Metabolic model guided strain design of cyanobacteria

What is flux balance analysis?

Orth, J. D., Thiele, I., & Palsson, B. Ø. (2010) · Nature Biotechnology · doi:10.1038/nbt.1614 · Cited by 3,903 · see citing works

Analysis of optimality in natural and perturbed metabolic networks

Segrè, D., Vitkup, D., & Church, G. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232349399 · Cited by 1,375 · see citing works

Optknock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimization

Burgard, A. P., Pharkya, P., & Maranas, C. D. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10803 · Cited by 1,262 · see citing works

The effects of alternate optimal solutions in constraint-based genome-scale metabolic models

Mahadevan, R., & Schilling, C. H. (2003) · Metabolic Engineering · doi:10.1016/j.ymben.2003.09.002 · Cited by 1,203 · see citing works

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol

Yim, H. H., Haselbeck, R. J., Niu, W., Pujol-Baxley, C., Burgard, A. P., Boldt, J., Khandurina, J., Trawick, J. D., Osterhout, R. E., Stephen, R., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.580 · Cited by 1,114 · see citing works

Metabolic control analysis: a survey of its theoretical and experimental development

Fell, D. A. (1992) · Biochemical Journal · doi:10.1042/bj2860313 · Cited by 782 · see citing works

Constraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods

Lewis, N. E., Nagarajan, H., & Palsson, B. O. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2737 · Cited by 779 · see citing works

Aquatic phototrophs: efficient alternatives to land-based crops for biofuels

Dismukes, G. C., Carrieri, D., Bennette, N., Ananyev, G. M., & Posewitz, M. C. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.05.007 · Cited by 733 · see citing works

Using Genome-scale Models to Predict Biological Capabilities

O’Brien, E. J., Monk, J. M., & Palsson, B. Ø. (2015) · Cell · doi:10.1016/j.cell.2015.05.019 · Cited by 709 · see citing works

Evolutionary programming as a platform for in silico metabolic engineering

Patil, K. R., Rocha, I., Förster, J., & Nielsen, J. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-308 · Cited by 455 · see citing works

OptForce: An Optimization Procedure for Identifying All Genetic Manipulations Leading to Targeted Overproductions

Ranganathan, S., Suthers, P. F., & Maranas, C. D. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000744 · Cited by 420 · see citing works

Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2

Yu, J., Liberton, M., Cliften, P. F., Head, R. D., Jacobs, J., Smith, R. D., Koppenaal, D., Brand, J. J., & Pakrasi, H. B. (2015) · Scientific Reports · doi:10.1038/srep08132 · Cited by 372 · see citing works

Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis

Young, J. D., Shastri, A. A., Stephanopoulos, G. N., & Morgan, J. A. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.08.002 · Cited by 347 · see citing works

Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA

Xu, P., Ranganathan, S., Fowler, Z. L., Maranas, C. D., & Koffas, M. A. G. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.06.008 · Cited by 346 · see citing works

An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems

Pharkya, P., & Maranas, C. D. (2005) · Metabolic Engineering · doi:10.1016/j.ymben.2005.08.003 · Cited by 329 · see citing works

In Silico Identification of Gene Amplification Targets for Improvement of Lycopene Production

Choi, H. S., Lee, S. Y., Kim, T. Y., & Woo, H. M. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00115-10 · Cited by 286 · see citing works

Improved vanillin production in baker's yeast through in silico design

Brochado, A. R., Matos, C., Møller, B. L., Hansen, J., Mortensen, U. H., & Patil, K. R. (2010) · Microbial Cell Factories · doi:10.1186/1475-2859-9-84 · Cited by 268 · see citing works

Ensemble Modeling of Metabolic Networks

Tran, L. M., Rizk, M. L., & Liao, J. C. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.135442 · Cited by 249 · see citing works

Flux Balance Analysis of Cyanobacterial Metabolism: The Metabolic Network of Synechocystis sp. PCC 6803

Knoop, H., Gründel, M., Zilliges, Y., Lehmann, R., Hoffmann, S., Lockau, W., & Steuer, R. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003081 · Cited by 248 · see citing works

Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways

Tepper, N., & Shlomi, T. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp704 · Cited by 238 · see citing works

The plasticity of cyanobacterial metabolism supports direct CO2 conversion to ethylene

