Engineering cyanobacteria for the production of aromatic natural products

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A., & Liu, D. R. (2016) · Nature · doi:10.1038/nature17946 · Cited by 5,437 · see citing works

Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity

Shen, N., Wang, T. A., Gan, Q., Liu, S., Wang, L., & Jin, B. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132531 · Cited by 2,161 · see citing works

Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic Stress

Sharma, A., Shahzad, B., Rehman, A., Bhardwaj, R., Landi, M., & Zheng, B. (2019) · Molecules · doi:10.3390/molecules24132452 · Cited by 2,090 · see citing works

The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants

Maeda, H. A., & Dudareva, N. (2012) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105439 · Cited by 1,568 · see citing works

Synthetic protein scaffolds provide modular control over metabolic flux

Dueber, J. E., Wu, G. C., Malmirchegini, G. R., Moon, T. S., Petzold, C. J., Ullal, A. V., Prather, K. L. J., & Keasling, J. D. (2009) · Nature Biotechnology · doi:10.1038/nbt.1557 · Cited by 1,242 · see citing works

The complex architecture of oxygenic photosynthesis

Nelson, N., & Shem, A. B. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1525 · Cited by 715 · see citing works

p ‐Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

Pei, K., Ou, J., Huang, J., & Ou, S. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7578 · Cited by 651 · see citing works

Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism

Lindberg, P., Park, S., & Melis, A. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2009.10.001 · Cited by 596 · see citing works

Design of Photobioreactors for Mass Cultivation of Photosynthetic Organisms

Huang, Q., Jiang, F., Wang, L., & Yang, C. (2017) · Engineering · doi:10.1016/j.eng.2017.03.020 · Cited by 487 · see citing works

The Shikimate Pathway as an Entry to Aromatic Secondary Metabolism

Herrmann, K. M. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.1.7 · Cited by 470 · see citing works

Biological Activities of Stilbenoids

Akinwumi, B. C., Bordun, K.-A., & Anderson, H. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030792 · Cited by 375 · see citing works

Engineering the spatial organization of metabolic enzymes: mimicking nature's synergy

Conrado, R. J., Varner, J. D., & DeLisa, M. P. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.07.006 · Cited by 372 · see citing works

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Liu, Q., Yu, T., Li, X., Chen, Y., Campbell, K., Nielsen, J., & Chen, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-12961-5 · Cited by 330 · see citing works

Diversity of P450 enzymes in the biosynthesis of natural products

Podust, L. M., & Sherman, D. H. (2012) · Natural Product Reports · doi:10.1039/c2np20020a · Cited by 322 · see citing works

A Review on Pharmacological Properties of Coumarins

Srikrishna, D., Godugu, C., & Dubey, P. K. (2016) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557516666160801094919 · Cited by 278 · see citing works

Towards bacterial strains overproducing l-tryptophan and other aromatics by metabolic engineering

Ikeda, M. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0252-y · Cited by 271 · see citing works

Biofilm-Based Algal Cultivation Systems

Gross, M., Jarboe, D., & Wen, Z. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6736-5 · Cited by 248 · see citing works

Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds—Present and Future Strain Construction Strategies

Averesch, N. J. H., & Krömer, J. O. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00032 · Cited by 232 · see citing works

Cyanobacteria: Promising biocatalysts for sustainable chemical production

Knoot, C. J., Ungerer, J., Wangikar, P. P., & Pakrasi, H. B. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.815886 · Cited by 225 · see citing works

Alleviation of feedback inhibition in Saccharomyces cerevisiae aromatic amino acid biosynthesis: Quantification of metabolic impact

Luttik, M. A. H., Vuralhan, Z., Suir, E., Braus, G. H., Pronk, J. T., & Daran, J.-M. G. (2008) · Metabolic Engineering · doi:10.1016/j.ymben.2008.02.002 · Cited by 217 · see citing works

Metabolic engineering of microorganisms for production of aromatic compounds

Hüccetoğulları, D., Luo, Z. W., & Lee, S. Y. (2019) · Microbial Cell Factories · doi:10.1186/s12934-019-1090-4 · Cited by 217 · see citing works

L-Tyrosine production by deregulated strains of Escherichia coli

Lütke‐Eversloh, T., & Stephanopoulos, G. N. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0792-9 · Cited by 209 · see citing works

