Serotonergic neurons signal reward and punishment on multiple timescales

A neural substrate of prediction and reward

Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works

Millisecond-timescale, genetically targeted optical control of neural activity

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works

The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes

Buzsáki, G., Anastassiou, C. A., & Koch, C. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3241 · Cited by 4,225 · see citing works

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

Nagel, G., Szellas, T., Huhn, W., Kateriya, S., Adeishvili, N., Berthold, P. R., Ollig, D., Hegemann, P., & Bamberg, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1936192100 · Cited by 2,672 · see citing works

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works

Structure and function of the brain serotonin system

Jacobs, B. L., & Azmitia, E. C. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.1.165 · Cited by 2,574 · see citing works

Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals

Steinbusch, H. W. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90146-9 · Cited by 2,415 · see citing works

An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat

Azmitia, E. C., & Segal, M. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901790311 · Cited by 1,908 · see citing works

Two types of dopamine neuron distinctly convey positive and negative motivational signals

Matsumoto, M., & Hikosaka, O. (2009) · Nature · doi:10.1038/nature08028 · Cited by 1,378 · see citing works

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature · doi:10.1038/nature10754 · Cited by 1,318 · see citing works

Efferent connections of the substantia nigra and ventral tegmental area in the rat

Beckstead, R. M., Domesick, V. B., & Nauta, W. J. H. (1979) · Brain Research · doi:10.1016/0006-8993(79)91001-1 · Cited by 1,293 · see citing works

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

Watabe‐Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A., & Uchida, N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.017 · Cited by 1,221 · see citing works

Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements

Harris, K. D., Henze, D. A., Csicsvari, J. L., Hirase, H., & Buzsáki, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.401 · Cited by 1,153 · see citing works

5-HT and mechanisms of defence

Deakin, J. F. W., & Graeff, F. G. (1991) · Journal of Psychopharmacology · doi:10.1177/026988119100500414 · Cited by 1,011 · see citing works

Reconciling the role of central serotonin neurons in human and animal behavior

Soubrié, P. (1986) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00022871 · Cited by 993 · see citing works

Intracellular Features Predicted by Extracellular Recordings in the Hippocampus In Vivo

Henze, D. A., Borhegyi, Z., Csicsvari, J., Mamiya, A., Harris, K. D., & Buzsáki, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.390 · Cited by 942 · see citing works

Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning

Schoenbaum, G. M., Chiba, A. A., & Gallagher, M. (1998) · Nature Neuroscience · doi:10.1038/407 · Cited by 849 · see citing works

Opponent interactions between serotonin and dopamine

Daw, N. D., Kakade, S., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00052-7 · Cited by 844 · see citing works

A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat

Vertes, R. P. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130409 · Cited by 842 · see citing works

Serotonin neurons of the midbrain raphe: Ascending projections

Moore, R. Y., Halaris, A. E., & Jones, B. E. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800302 · Cited by 803 · see citing works

Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor.

Maier, S. F., & Watkins, L. R. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.021 · Cited by 737 · see citing works

Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns

Berridge, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00072-x · Cited by 721 · see citing works

Speed and accuracy of olfactory discrimination in the rat

Uchida, N., & Mainen, Z. F. (2003) · Nature Neuroscience · doi:10.1038/nn1142 · Cited by 687 · see citing works

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

Peciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671 · see citing works

Major Depressive Disorder

D, M. F. M., & Kendler, K. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00112-4 · Cited by 619 · see citing works

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

Atasoy, D., Aponte, Y., Su, H. H., & Sternson, S. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1954-08.2008 · Cited by 614 · see citing works

5-HT1A receptor function in major depressive disorder

Savitz, J. B., Lucki, I., & Drevets, W. C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.009 · Cited by 573 · see citing works

Localization of serotonin in the central nervous system by immunohistochemistry: Description of a specific and sensitive technique and some applications

Steinbusch, H. W. M., Verhofstad, A. A. J., & Joosten, H. W. J. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90033-7 · Cited by 541 · see citing works

Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods

Peyron, C., Petit, J.-M., Rampon, C., Jouvet, M., & Luppi, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00268-6 · Cited by 509 · see citing works

Control of Dorsal Raphe Serotonergic Neurons by the Medial Prefrontal Cortex: Involvement of Serotonin-1A, GABA_A, and Glutamate Receptors

Celada, P., Puig, M. V., Casanovas, J. M., Guillazo, G., & Artigas, F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09917.2001 · Cited by 497 · see citing works

Dorsal raphe neurons signal reward through 5-HT and glutamate

Liu, Z., Zhou, J., Li, Y., Hu, F., Lu, Y., Ma, M., Feng, Q., Zhang, J.-E., Wang, D., Zeng, J., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.010 · Cited by 469 · see citing works

Serotonin and dopamine: unifying affective, activational, and decision functions.

Cools, R., Nakamura, K., & Daw, N. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.121 · Cited by 464 · see citing works

Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus

Bäckman, C. M., Malik, N., Zhang, Y., Shan, L., Grinberg, A., Hoffer, B. J., Westphal, H., & Tomac, A. C. (2006) · genesis · doi:10.1002/dvg.20228 · Cited by 463 · see citing works

Neural Activity in Barrel Cortex Underlying Vibrissa-Based Object Localization in Mice

O’Connor, D. H., Peron, S., Huber, D., & Svoboda, K. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.026 · Cited by 453 · see citing works

Nucleus Accumbens Neurons Are Innately Tuned for Rewarding and Aversive Taste Stimuli, Encode Their Predictors, and Are Linked to Motor Output

Roitman, M. F., Wheeler, R. A., & Carelli, R. M. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.055 · Cited by 453 · see citing works

A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei

Pollak Dorocic, I., Fürth, D., Xuan, Y., Johansson, Y., Pozzi, L., Silberberg, G., Carlén, M., & Meletis, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.002 · Cited by 451 · see citing works

Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists

Baraban, J. M., & Aghajanian, G. K. (1980) · Neuropharmacology · doi:10.1016/0028-3908(80)90187-2 · Cited by 442 · see citing works

