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Plasticity of intrinsic neuronal excitability
Open accessAbstract
Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a certain level of input-specificity or cell-specificity. We discuss here the nature of the learning rules shared by intrinsic and synaptic plasticity and the impact of intrinsic plasticity on temporal processing.
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“Unlike synaptic plasticity, which modifies the efficacy of connections between neurons, intrinsic excitability regulates neuronal gain and input–output transformations at the single cell level [24,25,26].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [24]
In the citing paper
“These changes can occur independently of synaptic remodeling yet powerfully influence circuit output and behavioral state [24,26].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [24]
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Shore, A. N., Qunies, A. M., Spitznagel, B. D., Weaver, C. D., Emmitte, K. A., Frankel, W. N., & Weston, M. C. (2024) · eLife · doi:10.7554/elife.92915.1 · Cited by 1
Chameh, H. M., Falby, M. R., Yang, Y., Movahed, M., Arbabi, K., Sarathy, C., Tripathy, S. J., Zhang, L., Lefebvre, J., & Valiante, T. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.09.658517 · Cited by 2
Metadata
- Authors
- Debanne, D., Inglebert, Y., & Russier, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Debanne, Dominique
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 54
- Pages
- 73-82
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2891094463
- Cited by
- 272
- References
- 84
- Citations by year
- 2026: 35 · 2025: 56 · 2024: 38 · 2023: 37 · 2022: 31 · 2021: 36 · 2020: 20 · 2019: 18
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- INSERM, CNRS, AMU, FRM (FDT2170437059, DVS20131228768)
- ANR NEUC 2014 (ANR-14-NEUC-0004)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- intrinsic plasticity, neuronal excitability, voltage-gated ion channels, synaptic plasticity, memory formation, glutamate receptors, learning rules, temporal processing, interneurons, principal cells
- MeSH terms
- Action Potentials, Animals, Brain, Humans, Learning, Neuronal Plasticity, Neurons
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