Xiong, W., Morgan, J. A., Ungerer, J. L., Wang, B., Maness, P., & Yu, J. (2015) · Nature Plants · doi:10.1038/nplants.2015.53 · Cited by 232 · see citing works

Cyanobacteria: Promising biocatalysts for sustainable chemical production

Knoot, C. J., Ungerer, J., Wangikar, P. P., & Pakrasi, H. B. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.815886 · Cited by 225 · see citing works

OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains

Kim, J., & Reed, J. L. (2010) · BMC Systems Biology · doi:10.1186/1752-0509-4-53 · Cited by 217 · see citing works

Increased Malonyl Coenzyme A Biosynthesis by Tuning the Escherichia coli Metabolic Network and Its Application to Flavanone Production

Fowler, Z. L., Gikandi, W. W., & Koffas, M. A. G. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00270-09 · Cited by 204 · see citing works

Industrial Systems Biology of Saccharomyces cerevisiae Enables Novel Succinic Acid Cell Factory

Otero, J. M., Cimini, D., Patil, K. R., Poulsen, S. G., Lisbeth Olsson, A., & Nielsen, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054144 · Cited by 167 · see citing works

Formulation, construction and analysis of kinetic models of metabolism: A review of modelling frameworks

Saa, P. A., & Nielsen, L. K. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.09.005 · Cited by 166 · see citing works

Enhanced limonene production in cyanobacteria reveals photosynthesis limitations

Wang, X., Liu, W., Xin, C., Zheng, Y., Cheng, Y., Sun, S., Li, R., Zhu, X., Dai, S. Y., Rentzepis, P. M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613340113 · Cited by 161 · see citing works

Production of 2,3-butanediol in Saccharomyces cerevisiae by in silico aided metabolic engineering

Ng, C. Y., Jung, M.-Y., Lee, J., & Oh, M. (2012) · Microbial Cell Factories · doi:10.1186/1475-2859-11-68 · Cited by 158 · see citing works

Large‐scale identification of genetic design strategies using local search

Lun, D. S., Rockwell, G. N., Guido, N. J., Baym, M., Kelner, J. A., Berger, B., Galagan, J. E., & Church, G. M. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.57 · Cited by 156 · see citing works

CRISPR-Based Technologies for Metabolic Engineering in Cyanobacteria

Behler, J., Vijay, D., Hess, W. R., & Akhtar, M. K. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.05.011 · Cited by 138 · see citing works

Metabolic engineering of the pentose phosphate pathway for enhanced limonene production in the cyanobacterium Synechocysti s sp. PCC 6803

Lin, P.-C., Saha, R., Zhang, F., & Pakrasi, H. B. (2017) · Scientific Reports · doi:10.1038/s41598-017-17831-y · Cited by 129 · see citing works

Mathematical optimization applications in metabolic networks

Zomorrodi, A. R., Suthers, P. F., Ranganathan, S., & Maranas, C. D. (2012) · Metabolic Engineering · doi:10.1016/j.ymben.2012.09.005 · Cited by 128 · see citing works

Unique attributes of cyanobacterial metabolism revealed by improved genome-scale metabolic modeling and essential gene analysis

Broddrick, J. T., Rubin, B. E., Welkie, D. G., Du, N., Mih, N., Diamond, S., Lee, J. J., Golden, S. S., & Palsson, B. Ø. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613446113 · Cited by 126 · see citing works

Genome Features and Biochemical Characteristics of a Robust, Fast Growing and Naturally Transformable Cyanobacterium Synechococcus elongatus PCC 11801 Isolated from India

Jaiswal, D., Sengupta, A., Sohoni, S. V., Sengupta, S., Phadnavis, A. G., Pakrasi, H. B., & Wangikar, P. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-34872-z · Cited by 120 · see citing works

Systematic overexpression study to find target enzymes enhancing production of terpenes in Synechocystis PCC 6803, using isoprene as a model compound

Englund, E., Shabestary, K., Hudson, E. P., & Lindberg, P. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.07.004 · Cited by 116 · see citing works

EMILiO: A fast algorithm for genome-scale strain design

Yang, L., Cluett, W. R., & Mahadevan, R. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.03.002 · Cited by 114 · see citing works

Genetic and nutrient modulation of acetyl-CoA levels in Synechocystis for n-butanol production

Anfelt, J., Kaczmarzyk, D., Shabestary, K., Renberg, B., Rockberg, J., Nielsen, J., Uhlén, M., & Hudson, E. P. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0355-9 · Cited by 113 · see citing works

