Physical exercise induces rapid release of small extracellular vesicles into the circulation
Open accessAbstract
Cells secrete extracellular vesicles (EVs) by default and in response to diverse stimuli for the purpose of cell communication and tissue homeostasis. EVs are present in all body fluids including peripheral blood, and their appearance correlates with specific physiological and pathological conditions. Here, we show that physical activity is associated with the release of nano-sized EVs into the circulation. Healthy individuals were subjected to an incremental exercise protocol of cycling or running until exhaustion, and EVs were isolated from blood plasma samples taken before, immediately after and 90 min after exercise. Small EVs with the size of 100-130 nm, that carried proteins characteristic of exosomes, were significantly increased immediately after cycling exercise and declined again within 90 min at rest. In response to treadmill running, elevation of small EVs was moderate but appeared more sustained. To delineate EV release kinetics, plasma samples were additionally taken at the end of each increment of the cycling exercise protocol. Release of small EVs into the circulation was initiated in an early phase of exercise, before the individual anaerobic threshold, which is marked by the rise of lactate. Taken together, our study revealed that exercise triggers a rapid release of EVs with the characteristic size of exosomes into the circulation, initiated in the aerobic phase of exercise. We hypothesize that EVs released during physical activity may participate in cell communication during exercise-mediated adaptation processes that involve signalling across tissues and organs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A single bout of exhaustive exercise triggers the release of EVs with the size and marker profile of exosomes, which are cleared from the circulation during the early recovery period after cycling, but stay elevated after running exercise.
“a single bout of exhaustive exercise triggers the release of EVs with the size and marker profile of exosomes, which are cleared from the circulation during the early recovery period after cycling, but stay elevated after running exercise.”
From Skeletal Muscle-Released Extracellular Vesicles: State of the Art (2019) · cites this paper as Frühbeis et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works
Self-citationMembrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Lötvall, J. O., Hill, A. F., Hochberg, F. H., Buzás, E. I., Vizio, D. D., Gardiner, C., Gho, Y. S., Kurochkin, I. V., Mathivanan, S., Quesenberry, P. J., et al. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.26913 · Cited by 2,710 · see citing works
Regulation of immune responses by extracellular vesicles
Robbins, P. D., & Morelli, A. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3622 · Cited by 2,260 · see citing works
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084 · see citing works
Biogenesis and secretion of exosomes
Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781 · see citing works
Heijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488 · see citing works
Ectosomes and exosomes: shedding the confusion between extracellular vesicles
Cocucci, E., & Meldolesi, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.004 · Cited by 1,435 · see citing works
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
Hergenreider, E., Heydt, S., Tréguer, K., Boettger, T., Horrevoets, A. J. G., Zeiher, A. M., Scheffer, M. P., Frangakis, A. S., Yin, X., Mayr, M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2441 · Cited by 1,300 · see citing works
Position statement. Part one: Immune function and exercise.
Walsh, N. P., Gleeson, M., Shephard, R. J., Gleeson, M., Woods, J. A., Bishop, N. C., Fleshner, M., Green, C., Pedersen, B. K., Hoffman-Goetz, L., et al. (2011) · PubMed · Cited by 1,250 · see citing works
Self-citationAs we wait: coping with an imperfect nomenclature for extracellular vesicles
Gould, S. J., & Raposo, G. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20389 · Cited by 864 · see citing works
Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells
Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835 · see citing works
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 812 · see citing works
Self-citationArraud, N., Linares, R., Tan, S., Gounou, C., Pasquet, J., Mornet, S., & Brisson, A. R. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12554 · Cited by 742 · see citing works
Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 729 · see citing works
Emerging role of extracellular vesicles in inflammatory diseases
Buzás, E. I., György, B., Nagy, G., Falus, A., & Gay, S. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.19 · Cited by 673 · see citing works
Microparticles in cardiovascular diseases
VANWIJK, M., VanBavel, E., Sturk, A., & Nieuwland, R. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00367-5 · Cited by 610 · see citing works
Exosomes and their roles in immune regulation and cancer
Greening, D. W., Gopal, S. K., Xu, R., Simpson, R. J., & Chen, W. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.009 · Cited by 608 · see citing works
Lachenal, G. M., Pernet‐Gallay, K., Chivet, M., Hemming, F. J., Belly, A., Bodon, G., Blot, B., Haase, G., Goldberg, Y., & Sadoul, R. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.004 · Cited by 595 · see citing works
Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis
Gardiner, C., Ferreira, Y. J., Dragovic, R., Redman, C. W. G., & Sargent, I. L. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.19671 · Cited by 586 · see citing works
Imai, T., Takahashi, Y., Nishikawa, M., Kato, K., Morishita, M., Yamashita, T., Matsumoto, A., Charoenviriyakul, C., & Takakura, Y. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26238 · Cited by 584 · see citing works
Krämer‐Albers, E., Bretz, N. P., Tenzer, S., Winterstein, C., Möbius, W., Berger, H., Nave, K., Schild, H., & Trotter, J. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200700522 · Cited by 548 · see citing works
Self-citationExosomes: Small vesicles participating in intercellular communication
Ludwig, A., & Giebel, B. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.10.005 · Cited by 539 · see citing works
Exosomes: Looking back three decades and into the future
Harding, C. V., Heuser, J. E., & Stahl, P. D. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201212113 · Cited by 464 · see citing works
Eldh, M., Ekström, K. M., Valadi, H., Sjöstrand, M., Olsson, B., Jernås, M., & Lötvall, J. O. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015353 · Cited by 461 · see citing works
Endothelial microparticles in diseases
Chironi, G. N., Boulanger, C. M., Simon, A., Dignat-George, F., Freyssinet, J.-M., & Tedgui, A. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0710-9 · Cited by 420 · see citing works
Cell-derived microparticles in haemostasis and vascular medicine
Burnier, L., Fontana, P., Kwak, B. R., & Angelillo‐Scherrer, A. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-08-0521 · Cited by 416 · see citing works
Lacroix, R., Judicone, C., PONCELET, P., Robert, S., ARNAUD, L., Sampol, J., & Dignat‐George, F. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04610.x · Cited by 401 · see citing works
Position statement. Part two: Maintaining immune health.
