citing works
Pettitt, A. (2015) · eNeuro · doi:10.1523/eneuro.0032-14.2015 · Cited by 7 · see citing works
Li, M., Zhang, L., Wu, Y., Li, Y., Chen, X., Chen, J., Wang, Q., Liao, C., & Han, Q. (2022) · Insects · doi:10.3390/insects13080671 · Cited by 6 · see citing works
Griffith, T. A., Russell, J. S., Naghipour, S., Helman, T. J., Peart, J. N., Stapelberg, N. J. C., Headrick, J. P., & Toit, E. F. D. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121137 · Cited by 5 · see citing works
Xie, Y., Li, C., Guan, M., Zhang, T., Ma, C., Wang, L., Li, X., Li, Y., Wang, Z., Wang, H., et al. (2025) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.70014 · Cited by 1 · see citing works
White, S. (2013) · ScholarlyCommons (University of Pennsylvania)
Griebel, G., & Beeské, S. (2014) · Methods and principles in medicinal chemistry · doi:10.1002/9783527679348.ch09
Базовкина, Д. В., & Kulikov, A. V. (2016) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-016-0278-x
Genetics of the Mind and Brain Disorders
Popovitchenko, T., & Rašin, M. (2017) · Springer series in cognitive and neural systems · doi:10.1007/978-3-319-29674-6_28
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Sizemore, T. R. (2021) · doi:10.33915/etd.8318
Bhimanwar, A. A., Ghaisas, M. M., & Shete, R. V. (2022) · Asian Pacific Journal of Health Sciences · doi:10.21276/apjhs.2022.9.4.38
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Tsybko, A. S. (2023) · Priroda · doi:10.7868/s0032874x23020011
Effets de l’exposition aux phtalates sur les comportements de reproduction de la souris femelle
Adam, N. (2022) · theses.fr (ABES) · doi:10.70675/f8535eb9z782dz40b8zb1d0z583132d3fd1b
BindingDB Entry 50010584: Design, Synthesis, and Biological Evaluation of New Peripheral 5HT
BindingDB (2021) · UC San Diego · doi:10.7270/q2cz3bpx
- Authors
- Donaldson, Z. R., Nautiyal, K. M., Ahmari, S. E., & Hen, R.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Donaldson, Zoe R
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 23
- Issue
- 3
- Pages
- 399-406
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC3652904
- OpenAlex
- W2081560912
- Cited by
- 42
- References
- 71
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 5 · 2013: 4
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (T32 MH015144, R37 MH068542, K08 MH087718)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- serotonin receptors, 5-HT1A receptor, mood, behavior, receptor subtypes, neuroendocrine regulation, mood disorders
- MeSH terms
- Affect, Animals, Behavior, Mental Disorders, Brain, Humans, Mice, Knockout, Receptor, Serotonin, 5-HT1A, Mice
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