In Silico Constraint-Based Strain Optimization Methods: the Quest for Optimal Cell Factories

Maia, P., Rocha, M., & Rocha, I. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00014-15 · Cited by 113 · see citing works

Genome-scale modeling for metabolic engineering

Simeonidis, E., & Price, N. D. (2015) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-014-1576-3 · Cited by 112 · see citing works

An integrated computational and experimental study for overproducing fatty acids in Escherichia coli

Ranganathan, S., Tee, T. W., Chowdhury, A., Zomorrodi, A. R., Yoon, J. M., Fu, Y., Shanks, J. V., & Maranas, C. D. (2012) · Metabolic Engineering · doi:10.1016/j.ymben.2012.08.008 · Cited by 112 · see citing works

A Review of Dynamic Modeling Approaches and Their Application in Computational Strain Optimization for Metabolic Engineering

Kim, O. D., Rocha, M., & Maia, P. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01690 · Cited by 103 · see citing works

Deciphering cyanobacterial phenotypes for fast photoautotrophic growth via isotopically nonstationary metabolic flux analysis

Abernathy, M. H., Yu, J., Ma, F., Liberton, M., Ungerer, J. L., Hollinshead, W. D., Gopalakrishnan, S., He, L., Maranas, C. D., Pakrasi, H. B., et al. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0958-y · Cited by 102 · see citing works

The Benefits of Photorespiratory Bypasses: How Can They Work?

Xin, C., Tholen, D., Devloo, V., & Zhu, X. (2014) · PLANT PHYSIOLOGY · doi:10.1104/pp.114.248013 · Cited by 97 · see citing works

Metabolic model of Synechococcus sp. PCC 7002: Prediction of flux distribution and network modification for enhanced biofuel production

Hendry, J. I., Prasannan, C. B., Joshi, A. A., Dasgupta, S., & Wangikar, P. P. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.02.128 · Cited by 94 · see citing works

Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques

Kim, J., Reed, J. L., & Maravelias, C. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024162 · Cited by 93 · see citing works

Reconstruction and Comparison of the Metabolic Potential of Cyanobacteria Cyanothece sp. ATCC 51142 and Synechocystis sp. PCC 6803

Saha, R., Verseput, A. T., Berla, B. M., Mueller, T. J., Pakrasi, H. B., & Maranas, C. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048285 · Cited by 93 · see citing works

Computational metabolic engineering strategies for growth-coupled biofuel production by Synechocystis

Shabestary, K., & Hudson, E. P. (2016) · Metabolic Engineering Communications · doi:10.1016/j.meteno.2016.07.003 · Cited by 90 · see citing works

Metabolomic analysis indicates a pivotal role of the hepatotoxin microcystin in high light adaptation of M icrocystis

Meißner, S., Steinhauser, D., & Dittmann, E. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12565 · Cited by 88 · see citing works

Genome-Scale Modeling of Light-Driven Reductant Partitioning and Carbon Fluxes in Diazotrophic Unicellular Cyanobacterium Cyanothece sp. ATCC 51142

Vu, T. T., Stolyar, S. M., Pinchuk, G. E., Hill, E. A., Kucek, L. A., Brown, R. N., Lipton, M. S. W., Osterman, A. L., Fredrickson, J. K., Konopka, A. E., et al. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002460 · Cited by 86 · see citing works

Constructing kinetic models of metabolism at genome‐scales: A review

Srinivasan, S., Cluett, W. R., & Mahadevan, R. (2015) · Biotechnology Journal · doi:10.1002/biot.201400522 · Cited by 85 · see citing works

Recent Applications of Metabolomics Toward Cyanobacteria

Schwarz, D., Orf, I., Kopka, J., & Hagemann, M. (2013) · Metabolites · doi:10.3390/metabo3010072 · Cited by 80 · see citing works

Isotopically nonstationary 13C flux analysis of cyanobacterial isobutyraldehyde production

Jazmin, L. J., Xu, Y. Q., Cheah, Y. E., Adebiyi, A. O., Johnson, C. H., & Young, J. D. (2017) · Metabolic Engineering · doi:10.1016/j.ymben.2017.05.001 · Cited by 78 · see citing works

Recent advances in synthetic biology of cyanobacteria

Sengupta, A., Pakrasi, H. B., & Wangikar, P. P. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9046-x · Cited by 78 · see citing works