Walsh, N. P., Gleeson, M., Pyne, D. B., Nieman, D. C., Dhabhar, F. S., Shephard, R. J., Oliver, S. J., Bermon, S., & Kajėnienė, A. (2011) · PubMed · Cited by 365 · see citing works
Extracellular Vesicles: Potential Roles in Regenerative Medicine
de Jong, O. G., van Balkom, B. W. M., Schiffelers, R. M., Bouten, C. V. C., & Verhaar, M. C. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00608 · Cited by 353 · see citing works
Isolation and characterization of platelet-derived extracellular vesicles
Aatonen, M. T., Öhman, T., Nyman, T. A., Laitinen, S., Grönholm, M., & Siljander, P. R. ‐. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24692 · Cited by 333 · see citing works
Willekens, F. L. A., Werre, J. M., Kruijt, J. K., Roerdinkholder-Stoelwinder, B., Groenen-Döpp, Y. A. M., van den Bos, A. G., Bosman, G. J. C. G. M., & van Berkel, T. J. C. (2005) · Blood · doi:10.1182/blood-2004-04-1578 · Cited by 280 · see citing works
Chmura, J., Nazar, K., & Kaciuba-Uściłko, H. (1994) · International Journal of Sports Medicine · doi:10.1055/s-2007-1021042 · Cited by 268 · see citing works
An Ultrastructural Basis for the Shape Changes Induced in Platelets by Chilling
White, J. G., & Krivit, W. A. (1967) · Blood · doi:10.1182/blood.v30.5.625.625 · Cited by 262 · see citing works
Pathologic function and therapeutic potential of exosomes in cardiovascular disease
Ailawadi, S., Wang, X., Gu, H., & Fan, G. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.008 · Cited by 259 · see citing works
Diagnostic and Prognostic Potential of Extracellular Vesicles in Peripheral Blood
Revenfeld, A. L., Bæk, R., Nielsen, M. H., Stensballe, A., Varming, K., & Jørgensen, M. M. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.05.008 · Cited by 257 · see citing works
Multivesicular Bodies Are an Intermediate Stage in the Formation of Platelet α-Granules
Heijnen, H. F. G., Debili, N., Vainchenker, W., BRETON-GORIUS, J., Geuze, H. J., & Sixma, J. J. (1998) · Blood · doi:10.1182/blood.v91.7.2313 · Cited by 247 · see citing works
Bretz, N. P., Ridinger, J., Rupp, A.-K., Rimbach, K., Keller, S., Rupp, C., Marmé, F., Umansky, L., Umansky, V., Eigenbrod, T., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.512806 · Cited by 231 · see citing works
Breitbach, S. A., Tug, S., & Simon, P. D. (2012) · Sports Medicine · doi:10.2165/11631380-000000000-00000 · Cited by 209 · see citing works
Self-citationShear Stress Regulates Endothelial Microparticle Release
Vion, A.-C., Ramkhelawon, B., Loyer, X., Chironi, G. N., Devue, C., Loirand, G., Tedgui, A., Lehoux, S., & Boulanger, C. M. (2013) · Circulation Research · doi:10.1161/circresaha.112.300818 · Cited by 187 · see citing works
Short-Term Treadmill Running as a Model for Studying Cell-Free DNA Kinetics In Vivo
Beiter, T., Fragasso, A., Hudemann, J., Niess, A. M., & Simon, P. D. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.158030 · Cited by 125 · see citing works
Self-citationExtracellular Vesicles as Therapeutic Tools in Cardiovascular Diseases
Fleury, A., Martínez, M. C., & Lay, S. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00370 · Cited by 125 · see citing works
Exosomes: An emerging factor in stress-induced immunomodulation
Beninson, L. A., & Fleshner, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2013.12.001 · Cited by 124 · see citing works
Obregon, C., Rothen‐Rutishauser, B., Kiama, S. G., Gehr, P., & Nicod, L. P. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060453 · Cited by 119 · see citing works
Exercise Intensity and Duration Affect Blood Soluble HSP72
Fehrenbach, E., Niess, A. M., Voelker, K., Northoff, H., & Mooren, F. C. (2005) · International Journal of Sports Medicine · doi:10.1055/s-2004-830334 · Cited by 118 · see citing works
Power Output during Stage Racing in Professional Road Cycling
VOGT, S., HEINRICH, L., Schumacher, Y. O., BLUM, A., Röecker, K., Dickhuth, H., & Schmid, A. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000183196.63081.6a · Cited by 113 · see citing works
Breitbach, S. A., Sterzing, B., Magallanes, C., Tug, S., & Simon, P. D. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00002.2014 · Cited by 110 · see citing works
Self-citationWilson, H. L., Francis, S., Dower, S., & Crossman, D. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1202 · Cited by 104 · see citing works
Bastos-Amador, P., Royo, F., González, E., Conde‐Vancells, J., Palomo-Diez, L., Borràs, F. E., & Falcón‐Pérez, J. M. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.03.054 · Cited by 97 · see citing works
Effect of strenuous physical exercise on circulating cell-derived microparticles
