Cited by 843Memory and Neural MechanismsMemory Processes and InfluencesNeurogenesis and neuroplasticity mechanisms

Time cells in the hippocampus: a new dimension for mapping memories

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Eichenbaum, Howard·2014·Nature Reviews Neuroscience

Abstract

Recent studies have revealed the existence of hippocampal neurons that fire at successive moments in temporally structured experiences. Several studies have shown that such temporal coding is not attributable to external events, specific behaviours or spatial dimensions of an experience. Instead, these cells represent the flow of time in specific memories and have therefore been dubbed 'time cells'. The firing properties of time cells parallel those of hippocampal place cells; time cells thus provide an additional dimension that is integrated with spatial mapping. The robust representation of both time and space in the hippocampus suggests a fundamental mechanism for organizing the elements of experience into coherent memories.

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Authors
Eichenbaum, H.
Affiliations
Boston University (US)
Corresponding author
Eichenbaum, Howard
Venue
Nature Reviews Neuroscience
Published
2014-10-01
Volume
15
Issue
11
Pages
732-744
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2087514146
Cited by
843
References
108
Citations by year
2026: 66 · 2025: 83 · 2024: 58 · 2023: 74 · 2022: 79 · 2021: 68 · 2020: 58 · 2019: 126 · 2018: 62 · 2017: 82 · 2016: 51 · 2015: 33 · 2014: 2 · 2013: 1
FWCI
5.40
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (MH 094263, MH095297, P50MH094263, R01MH095297)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
time cells, hippocampus, place cells, temporal coding, memory representation, spatial mapping, memory organization, hippocampal neurons
MeSH terms
Action Potentials, Animals, Brain Mapping, Hippocampus, Humans, Memory, Models, Neurological, Neurons, Time Perception

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