Rerouting of carbon flux in a glycogen mutant of cyanobacteria assessed via isotopically non‐stationary 13C metabolic flux analysis

Hendry, J. I., Prasannan, C. B., Ma, F., Möllers, K. B., Jaiswal, D., Digmurti, M. G., Allen, D. K., Frigaard, N., Dasgupta, S., & Wangikar, P. P. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26350 · Cited by 74 · see citing works

Reconstruction and verification of a genome-scale metabolic model for Synechocystis sp. PCC6803

Yoshikawa, K., Kojima, Y., Nakajima, T., Furusawa, C., Hirasawa, T., & Shimizu, H. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3559-x · Cited by 70 · see citing works

Elucidation of photoautotrophic carbon flux topology in Synechocystis PCC 6803 using genome-scale carbon mapping models

Gopalakrishnan, S., Pakrasi, H. B., & Maranas, C. D. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.03.008 · Cited by 63 · see citing works

Genome-Scale Fluxome of Synechococcus elongatus UTEX 2973 Using Transient 13 C-Labeling Data

Hendry, J. I., Gopalakrishnan, S., Ungerer, J. L., Pakrasi, H. B., Tang, Y., & Maranas, C. D. (2018) · PLANT PHYSIOLOGY · doi:10.1104/pp.18.01357 · Cited by 61 · see citing works

Identifying the Metabolic Differences of a Fast-Growth Phenotype in Synechococcus UTEX 2973

Mueller, T. J., Ungerer, J. L., Pakrasi, H. B., & Maranas, C. D. (2017) · Scientific Reports · doi:10.1038/srep41569 · Cited by 58 · see citing works

Comparative metabolomic analysis of the effects of light quality on polysaccharide production of cyanobacterium Nostoc flagelliforme

Han, P.-P., Shen, S.-G., Wang, H., Sun, Y., Dai, Y., & Jia, S. (2015) · Algal Research · doi:10.1016/j.algal.2015.02.019 · Cited by 51 · see citing works

Metabolic engineering of Synechocystis sp. PCC 6803 for enhanced ethanol production based on flux balance analysis

Yoshikawa, K., Toya, Y., & Shimizu, H. (2017) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-017-1744-8 · Cited by 50 · see citing works

Flux balance analysis of photoautotrophic metabolism: Uncovering new biological details of subsystems involved in cyanobacterial photosynthesis

Qian, X., Kim, M. K., Kumaraswamy, G. K., Agarwal, A., Lun, D. S., & Dismukes, G. C. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.12.007 · Cited by 46 · see citing works

Metabolic engineering of Synechococcus elongatus PCC 7942 for improvement of 1,3-propanediol and glycerol production based on in silico simulation of metabolic flux distribution

Hirokawa, Y., Matsuo, S., Hamada, H., Matsuda, F., & Hanai, T. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0824-4 · Cited by 45 · see citing works

Transomics data-driven, ensemble kinetic modeling for system-level understanding and engineering of the cyanobacteria central metabolism

Nishiguchi, H., Hiasa, N., Uebayashi, K., Liao, J. C., Shimizu, H., & Matsuda, F. (2019) · Metabolic Engineering · doi:10.1016/j.ymben.2019.01.004 · Cited by 43 · see citing works

Different strategies of metabolic regulation in cyanobacteria: from transcriptional to biochemical control

Jablonský, J., Papáček, Š., & Hagemann, M. (2016) · Scientific Reports · doi:10.1038/srep33024 · Cited by 42 · see citing works

Kinetic modeling of the Calvin cycle identifies flux control and stable metabolomes in Synechocystis carbon fixation

Janasch, M., Asplund‐Samuelsson, J., Steuer, R., & Hudson, E. P. (2018) · Journal of Experimental Botany · doi:10.1093/jxb/ery382 · Cited by 39 · see citing works

Proteomics of cyanobacteria: current horizons

Battchikova, N., Muth‐Pawlak, D., & Aro, E. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.02.012 · Cited by 23 · see citing works

Phosphoglycerate Mutases Function as Reverse Regulated Isoenzymes in Synechococcus elongatus PCC 7942

Jablonský, J., Hagemann, M., Schwarz, D., & Olaf Wolkenhauer, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058281 · Cited by 22 · see citing works