Chaar, V., Romana, M., Julien Tripette, A., Broquère, C., Huisse, M., Hüe, O., Hardy‐Dessources, M., & Connes, P. (2011) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2010-1361 · Cited by 90 · see citing works
Tug, S., Helmig, S., Giacca, M., Schmeier-Jürchott, A., Wagner, E. M., Zimmermann, T., Radsak, M. P., Giacca, M., & Simon, P. D. (2026) · PubMed · doi:10.22029/eir.2015.1703 · Cited by 87 · see citing works
Self-citationDynamic Release and Clearance of Circulating Microparticles During Cardiac Stress
Augustine, D. X., Ayers, L., Lima, E., Newton, L., Lewandowski, A. J., Davis, E., Ferry, B. L., & Leeson, P. (2013) · Circulation Research · doi:10.1161/circresaha.114.301904 · Cited by 79 · see citing works
Wahl, P., Jansen, F., Achtzehn, S., Schmitz, T., Bloch, W., Mester, J., & Werner, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096024 · Cited by 78 · see citing works
Release of bulk cell free DNA during physical exercise occurs independent of extracellular vesicles
Helmig, S., Frühbeis, C., Krämer‐Albers, E., Simon, P. D., & Tug, S. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3207-8 · Cited by 74 · see citing works
Self-citationCell-Derived Microparticles Promote Coagulation after Moderate Exercise
Soßdorf, M., Otto, G. P., Claus, R. A., Gabriel, H. H. W., & Lösche, W. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182068645 · Cited by 74 · see citing works
Novel insights into exosome-induced, tumor-associated inflammation and immunomodulation.
Altevogt, P., Bretz, N. P., Ridinger, J., Utikal, J., & Umansky, V. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.04.008 · Cited by 70 · see citing works
Beninson, L. A., Brown, P. N., Loughridge, A. B., Saludes, J. P., Maslanik, T., Hills, A., Woodworth, T. T., Craig, W. C., Yin, H. H., & Fleshner, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108748 · Cited by 65 · see citing works
Catecholamine and blood lactate responses to incremental rowing and running exercise
WELTMAN, A. L., Wood, C. M., Womack, C. J., Davis, S. E., Blumer, J. L., Álvarez, J., Sauer, K., & Gaesser, G. A. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.3.1144 · Cited by 62 · see citing works
Chen, J., Wang, J., & Chen, Y. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-09-0633 · Cited by 58 · see citing works
Hoen, E. N. M. N., van der Vlist, E. J., de Boer-Brouwer, M., Arkesteijn, G. J. A., Stoorvogel, W., & Wauben, M. H. M. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0911480 · Cited by 57 · see citing works
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27
Kato, K., Ito, H., Iwamoto, I., Iida, K., & Inaguma, Y. (2001) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2001)006 · Cited by 51 · see citing works
A Comparison of the Blood Lactate and Plasma Catecholamine Thresholds in Untrained Male Subjects
Schneider, D., McGuiggin, M. E., & Kamimori, G. H. (1992) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024565 · Cited by 39 · see citing works
Guiraud, T., Gayda, M., Juneau, M., Bosquet, L., Meyer, P., Théberge-Julien, G., Galinier, M., Nozza, A., Lambert, J., Rhéaume, É., et al. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.03.024 · Cited by 35 · see citing works
Maruyama, K., Kadono, T., & Morishita, E. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11791 · Cited by 26 · see citing works
Chen, Y., Chen, Y.-C., & Wang, J. (2013) · Clinical Science · doi:10.1042/cs20120540 · Cited by 25 · see citing works
Release of pro-coagulant microparticles after moderate endurance exercise
Sossdorf, M., Otto, G. P., Claus, R. A., Gabriel, H. H., & Lösche, W. (2010) · Platelets · doi:10.3109/09537101003698564 · Cited by 20 · see citing works
Acute changes in lipoprotein subclasses during exercise
Søndergaard, E., Poulsen, M. K., Jensen, M. D., & Nielsen, S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.08.011 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
Whitham, M., Parker, B. L., Friedrichsen, M. H., Hingst, J. R., Hjorth, M., Hughes, W. E., Egan, C. L., Cron, L., Watt, K. I., Kuchel, R. P., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.001 · Cited by 689 · see citing works
The potential of endurance exercise-derived exosomes to treat metabolic diseases
Safdar, A., Saleem, A., & Tarnopolsky, M. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.76 · Cited by 463 · see citing works
Longterm Exercise-Derived Exosomal miR-342-5p
Hou, Z., Qin, X., Hu, Y., Zhang, X., Li, G., Wu, J., Li, J., Sha, J., Chen, J., Xia, J., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314635 · Cited by 333 · see citing works