Coumarins as potential antidiabetic agents

Li, H., Yao, Y., & Li, L. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12774 · Cited by 207 · see citing works

CRISPR interference as a titratable, trans-acting regulatory tool for metabolic engineering in the cyanobacterium Synechococcus sp. strain PCC 7002

Gordon, G. C., Korosh, T. C., Cameron, J. C., Markley, A. L., Begemann, M. B., & Pfleger, B. F. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.07.007 · Cited by 189 · see citing works

Ethylene Synthesis and Regulated Expression of Recombinant Protein in Synechocystis sp. PCC 6803

Guerrero, F., Carbonell, V., Cossu, M., Correddu, D., & Jones, P. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050470 · Cited by 183 · see citing works

Discovery of a super-strong promoter enables efficient production of heterologous proteins in cyanobacteria

Zhou, J., Zhang, H., Meng, H., Zhu, Y., Bao, G., Zhang, Y., Li, Y., & Ma, Y. (2014) · Scientific Reports · doi:10.1038/srep04500 · Cited by 169 · see citing works

Evaluation of promoters and ribosome binding sites for biotechnological applications in the unicellular cyanobacterium Synechocystis sp. PCC 6803

Englund, E., Liang, F., & Lindberg, P. (2016) · Scientific Reports · doi:10.1038/srep36640 · Cited by 166 · see citing works

Impact of Alkyl Esters of Caffeic and Ferulic Acids on Tumor Cell Proliferation, Cyclooxygenase Enzyme, and Lipid Peroxidation

Bolleddula, J., Mulabagal, V., Zhang, Y., DeWitt, D. L., & Nair, M. G. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060899p · Cited by 157 · see citing works

Mutational analysis of the feedback sites of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli

Kikuchi, Y., Tsujimoto, K., & Kurahashi, O. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.2.761-762.1997 · Cited by 155 · see citing works

Parameters influencing the design of photobioreactor for the growth of microalgae

Vasumathi, K., Premalatha, M., & Subramanian, P. (2012) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2012.06.013 · Cited by 151 · see citing works

Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells

Wang, Y., & Yu, O. S. (2011) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2011.11.003 · Cited by 147 · see citing works

Theophylline-Dependent Riboswitch as a Novel Genetic Tool for Strict Regulation of Protein Expression in Cyanobacterium Synechococcus elongatus PCC 7942

Nakahira, Y., Ogawa, A., Asano, H., Oyama, T., & Tozawa, Y. (2013) · Plant and Cell Physiology · doi:10.1093/pcp/pct115 · Cited by 143 · see citing works

Heterotrophic vs autotrophic production of microalgae: bringing some light into the everlasting cost controversy

Ruiz, J., Wijffels, R. H., Dominguez, M., & Barbosa, M. J. (2022) · Algal Research · doi:10.1016/j.algal.2022.102698 · Cited by 141 · see citing works

The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation

Yokoyama, R., de Oliveira, M. V. V., Kleven, B., & Maeda, H. A. (2020) · The Plant Cell · doi:10.1093/plcell/koaa042 · Cited by 133 · see citing works

Plant Photosystem I Design in the Light of Evolution

Amunts, A., & Nelson, N. (2009) · Structure · doi:10.1016/j.str.2009.03.006 · Cited by 117 · see citing works

Synergistic substrate cofeeding stimulates reductive metabolism

Park, J. O., Liu, N., Holinski, K. M., Emerson, D. F., Qiao, K., Woolston, B. M., Xu, J., Lazar, Z., Islam, M. A., Vidoudez, C., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0077-0 · Cited by 115 · see citing works

Feedback Inhibition of Chorismate Mutase/Prephenate Dehydrogenase (TyrA) of Escherichia coli : Generation and Characterization of Tyrosine-Insensitive Mutants

Lütke‐Eversloh, T., & Stephanopoulos, G. N. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.11.7224-7228.2005 · Cited by 112 · see citing works

Development and optimization of genetic toolboxes for a fast-growing cyanobacterium Synechococcus elongatus UTEX 2973

Li, S., Sun, T., Xu, C., Chen, L., & Zhang, W. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.06.002 · Cited by 112 · see citing works

Current knowledge and recent advances in understanding metabolism of the model cyanobacteriumSynechocystissp. PCC 6803

