Mixed Culture Biotechnology for Bioenergy Production
Abstract
Mixed culture biotechnology (MCB) could become an attractive addition or alternative to traditional pure culture based biotechnology for the production of chemicals and/or bioenergy. On the basis of ecological selection principles, MCB-based processes can be established that generate a narrow product spectrum from a mixed substrate. Three example processes are briefly discussed in this paper: anaerobic digestion aimed at the production of methane-containing biogas, mixed culture fermentation for the production of solvents or biohydrogen, and a two-step process for the production of polyhydroxyalkanoates. These examples give an idea of the potential contribution of mixed culture biotechnology to sustainable production of bioenergy from waste.
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Mixed cultures leverage species diversity, enabling adaptation to varying light, temperature, and pH conditions.
“Mixed cultures leverage species diversity [127], enabling adaptation to varying light, temperature, and pH conditions [128].”
From A Review of Algae-Based Carbon Capture, Utilization, and Storage (Algae-Based CCUS) (2024) · cites this paper as [127]
Cites
Microbial Fuel Cells: Methodology and Technology
Logan, B. E., Hamelers, H. V. M., Rozendal, R. A., Schröder, U., Keller, J., Freguia, S., Aelterman, P., Verstraete, W., & Rabaey, K. (2006) · Environmental Science & Technology · doi:10.1021/es0605016 · Cited by 6,095 · see citing works
Fermentative Hydrogen Production From Wastewater and Solid Wastes by Mixed Cultures
Li, C., & Fang, H. H. P. (2006) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643380600729071 · Cited by 822 · see citing works
Bacteria engineered for fuel ethanol production: current status
Dien, B. S., Cotta, M. A., & Jeffries, T. W. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1444-y · Cited by 796 · see citing works
Principle and perspectives of hydrogen production through biocatalyzed electrolysis
Rozendal, R. A., Hamelers, H. V. M., Euverink, G. J. W., Metz, S. J., & Buisman, C. J. N. (2006) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2005.12.006 · Cited by 734 · see citing works
van Maris, A. J. A., Abbott, D. A., Bellissimi, E., van den Brink, J., Kuyper, M., Luttik, M. A. H., Wisselink, H. W., Scheffers, W. A., van Dijken, J. P., & Pronk, J. T. (2006) · Antonie van Leeuwenhoek · doi:10.1007/s10482-006-9085-7 · Cited by 546 · see citing works
Photobiological hydrogen production: photochemical efficiency and bioreactor design
Akkerman, I. (2002) · International Journal of Hydrogen Energy · doi:10.1016/s0360-3199(02)00071-x · Cited by 542 · see citing works
Hydrogen and methane production from household solid waste in the two-stage fermentation process
Liu, D., Liu, D., Zeng, R. J., & Angelidaki, İ. (2006) · Water Research · doi:10.1016/j.watres.2006.03.029 · Cited by 444 · see citing works
Acetate as a carbon source for hydrogen production by photosynthetic bacteria
Barbosa, M. J., Rocha, J. M. S., TRAMPER, J., & Wijffels, R. H. (2001) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00368-0 · Cited by 339 · see citing works
Production of Polyhydroxyalkanoates by Mixed Microbial Cultures
Reis, M. A. M., Serafim, L. S., Lemos, P. C., Ramos, A. M., Aguiar, F. R., & Van Loosdrecht, M. C. M. (2003) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-003-0322-4 · Cited by 301 · see citing works
pH influence on acidogenic dissimilation of glucose in an anaerobic digestor
Zoetemeyer, R. J., van den Heuvel, J. C., & Cohen, A. (1982) · Water Research · doi:10.1016/0043-1354(82)90190-7 · Cited by 287 · see citing works
Poly-β-hydroxybutyrate metabolism in dynamically fed mixed microbial cultures