Palviainen, M., Saraswat, M., Varga, Z., Kitka, D., Neuvonen, M., Puhka, M., Joenväärä, S., Renkonen, R., Nieuwland, R., Takatalo, M. S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236439 · Cited by 286 · see citing works
Xin, H., Wang, F., Li, Y., Lu, Q.-E., Cheung, W. L., Zhang, Y., Zhang, Z. G., & Chopp, M. (2016) · Cell Transplantation · doi:10.3727/096368916x693031 · Cited by 271 · see citing works
Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges
Lane, R. E., Korbie, D. J., Hill, M. M. C., & Trau, M. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-018-0192-7 · Cited by 245 · see citing works
Brahmer, A., Neuberger, E. W. I., Esch-Heisser, L., Haller, N., Jørgensen, M. M., Bæk, R., Möbius, W., Simon, P. D., & Krämer‐Albers, E. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1615820 · Cited by 245 · see citing works
Self-citationExosomes as Mediators of the Systemic Adaptations to Endurance Exercise
Safdar, A., & Tarnopolsky, M. A. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029827 · Cited by 203 · see citing works
Bei, Y., Xu, T., Lv, D., Yu, P., Xu, J., Che, L., Das, A., Tigges, J., Toxavidis, V., Ghiran, I. C., et al. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0628-z · Cited by 201 · see citing works
A critical systematic review of extracellular vesicle clinical trials
Mizenko, R. R., Feaver, M., Bozkurt, B. T., Lowe, N. M., Nguyen, B., Huang, K., Wang, A., & Carney, R. P. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12510 · Cited by 200 · see citing works
Extracellular Vesicles and Exosomes: Insights From Exercise Science
Nederveen, J. P., Warnier, G., Carlo, A. D., Nilsson, M. I., & Tarnopolsky, M. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.604274 · Cited by 192 · see citing works
Therapeutic and diagnostic applications of extracellular vesicles
Stremersch, S., Smedt, S. C. D., & Raemdonck, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.054 · Cited by 187 · see citing works
Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., Patterson, N. L., & McMullen, J. R. (2017) · Physiological Reviews · doi:10.1152/physrev.00043.2016 · Cited by 168 · see citing works
Extracellular Vesicles in Blood: Sources, Effects, and Applications
Alberro, A., Iparraguirre, L., Fernandes, A. M. A., & Otaegui, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158163 · Cited by 168 · see citing works
Metabolic communication during exercise
Murphy, R. M., Watt, M. J., & Febbraio, M. A. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0258-x · Cited by 158 · see citing works
Castaño, C., Mirasierra, M., Vallejo, M., Novials, A., & Párrizas, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016112117 · Cited by 154 · see citing works
Exercise mimetics: harnessing the therapeutic effects of physical activity
Gubert, C., & Hannan, A. J. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00217-1 · Cited by 153 · see citing works
A review on comparative studies addressing exosome isolation methods from body fluids
Martins, T. S., Vaz, M., & Henriques, A. G. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04174-5 · Cited by 145 · see citing works
Ma, S., Xing, X., Huang, H., Gao, X., Xu, X., Yang, J., Liao, C., Zhang, X., Liu, J., Tian, W., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.10.013 · Cited by 145 · see citing works
The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise
Vechetti, I. J., Valentino, T., Mobley, C. B., & McCarthy, J. J. (2021) · The Journal of Physiology · doi:10.1113/jp278929 · Cited by 141 · see citing works
Skeletal Muscle-Released Extracellular Vesicles: State of the Art
Rome, S., Forterre, A., Mizgier, M. L., & Bouzakri, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00929 · Cited by 139 · see citing works
Forms of extracellular mitochondria and their impact in health
Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138 · see citing works
Extracellular vesicles: interneural shuttles of complex messages
Krämer-Albers, E.-M., & Hill, A. F. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.016 · Cited by 133 · see citing works
Self-citationThe regulation of autophagy during exercise in skeletal muscle
Vainshtein, A., & Hood, D. A. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00550.2015 · Cited by 132 · see citing works
Piffoux, M., Nicolás‐Boluda, A., Mulens-Arias, V., Richard, S., Rahmi, G., Gazeau, F., Wilhelm, C., & Silva, A. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.009 · Cited by 126 · see citing works
D’Souza, R. F., Woodhead, J. S. T., Zeng, N., Blenkiron, C., Merry, T. L., Cameron‐Smith, D., & Mitchell, C. J. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00138.2018 · Cited by 123 · see citing works
