The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Plasticity of intrinsic neuronal excitability
Open accessAbstract
Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a certain level of input-specificity or cell-specificity. We discuss here the nature of the learning rules shared by intrinsic and synaptic plasticity and the impact of intrinsic plasticity on temporal processing.
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“Unlike synaptic plasticity, which modifies the efficacy of connections between neurons, intrinsic excitability regulates neuronal gain and input–output transformations at the single cell level [24,25,26].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [24]
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“These changes can occur independently of synaptic remodeling yet powerfully influence circuit output and behavioral state [24,26].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [24]
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Cites
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Whittington, M. A., Traub, R. D., & Jefferys, J. G. R. (1995) · Nature · doi:10.1038/373612a0 · Cited by 1,613
Variability, compensation and homeostasis in neuron and network function
Marder, E., & Goaillard, J.-M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1949 · Cited by 1,212
The Spike-Timing Dependence of Plasticity
Feldman, D. E. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.001 · Cited by 1,071
The other side of the engram: experience-driven changes in neuronal intrinsic excitability
Zhang, W., & Linden, D. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1248 · Cited by 889
Time cells in the hippocampus: a new dimension for mapping memories
Eichenbaum, H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3827 · Cited by 843
Plasticity in the intrinsic excitability of cortical pyramidal neurons
Desai, N. S., Rutherford, L. C., & Turrigiano, G. G. (1999) · Nature Neuroscience · doi:10.1038/9165 · Cited by 806
Graded persistent activity in entorhinal cortex neurons
Egorov, A. V., Hamam, B. N., Fransén, E., Hasselmo, M. E., & Alonso, A. A. (2002) · Nature · doi:10.1038/nature01171 · Cited by 769
Dendritic Excitability and Synaptic Plasticity
Sjöström, P. J., Rancz, E. A., Roth, A., & Häusser, M. (2008) · Physiological Reviews · doi:10.1152/physrev.00016.2007 · Cited by 740
Compartmentalized dendritic plasticity and input feature storage in neurons
Losonczy, A., Makara, J. K., & Magee, J. C. (2008) · Nature · doi:10.1038/nature06725 · Cited by 598
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Tang, J., Yuan, F., Shen, X., Wang, Z., Rao, M., He, Y., Sun, Y., Li, X., Zhang, W., Li, Y., et al. (2019) · Advanced Materials · doi:10.1002/adma.201902761 · Cited by 850
Zheng, Z.-H., Tu, J., Li, X., Hua, Q., Liu, W.-Z., Liu, Y., Pan, B., Hu, P., & Zhang, W. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.007 · Cited by 319
Górriz, J. M., Álvarez, I., Álvarez-Marquina, A., Arco, J. E., Atzmueller, M., Ballarini, F., Barakova, E. I., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., et al. (2023) · Information Fusion · doi:10.1016/j.inffus.2023.101945 · Cited by 251
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Metadata
- Authors
- Debanne, D., Inglebert, Y., & Russier, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Debanne, Dominique
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 54
- Pages
- 73-82
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2891094463
- Cited by
- 272
- References
- 84
- Citations by year
- 2026: 35 · 2025: 56 · 2024: 38 · 2023: 37 · 2022: 31 · 2021: 36 · 2020: 20 · 2019: 18
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- INSERM, CNRS, AMU, FRM (FDT2170437059, DVS20131228768)
- ANR NEUC 2014 (ANR-14-NEUC-0004)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- intrinsic plasticity, neuronal excitability, voltage-gated ion channels, synaptic plasticity, memory formation, glutamate receptors, learning rules, temporal processing, interneurons, principal cells
- MeSH terms
- Action Potentials, Animals, Brain, Humans, Learning, Neuronal Plasticity, Neurons
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