Mills, L. A., McCormick, A. J., & Lea‐Smith, D. J. (2020) · Bioscience Reports · doi:10.1042/bsr20193325 · Cited by 111 · see citing works

Aromatic Amino Acids: A Complex Network Ripe for Future Exploration

Lynch, J. H., & Dudareva, N. (2020) · Trends in Plant Science · doi:10.1016/j.tplants.2020.02.005 · Cited by 106 · see citing works

Antimicrobial Activity of Naturally Occurring Phenols and Derivatives Against Biofilm and Planktonic Bacteria

Walsh, D. J., Livinghouse, T., Goeres, D. M., Mettler, M. K., & Stewart, P. S. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00653 · Cited by 104 · see citing works

Metabolic Engineering of Escherichia coli for the Synthesis of the Plant Polyphenol Pinosylvin

Wesenhagen, P. V., & Marienhagen, J. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.02966-14 · Cited by 97 · see citing works

Combinatorial biosynthesis of plant-specific coumarins in bacteria

Lin, Y., Sun, X., Yuan, Q., & Yan, Y. (2013) · Metabolic Engineering · doi:10.1016/j.ymben.2013.04.004 · Cited by 97 · see citing works

Synthetic tolerance: three noncoding small RNAs, DsrA, ArcZ and RprA, acting supra-additively against acid stress

Gaida, S. M., Al-Hinai, M. A., Indurthi, D. C., Nicolaou, S., & Papoutsakis, E. T. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt651 · Cited by 96 · see citing works

Synthetic scaffolds for pathway enhancement

Siu, K., Chen, R. P., Sun, Q. H., Chen, L., Tsai, S., & Chen, W. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.08.009 · Cited by 95 · see citing works

Light-Driven Cytochrome P450 Hydroxylations

Jensen, K., Jensen, P. E., & Møller, B. L. (2011) · ACS Chemical Biology · doi:10.1021/cb100393j · Cited by 95 · see citing works

Redirecting Photosynthetic Electron Flow into Light-Driven Synthesis of Alternative Products Including High-Value Bioactive Natural Compounds

Lassen, L. M. M., Nielsen, A. Z., Ziersen, B., Gnanasekaran, T., Møller, B. L., & Jensen, P. E. (2013) · ACS Synthetic Biology · doi:10.1021/sb400136f · Cited by 91 · see citing works

Understanding metabolism with flux analysis: From theory to application

Dai, Z., & Locasale, J. W. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.09.005 · Cited by 90 · see citing works

Engineering the shikimate pathway for biosynthesis of molecules with pharmaceutical activities in E. coli

Jiang, M. S., & Zhang, H. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.01.016 · Cited by 89 · see citing works

Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus

Wong, R. H. X., Nealon, R. S., Scholey, A. B., & Howe, P. R. C. (2016) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.03.003 · Cited by 89 · see citing works

Enhanced l-phenylalanine biosynthesis by co-expression of pheAfbr and aroFwt

Zhou, H., Liao, X., Wang, T., Du, G., & Chen, J. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.01.043 · Cited by 86 · see citing works

Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways

Rostom, B., Karaky, R., Kassab, I., & Veitía, M. S. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174867 · Cited by 85 · see citing works

Recent advances in microbial production of aromatic natural products and their derivatives

Wang, J., Shen, X., Rey, J. F., Yuan, Q., & Yan, Y. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8599-4 · Cited by 84 · see citing works

Metabolic engineering of Synechocystis sp. PCC 6803 for the production of aromatic amino acids and derived phenylpropanoids

Brey, L. M. F., Włodarczyk, A., Thøfner, J. F. B., Burow, M., Crocoll, C., Nielsen, I., Nielsen, A. J., & Jensen, P. E. (2019) · Metabolic Engineering · doi:10.1016/j.ymben.2019.11.002 · Cited by 84 · see citing works

A Rhamnose-Inducible System for Precise and Temporal Control of Gene Expression in Cyanobacteria

Kelly, C. L., Taylor, G. M., Hitchcock, A., Torres-Méndez, A., & Heap, J. T. (2018) · ACS Synthetic Biology · doi:10.1021/acssynbio.7b00435 · Cited by 80 · see citing works

Re-direction of carbon flux to key precursor malonyl-CoA via artificial small RNAs in photosynthetic Synechocystis sp. PCC 6803