Beun, J. J., Dircks, K., van Loosdrecht, M. C. M., & Heijnen, J. J. (2002) · Water Research · doi:10.1016/s0043-1354(01)00317-7 · Cited by 260 · see citing works
Influence of the pH on (open) mixed culture fermentation of glucose: A chemostat study
Temudo, M. F., Kleerebezem, R., & van Loosdrecht, M. C. M. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21412 · Cited by 250 · see citing works
Self-citationModeling product formation in anaerobic mixed culture fermentations
Rodríguez, J., Kleerebezem, R., Lema, J. M., & van Loosdrecht, M. C. M. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20765 · Cited by 236 · see citing works
Self-citationLettinga, G., Pol, L. W. H., Koster, I. W., Wiegant, W. M., de Zeeuw, W. J., Rinzema, A., Grin, P. C., Roersma, R. E., & Hobma, S. W. (1984) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.1984.10647801 · Cited by 174 · see citing works
Alatriste‐Mondragón, F., Samar, P., Cox, H. H. J., Ahring, B. K., & Iranpour, R. (2006) · Water Environment Research · doi:10.2175/106143006x111673 · Cited by 162 · see citing works
Zoetemeyer, R. J., Arnoldy, P., Cohen, A., & Boelhouwer, C. (1982) · Water Research · doi:10.1016/0043-1354(82)90191-9 · Cited by 145 · see citing works
Environmental Implications of Municipal Solid Waste-Derived Ethanol
Kalogo, Y., Habibi, S., MacLean, H. L., & Joshi, S. (2006) · Environmental Science & Technology · doi:10.1021/es061117b · Cited by 129 · see citing works
Application of the redox potential for controling a sulfide oxidizing bioreactor
Janssen, A. J. H., Meijer, S., Bontsema, J., & Lettinga, G. (1998) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19981020)60:2 · Cited by 123 · see citing works
Gómez, X., Morán, A., Revuelta, M. J. C., & Sánchez, M. E. (2006) · Journal of Power Sources · doi:10.1016/j.jpowsour.2006.01.006 · Cited by 117 · see citing works
Microbial energetics applied to waste repositories
Hanselmann, K. W. (1991) · Cellular and Molecular Life Sciences · doi:10.1007/bf01958816 · Cited by 100 · see citing works
Advanced Bioethanol Production Technologies: A Perspective
Himmel, M. E., Adney, W. S., Baker, J. O., Elander, R. T., McMillan, J. D., Nieves, R. A., Sheehan, J., Thomas, S. R., Vinzant, T. B., & Zhang, M. (1997) · ACS symposium series · doi:10.1021/bk-1997-0666.ch001 · Cited by 94 · see citing works
Energetic and rate effects on methanogenesis of ethanol and propionate in perturbed CSTRs
Smith, D. P., & McCarty, P. L. (1989) · Biotechnology and Bioengineering · doi:10.1002/bit.260340106 · Cited by 71 · see citing works
Anaerobic Treatment of Low, Medium and High Strength Effluent in the Agro-industry
Driessen, W., & Yspeert, P. (1999) · Water Science & Technology · doi:10.1016/s0273-1223(99)00629-0 · Cited by 70 · see citing works
Mercille, S., Johnson, M., Lanthier, S., Kamen, A., & Massie, B. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000220)67:4 · Cited by 66 · see citing works
Modelling of activated sludge processes with structured biomass
van Loosdrecht, M. C. M., & Heijnen, J. J. (2002) · Water Science & Technology · doi:10.2166/wst.2002.0090 · Cited by 65 · see citing works
Reduced product formation following perturbation of ethanol‐ and propionate‐fed methanogenic CSTRs
Smith, D. P., & McCarty, P. L. (1989) · Biotechnology and Bioengineering · doi:10.1002/bit.260340702 · Cited by 64 · see citing works
Anaerobic-aerobic treatment of toxic pulping black liquor with upfront effluent recirculation
Kortekaas, S., Vidal, G., He, Y., Lettinga, G., & Field, J. A. (1998) · Journal of Fermentation and Bioengineering · doi:10.1016/s0922-338x(98)80041-x · Cited by 53 · see citing works
Gonzalez-Gil, G., Kleerebezem, R., van Aelst, A., Zoutberg, G. R., Versprille, A. I., & Lettinga, G. (1999) · Water Science & Technology · doi:10.1016/s0273-1223(99)00626-5 · Cited by 38 · see citing works
