Extracellular vesicles: interneural shuttles of complex messages
Abstract
A core function of neural cells is the exchange and integration of information. Extracellular vesicles such as exosomes and microvesicles recently entered the scene of neuroscience as novel vehicles transmitting complex signals between neural cells. Carrying a defined but mixed cargo of biomolecules, extracellular vesicles possess versatile biological activities with the ability to profoundly modulate the molecular configuration and behaviour of target cells. Extracellular vesicles are suggested to carry out functions during neural development and maintenance, they appear to spread neuropathology and furthermore, convey neuroprotection and regeneration. Understanding the molecular mechanisms of this sophisticated cellular crosstalk will fundamentally improve our insight in complex intercellular processes in the healthy and diseased nervous system.
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Microglia and other glial cells can communicate with neurons through secretion of EVs.
“Recent evidence indicates that microglia and other glial cells can communicate with neurons through secretion of EVs”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [43]
Cites
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Self-citationTDP-43 is intercellularly transmitted across axon terminals
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The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?
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- Authors
- Krämer-Albers, E.-M., & Hill, A. F.
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 39
- Pages
- 101-107
- ISSN
- 0959-4388
- Cited by
- 133
- References
- 7
- Language
- en
- Funders
- Deutsche Forschungsgemeinschaft
- Australian Research Council
- National Health and Medical Research Council
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