Extracellular vesicles and their nucleic acids for biomarker discovery
Momen‐Heravi, F., Getting, S. J., & Moschos, S. A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.002 · Cited by 121 · see citing works
Moderate Exercise Enhances Endothelial Progenitor Cell Exosomes Release and Function
Ma, C., Wang, J., Liu, H., Chen, Y., Ma, X., Chen, S., Chen, Y., Bihl, J. C., & Yang, Y. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001672 · Cited by 114 · see citing works
Extracellular Vesicles: Delivery Vehicles of Myokines
Trovato, E., Felice, V. D., & Barone, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00522 · Cited by 111 · see citing works
Extracellular Vesicles as Biomarkers in Cancer Immunotherapy
Mathew, M., Zade, M., Mezghani, N., Patel, R. D., Wang, Y., & Momen‐Heravi, F. (2020) · Cancers · doi:10.3390/cancers12102825 · Cited by 109 · see citing works
The Utility of Exosomes in Diagnosis and Therapy of Diabetes Mellitus and Associated Complications
Sun, Y., Tao, Q., Wu, X., Zhang, L., Liu, Q., & Wang, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.756581 · Cited by 109 · see citing works
Wang, W., Li, M., Chen, Z., Xu, L., Chang, M., Wang, K., Deng, C., Gu, Y., Zhou, S., Shen, Y., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114954 · Cited by 107 · see citing works
de Oliveira, G. P., Porto, W. F., Palu, C. C., Pereira, L. M., Petriz, B. A., de Almeida, J. A., Viana, J., Filho, N. N. A., Franco, O. L., & Pereira, R. W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00532 · Cited by 104 · see citing works
Rong, S., Wang, L., Peng, Z., Liao, Y., Li, D., Yang, X., Nussler, A. K., Liu, L., Bao, W., & Yang, W. Q. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12536 · Cited by 104 · see citing works
Exosome-Mediated Impact on Systemic Metabolism
Rocha, K. C. E., Ying, W., & Olefsky, J. M. (2024) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-024535 · Cited by 103 · see citing works
Prattichizzo, F., Matacchione, G., Giuliani, A., Sabbatinelli, J., Olivieri, F., de Candia, P., Nigris, V. D., & Ceriello, A. (2020) · Theranostics · doi:10.7150/thno.51605 · Cited by 98 · see citing works
An estimate of extracellular vesicle secretion rates of human blood cells
Auber, M., & Svenningsen, P. (2022) · Journal of Extracellular Biology · doi:10.1002/jex2.46 · Cited by 97 · see citing works
Raudenská, M., Balvan, J., & Masařík, M. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01423-6 · Cited by 96 · see citing works
Every exercise bout matters: linking systemic exercise responses to breast cancer control
Dethlefsen, C., Pedersen, K. S., & Højman, P. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4129-4 · Cited by 94 · see citing works
Nie, Y., Sato, Y., Garner, R. T., Kargl, C. K., Wang, C., Kuang, S., Gilpin, C. J., & Gavin, T. P. (2019) · Experimental Physiology · doi:10.1113/ep087396 · Cited by 93 · see citing works
Exosomes and Extracellular RNA in Muscle and Bone Aging and Crosstalk
Qin, W., & Dallas, S. L. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00537-7 · Cited by 93 · see citing works
Effects of exercise on exosome release and cargo in in vivo and ex vivo models: A systematic review
Estébanez, B., Jiménez‐Pavón, D., Huang, C., Cuevas, M. J., & González‐Gallego, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30094 · Cited by 93 · see citing works
Nair, V. D., Ge, Y., Li, S., Pinças, H., Jain, N., Seenarine, N., Amper, M. A. S., Goodpaster, B. H., Walsh, M. J., Coen, P. M., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00605 · Cited by 90 · see citing works
Extracellular vesicles as signaling mediators in type 2 diabetes mellitus
Hooten, N. N., & Evans, M. K. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00536.2019 · Cited by 89 · see citing works
Molecular insights of exercise therapy in disease prevention and treatment
Walzik, D., Chirino, T. Y. W., Zimmer, P., & Joisten, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01841-0 · Cited by 89 · see citing works
Lopes-Rodrigues, V., Luca, A. D., Mleczko, J., Meleady, P., Henry, M. A., Pešić, M., Cabrera, D., Liempd, S. M. V., Lima, R. T., O'Connor, R. A., et al. (2017) · Scientific Reports · doi:10.1038/srep44541 · Cited by 88 · see citing works
Iftikhar, H., & Carney, G. E. (2016) · BioEssays · doi:10.1002/bies.201500130 · Cited by 87 · see citing works
Lovett, J. A. C., Durcan, P., & Myburgh, K. H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01149 · Cited by 85 · see citing works
Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry
Danielson, K., Estanislau, J., Tigges, J., Toxavidis, V., Camacho, V., Felton, E. J., Khoory, J. A., Kreimer, S. D., Ivanov, A. R., Mantel, P., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144678 · Cited by 84 · see citing works
Luo, Z., Mei, J., Wang, X., Wang, R., He, Z., Geffen, Y., Sun, X., Zhang, X., Xu, J., Wan, R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114697 · Cited by 83 · see citing works
Cui, S., Sun, B., Yin, X., Guo, X., Chao, D., Zhang, C., Zheng, J., Chen, X., & Ma, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-02294-y · Cited by 83 · see citing works
Circulating extracellular vesicles in the aging process: impact of aerobic exercise
Bertoldi, K., Cechinel, L. R., Schallenberger, B., Corssac, G. B., Davies, S., Külkamp‐Guerreiro, I. C., Belló‐Klein, A., Araújo, A. S. D. R., & Siqueira, I. R. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3160-4 · Cited by 82 · see citing works
Koster, H. J., Rojalin, T., Powell, A., Pham, D., Mizenko, R. R., Birkeland, A. C., & Carney, R. P. (2021) · Nanoscale · doi:10.1039/d1nr03334d · Cited by 81 · see citing works
Vatter, F. A. P., Cioffi, M., Hanna, S. J., Castarède, I., Caielli, S., Pascual, V., Matei, I. R., & Lyden, D. C. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202579 · Cited by 80 · see citing works
Acute Kidney Injury by Ischemia/Reperfusion and Extracellular Vesicles
Nørgård, M. Ø., & Svenningsen, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015312 · Cited by 80 · see citing works
Contribution of Extracellular Vesicles in Rebuilding Injured Muscles
Bittel, D. C., & Jaiswal, J. K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00828 · Cited by 79 · see citing works
Watanabe, S., Sudo, Y., Makino, T., Kimura, S., Tomita, K., Noguchi, M., Sakurai, H., Shimizu, M., Takahashi, Y., Sato, R., et al. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac173 · Cited by 79 · see citing works
Dave, K. M., Pinky, P. P., & Manickam, D. S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114068 · Cited by 78 · see citing works
De Gasperi, R., Hamidi, S., Harlow, L. M., Ksiezak-Reding, H., Bauman, W. A., & Cardozo, C. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-13105-9 · Cited by 75 · see citing works
A size-exclusion-based approach for purifying extracellular vesicles from human plasma
Vanderboom, P. M., Dasari, S., Ruegsegger, G. N., Pataky, M. W., Lucien, F., Heppelmann, C. J., Lanza, I. R., & Nair, K. S. (2021) · Cell Reports Methods · doi:10.1016/j.crmeth.2021.100055 · Cited by 75 · see citing works
“The effects of exercise on EV release into circulation has been investigated by others (Frühbeis et al., 2015; Whitham et al., 2018), and we considered acute exercise as an appropriate physiological intervention to determine the ability of the approach to detect the EV proteome changes.”
BackgroundEstrada, A. L., Valenti, Z. J., Hehn, G., Amorese, A. J., Williams, N. S., Balestrieri, N. P., Deighan, C., Allen, C., Spangenburg, E. E., Kruh‐Garcia, N. A., et al. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00580.2020 · Cited by 75 · see citing works
Rojalin, T., Koster, H. J., Liu, J., Mizenko, R. R., Tran, D., Wachsmann‐Hogiu, S., & Carney, R. P. (2020) · ACS Sensors · doi:10.1021/acssensors.0c00953 · Cited by 74 · see citing works
The wonder exerkines—novel insights: a critical state-of-the-art review
Magliulo, L., Bondi, D., Pini, N., Marramiero, L., & Filippo, E. S. D. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04264-5 · Cited by 74 · see citing works
Release of bulk cell free DNA during physical exercise occurs independent of extracellular vesicles
Helmig, S., Frühbeis, C., Krämer‐Albers, E., Simon, P. D., & Tug, S. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3207-8 · Cited by 74 · see citing works
Self-citationThe influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma
Yuwono, N. L., Warton, K., & Ford, C. E. (2021) · eLife · doi:10.7554/elife.69679 · Cited by 71 · see citing works
Factors mediating exercise‐induced organ crosstalk
Sabaratnam, R., Wojtaszewski, J. F. P., & Højlund, K. (2022) · Acta Physiologica · doi:10.1111/apha.13766 · Cited by 69 · see citing works
Rayamajhi, S., Sipes, J., Tetlow, A. L., Saha, S., Bansal, A. K., & Godwin, A. K. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvad176 · Cited by 69 · see citing works
The Effects of Acute and Chronic Exercise on Skeletal Muscle Proteome
Petriz, B. A., Gomes, C. P. C., de Almeida, J. A., de Oliveira, G. P., Ribeiro, F. M., Pereira, R. W., & Franco, O. L. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25477 · Cited by 66 · see citing works
Do skeletal muscle-secreted factors influence the function of pancreatic β-cells?