Sun, T., Li, S., Song, X., Pei, G., Diao, J., Cui, J., Shi, M., Chen, L., & Zhang, W. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-018-1032-0 · Cited by 80 · see citing works

Construction of new synthetic biology tools for the control of gene expression in the cyanobacterium Synechococcus sp. strain PCC 7002

Zess, E. K., Begemann, M. B., & Pfleger, B. F. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25713 · Cited by 79 · see citing works

Metabolic engineering of light-driven cytochrome P450 dependent pathways into Synechocystis sp. PCC 6803

Włodarczyk, A., Gnanasekaran, T., Nielsen, A. Z., Zulu, N. N., Mellor, S. B., Luckner, M., Thøfner, J. F. B., Olsen, C. E., Motawia, M. S., Burow, M., et al. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.10.009 · Cited by 78 · see citing works

From cyanochemicals to cyanofactories: a review and perspective

Zhou, J., Zhu, T., Cai, Z., & Li, Y. (2016) · Microbial Cell Factories · doi:10.1186/s12934-015-0405-3 · Cited by 78 · see citing works

Influence of Codon Bias on the Expression of Foreign Genes in Microalgae

Heitzer, M., Eckert, A., Fuhrmann, M., & Griesbeck, C. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-75532-8_5 · Cited by 73 · see citing works

Beneficial effects of astringinin, a resveratrol analogue, on the ischemia and reperfusion damage in rat heart

Hung, L., Chen, J., Lee, R., Liang, H., & Su, M. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00474-9 · Cited by 73 · see citing works

Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense

Wang, N., Yi, W. J., Tan, L., Zhang, J. H., Xu, J., Chen, Y., Qin, M., Yu, S., Guan, J. Z., & Zhang, R. (2017) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-017-0135-4 · Cited by 73 · see citing works

Antiangiogenic Effects of Coumarins against Cancer: From Chemistry to Medicine

Majnooni, M. B., Fakhri, S., Smeriglio, A., Trombetta, D., Croley, C. R., Bhattacharyya, P., Sobarzo‐Sánchez, E., Farzaei, M. H., & Bishayee, A. (2019) · Molecules · doi:10.3390/molecules24234278 · Cited by 73 · see citing works

Genetically engineering <i>Synechocystis</i> sp. Pasteur Culture Collection 6803 for the sustainable production of the plant secondary metabolite <i>p</i> -coumaric acid

Xue, Y., Zhang, Y., Cheng, D., Daddy, S., & He, Q. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323725111 · Cited by 72 · see citing works

High density cultivation for efficient sesquiterpenoid biosynthesis in Synechocystis sp. PCC 6803

Dienst, D. D., Wichmann, J., Mantovani, O., Rodrigues, J. S., & Lindberg, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-62681-w · Cited by 71 · see citing works

Genetic analysis of amino acid transport in the facultatively heterotrophic cyanobacterium Synechocystis sp. strain 6803

Labarre, J., Thuriaux, P., & Chauvat, F. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.10.4668-4673.1987 · Cited by 70 · see citing works

The antithrombotic activity of natural and synthetic coumarins

Gao, L., Wang, F., Chen, Y., Li, F., Han, B., & Liu, D. (2021) · Fitoterapia · doi:10.1016/j.fitote.2021.104947 · Cited by 70 · see citing works

PhERF6, interacting with EOBI, negatively regulates fragrance biosynthesis in petunia flowers

Liu, F., Xiao, Z., Yang, L., Chen, Q., Shao, L., Liu, J., & Yu, Y. (2017) · New Phytologist · doi:10.1111/nph.14675 · Cited by 68 · see citing works

Fusion of Ferredoxin and Cytochrome P450 Enables Direct Light-Driven Biosynthesis

Mellor, S. B., Nielsen, A. Z., Burow, M., Motawia, M. S., Jakubauskas, D., Møller, B. L., & Jensen, P. E. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00190 · Cited by 67 · see citing works

Comparative Regulation of Isoenzymic 3-Deoxy- d - arabino -Heptulosonate 7-Phosphate Synthetases in Microorganisms

Jensen, R. A., & Nasser, D. S. (1968) · Journal of Bacteriology · doi:10.1128/jb.95.1.188-196.1968 · Cited by 65 · see citing works