Self-citationStability and activity of anaerobic sludge from UASB reactors treating sewage in subtropical regions
Seghezzo, L., Cuevas, C. M., Trupiano, A. P., Guerra, R. G., González, S. M., Zeeman, G., & Lettinga, G. (2006) · Water Science & Technology · doi:10.2166/wst.2006.509 · Cited by 16 · see citing works
van Lier, J. B., Lens, P. N. L., & Pol, L. W. H. (2001) · Water Science & Technology · doi:10.2166/wst.2001.0218 · Cited by 13 · see citing works
Characterisation of high-rate acidogenesis processes using a titration and off-gas analysis sensor
Wangnai, C., Zeng, R. J., & Keller, J. (2005) · Water Science & Technology · doi:10.2166/wst.2005.0547 · Cited by 5 · see citing works
Hartmann, H., & Ahring, B. K. (2006) · Water Science & Technology · doi:10.2166/wst.2006.260 · Cited by 1 · see citing works
Electricity and hydrogen production using different types of microbial fuel cell technologiesPreprint
Logan, B. E., Liu, H., Heilmann, J., Oh, S., Cheng, S., & Grot, S. A. (2005) · Am. Chem. Soc., Div. Fuel Chem., Prepr.; (United States) · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
A review of the substrates used in microbial fuel cells (MFCs) for sustainable energy production
Pant, D., Bogaert, G. V., Diels, L., & Vanbroekhoven, K. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.10.017 · Cited by 1,876 · see citing works
A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry
Chen, G. (2009) · Chemical Society Reviews · doi:10.1039/b812677c · Cited by 1,302 · see citing works
Recent advances in lactic acid production by microbial fermentation processes
Abdel-Rahman, M. A., Tashiro, Y., & Sonomoto, K. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.04.002 · Cited by 1,022 · see citing works
Meereboer, K. W., Misra, M., & Mohanty, A. K. (2020) · Green Chemistry · doi:10.1039/d0gc01647k · Cited by 978 · see citing works
Waste to bioproduct conversion with undefined mixed cultures: the carboxylate platform
Agler, M. T., Wrenn, B. A., Zinder, S. H., & Angenent, L. T. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.11.006 · Cited by 821 · see citing works
Recent Advances and Challenges towards Sustainable Polyhydroxyalkanoate (PHA) Production
Kourmentza, K., Plácido, J., Venetsaneas, N., Figols, A. B., Varrone, C., Gavala, H. N., & Reis, M. A. M. (2017) · Bioengineering · doi:10.3390/bioengineering4020055 · Cited by 784 · see citing works
Chain elongation with reactor microbiomes: open-culture biotechnology to produce biochemicals
Angenent, L. T., Richter, H., Buckel, W., Spirito, C. M., Steinbusch, K. J. J., Plugge, C. M., Strik, D. P. B. T. B., Grootscholten, T. I. M., Buisman, C. J. N., & Hamelers, H. V. M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b04847 · Cited by 689 · see citing works
Second generation bioethanol production: A critical review
Aditiya, H. B., Mahlia, T. M. I., Chong, W. T., Nur, H., & Sebayang, A. H. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2016.07.015 · Cited by 655 · see citing works
Co-culture systems and technologies: taking synthetic biology to the next level
Goers, L., Freemont, P. S., & Polizzi, K. M. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0065 · Cited by 623 · see citing works
The Chemomechanical Properties of Microbial Polyhydroxyalkanoates
Laycock, B., Halley, P., Pratt, S., Werker, A., & Lant, P. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.06.003 · Cited by 604 · see citing works
Puyol, D., Batstone, D. J., Hülsen, T., Astals, S., Peces, M., & Krömer, J. O. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02106 · Cited by 594 · see citing works
Advances in fermentative biohydrogen production: the way forward?