A Critical Review of Genome Editing and Synthetic Biology Applications in Metabolic Engineering of Microalgae and Cyanobacteria

Ng, I., Keskin, B. B., & Tan, S. (2020) · Biotechnology Journal · doi:10.1002/biot.201900228 · Cited by 135 · see citing works

The era of big data: Genome-scale modelling meets machine learning

Antonakoudis, A., Barbosa, R., Kotidis, P., & Kontoravdi, C. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.10.011 · Cited by 88 · see citing works

Challenges and Perspectives of Polyhydroxyalkanoate Production From Microalgae/Cyanobacteria and Bacteria as Microbial Factories: An Assessment of Hybrid Biological System

Afreen, R., Tyagi, S., Singh, G. P., & Singh, M. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.624885 · Cited by 86 · see citing works

A review on cyanobacteria cultivation for carbohydrate-based biofuels: Cultivation aspects, polysaccharides accumulation strategies, and biofuels production scenarios

Arias, D. M., Ortíz-Sánchez, E., Okoye, P. U., Rodriguez-Rangel, H., Ortega, A. B., Longoria, A., Domínguez-Espíndola, R. B., & Sebastian, P. J. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148636 · Cited by 71 · see citing works

A Hybrid Flux Balance Analysis and Machine Learning Pipeline Elucidates Metabolic Adaptation in Cyanobacteria

Vijayakumar, S., Rahman, P. K. S. M., & Angione, C. (2020) · iScience · doi:10.1016/j.isci.2020.101818 · Cited by 69 · see citing works

Recent advances in domesticating non‐model microorganisms

Fatma, Z., Schultz, J. C., & Zhao, H. (2020) · Biotechnology Progress · doi:10.1002/btpr.3008 · Cited by 68 · see citing works

Progress and challenges in engineering cyanobacteria as chassis for light‐driven biotechnology

Hitchcock, A., Hunter, C. N., & Canniffe, D. P. (2019) · Microbial Biotechnology · doi:10.1111/1751-7915.13526 · Cited by 66 · see citing works

Biocatalysis in Green and Blue: Cyanobacteria

Jodlbauer, J., Rohr, T., Oliver Spadiut, A., Mihovilovič, M. D., & Rudroff, F. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.12.009 · Cited by 63 · see citing works

Genetic, Genomics, and Responses to Stresses in Cyanobacteria: Biotechnological Implications

Cassier‐Chauvat, C., Blanc-Garin, V., & Chauvat, F. (2021) · Genes · doi:10.3390/genes12040500 · Cited by 47 · see citing works

Cyanobacteria as cell factories: the roles of host and pathway engineering and translational research

Jaiswal, D., Sahasrabuddhe, D., & Wangikar, P. P. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.09.010 · Cited by 44 · see citing works

Applications of genome-scale metabolic models to investigate microbial metabolic adaptations in response to genetic or environmental perturbations

Carter, E. L., Constantinidou, C., & Alam, M. T. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad439 · Cited by 43 · see citing works

Light and carbon: Synthetic biology toward new cyanobacteria-based living biomaterials

Goodchild-Michelman, I. M., Church, G. M., Schubert, M. G., & Tang, T.-C. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100583 · Cited by 41 · see citing works

Engineering biology approaches for food and nutrient production by cyanobacteria

Liu, D., Liberton, M., Hendry, J. I., Aminian-Dehkordi, J., Maranas, C. D., & Pakrasi, H. B. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.09.011 · Cited by 38 · see citing works

Current processes and future challenges of photoautotrophic production of acetyl-CoA-derived solar fuels and chemicals in cyanobacteria

Miao, R., Xie, H., Liu, X., Lindberg, P., & Lindblad, P. C. (2020) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2020.04.013 · Cited by 30 · see citing works

Progress and Prospects of Natural Glycoside Sweetener Biosynthesis: A Review

Qu, G., Liu, Y., Ma, Q., Li, J., Du, G., Liu, L., & Lv, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c05074 · Cited by 28 · see citing works

Engineering highly productive cyanobacteria towards carbon negative emissions technologies

Victoria, A. J., Astbury, M. J., & McCormick, A. J. (2024) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2024.103141 · Cited by 27 · see citing works

Optimal energy and redox metabolism in the cyanobacterium Synechocystis sp. PCC 6803