Computation of measures of effect size for neuroscience data sets

Hentschke, H., & Stüttgen, M. C. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07902.x · Cited by 405 · see citing works

Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey

Schultz, W. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.5.1439 · Cited by 390 · cited 2× · see citing works

Serotonin in Affective Control

Dayan, P., & Huys, Q. J. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135607 · Cited by 381 · see citing works

The organization of divergent axonal projections from the midbrain raphe nuclei in the rat

Imai, H., Steindler, D. A., & Kitai, S. T. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902430307 · Cited by 369 · see citing works

PINP: A New Method of Tagging Neuronal Populations for Identification during In Vivo Electrophysiological Recording

Lima, S. Q., Hromádka, T., Znamenskiy, P., & Zador, A. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006099 · Cited by 356 · see citing works

Emotion Explained

Rolls, E. T. (2005) · doi:10.1093/acprof:oso/9780198570035.001.0001 · Cited by 339 · see citing works

Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons

Weissbourd, B., Ren, J., DeLoach, K. E., Guenthner, C. J., Miyamichi, K., & Luo, L. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.024 · Cited by 337 · see citing works

Targeted gene expression in dopamine and serotonin neurons of the mouse brain

Zhuang, X., Masson, J., Gingrich, J. A., Rayport, S., & Hen, R. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.09.020 · Cited by 316 · see citing works

The temporal precision of reward prediction in dopamine neurons

Fiorillo, C. D., Newsome, W. T., & Schultz, W. (2008) · Nature Neuroscience · doi:10.1038/nn.2159 · Cited by 310 · see citing works

Statistical Issues in the Analysis of Neuronal Data

Kass, R. E., Ventura, V., & Brown, E. N. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00648.2004 · Cited by 295 · see citing works

Optogenetic Activation of Dorsal Raphe Serotonin Neurons Enhances Patience for Future Rewards

Miyazaki, K. W., Miyazaki, K., Tanaka, K. F., Yamanaka, A., Takahashi, A., Tabuchi, S., & Doya, K. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.041 · Cited by 278 · see citing works

Reconciling the Role of Serotonin in Behavioral Inhibition and Aversion: Acute Tryptophan Depletion Abolishes Punishment-Induced Inhibition in Humans

Crockett, M. J., Clark, L., & Robbins, T. W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2513-09.2009 · Cited by 271 · see citing works

Activation of Dorsal Raphe Serotonin Neurons Underlies Waiting for Delayed Rewards

Miyazaki, K., Miyazaki, K. W., & Doya, K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3714-10.2011 · Cited by 257 · see citing works

A normative perspective on motivation

NIV, Y., JOEL, D., & DAYAN, P. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.06.010 · Cited by 251 · see citing works

Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems

Ogawa, S. K., Cohen, J. Y., Hwang, D., Uchida, N., & Watabe-Uchida, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.042 · Cited by 249 · see citing works

Fast synaptic subcortical control of hippocampal circuits

Varga, V., Losonczy, A., Zemelman, B. V., Borhegyi, Z., Nyiri, G., Domonkos, A., Hangya, B., Holderith, N., Magee, J. C., & Freund, T. F. (2009) · Science · doi:10.1126/science.1178307 · Cited by 248 · see citing works

Organization of raphe-cortical projections in rat: A quantitative retrograde study

O’Hearn, E., & Molliver, M. E. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90232-6 · Cited by 247 · see citing works

Reward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus

Nakamura, K., Matsumoto, M., & Hikosaka, O. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0021-08.2008 · Cited by 243 · see citing works

How silent is the brain: is there a “dark matter” problem in neuroscience?

Shoham, S., O’Connor, D. H., & Segev, R. (2006) · Journal of Comparative Physiology A · doi:10.1007/s00359-006-0117-6 · Cited by 238 · see citing works

5-Hydroxytryptamine and punishment

Tye, N. C., Everitt, B. J., & Iversen, S. D. (1977) · Nature · doi:10.1038/268741a0 · Cited by 232 · see citing works

Serotonergic and non-serotonergic neurons of the dorsal raphe: reciprocal changes in firing induced by peripheral nerve stimulation

Aghajanian, G. K., Wang, R. Y., & Baraban, J. M. (1978) · Brain Research · doi:10.1016/0006-8993(78)91140-x · Cited by 226 · see citing works

Vesicular glutamate transporter 3‐expressing nonserotonergic projection neurons constitute a subregion in the rat midbrain raphe nuclei

Hioki, H., Nakamura, H., Ma, Y., Konno, M., Hayakawa, T., Nakamura, K., Fujiyama, F., & Kaneko, T. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22237 · Cited by 218 · see citing works

An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat

Fibiger, H. C., & Miller, J. J. (1977) · Neuroscience · doi:10.1016/0306-4522(77)90120-8 · Cited by 213 · see citing works

Corticotropin-Releasing Factor Increases<i>In Vitro</i>Firing Rates of Serotonergic Neurons in the Rat Dorsal Raphe Nucleus: Evidence for Activation of a Topographically Organized Mesolimbocortical Serotonergic System

Lowry, C. A., Rodda, J. E., Lightman, S. L., & Ingram, C. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07728.2000 · Cited by 211 · see citing works

Activation of Dorsal Raphe Serotonergic Neurons Promotes Waiting but Is Not Reinforcing

Fonseca, M. S., Murakami, M., & Mainen, Z. F. (2015) · Current Biology · doi:10.1016/j.cub.2014.12.002 · Cited by 210 · see citing works

The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger

Amo, R., Fredes, F., Kinoshita, M., Aoki, R., Aizawa, H., Agetsuma, M., Aoki, T., Shiraki, T., Kakinuma, H., Matsuda, M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.035 · Cited by 207 · see citing works

Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies

Kirby, L. G., Pernar, L. I. M., Valentino, R. J., & Beck, S. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00584-5 · Cited by 205 · see citing works

Serotonergic versus nonserotonergic dorsal raphe projection neurons: differential participation in reward circuitry

McDevitt, R. A., Tiran-Cappello, A., Shen, H., Balderas, I., Britt, J. P., Marino, R. A. M., Chung, S. L., Richie, C. T., Harvey, B. K., & Bonci, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.037 · Cited by 203 · see citing works