Novel mutations in the pheA gene of Escherichia coli K-12 which result in highly feedback inhibition-resistant variants of chorismate mutase/prephenate dehydratase

Nelms, J. M., Edwards, R. M., Warwick, J., & Fotheringham, I. (1992) · Applied and Environmental Microbiology · doi:10.1128/aem.58.8.2592-2598.1992 · Cited by 65 · see citing works

Overexpression of a Novel Cytochrome P450 Promotes Flavonoid Biosynthesis and Osmotic Stress Tolerance in Transgenic Arabidopsis

Ahmad, N., Jianyu, L., Xu, T., Noman, M., Jameel, A., Yao, N., Yuanyuan, D., Nan, W., Li, X., Fawei, W., et al. (2019) · Genes · doi:10.3390/genes10100756 · Cited by 65 · see citing works

Continuous background light significantly increases flashing-light enhancement of photosynthesis and growth of microalgae

Abu-Ghosh, S., Fixler, D., Dubinsky, Z., & Iluz, D. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.03.119 · Cited by 63 · see citing works

Natural and nature-inspired stilbenoids as antiviral agents

Mattio, L. M., Catinella, G., Pinto, A., & Dallavalle, S. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112541 · Cited by 63 · see citing works

Phenolic Acids - Versatile Natural Moiety with Numerous Biological Applications

Sehrawat, R., Rathee, P., Akkol, E., Khatkar, S., Lather, A., Redhu, N., & Khatkar, A. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026622666220623114450 · Cited by 62 · see citing works

Anchoring a Plant Cytochrome P450 via PsaM to the Thylakoids in Synechococcus sp. PCC 7002: Evidence for Light-Driven Biosynthesis

Lassen, L. M. M., Nielsen, A. Z., Olsen, C. E., Białek, W., Jensen, K., Møller, B. L., & Jensen, P. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102184 · Cited by 59 · see citing works

Exploring the potential of high-density cultivation of cyanobacteria for the production of cyanophycin

Lippi, L., Bähr, L., Wüstenberg, A., Wilde, A., & Steuer, R. (2018) · Algal Research · doi:10.1016/j.algal.2018.02.028 · Cited by 57 · see citing works

Apigenin exhibits protective effects in a mouse model of d -galactose-induced aging via activating the Nrf2 pathway

Sang, Y., Zhang, F., Wang, H., Yao, J., Chen, R., Zhou, Z., Yang, K., Xie, Y., Wan, T., & Ding, H. (2017) · Food & Function · doi:10.1039/c7fo00037e · Cited by 55 · see citing works

Cloning, primary structure and regulation of the ARO4 gene, encoding the tyrosine-inhibited 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae

Künzler, M., Paravicini, G., Egli, C., Irniger, S., & Braus, G. H. (1992) · Gene · doi:10.1016/0378-1119(92)90670-k · Cited by 54 · see citing works

A Single Ser-180 Mutation Desensitizes Feedback Inhibition of the Phenylalanine-Sensitive 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate (DAHP) Synthetase in Escherichia coli1

Ger, Y.-M., Chen, S.-L., Chiang, H., & Shiuan, D. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124657 · Cited by 54 · see citing works

Regulatory systems for gene expression control in cyanobacteria

Till, P., Toepel, J., Bühler, B., Mach, R. L., & Mach-Aigner, A. R. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10344-w · Cited by 54 · see citing works

Metabolic systems biology and multi-omics of cyanobacteria: Perspectives and future directions

Pathania, R., Srivastava, A., Srivastava, S., & Shukla, P. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126007 · Cited by 54 · see citing works

A novel photobioreactor creating fluctuating light from solar energy for a higher light-to-biomass conversion efficiency

Iluz, D., & Abu‐Ghosh, S. (2016) · Energy Conversion and Management · doi:10.1016/j.enconman.2016.08.045 · Cited by 53 · see citing works

Enzymological Basis for Growth Inhibition by l -Phenylalanine in the Cyanobacterium Synechocystis sp. 29108

Hall, G. C., & Jensen, R. A. (1980) · Journal of Bacteriology · doi:10.1128/jb.144.3.1034-1042.1980 · Cited by 50 · see citing works

Biotransformation of phenylpropanoid compounds to vanilla flavor metabolites in cultures of Haematococcus pluvialis