Kugler, A., & Stensjö, K. (2023) · npj Systems Biology and Applications · doi:10.1038/s41540-023-00307-3 · Cited by 24 · see citing works

Highlighting the potential of Synechococcus elongatus PCC 7942 as platform to produce α-linolenic acid through an updated genome-scale metabolic modeling

Santos‐Merino, M., Gargantilla-Becerra, Á., de la Cruz, F., & Nogales, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1126030 · Cited by 17 · see citing works

Transporter engineering for the development of cyanobacteria as cell factories: A text analytics guided survey

Sengupta, S., Sahasrabuddhe, D., & Wangikar, P. P. (2022) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107816 · Cited by 16 · see citing works

Enhancing in silico strain design predictions through next generation metabolic modeling approaches

Alsiyabi, A., Chowdhury, N. B., Long, D. S., & Saha, R. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107806 · Cited by 13 · see citing works

Fusion constructs enhance heterologous β-phellandrene production in Synechocystis sp. PCC 6803

Valsami, E., Psychogyiou, M. E., Pateraki, A., Chrysoulaki, E., Melis, A., & Ghanotakis, D. F. (2020) · Journal of Applied Phycology · doi:10.1007/s10811-020-02186-1 · Cited by 14 · see citing works

Designer endosymbionts: Converting free-living bacteria into organelles

Meaney, R. S., Hamadache, S., Soltysiak, M. P. M., & Karas, B. J. (2020) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2020.09.008 · Cited by 14 · see citing works

Rhythm of the Night (and Day): Predictive Metabolic Modeling of Diurnal Growth in Chlamydomonas

Metcalf, A. J., & Boyle, N. R. (2022) · mSystems · doi:10.1128/msystems.00176-22 · Cited by 13 · see citing works

Engineering Cyanobacteria as Host Organisms for Production of Terpenes and Terpenoids

Rodrigues, J. S., & Lindberg, P. (2021) · doi:10.1002/9783527824908.ch9 · Cited by 13 · see citing works

A systematic overexpression approach reveals native targets to increase squalene production in Synechocystis sp. PCC 6803

Germann, A. T., Nakielski, A., Dietsch, M., Petzel, T., Moser, D., Triesch, S. S., Westhoff, P., & Axmann, I. M. I. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1024981 · Cited by 12 · see citing works

A Genome-Scale Metabolic Model of Anabaena 33047 to Guide Genetic Modifications to Overproduce Nylon Monomers

Hendry, J. I., Dinh, H. V., Sarkar, D., Wang, L., Bandyopadhyay, A., Pakrasi, H. B., & Maranas, C. D. (2021) · Metabolites · doi:10.3390/metabo11030168 · Cited by 11 · see citing works

Engineering cyanobacteria for the production of aromatic natural products

Gu, F., Li, C., Zheng, H., & Ni, J. (2024) · Blue Biotechnology · doi:10.1186/s44315-024-00002-w · Cited by 9 · see citing works

Heterologous β-phellandrene production by alginate immobilized Synechocystis sp. PCC 6803

Valsami, E., Pateraki, A., Melis, A., & Ghanotakis, D. F. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02451-x · Cited by 9 · see citing works

Reprogramming Metabolic Networks and Manipulating Circadian Clocks for Biotechnological Applications

Wang, B., Young, J. D., & Xu, Y. Q. (2021) · Springer eBooks · doi:10.1007/978-3-030-72158-9_14 · Cited by 7 · see citing works

Introduction to Cyanobacteria

Lindberg, P., Kenkel, A., & Bühler, K. (2023) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2023_217 · Cited by 5 · see citing works

Editorial overview: Analytical biotechnology in the era of high-performance omics, synthetic biology, and machine learning

Tang, Y., & Aristilde, L. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.07.009 · Cited by 5 · see citing works

Advances in organic acid production using cyanobacteria: Strategies and applications

Pathania, R., & Srivastava, A. (2025) · Blue Biotechnology · doi:10.1186/s44315-025-00045-7 · Cited by 4 · see citing works

Single microbe photoelectrochemical device using scanning electrochemical microscopy

Samuel, A. K., Shinde, S., Palaniappan, A., Bhalla, P., & Chandiran, A. K. (2024) · Journal of Materials Chemistry C · doi:10.1039/d4tc03265a · Cited by 4 · see citing works

Photonic-chemostat engineering for efficient continuous cultivation of cyanobacteria