Interactions Between Transient and Sustained Neural Signals Support the Generation and Regulation of Anxious Emotion

Somerville, L. H., Wagner, D. D., Wig, G. S., Moran, J. M., Whalen, P. J., & Kelley, W. M. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhr373 · Cited by 196 · see citing works

A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons

Qi, J., Zhang, S. S., Wang, H., Wang, H., Buendia, J. D. J. A., Hoffman, A. F., Lupica, C. R., Seal, R. P., & Morales, M. (2014) · Nature Communications · doi:10.1038/ncomms6390 · Cited by 195 · see citing works

Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo

Allers, K. A., & Sharp, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00518-9 · Cited by 188 · see citing works

Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain

Fu, W.-Y., Maître, E. L., Fabre, V., Bernard, J., Xu, Q., & Hökfelt, T. G. M. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22407 · Cited by 186 · see citing works

Neuronal Activity in the Rodent Dorsal Striatum in Sequential Navigation: Separation of Spatial and Reward Responses on the Multiple T Task

Schmitzer-Torbert, N. C., & Redish, A. D. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00687.2003 · Cited by 176 · see citing works

Transient Firing of Dorsal Raphe Neurons Encodes Diverse and Specific Sensory, Motor, and Reward Events

Ranade, S., & Mainen, Z. F. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00507.2009 · Cited by 174 · see citing works

Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat

Maswood, S., Barter, J. E., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01313-9 · Cited by 173 · see citing works

Identification and distribution of projections from monoaminergic and cholinergic nuclei to functionally differentiated subregions of prefrontal cortex

Chandler, D. J., Lamperski, C. S., & Waterhouse, B. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.04.057 · Cited by 173 · see citing works

Bcl-x Is Required for Proper Development of the Mouse Substantia Nigra

Savitt, J. M., Jang, S. S., Mu, W., Dawson, V. L., & Dawson, T. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0760-05.2005 · Cited by 173 · see citing works

Intracellular recordings from serotonergic dorsal raphe neurons: pacemaker potentials and the effects of LSD

Aghajanian, G. K., & VanderMaelen, C. P. (1982) · Brain Research · doi:10.1016/0006-8993(82)90124-x · Cited by 171 · see citing works

Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat

Levine, E., & Jacobs, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-10-04037.1992 · Cited by 164 · see citing works

A subgroup of dorsal raphe serotonergic neurons in the cat is strongly activated during oral-buccal movements

Fornal, C. A., Metzler, C. W., Marrosu, F., Luiz E. Ribiero-do-Valle, & Jacobs, B. L. (1996) · Brain Research · doi:10.1016/0006-8993(96)00006-6 · Cited by 160 · see citing works

Serotonergic neuron diversity: Identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm

Kocsis, B., Varga, V., Dahan, L., & Attila Gabor, S. I. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508360103 · Cited by 158 · see citing works

Extracellular microelectrode sampling bias

Towe, A. L., & Harding, G. W. (1970) · Experimental Neurology · doi:10.1016/0014-4886(70)90065-8 · Cited by 152 · see citing works

Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake–sleep states

Sakai, K., & Crochet, S. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00103-8 · Cited by 148 · see citing works

Coding of Task Reward Value in the Dorsal Raphe Nucleus

Bromberg-Martin, E. S., Hikosaka, O., & Nakamura, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0015-10.2010 · Cited by 143 · see citing works

Quantitative analysis of the distribution of serotonin-immunoreactive cell bodies in the mouse brain

Ishimura, K., Takeuchi, Y., Fujiwara, K., Tominaga, M., Yoshioka, H., & Sawada, T. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90691-x · Cited by 142 · see citing works

Behavioral inhibition induced by electrical stimulation of the median raphe nucleus of the rat

Graeff, F. G., & Filho, N. G. S. (1978) · Physiology & Behavior · doi:10.1016/0031-9384(78)90116-6 · Cited by 141 · see citing works

Raphe unit activity in freely moving cats: Effects of phasic auditory and visual stimuli

Heym, J. H., Trulson, M. E., & Jacobs, B. L. (1982) · Brain Research · doi:10.1016/0006-8993(82)90608-4 · Cited by 138 · see citing works

The dorsomedial striatum encodes net expected return, critical for energizing performance vigor

Wang, A. Y., Miura, K., & Uchida, N. (2013) · Nature Neuroscience · doi:10.1038/nn.3377 · Cited by 128 · see citing works

The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex

Ceci, A., Baschirotto, A., & Borsini, F. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90177-5 · Cited by 126 · see citing works

Activity of serotonin-containing neurons in nucleus raphe magnus in freely moving cats

Fornal, C. A., Auerbach, S. B., & Jacobs, B. L. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90074-3 · Cited by 115 · see citing works

Multiple messengers in descending serotonin neurons: localization and functional implications

Hökfelt, T. G. M., Arvidsson, U., Cullheim, S., Millhorn, D. E., Nicholas, A. P., Pieribone, V. A., Seroogy, K. B., & Ulfhake, B. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(99)00037-x · Cited by 113 · see citing works

Electrophysiological diversity of the dorsal raphe cells across the sleep–wake cycle of the rat

Urbain, N., Creamer, K., & Debonnel, G. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108514 · Cited by 108 · see citing works

Neurochemical identification of stereotypic burst‐firing neurons in the rat dorsal raphe nucleus using juxtacellular labelling methods

Hajós, M., Allers, K. A., Jennings, K. A., Sharp, T., Charette, G., Attila Gabor, S. I. K., & Kocsis, B. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05276.x · Cited by 108 · see citing works

Phasic responses in dorsal raphe serotonin neurons to noxious stimuli

Schweimer, J. V., & Ungless, M. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.058 · Cited by 102 · see citing works

Increased Intrinsic Excitability of Lateral Wing Serotonin Neurons of the Dorsal Raphe: A Mechanism for Selective Activation in Stress Circuits

Crawford, L. K., Craige, C. P., & Beck, S. G. (2010) · Journal of Neurophysiology · doi:10.1152/jn.01132.2009 · Cited by 96 · see citing works

D2-Like Dopamine Receptors Depolarize Dorsal Raphe Serotonin Neurons through the Activation of Nonselective Cationic Conductance

Aman, T. K., Shen, R., & Haj‐Dahmane, S. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111690 · Cited by 96 · see citing works

Electrophysiological effects of cocaine and procaine on dorsal raphe serotonin neurons

Cunningham, K. A., & Lakoski, J. M. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90128-8 · Cited by 94 · see citing works

Distribution of VGLUT3 in Highly Collateralized Axons from the Rat Dorsal Raphe Nucleus as Revealed by Single-Neuron Reconstructions

Gagnon, D., & Parent, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087709 · Cited by 90 · see citing works

Serotonin: modulator of a drive to withdraw.