Hallenbeck, P. C., & Ghosh, D. (2009) · Trends in biotechnology · doi:10.1016/j.tibtech.2009.02.004 · Cited by 581 · see citing works
A New Planning and Design Paradigm to Achieve Sustainable Resource Recovery from Wastewater
Guest, J. S., Skerlos, S. J., Barnard, J., Beck, M. B., Daigger, G. T., Hilger, H. A., Jackson, S. J., Karvazy, K., Kelly, L., Macpherson, L., et al. (2009) · Environmental Science & Technology · doi:10.1021/es9010515 · Cited by 556 · see citing works
Wainaina, S., Lukitawesa, L., Awasthi, M. K., & Taherzadeh, M. J. (2019) · Bioengineered · doi:10.1080/21655979.2019.1673937 · Cited by 556 · see citing works
RetractedFermentative hydrogen production: Principles, progress, and prognosis
Hallenbeck, P. C. (2009) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2008.12.080 · Cited by 553 · see citing works
Luo, J., Zhang, S., Sun, M., Yang, L., Luo, S., & Crittenden, J. C. (2019) · ACS Nano · doi:10.1021/acsnano.9b03649 · Cited by 481 · see citing works
Steinbusch, K. J. J., Hamelers, H. V. M., Plugge, C. M., & Buisman, C. J. N. (2011) · Energy Environ. Sci. · doi:10.1039/c0ee00282h · Cited by 453 · see citing works
Enrichment of a Mixed Bacterial Culture with a High Polyhydroxyalkanoate Storage Capacity
Johnson, K., Jiang, Y., Kleerebezem, R., Gerard Muyzer, C., & van Loosdrecht, M. C. M. (2009) · Biomacromolecules · doi:10.1021/bm8013796 · Cited by 390 · see citing works
Self-citationVanwonterghem, I., Jensen, P. D., Ho, D., Batstone, D. J., & Tyson, G. W. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.11.004 · Cited by 374 · see citing works
Anaerobic digestion without biogas?
Kleerebezem, R., Joosse, B., Rozendal, R. A., & van Loosdrecht, M. C. M. (2015) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-015-9374-6 · Cited by 358 · see citing works
Self-citationAlbuquerque, M. G. E., Torres, C. A. V., & Reis, M. A. M. (2010) · Water Research · doi:10.1016/j.watres.2010.03.021 · Cited by 334 · see citing works
Cabrol, L., Marone, A., Tapia-Venegas, E., Steyer, J.-P., Ruiz-Filippi, G., & Trably, E. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw043 · Cited by 329 · see citing works
Sustainable wastewater treatment: How might microbial fuel cells contribute
Oh, S. T., Kim, J. R., Premier, G. C., Lee, T. H., Kim, C., & Sloan, W. T. (2010) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.07.008 · Cited by 327 · see citing works
Bioelectrochemical Ethanol Production through Mediated Acetate Reduction by Mixed Cultures
Steinbusch, K. J. J., Hamelers, H. V. M., Schaap, J. D., Kampman, C., & Buisman, C. J. N. (2009) · Environmental Science & Technology · doi:10.1021/es902371e · Cited by 306 · see citing works
Albuquerque, M. G. E., Martino, V. P., Pollet, É., Avérous, L., & Reis, M. A. M. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.10.070 · Cited by 301 · see citing works
Relevance of microbial coculture fermentations in biotechnology
Bader, J., Mast-Gerlach, E., Popović, M. K., Bajpai, R., & Ståhl, U. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04659.x · Cited by 285 · see citing works
Conversion of l-lactate into n-caproate by a continuously fed reactor microbiome
Kucek, L. A., Nguyen, M. T., & Angenent, L. T. (2016) · Water Research · doi:10.1016/j.watres.2016.02.018 · Cited by 279 · see citing works
Stability problems in the hydrogen production by dark fermentation: Possible causes and solutions
Castelló, E., Júnior, A. D. N. F., Andreani, C. L., Anzola-Rojas, M. D. P., Borzacconi, L., Buitrón, G., Carrillo‐Reyes, J., Gomes, S. D., Maintinguer, S. I., Moreno‐Andrade, I., et al. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.109602 · Cited by 263 · see citing works