Barlow, J. P., & Solomon, T. P. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00353.2017 · Cited by 66 · see citing works
Extracellular vesicles in lung health, disease, and therapy
McVey, M. J., Maishan, M., Blokland, K. E. C., Bartlett, N. W., & Kuebler, W. M. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00546.2018 · Cited by 66 · see citing works
Just, J., Yan, Y., Farup, J., Sieljacks, P., Sloth, M., Venø, M. T., Gu, T., de Paoli, F. V., Nyengaard, J. R., Bæk, R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62456-3 · Cited by 65 · see citing works
Tao, L., Wang, J., Wang, K., Liu, Q., Li, H., Xu, S., Gu, C., & Zhu, Y. (2024) · Aging Cell · doi:10.1111/acel.14181 · Cited by 64 · see citing works
Chong, M. C., Silva, A., James, P. F., Wu, S. S. X., & Howitt, J. A. (2022) · Aging Cell · doi:10.1111/acel.13647 · Cited by 62 · see citing works
Lisi, V., Senesi, G., Bertola, N., Pecoraro, M., Bolis, S., Gualerzi, A., Picciolini, S., Raimondi, A., Fantini, C., Moretti, E., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102737 · Cited by 62 · see citing works
Circulating extracellular vesicles are associated with lipid and insulin metabolism
Kobayashi, Y., Eguchi, A., Tempaku, M., Honda, T., Togashi, K., Iwasa, M., Hasegawa, H., Takei, Y., Sumida, Y., & Taguchi, O. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00160.2018 · Cited by 62 · see citing works
Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60 · see citing works
Cui, S. F., Wang, C., Yin, X., Dong, T., Lu, Q. J., Zhang, C. Y., Chen, X., & Ma, J. Z. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00102 · Cited by 60 · see citing works
Xhuti, D., Nilsson, M. I., Manta, K., Tarnopolsky, M. A., & Nederveen, J. P. (2023) · The Journal of Physiology · doi:10.1113/jp282663 · Cited by 59 · see citing works
A systematic review of the biological mechanisms linking physical activity and breast cancer
Hong, B. S., & Lee, K. P. (2020) · Physical Activity and Nutrition · doi:10.20463/pan.2020.0018 · Cited by 59 · see citing works
Liang, X., Fa, W., Wang, N., Peng, Y., Liu, C., Zhu, M., Tian, N., Wang, Y., Han, X., Qiu, C., et al. (2022) · Aging Cell · doi:10.1111/acel.13748 · Cited by 59 · see citing works
Adamczyk, A. M., Leicaj, M. L., Fabiano, M. P., Cabrerizo, G., Bannoud, N., Croci, D. O., Witwer, K. W., Lenicov, F. R., Ostrowski, M., & Pérez, P. S. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12331 · Cited by 58 · see citing works
Novel approaches to restore beta cell function in prediabetes and type 2 diabetes
Salunkhe, V. A., Veluthakal, R., Kahn, S. E., & Thurmond, D. C. (2018) · Diabetologia · doi:10.1007/s00125-018-4658-3 · Cited by 57 · see citing works
Metabolic Messengers: small extracellular vesicles
Rohm, T. V., Rocha, K. C. E., & Olefsky, J. M. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01214-5 · Cited by 56 · see citing works
Abdelsaid, K., Varadarajan, S., Harris, R. A., Das, A., Youn, S., Liu, Y., McMenamin, M., Hou, Y., Fulton, D., Hamrick, M. W., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101323r · Cited by 54 · see citing works
Apostolopoulou, M., Mastrototaro, L., Hartwig, S., Pesta, D. H., Straßburger, K., Filippo, E. D., Jeleník, T., Karusheva, Y., Gancheva, S., Markgraf, D. F., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi9551 · Cited by 53 · see citing works
Extrinsic and intrinsic preanalytical variables affecting liquid biopsy in cancer
Batool, S. M., Hsia, T., Beecroft, A., Lewis, B. E., Ekanayake, E., Rosenfeld, Y. B., Escobedo, A. K., Gamblin, A. S., Rawal, S., Côté, R. J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101196 · Cited by 51 · see citing works
Bizjak, D. A., Tomschi, F., Bales, G., Nader, E., Romana, M., Connes, P., Bloch, W., & Grau, M. (2020) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2019.02.002 · Cited by 49 · see citing works