Tops, M., Russo, S., Boksem, M. A. S., & Tucker, D. M. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.03.009 · Cited by 86 · see citing works

D2‐like dopamine receptor activation excites rat dorsal raphe 5‐HT neurons in vitro

Haj‐Dahmane, S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01616.x · Cited by 85 · see citing works

Reserpine suppression of dorsal raphe neuronal firing: mediation by adrenergic system

Baraban, J. M., Wang, R. Y., & Aghajanian, G. K. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90018-3 · Cited by 82 · see citing works

Discharge modulation of rat dorsal raphe neurons during sleep and waking: effects of preoptic/basal forebrain warming

Guzmán-Marı́n, R., Alam, M. N., Szymusiak, R. S., Drucker-Colı́n, R., Gong, H., & McGinty, D. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02561-0 · Cited by 76 · see citing works

Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus

Martín‐Ruiz, R., Ugedo, L., Honrubia, M., Mengod, G., & Artigas, F. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00275.x · Cited by 72 · see citing works

Nucleus raphe dorsalis: A morphometric golgi study in rats of three age groups

Díaz-Cintra, S. Y., Cintra, L., Kemper, T. L., Resnick, O., & Morgane, P. J. (1981) · Brain Research · doi:10.1016/0006-8993(81)90675-2 · Cited by 71 · see citing works

Serotonergic and Nonserotonergic Dorsal Raphe Neurons Are Pharmacologically and Electrophysiologically Heterogeneous

Marinelli, S., Schnell, S. A., Hack, S. P., Christie, M. J., Wessendorf, M. W., & Vaughan, C. W. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00437.2004 · Cited by 71 · see citing works

Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system

Dai, J., Hu, Z., Shi, M., Guo, C., & Ding, Y. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21759 · Cited by 62 · see citing works

Correlative firing patterns of serotonergic neurons in rat dorsal raphe nucleus

Wang, R., & Aghajanian, G. K. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-01-00011.1982 · Cited by 61 · see citing works

Locally collateralizing glutamate neurons in the dorsal raphe nucleus responsive to substance P contain vesicular glutamate transporter 3 (VGLUT3)

Commons, K. G. (2009) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2009.05.005 · Cited by 60 · see citing works

Activation of the central serotonergic system in response to delayed but not omitted rewards

Miyazaki, K. W., Miyazaki, K., & Doya, K. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07480.x · Cited by 59 · see citing works

Sensorimotor-related discharge of simultaneously recorded, single neurons in the dorsal raphe nucleus of the awake, unrestrained rat

Waterhouse, B. D., Devilbiss, D. M., Seiple, S., & Markowitz, R. S. (2004) · Brain Research · doi:10.1016/j.brainres.2003.11.030 · Cited by 56 · see citing works

Modulation of intracranial self-stimulation behaviour by local perfusions of dopamine, noradrenaline and serotonin within the caudate nucleus and nucleus accumbens

Redgrave, P. (1978) · Brain Research · doi:10.1016/0006-8993(78)91023-5 · Cited by 55 · see citing works

Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus

Gocho, Y., Sakai, A., Yanagawa, Y., Suzuki, H., & Saitow, F. (2012) · The Journal of Physiological Sciences · doi:10.1007/s12576-012-0250-7 · Cited by 50 · see citing works

Neurons in Monkey Dorsal Raphe Nucleus Code Beginning and Progress of Step-by-Step Schedule, Reward Expectation, and Amount of Reward Outcome in the Reward Schedule Task

Inaba, K., Mizuhiki, T., Setogawa, T., Toda, K., Richmond, B. J., & Shidara, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4388-12.2013 · Cited by 46 · see citing works

The midbrain raphe nuclei mediate primary reinforcement via GABAA receptors

Liu, Z., & Ikemoto, S. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05319.x · Cited by 42 · see citing works

Genetic approaches for understanding the role of serotonin receptors in mood and behavior

Donaldson, Z. R., Nautiyal, K. M., Ahmari, S. E., & Hen, R. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.011 · Cited by 42 · see citing works

Single-unit responses of serotonergic dorsal raphe nucleus neurons to environmental heating and pyrogen administration in freely moving cats.

Fornal, C. A., Litto, W., Morilak, D. A., & Jacobs, B. L. (1987) · Experimental Neurology · doi:10.1016/0014-4886(87)90250-0 · Cited by 40 · see citing works

Differential responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to systemic morphine in rats

Chiang, C., & Pan, Z. Z. (1985) · Brain Research · doi:10.1016/0006-8993(85)91620-8 · Cited by 38 · see citing works

Spike-timing relationship of neurochemically-identified dorsal raphe neurons during cortical slow oscillations

Schweimer, J. V., Mallet, N. P., Sharp, T., & Ungless, M. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.072 · Cited by 35 · see citing works

Factors affecting the activity of 5-HT-containing neurones

Bramwell, G. J. (1974) · Brain Research · doi:10.1016/0006-8993(74)90450-8 · Cited by 34 · see citing works

Intracellular horseradish peroxidase labeling of rapidly firing dorsal raphe projection neurons

Park, M. R. (1987) · Brain Research · doi:10.1016/0006-8993(87)91054-7 · Cited by 34 · see citing works

Single-unit recordings at dorsal raphe nucleus in the awake-anesthetized rat: spontaneous activity and responses to cutaneous innocuous and noxious stimulations