Kröber, M., Bekel, T., Diaz, N. N., Goesmann, A., Jaenicke, S., Krause, L., Miller, D., Runte, K. J., Viehöver, P., Pühler, A., et al. (2009) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2009.02.010 · Cited by 261 · see citing works
Zhu, X., Zhou, Y., Wang, Y., Wu, T., Li, X., Li, D., & Tao, Y. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0788-y · Cited by 260 · see citing works
Cellulose solvent-based pretreatment for enhanced second-generation biofuel production: a review
Satari, B., Karimi, K., & Kumar, R. (2018) · Sustainable Energy & Fuels · doi:10.1039/c8se00287h · Cited by 250 · see citing works
Bacillus subtilis as potential producer for polyhydroxyalkanoates
Singh, M., Patel, S. K., & Kalia, V. C. (2009) · Microbial Cell Factories · doi:10.1186/1475-2859-8-38 · Cited by 238 · see citing works
Carbon recovery from wastewater through bioconversion into biodegradable polymers
Valentino, F., Morgan-Sagastume, F., Campanari, S., Villano, M., Werker, A., & Majone, M. (2016) · New Biotechnology · doi:10.1016/j.nbt.2016.05.007 · Cited by 232 · see citing works
The chemomechanical properties of microbial polyhydroxyalkanoates
Laycock, B. G., Halley, P. J., Pratt, S., Werker, A., & Lant, P. A. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.06.008 · Cited by 230 · see citing works
Waste to resource: Converting paper mill wastewater to bioplastic
Jiang, Y., Marang, L., Tamis, J., van Loosdrecht, M. C. M., Dijkman, H., & Kleerebezem, R. (2012) · Water Research · doi:10.1016/j.watres.2012.07.028 · Cited by 229 · see citing works
Self-citationCell wall hemicellulose for sustainable industrial utilization
Qaseem, M. F., Shaheen, H., & Wu, A. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2021.110996 · Cited by 229 · see citing works
The role of anaerobic digestion in the emerging energy economy
Batstone, D. J., & Virdis, B. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.01.013 · Cited by 223 · see citing works
Metabolic and practical considerations on microbial electrosynthesis
Rabaey, K., Girguis, P. R., & Nielsen, L. K. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.01.010 · Cited by 223 · see citing works
Cavınato, C., Giuliano, A., Bolzonella, D., Pavan, P., & Cecchi, F. (2012) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2012.03.065 · Cited by 221 · see citing works
Wastewater as a resource: Strategies to recover resources from Amsterdam’s wastewater
van der Hoek, J. P., Fooij, H. D., & Struker, A. (2016) · Resources Conservation and Recycling · doi:10.1016/j.resconrec.2016.05.012 · Cited by 219 · see citing works
Choong, Y. Y., Chou, K. W., & Norli, I. (2017) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2017.10.036 · Cited by 212 · see citing works
Morgan-Sagastume, F., Hjort, M., Cirne, D. G., Gérardin, F., Lacroix, S., Gaval, G., Karabegovic, L., Alexandersson, T., Johansson, P. J., Karlsson, A., et al. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.01.046 · Cited by 208 · see citing works
Zhang, F., Ding, J., Zhang, Y., Chen, M., Ding, Z., van Loosdrecht, M. C. M., & Zeng, R. J. (2013) · Water Research · doi:10.1016/j.watres.2013.07.033 · Cited by 207 · see citing works
Consolidated bioprocessing of lignocellulose by a microbial consortium
Brethauer, S., & Studer, M. H. (2014) · Energy & Environmental Science · doi:10.1039/c3ee41753k · Cited by 205 · see citing works
Biohydrogen production from food waste: Current status, limitations, and future perspectives
Yun, Y., Lee, M., Im, S., Marone, A., Trably, É., Shin, S.-R., Kim, M.-G., Cho, S., & Kim, D. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.06.107 · Cited by 205 · see citing works