Doncheva, A. I., Romero, S., Ramírez‐Garrastacho, M., Lee-Ødegård, S., Kolnes, K. J., Tangen, D. S., Olsén, T., Drevon, C. A., Llorente, A., Dalen, K. T., et al. (2022) · Acta Physiologica · doi:10.1111/apha.13862 · Cited by 49 · see citing works
Darragh, I. A. J., O’Driscoll, L., & Egan, B. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.738333 · Cited by 48 · see citing works
Redox Signaling in Widespread Health Benefits of Exercise
Louzada, R. A. N., Bouvière, J., Matta, L., Werneck‐de‐Castro, J. P., Dupuy, C., de Carvalho, D. P., & Fortunato, R. S. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7949 · Cited by 47 · see citing works
Energetic Stress‐Induced Metabolic Regulation by Extracellular Vesicles
Crewe, C. (2023) · Comprehensive physiology · doi:10.1002/cphy.c230001 · Cited by 47 · see citing works
Multivesicular body and exosome pathway responses to acute exercise
Garner, R. T., Solfest, J. S., Nie, Y., Kuang, S., Stout, J., & Gavin, T. P. (2020) · Experimental Physiology · doi:10.1113/ep088017 · Cited by 45 · see citing works
Wang, Y., Liu, Y., Zhang, S., Li, N., Xing, C., Wang, C., Wang, J., Wei, M., Yang, G., & Yuan, L. (2023) · Aging and Disease · doi:10.14336/ad.2022.1131 · Cited by 44 · see citing works
Sex Bias in Cohorts Included in Sports Medicine Research
Hagstrom, A. D., Yuwono, N. L., Warton, K., & Ford, C. E. (2021) · Sports Medicine · doi:10.1007/s40279-020-01405-6 · Cited by 44 · see citing works
Shi, H., Hao, X., Sun, Y., Zhao, Y., Wang, Y., Cao, X., Gong, Z., Ji, S., Lu, J., Yan, Y., et al. (2024) · Acta Physiologica · doi:10.1111/apha.14103 · Cited by 43 · see citing works
Extracellular vesicle-mediated bidirectional communication between heart and other organs
Gabisonia, K., Khan, M., & Recchia, F. A. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00659.2021 · Cited by 43 · see citing works
Huang, K., Upadhyay, G. K., Ahn, Y., Sakakura, M., Pagan‐Diaz, G. J., Cho, Y., Weiss, A. C., Huang, C., Mitchell, J. W., Li, J., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313590121 · Cited by 42 · see citing works
Yin, X., Zhao, Y., Zheng, Y., Wang, J. Z., Li, W., Lu, Q. J., Huang, Q. N., Zhang, C. Y., Chen, X., & Zheng, J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01275 · Cited by 42 · see citing works
Soluble factors influencing the neural stem cell niche in brain physiology, inflammation, and aging
Willis, C. M., Nicaise, A. M., Krzak, G., Ionescu, R.-B., Pappa, V., D’Angelo, A., Agarwal, R., Repollés-de-Dalmau, M., Peruzzotti‐Jametti, L., & Pluchino, S. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114124 · Cited by 41 · see citing works
Neuberger, E. W. I., Hillen, B., Mayr, K., Simon, P. D., Krämer‐Albers, E., & Brahmer, A. (2021) · Genes · doi:10.3390/genes12040522 · Cited by 39 · see citing works
Self-citation
- Authors
- Frühbeis, C., Helmig, S., Tug, S., Simon, P., & Krämer‐Albers, E.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Simon, Perikles
- Krämer‐Albers, Eva‐Maria
- Venue
- Journal of Extracellular Vesicles
- Publisher
- Wiley
- Published
- 2015-01
- Volume
- 4
- Issue
- 1
- Pages
- 28239-28239
- ISSN
- 2001-3078 (ISSN-L)
- PMC
- PMC4491306
- OpenAlex
- W2164210247
- Cited by
- 360
- References
- 70
- Citations by year
- 2026: 42 · 2025: 43 · 2024: 44 · 2023: 43 · 2022: 50 · 2021: 47 · 2020: 35 · 2019: 20 · 2018: 14 · 2017: 10 · 2016: 10 · 2015: 2
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Extracellular Vesicles (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Gutenberg Open Science (submittedVersion, cc-by-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Gutenberg Open Science
- Funders
- California Department of Fish and Game (KR3668/1-1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- extracellular vesicles, exosomes, physical activity, plasma vesicles, cycling exercise, treadmill running, anaerobic threshold, lactate, exercise adaptation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