Montagne-Clavel, J., Oliveras, J. L., & Martin, G. E. (1995) · Pain · doi:10.1016/0304-3959(94)00129-3 · Cited by 34 · see citing works

Association with Reward Negatively Modulates Short Latency Phasic Conditioned Responses of Dorsal Raphe Nucleus Neurons in Freely Moving Rats

Li, Y., Dalphin, N., & Hyland, B. I. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5679-12.2013 · Cited by 30 · see citing works

Regularity of the spontaneous discharge of neurons in the nucleus raphe dorsalis of the cat

Nakahama, H., Shima, K., Yamamoto, M., & Aya, K. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90034-3 · Cited by 25 · see citing works

The GABAB receptor agonist baclofen administered into the median and dorsal raphe nuclei is rewarding as shown by intracranial self-administration and conditioned place preference in rats

Shin, R. S., & Ikemoto, S. (2010) · Psychopharmacology · doi:10.1007/s00213-009-1757-3 · Cited by 24 · see citing works

Anti-5-hydroxytryptamine antibodies: studies on their cross-reactivity in vitro and their immunohistochemical specificity

Bras, H., Chazal, G., Destombes, J., & Puizillout, J. J. (1986) · Experimental Brain Research · doi:10.1007/bf00237485 · Cited by 13 · see citing works

Spontaneous unit activity of neurons within the dorsal raphe nucleus of the neonatal rat

Gallager, D. W. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90453-2 · Cited by 7 · see citing works

The brain on drugs: from reward to addiction

Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306 · see citing works

Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

Morales, M., & Margolis, E. B. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.165 · Cited by 1,108 · see citing works

What does dopamine mean?

Berke, J. D. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0152-y · Cited by 904 · see citing works

Serotonin and brain function: a tale of two receptors

Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739 · see citing works

Dissociable dopamine dynamics for learning and motivation

Mohebi, A., Pettibone, J. R., Hamid, A., Wong, J.-M. T., Vinson, L. T., Patriarchi, T., Tian, L., Kennedy, R. T., & Berke, J. D. (2019) · Nature · doi:10.1038/s41586-019-1235-y · Cited by 714 · see citing works

Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems

Ren, J., Friedmann, D., Xiong, J., Liu, C. D., Ferguson, B. R., Weerakkody, T., DeLoach, K. E., Ran, C., Pun, A., Sun, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.043 · Cited by 498 · see citing works

Serotonin neurons in the dorsal raphe nucleus encode reward signals

Li, Y., Zhong, W., Wang, D., Feng, Q., Liu, Z., Zhou, J., Jia, C., Hu, F., Zeng, J., Guo, Q., et al. (2016) · Nature Communications · doi:10.1038/ncomms10503 · Cited by 420 · see citing works

Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback

Hangya, B., Ranade, S. P., Lorenc, M., & Kepecs, A. (2015) · Cell · doi:10.1016/j.cell.2015.07.057 · Cited by 399 · see citing works

Mood as representation of momentum

Eldar, E., Rutledge, R. B., Dolan, R. J., & Niv, Y. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.07.010 · Cited by 383 · see citing works

The Roles of Serotonin in Neuropsychiatric Disorders

Pourhamzeh, M., Moravej, F. G., Arabi, M., Shahriari, E., Mehrabi, S., Ward, R. T., Ahadi, R., & Joghataei, M. T. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01064-9 · Cited by 384 · see citing works

Medial prefrontal cortex in neurological diseases

Xu, P., Chen, A., Li, Y., Xing, X., & Lü, H. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00006.2019 · Cited by 346 · see citing works

Embracing diversity in the 5-HT neuronal system

Okaty, B. W., Commons, K. G., & Dymecki, S. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0151-3 · Cited by 319 · see citing works

Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

Ren, J., Isakova, A., Friedmann, D., Zeng, J., Grutzner, S. M., Pun, A., Zhao, G. Q., Kolluru, S. S., Wang, R., Lin, R., et al. (2019) · eLife · doi:10.7554/elife.49424 · Cited by 304 · see citing works

The Serotonergic Raphe Promote Sleep in Zebrafish and Mice

Oikonomou, G., Altermatt, M., Zhang, R., Coughlin, G. M., Montz, C. J., Gradinaru, V., & Prober, D. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.038 · Cited by 295 · see citing works

Beyond happiness: Building a science of discrete positive emotions.

Shiota, M. N., Campos, B., Oveis, C., Hertenstein, M. J., Simon-Thomas, E. R., & Keltner, D. J. (2017) · American Psychologist · doi:10.1037/a0040456 · Cited by 279 · see citing works

Dopamine neurons encode performance error in singing birds

Gadagkar, V., Puzerey, P. A., Chen, R., Baird-Daniel, E., Farhang, A., & Goldberg, J. H. (2016) · Science · doi:10.1126/science.aah6837 · Cited by 270 · see citing works

Reward and aversion

Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253 · see citing works

Molecular and anatomical organization of the dorsal raphe nucleus

Huang, K. W., Ochandarena, N. E., Philson, A. C., Hyun, M., Birnbaum, J. E., Cicconet, M., & Sabatini, B. L. (2019) · eLife · doi:10.7554/elife.46464 · Cited by 267 · see citing works

Medial and orbital frontal cortex in decision-making and flexible behavior

Klein-Flügge, M. C., Bongioanni, A., & Rushworth, M. F. S. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.022 · Cited by 244 · see citing works

Control of synaptic plasticity in deep cortical networks

Roelfsema, P. R., & Holtmaat, A. J. D. G. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.6 · Cited by 245 · see citing works

Activity patterns of serotonin neurons underlying cognitive flexibility

Matias, S., Lottem, E., Dugué, G. P., & Mainen, Z. F. (2017) · eLife · doi:10.7554/elife.20552 · Cited by 239 · see citing works

Distributed and Mixed Information in Monosynaptic Inputs to Dopamine Neurons

Tian, J., Huang, R., Cohen, J. Y., Osakada, F., Kobak, D., Machens, C. K., Callaway, E. M., Uchida, N., & Watabe-Uchida, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.018 · Cited by 224 · see citing works