Kucek, L. A., Spirito, C. M., & Angenent, L. T. (2016) · Energy & Environmental Science · doi:10.1039/c6ee01487a · Cited by 203 · see citing works
Fang, W., Zhang, X., Zhang, P., Wan, J., Guo, H., Ghasimi, D. S. M., Morera, X. C., & Zhang, T. (2019) · Journal of Environmental Sciences · doi:10.1016/j.jes.2019.05.027 · Cited by 202 · see citing works
Brentner, L. B., Peccia, J., & Zimmerman, J. B. (2010) · Environmental Science & Technology · doi:10.1021/es9030613 · Cited by 200 · see citing works
Rahman, Z. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122682 · Cited by 192 · see citing works
A Glimpse of the World of Volatile Fatty Acids Production and Application: A review
Agnihotri, S., Yin, D., Mahboubi, A., Sapmaz, T., Varjani, S., Qiao, W., Köseoğlu-İmer, D. Y., & Taherzadeh, M. J. (2021) · Bioengineered · doi:10.1080/21655979.2021.1996044 · Cited by 191 · see citing works
RetractedCavınato, C., Bolzonella, D., Fatone, F., Cecchi, F., & Pavan, P. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.03.084 · Cited by 189 · see citing works
Chemical inhibitors of methanogenesis and putative applications
Liu, H., Wang, J., Wang, A., & Chen, J. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-3066-5 · Cited by 187 · see citing works
Towards a carbon-negative sustainable bio-based economy
Vanholme, B., Desmet, T., Ronsse, F., Rabaey, K., Breusegem, F. V., Mey, M. D., Soetaert, W., & Boerjan, W. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00174 · Cited by 172 · see citing works
Biohydrogen Production from Lignocellulosic Biomass: Technology and Sustainability
Singh, A., Sevda, S., Abu-Reesh, I. M., Vanbroekhoven, K., Rathore, D., & Pant, D. (2015) · Energies · doi:10.3390/en81112357 · Cited by 172 · see citing works
Metabolic Interactions of a Chain Elongation Microbiome
Han, W., He, P., Shao, L., & Lü, F. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.01614-18 · Cited by 172 · see citing works
Moscoviz, R., Trably, E., Bernet, N., & Carrère, H. (2018) · Green Chemistry · doi:10.1039/c8gc00572a · Cited by 171 · see citing works
Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation
Groof, V. D., Coma, M., Arnot, T., Leak, D. J., & Lanham, A. B. (2019) · Molecules · doi:10.3390/molecules24030398 · Cited by 171 · see citing works
Biosystems analysis and engineering of microbial consortia for industrial biotechnology
Sabra, W. A., Dietz, D., Tjahjasari, D., & Zeng, A. (2010) · Engineering in Life Sciences · doi:10.1002/elsc.201000111 · Cited by 166 · see citing works
Benomar, S., Ranava, D., Cárdenas, M. L., Trably, É., Rafrafi, Y., Ducret, A., Hamelin, J., Lojou, É., Steyer, J., & Giudici‐Orticoni, M. (2015) · Nature Communications · doi:10.1038/ncomms7283 · Cited by 166 · see citing works
Advances in the development and application of microbial consortia for metabolic engineering
Jawed, K., Yazdani, S. S., & Koffas, M. A. G. (2019) · Metabolic Engineering Communications · doi:10.1016/j.mec.2019.e00095 · Cited by 161 · see citing works
Reis, M. A. M., Albuquerque, M., Villano, M., & Majone, M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-08-088504-9.00464-5 · Cited by 159 · see citing works
Complex Effluent Streams as a Potential Source of Volatile Fatty Acids
Zacharof, M., & Lovitt, R. W. (2013) · Waste and Biomass Valorization · doi:10.1007/s12649-013-9202-6 · Cited by 159 · see citing works
Developing symbiotic consortia for lignocellulosic biofuel production
Zuroff, T. R., & Curtis, W. R. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3762-9 · Cited by 159 · see citing works
Polyhydroxybutyrate production from lactate using a mixed microbial culture
