Cited by 1533D Printing in Biomedical ResearchHydrogels: synthesis, properties, applicationsAngiogenesis and VEGF in Cancer

Hydrogels to model 3D in vitro microenvironment of tumor vascularization

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Song, Hyun-Ho Greco, Park, Kyung Min, Gerecht, Sharon·2014·Advanced Drug Delivery Reviews

Abstract

A growing number of failing clinical trials for cancer therapy is substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is still very new. In this review, we explore current use of hydrogels and their design parameters to engineer vasculogenesis and angiogenesis and to evaluate the angiogenic capability of cancerous cells and tissues. When coupled with other technologies such as lithography and three-dimensional printing, one can even create an advanced microvessel model as microfluidic channels to more accurately capture the native angiogenesis process.

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Crossref · 10.1016/j.addr.2014.06.002

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  1. [32]Liang Y Jeong J DeVolder RJ Cha C Wang F Tong YW Kong H A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity Biomaterials 32 2011 9308 9315 21911252

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Authors
Song, H.-H. G., Park, K. M., & Gerecht, S.
Affiliations
Johns Hopkins University (US)
Corresponding author
Gerecht, Sharon
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2014-12
Volume
79-80
Pages
19-29
ISSN
0169-409X (ISSN-L)
OpenAlex
W2005675505
Cited by
153
References
151
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 14 · 2021: 14 · 2020: 16 · 2019: 10 · 2018: 19 · 2017: 21 · 2016: 20 · 2015: 13
FWCI
1.55
Type
journal article
Language
en
Open access
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute Physical Sciences—Oncology Network (U54CA143868)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
hydrogels, tumor angiogenesis, tumor vasculature, 3D tumor microenvironment, in vitro vascularization, microfluidic channels, 3D printing, lithography
MeSH terms
Animals, Humans, Models, Biological, Neoplasms, Neovascularization, Pathologic, Cell Culture Techniques, Hydrogels, Tissue Engineering, Microfluidics, Tumor Microenvironment, In Vitro Techniques

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