Serotonin, Amygdala and Fear: Assembling the Puzzle

Bocchio, M., McHugh, S. B., Bannerman, D. M., Sharp, T., & Capogna, M. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00024 · Cited by 207 · see citing works

Midbrain dopamine neurons signal belief in choice accuracy during a perceptual decision

Lak, A., Nomoto, K., Keramati, M., Sakagami, M., & Kepecs, A. (2017) · Current Biology · doi:10.1016/j.cub.2017.02.026 · Cited by 170 · see citing works

Modeling Trait Anxiety: From Computational Processes to Personality

Raymond, J. G., Steele, J. D., & Seriès, P. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00001 · Cited by 203 · see citing works

Somatosensory Cortex Plays an Essential Role in Forelimb Motor Adaptation in Mice

Mathis, M. W., Mathis, A., & Uchida, N. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.049 · Cited by 193 · see citing works

Serotonin neurons modulate learning rate through uncertainty

Grossman, C. D., Bari, B. A., & Cohen, J. Y. (2022) · Current Biology · doi:10.1016/j.cub.2021.12.006 · Cited by 164 · see citing works

Dorsal raphe dual serotonin-glutamate neurons drive reward by establishing excitatory synapses on VTA mesoaccumbens dopamine neurons

Wang, H.-L., Zhang, S., Qi, J., Wang, H., Cachope, R., Mejias-Aponte, C. A., Gomez, J. A., Mateo-Semidey, G. E., Beaudoin, G. M. J., Paladini, C. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.014 · Cited by 176 · see citing works

An Update on the Role of Serotonin and its Interplay with Dopamine for Reward

Fischer, A. G., & Ullsperger, M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00484 · Cited by 176 · see citing works

Stable representations of decision variables for flexible behavior

Bari, B. A., Grossman, C. D., Lubin, E. E., Rajagopalan, A. E., Cressy, J. I., & Cohen, J. Y. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.001 · Cited by 173 · see citing works

Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors

Stephenson‐Jones, M., Bravo-Rivera, C., Ahrens, S., Furlan, A., Xiao, X., Fernandes-Henriques, C., & Li, B. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.006 · Cited by 172 · see citing works

Habenula Lesions Reveal that Multiple Mechanisms Underlie Dopamine Prediction Errors

Tian, J., & Uchida, N. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.028 · Cited by 165 · see citing works

Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System

Peters, K. Z., Cheer, J. F., & Tonini, R. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.02.001 · Cited by 171 · see citing works

The Serotonergic System Tracks the Outcomes of Actions to Mediate Short-Term Motor Learning

Kawashima, T., Zwart, M., Yang, C.-T., Mensh, B. D., & Ahrens, M. B. (2016) · Cell · doi:10.1016/j.cell.2016.09.055 · Cited by 166 · see citing works

Nucleus Accumbens Modulation in Reward and Aversion

Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163 · see citing works

Anterior cingulate is a source of valence-specific information about value and uncertainty

Monosov, I. E. (2017) · Nature Communications · doi:10.1038/s41467-017-00072-y · Cited by 163 · see citing works

Animal affect and decision-making

Mendl, M., & Paul, E. S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.025 · Cited by 161 · see citing works

Pivotal mental states

Brouwer, A., & Carhart-Harris, R. L. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120959637 · Cited by 159 · see citing works

Monoaminergic Neuromodulation of Sensory Processing

Jacob, S. N., & Nienborg, H. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00051 · Cited by 143 · see citing works

Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

Correia, P. A., Lottem, E., Banerjee, D., Machado, A. S., Carey, M. R., & Mainen, Z. F. (2017) · eLife · doi:10.7554/elife.20975 · Cited by 138 · see citing works

Architectural Representation of Valence in the Limbic System

Namburi, P., Al‐Hasani, R., Calhoon, G. G., Bruchas, M. R., & Tye, K. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.358 · Cited by 133 · see citing works

Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors

Paquelet, G. E., Carrion, K., Lacefield, C., Zhou, P., Hen, R., & Miller, B. R. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.015 · Cited by 129 · see citing works

Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation

Teixeira, C. M., Rosen, Z. B., Suri, D., Sun, Q., Hersh, M. A., Sargin, D., Dincheva, I., Morgan, A. A., Spivack, S., Krok, A. C., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.030 · Cited by 135 · see citing works

Control of amygdala circuits by 5-HT neurons via 5-HT and glutamate cotransmission

Sengupta, A., Bocchio, M., Bannerman, D. M., Sharp, T., & Capogna, M. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2238-16.2016 · Cited by 136 · see citing works

Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway

Zhang, B.-B., Yao, Y.-Y., Zhang, H.-F., Kawakami, K., & Du, J.-L. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.011 · Cited by 115 · see citing works

ASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviors

Rhoades, J. L., Nelson, J. C., Nwabudike, I., Yu, S. K., McLachlan, I. G., Madan, G. K., Abebe, E., Powers, J. R., Colón‐Ramos, D. A., & Flavell, S. W. (2018) · Cell · doi:10.1016/j.cell.2018.11.023 · Cited by 125 · see citing works

Control of movement vigor and decision making during foraging

Yoon, T., Geary, R., Ahmed, A. A., & Shadmehr, R. (2018) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1812979115 · Cited by 108 · see citing works

An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals

Iigaya, K., Fonseca, M. S., Murakami, M., Mainen, Z. F., & Dayan, P. (2018) · Nature Communications · doi:10.1038/s41467-018-04840-2 · Cited by 120 · see citing works

Sensory processing sensitivity and serotonin gene variance: Insights into mechanisms shaping environmental sensitivity

Homberg, J. R., Schubert, D., Asan, E., & Aron, E. N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.029 · Cited by 121 · see citing works

A specific role for serotonin in overcoming effort cost

Meyniel, F., Goodwin, G. M., Deakin, J. F. W., Klinge, C., MacFadyen, C., Milligan, H., Mullings, E. L., Pessiglione, M., & Raphaël Gaillard, B. (2016) · eLife · doi:10.7554/elife.17282 · Cited by 120 · see citing works