Jiang, Y., Marang, L., Kleerebezem, R., Gerard Muyzer, C., & van Loosdrecht, M. C. M. (2011) · Biotechnology and Bioengineering · doi:10.1002/bit.23148 · Cited by 157 · see citing works
Self-citationKongjan, P., O‐Thong, S., Kotay, S. M., Min, B., & Angelidaki, İ. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22616 · Cited by 155 · see citing works
Challenges and Opportunities for Customizing Polyhydroxyalkanoates
Singh, M., Kumar, P., Ray, S., & Kalia, V. C. (2015) · Indian Journal of Microbiology · doi:10.1007/s12088-015-0528-6 · Cited by 155 · see citing works
Tamis, J., Lužkov, K., Jiang, Y., van Loosdrecht, M. C. M., & Kleerebezem, R. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.10.022 · Cited by 152 · see citing works
Self-citationKongjan, P., Min, B., & Angelidaki, İ. (2008) · Water Research · doi:10.1016/j.watres.2008.12.016 · Cited by 149 · see citing works
Metabolic Network Modeling of Microbial Interactions in Natural and Engineered Environmental Systems
Perez‐Garcia, O., Lear, G., & Singhal, N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00673 · Cited by 149 · see citing works
Carbon and nitrogen removal and enhanced methane production in a microbial electrolysis cell
Villano, M., Scardala, S., Aulenta, F., & Majone, M. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.11.080 · Cited by 147 · see citing works
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Ganigué, R., Sánchez-Paredes, P., Bañeras, L., & Colprim, J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00702 · Cited by 147 · see citing works
Li, W., & Yu, H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.08.012 · Cited by 145 · see citing works
Temudo, M. F., Gerard Muyzer, C., Kleerebezem, R., & van Loosdrecht, M. C. M. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1669-x · Cited by 145 · see citing works
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Panahi, H. K. S., Dehhaghi, M., Guillemin, G. J., Gupta, V. K., Lam, S. S., Aghbashlo, M., & Tabatabaei, M. (2021) · Current Opinion in Food Science · doi:10.1016/j.cofs.2021.11.001 · Cited by 144 · see citing works
van der Hoek, J. P., Duijff, R., & Reinstra, O. (2018) · Sustainability · doi:10.3390/su10124605 · Cited by 143 · see citing works
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Kim, M. S., Na, J., Lee, M., Ryu, H., Chang, Y., Triolo, J. M., Yun, Y., & Kim, D.-H. (2016) · Water Research · doi:10.1016/j.watres.2016.03.064 · Cited by 140 · see citing works
Huang, L., Chen, Z., Wen, Q., Zhao, L., Lee, D., Yang, L., & Wang, Y. (2017) · Water Research · doi:10.1016/j.watres.2017.12.033 · Cited by 139 · see citing works
Aslam, M., Ahmad, R., Yasin, M., Khan, A. L., Shahid, M. K., Hossain, S., Khan, Z., Jamil, F., Rafiq, S., Bilad, M. R., et al. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.08.050 · Cited by 138 · see citing works
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Yang, G., & Wang, J. (2019) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2019.08.039 · Cited by 131 · see citing works
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Self-citationInfantes, D., del Campo, A. G., Villaseñor, J., & Fernández-Morales, F. J. (2011) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2011.09.061 · Cited by 130 · see citing works
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Arslan, D., Steinbusch, K. J. J., Diels, L., Hamelers, H. V. M., Strik, D. P. B. T. B., Buisman, C. J. N., & Wever, H. D. (2016) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2016.1145959 · Cited by 126 · see citing works
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Zhang, Y.-H. P. (2009) · Energy & Environmental Science · doi:10.1039/b818694d · Cited by 125 · see citing works