Rahman, M. R., Noori, M. T., & Hellgardt, K. (2026) · RSC Advances · doi:10.1039/d5ra09945e · Cited by 3 · see citing works

Metabolism of microalgae and metabolic engineering for biomaterial applications

de Morais, M. G., Cassuriaga, A. P. A., Cruz, C. G., Moraes, L., & Costa, J. A. V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-96142-4.00010-5 · Cited by 3 · see citing works

Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression

Walshe, J., & Saha, S. K. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48060638 · Cited by 1 · see citing works

Metabolic Pathway Engineering in Cyanobacteria for Environmental Applications

Khan, A. Z., Asghar, A., Haider, M. N., Khan, A., Bose, A., & O’Higgins, L. (2024) · Springer eBooks · doi:10.1007/978-3-031-70698-1_5 · Cited by 1 · see citing works

Trends in cyanobacterial Phycobiliproteins - structure, function, and applications: A review

Mikkili, I., Borugadda, S., & Kanaparthy, A. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148517 · Cited by 2 · see citing works

Greenhouse environmental control target constrained by discrete surface curvature and multi-objective optimization algorithm

Gao, P., Lu, M., Li, H., Mao, H., Hu, J., & Wu, H. (2023) · Computers and Electronics in Agriculture · doi:10.1016/j.compag.2023.108431 · Cited by 1 · see citing works

Rhythm of The Night (and Day): Predictive metabolic modeling of circadian growth in ChlamydomonasPreprint

Metcalf, A. J., & Boyle, N. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.24.477634 · Cited by 1 · see citing works

Engineering Cyanobacteria for Efficient Photosynthetic Production: Ethanol Case Study

Luan, G., & Lü, X. (2021) · Wiley eBooks · doi:10.1002/9783527824908.ch8

Metabolic engineering of cyanobacteria for biotechnological applications

Verma, S., Choudhary, P., Vishwakarma, R., Thapa, S., & Chakdar, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13231-5.00015-5 · Cited by 1 · see citing works

Discovery and green metabolic engineering of a self-sufficient genistein pathway in Paenibacillus jilinensis

Zhang, J. B., Chen, W., Yang, Y., & Liu, Z. (2025) · Green Chemistry · doi:10.1039/d5gc01323b

Ingénierie du métabolisme de capture du CO₂ chez les cyanobactéries pour la photoproduction de molécules à haute valeur ajoutée (terpènes)

Blanc-Garin, V. (2021) · theses.fr (ABES) · doi:10.70675/1695feceza8cez4afbzac20z11f87ea446d7

Exploring the biology of cyanobacteria in life support systems on Mars

Rodrigues, D., & McCormick, A. J. (2026) · Frontiers in Astronomy and Space Sciences · doi:10.3389/fspas.2026.1853934

Cyanobacterial biorefinery: sustainable wastewater management for generation of biofuels and high-value products aligning with a circular economy approach

Kikani, B. A., Andhare, P., Sonavane, B., Dube, S., Desai, C., & Madamwar, D. (2026) · Systems Microbiology and Biomanufacturing · doi:10.1007/s43393-026-00535-8

Metabolic engineering of cyanobacteria for biotechnological applications

Verma, S., Choudhary, P., Vishwakarma, R., Thapa, S., & Chakdar, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13231-5.00015-5 · Cited by 1 · see citing works

Current Status and Future Strategies to Increase Secondary Metabolite Production from Cyanobacteria

Jeong, Y., Cho, S.-H., Lee, H., Choi, H., Kim, D., Lee, C., Cho, S., & Cho, B. (2020) · Microorganisms · doi:10.3390/microorganisms8121849 · Cited by 58 · see citing works

State-of-the-Art Genetic Modalities to Engineer Cyanobacteria for Sustainable Biosynthesis of Biofuel and Fine-Chemicals to Meet Bio–Economy Challenges

Khan, A. Z., Bilal, M., Mehmood, S., Sharma, A. K., & Iqbal, H. M. N. (2019) · Life · doi:10.3390/life9030054 · Cited by 36 · see citing works

Metabolic engineering tools in model cyanobacteria

Carroll, A. L., Case, A. E., Zhang, A., & Atsumi, S. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.03.014 · Cited by 75 · see citing works

Review Advances in Metabolic Engineering of Cyanobacteria for Photosynthetic Biochemical Production

Lai, M. C., & Lan, E. I. (2016)