A Locus Coeruleus- Dorsal CA1 Dopaminergic Circuit Modulates Memory Linking

Chowdhury, A., Luchetti, A., Fernandes, G., Filho, D. A., Kastellakis, G., Tzilivaki, A., Ramirez, E. M., Tran, M. Y., Poirazi, P., & Silva, A. J. (2021) · Neuron · doi:10.1016/j.neuron.2022.08.001 · Cited by 120 · see citing works

Reward processing by the dorsal raphe nucleus: 5-HT and beyondPreprint

Luo, M., Zhou, J., & Liu, Z. (2015) · Learning & Memory · doi:10.1101/lm.037317.114 · Cited by 117 · see citing works

Activation of raphe nuclei triggers rapid and distinct effects on parallel olfactory bulb output channels

Kapoor, V., Provost, A. C., Agarwal, P., & Murthy, V. N. (2016) · Nature Neuroscience · doi:10.1038/nn.4219 · Cited by 108 · see citing works

Mechanisms of neuromodulatory volume transmission

Özçete, Ö. D., Banerjee, A., & Kaeser, P. S. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02608-3 · Cited by 123 · see citing works

A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory

Sengupta, A., & Holmes, A. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.029 · Cited by 113 · see citing works

Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks

Salvan, P., Fonseca, M., Winkler, A. M., Beauchamp, A., Lerch, J. P., & Johansen-Berg, H. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01213-3 · Cited by 101 · see citing works

Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective

Bazzari, A. H., & Parri, H. R. (2019) · Brain Sciences · doi:10.3390/brainsci9110300 · Cited by 99 · see citing works

The Protective Action Encoding of Serotonin Transients in the Human Brain

Moran, R., Kishida, K. T., Lohrenz, T. M., Sáez, I., Laxton, A. W., Witcher, M. R., Tatter, S. B., Ellis, T. L., Phillips, P. E. M., Dayan, P., et al. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.304 · Cited by 92 · see citing works

Target-specific modulation of the descending prefrontal cortex inputs to the dorsal raphe nucleus by cannabinoids

Geddes, S. D., Assadzada, S., Lemelin, D., Sokolovski, A., Bergeron, R., Haj-Dahmane, S., & Béïque, J.-C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522754113 · Cited by 90 · see citing works

The foraging brain

Calhoun, A. J., & Hayden, B. Y. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.07.003 · Cited by 91 · see citing works

Dopamine and the motivation of cognitive control

Cools, R., Froböse, M. I., Aarts, E., & Hofmans, L. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804281-6.00007-0 · Cited by 93 · see citing works

Dopamine transients follow a striatal gradient of reward time horizons

Mohebi, A., Wei, W., Pelattini, L., Kim, K., & Berke, J. D. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01566-3 · Cited by 99 · see citing works

Recent advances in understanding the role of phasic dopamine activity

Schultz, W. (2019) · F1000Research · doi:10.12688/f1000research.19793.1 · Cited by 89 · see citing works

Vigor

Shadmehr, R., & Ahmed, A. A. (2020) · The MIT Press eBooks · doi:10.7551/mitpress/12940.001.0001 · Cited by 103 · see citing works

Learning and Stress Shape the Reward Response Patterns of Serotonin Neurons

Zhong, W., Li, Y., Feng, Q., & Luo, M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1181-17.2017 · Cited by 84 · see citing works

Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience

Miyazaki, K., Miyazaki, K. W., Yamanaka, A., Tokuda, T., Tanaka, K. F., & Doya, K. (2018) · Nature Communications · doi:10.1038/s41467-018-04496-y · Cited by 79 · see citing works

Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety

Yu, X., Zhu, Y., Sun, Q., Deng, F., Wan, J., Zheng, D., Gong, W., Xie, S., Shen, C.-J., Fu, J., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01200-8 · Cited by 83 · see citing works

The good, the bad and the brain: neural correlates of appetitive and aversive values underlying decision making

Pessiglione, M., & Delgado, M. R. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.08.006 · Cited by 82 · see citing works

Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale

Dag, U., Nwabudike, I., Kang, D., Gomes, M. A., Kim, J. S., Atanas, A. A., Bueno, E., Estrem, C., Pugliese, S. M., Wang, Z., et al. (2023) · Cell · doi:10.1016/j.cell.2023.04.023 · Cited by 93 · see citing works

Reward Contributions to Serotonergic Functions

Liu, Z., Lin, R., & Luo, M. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-093019-112252 · Cited by 78 · see citing works

Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding

Han, Y., Xia, G., Srisai, D., Meng, F., He, Y., Ran, Y., He, Y., Farías, M., Hoang, G. N., Tóth, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23846-x · Cited by 78 · see citing works

Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe

Pinto, D. F. C., Yang, H., Dorocic, I. P., de Jong, J. W., Han, V. J., Peck, J. R., Zhu, Y., Liu, C. J., Beier, K. T., Smidt, M. P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12392-2 · Cited by 76 · see citing works

Do dorsal raphe 5-HT neurons encode “beneficialness”?

Luo, M., Li, Y., & Zhong, W. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.008 · Cited by 76 · see citing works

Optogenetic Activation of Dorsal Raphe Serotonin Neurons Rapidly Inhibits Spontaneous But Not Odor-Evoked Activity in Olfactory Cortex

Lottem, E., Lörincz, M. L., & Mainen, Z. F. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3008-15.2016 · Cited by 73 · see citing works

Ascending serotonin neuron diversity under two umbrellas

Commons, K. G. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1176-7 · Cited by 72 · see citing works

The role of the serotonergic system in motor control

Kawashima, T. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.07.005 · Cited by 72 · see citing works

Rostral and Caudal Ventral Tegmental Area GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid Dependence

Li, Y., Li, C., Wang, X., Jin, S., Wu, Z.-H., Jiang, P., Dong, P., He, X., Xu, F., Duan, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.012 · Cited by 72 · see citing works

Striatal Low-Threshold Spiking Interneurons Regulate Goal-Directed Learning

Holly, E. N., Davatolhagh, M. F., Choi, K., Alabi, O. O., Cifuentes, L. V., & Fuccillo, M. V. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.016 · Cited by 66 · see citing works