The potential of microbial processes for lignocellulosic biomass conversion to ethanol: a review
Dionisi, D., Anderson, J. A., Aulenta, F., McCue, A. J., & Paton, G. I. (2014) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.4544 · Cited by 124 · see citing works
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Marshall, C. W., LaBelle, E. V., & May, H. D. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.03.016 · Cited by 120 · see citing works
Fadzli, F. S., Bhawani, S. A., & Mohammad, R. E. A. (2021) · Journal of Chemistry · doi:10.1155/2021/4570388 · Cited by 120 · see citing works
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Arcos-Hernandez, M., Laycock, B. G., Donose, B. C., Pratt, S., Halley, P. J., Al-luaibi, S. S., Werker, A., & Lant, P. A. (2012) · European Polymer Journal · doi:10.1016/j.eurpolymj.2012.10.025 · Cited by 119 · see citing works
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Coma, M., Martínez-Hernández, E., Abeln, F., Raikova, S., Donnelly, J., Arnot, T., Allen, M. J., Hồng, Đ. D., & Chuck, C. J. (2017) · Faraday Discussions · doi:10.1039/c7fd00070g · Cited by 119 · see citing works
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Said, S. B., & Or, D. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01125 · Cited by 117 · see citing works
Microbial cell immobilization in biohydrogen production: a short overview
Sekoai, P. T., Awosusi, A. A., Yoro, K. O., Singo, M., Oloye, O., Ayeni, A. O., Bodunrin, M. O., & Daramola, M. O. (2017) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2017.1312274 · Cited by 116 · see citing works
Dong, B., Xia, Z., Sun, J., Dai, X., Chen, X., & Ni, B. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.07.424 · Cited by 115 · see citing works
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Taffs, R. L., Aston, J. E., Brileya, K. A., Jay, Z. J., Klatt, C. G., McGlynn, S. E., Mallette, N., Montross, S. N., Gerlach, R., Inskeep, W. P., et al. (2009) · BMC Systems Biology · doi:10.1186/1752-0509-3-114 · Cited by 115 · see citing works
Microbial diversity and genomics in aid of bioenergy
Kalia, V. C., & Purohit, H. J. (2008) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-007-0300-y · Cited by 113 · see citing works
Scaling-up microbial community-based polyhydroxyalkanoate production: status and challenges
Estévez-Alonso, Á., Pei, R., van Loosdrecht, M. C. M., Kleerebezem, R., & Werker, A. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.124790 · Cited by 111 · see citing works
Self-citationSarkar, O., Kumar, A. N., Dahiya, S., Krishna, K. V., Yeruva, D. K., & Mohan, S. V. (2016) · RSC Advances · doi:10.1039/c5ra24254a · Cited by 111 · see citing works
- Authors
- Kleerebezem, R., & van Loosdrecht, M. C.
- Affiliations
- Delft University of Technology (NL)
- Corresponding author
- Kleerebezem, Robbert
- ORCID
- Kleerebezem, Robbert
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 18
- Issue
- 3
- Pages
- 207-212
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2031663630
- Cited by
- 624
- References
- 34
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 33 · 2023: 34 · 2022: 39 · 2021: 38 · 2020: 43 · 2019: 49 · 2018: 42 · 2017: 43 · 2016: 48 · 2015: 39 · 2014: 35 · 2013: 30 · 2012: 24
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- bioenergy production, anaerobic digestion, biogas, methane production, mixed culture fermentation, biohydrogen, solvents, polyhydroxyalkanoates, waste valorization, ecological selection
- MeSH terms
- Anaerobiosis, Biotechnology, Fermentation, Hydrocarbons, Hydrogen, Solvents
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