Hydrogels to model 3D in vitro microenvironment of tumor vascularization
Open accessAbstract
A growing number of failing clinical trials for cancer therapy is substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is still very new. In this review, we explore current use of hydrogels and their design parameters to engineer vasculogenesis and angiogenesis and to evaluate the angiogenic capability of cancerous cells and tissues. When coupled with other technologies such as lithography and three-dimensional printing, one can even create an advanced microvessel model as microfluidic channels to more accurately capture the native angiogenesis process.
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- [32]Liang Y Jeong J DeVolder RJ Cha C Wang F Tong YW Kong H A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity Biomaterials 32 2011 9308 9315 21911252
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- Authors
- Song, H.-H. G., Park, K. M., & Gerecht, S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Gerecht, Sharon
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 79-80
- Pages
- 19-29
- ISSN
- 0169-409X (ISSN-L)
- PMC
- PMC4258430
- OpenAlex
- W2005675505
- Semantic Scholar
- 43e46e96f7d7e7110e9d380d740bd105824a649b
- Cited by
- 153
- References
- 151
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 14 · 2021: 14 · 2020: 16 · 2019: 10 · 2018: 19 · 2017: 21 · 2016: 20 · 2015: 13
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute Physical Sciences—Oncology Network (U54CA143868)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- hydrogels, tumor angiogenesis, tumor vasculature, 3D tumor microenvironment, in vitro vascularization, microfluidic channels, 3D printing, lithography
- MeSH terms
- Animals, Humans, Models, Biological, Neoplasms, Neovascularization, Pathologic, Cell Culture Techniques, Hydrogels, Tissue Engineering, Microfluidics, Tumor Microenvironment, In Vitro Techniques
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