The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
How cells sense extracellular matrix stiffness: a material's perspective
Open accessAbstract
The mechanical properties of the extracellular matrix (ECM) in which cells reside have emerged as an important regulator of cell fate. While materials based on natural ECM have been used to implicate the role of substrate stiffness for cell fate decisions, it is difficult in these matrices to isolate mechanics from other structural parameters. In contrast, fully synthetic hydrogels offer independent control over physical and adhesive properties. New synthetic materials that also recreate the fibrous structural hierarchy of natural matrices are now being designed to study substrate mechanics in more complex ECMs. This perspective examines the ways in which new materials are being used to advance our understanding of how extracellular matrix stiffness impacts cell function.
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Cites
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577
Cited by
The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 608
Mouser, V. H. M., Melchels, F. P. W., Visser, J., Dhert, W. J. A., Gawlitta, D., & Malda, J. (2016) · Biofabrication · doi:10.1088/1758-5090/8/3/035003 · Cited by 359
Hydrogels to model 3D in vitro microenvironment of tumor vascularization
Song, H.-H. G., Park, K. M., & Gerecht, S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.06.002 · Cited by 153
Biomaterial-based physical regulation of macrophage behaviour
Zhou, H., Xue, Y., Dong, L., & Wang, C. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00107h · Cited by 47
Fabiano, E. D., Poole, J. M., & Reinhart-King, C. A. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00892.2024 · Cited by 17
Metadata
- Authors
- Trappmann, B., & Chen, C. S.
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 24
- Issue
- 5
- Pages
- 948-953
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2033627257
- Cited by
- 187
- References
- 4
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