Multiple Dopamine Systems: Weal and Woe of DopaminePreprint

Watabe‐Uchida, M., & Uchida, N. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037648 · Cited by 68 · see citing works

Next generation genetically encoded fluorescent sensors for serotonin

Kubitschke, M., Müller, M. C. M., Wallhorn, L., Pulin, M., Mittag, M., Pollok, S., Ziebarth, T., Bremshey, S., Gerdey, J., Claussen, K. C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35200-w · Cited by 66 · see citing works

Transient and sustained effects of dopamine and serotonin signaling in motivation‐related behavior

Yagishita, S. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12942 · Cited by 64 · see citing works

Antidepressant and anxiolytic effects of activating 5HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them – A scoping review of available literature

Miranda, L. (2025) · Brain Research · doi:10.1016/j.brainres.2024.149226 · Cited by 66 · see citing works

Intrinsic and Extrinsic Neuromodulation of Olfactory Processing

Lizbinski, K. M., & Dacks, A. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00424 · Cited by 60 · see citing works

Understanding the effects of serotonin in the brain through its role in the gastrointestinal tract

Shine, J. M., O’Callaghan, C., Walpola, I. C., Wainstein, G., Taylor, N. L., Aru, J., Huebner, B., & John, Y. J. (2022) · Brain · doi:10.1093/brain/awac256 · Cited by 63 · see citing works

Timescales of cognition in the brain

Soltani, A., Murray, J. D., Seo, H., & Lee, D. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.03.003 · Cited by 60 · see citing works

Valence encoding in the amygdala influences motivated behavior

Smith, D. M., & Torregrossa, M. M. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113370 · Cited by 60 · see citing works

Serotonin promotes exploitation in complex environments by accelerating decision-making

Iwanir, S., Brown, A. S., Nagy, S., Najjar, D., Kazakov, A., Lee, K. S., Zaslaver, A., Levine, E., & Biron, D. (2016) · BMC Biology · doi:10.1186/s12915-016-0232-y · Cited by 57 · see citing works

Safety out of control: dopamine and defence

Lloyd, K., & Dayan, P. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0099-7 · Cited by 59 · see citing works

Reward from bugs to bipeds: a comparative approach to understanding how reward circuits function

Scaplen, K. M., & Kaun, K. R. (2016) · Journal of Neurogenetics · doi:10.1080/01677063.2016.1180385 · Cited by 54 · see citing works

The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances

Hill, J. W., & Faulkner, L. D. (2016) · Neuroendocrinology · doi:10.1159/000450649 · Cited by 56 · see citing works

Deviation from the matching law reflects an optimal strategy involving learning over multiple timescales

Iigaya, K., Ahmadian, Y., Sugrue, L. P., Corrado, G. S., Loewenstein, Y., Newsome, W. T., & Fusi, S. (2019) · Nature Communications · doi:10.1038/s41467-019-09388-3 · Cited by 58 · see citing works

Serotonin Decreases the Gain of Visual Responses in Awake Macaque V1

Seillier, L., Lorenz, C., Kawaguchi, K., Ott, T., Nieder, A., Pourriahi, P., & Nienborg, H. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1339-17.2017 · Cited by 57 · see citing works

Mechanisms of 5‐HT 1A receptor‐mediated transmission in dorsal raphe serotonin neurons

Courtney, N. A., & Ford, C. (2015) · The Journal of Physiology · doi:10.1113/jp271716 · Cited by 55 · see citing works

Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices

Mlinar, B., Montalbano, A., Piszczek, Ł., Gross, C. T., & Corradetti, R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00195 · Cited by 53 · see citing works

Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals

Scholl, J., Kolling, N., Nelissen, N., Browning, M., Rushworth, M. F. S., & Harmer, C. J. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000756 · Cited by 58 · see citing works

Glutamatergic and GABAergic neurons in pontine central gray mediate opposing valence-specific behaviors through a global network

Xiao, C., Wei, J., Zhang, G., Tao, C., Huang, J., Shen, L., Wickersham, I. R., Tao, H. W., & Zhang, L. I. (2023) · Neuron · doi:10.1016/j.neuron.2023.02.012 · Cited by 58 · see citing works

5-HT1AReceptor-Mediated Autoinhibition and the Control of Serotonergic Cell Firing

Andrade, R., Huereca, D., Lyons, J. G., Andrade, E. M., & McGregor, K. M. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00034 · Cited by 52 · see citing works

A Selective Role for Dopamine in Learning to Maximize Reward But Not to Minimize Effort: Evidence from Patients with Parkinson's Disease

Skvortsova, V., Degos, B., Welter, M., Vidailhet, M., & Pessiglione, M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2081-16.2017 · Cited by 51 · see citing works

Aversive Motivation and Cognitive ControlPreprint

Yee, D. M., Leng, X., Shenhav, A., & Braver, T. S. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.016 · Cited by 57 · see citing works

Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia

Li, A., Li, R., Ouyang, P., Li, H., Wang, S., Zhang, X., Wang, D., Ran, M., Zhao, G., Yang, Q., et al. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13656 · Cited by 52 · see citing works

Serotonin neurons in the dorsal raphe nucleus encode reward signals

Li, Y., Zhong, W., Wang, D., Feng, Q., Liu, Z., Zhou, J., Jia, C., Hu, F., Zeng, J., Guo, Q., et al. (2016) · Nature Communications · doi:10.1038/ncomms10503 · Cited by 420 · see citing works

Reward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus

Nakamura, K., Matsumoto, M., & Hikosaka, O. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0021-08.2008 · Cited by 243 · see citing works

Dopamine and serotonin signals for reward across time scales

Cohen, J. Y. (2015) · Science · doi:10.1126/science.aad3003 · Cited by 13 · see citing works

Extracting Value Coding Features from Individual Serotonin NeuronsPreprint

Harkin, E. F., Béïque, J.-C., & Naud, R. (2025) · eLife · doi:10.7554/elife.108775.1

Behavioral/Systems/Cognitive Reward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus

Nakamura, K., Matsumoto, M., & Hikosaka, O. (2015)