Tripathi, U., Rao, S. R., & Ravishankar, G. A. (2002) · Process Biochemistry · doi:10.1016/s0032-9592(02)00135-8 · Cited by 50 · see citing works

Functional expression of an Arabidopsis p450 enzyme, p-coumarate-3-hydroxylase, in the cyanobacterium Synechocystis PCC 6803 for the biosynthesis of caffeic acid

Xue, Y., Zhang, Y., Grace, S. C., & He, Q. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-0113-5 · Cited by 49 · see citing works

Recent advances in synthetic biology of cyanobacteria for improved chemicals production

Wang, F., Gao, Y., & Yang, G. (2020) · Bioengineered · doi:10.1080/21655979.2020.1837458 · Cited by 49 · see citing works

Cloning of the ARO3 gene of Saccharomyces cerevisiae and its regulation

Teshiba, S., Furter, R., Niederberger, P., Braus, G. H., Paravicini, G., & Hütter, R. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf00430450 · Cited by 48 · see citing works

AraBAD Based Toolkit for Gene Expression and Metabolic Robustness Improvement in Synechococcus elongatus

Cao, Y., Li, Q., Xia, P., Wei, L., Guo, N., Li, J.-W., & Wang, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-17035-4 · Cited by 46 · see citing works

Metabolic model guided strain design of cyanobacteria

Hendry, J. I., Bandyopadhyay, A., Srinivasan, S., Pakrasi, H. B., & Maranas, C. D. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.08.011 · Cited by 46 · see citing works

Proteins of the cyanobacterial photosystem I

Xu, W., Tang, H., Wang, Y., & Chitnis, P. R. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(01)00208-0 · Cited by 45 · see citing works

Heterologous production of resveratrol in bacterial hosts: current status and perspectives

Braga, A., Ferreira, P., Oliveira, J., Rocha, I., & Faria, N. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2506-8 · Cited by 45 · see citing works

N-Prenylation of Tryptophan by an Aromatic Prenyltransferase from the Cyanobactin Biosynthetic Pathway

Dalponte, L., Parajuli, A., Younger, E. F. P., Mattila, A., Jokela, J., Wahlsten, M., Leikoski, N., Sivonen, K., Jarmusch, S. A., Houssen, W. E., et al. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00879 · Cited by 44 · see citing works

Light-driven biosynthesis of volatile, unstable and photosensitive chemicals from CO2

Li, C., Yin, L., Wang, J., Zheng, H., & Ni, J. (2023) · Nature Synthesis · doi:10.1038/s44160-023-00331-5 · Cited by 43 · see citing works

Subunit Communication in the Anthranilate Synthase Complex from Salmonella typhimurium

Caligiuri, M., & Bauerle, R. H. (1991) · Science · doi:10.1126/science.2063197 · Cited by 42 · see citing works

Remodeling of the Photosynthetic Chain Promotes Direct CO2 Conversion into Valuable Aromatic Compounds

Ni, J., Liu, H., Tao, F., Wu, Y., & Xu, P. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201808402 · Cited by 42 · see citing works

Multifaceted plant responses to circumvent Phe hyperaccumulation by downregulation of flux through the shikimate pathway and by vacuolar Phe sequestration

Lynch, J. H., Orlova, I., Zhao, C., Guo, L., Jaini, R., Maeda, H. A., Akhtar, T. A., Cruz‐Lebron, J., Rhodes, D., Morgan, J. A., et al. (2017) · The Plant Journal · doi:10.1111/tpj.13730 · Cited by 40 · see citing works

Synthetic metabolic pathways for conversion of CO2 into secreted short-to medium-chain hydrocarbons using cyanobacteria

Yunus, I. S., Anfelt, J., Sporre, E., Miao, R., Hudson, E. P., & Jones, P. R. (2022) · Metabolic Engineering · doi:10.1016/j.ymben.2022.01.017 · Cited by 40 · see citing works

Mutation analysis of the feedback inhibition site of phenylalanine‐sensitive 3‐deoxy‐ D ‐arabino‐heptulosonate 7‐phosphate synthase of Escherichia coli

Hu, C., Jiang, P., Xu, J., Wu, Y., & Huang, W. (2003) · Journal of Basic Microbiology · doi:10.1002/jobm.200310244 · Cited by 39 · see citing works

Bioprocess Optimization for the Production of Aromatic Compounds With Metabolically Engineered Hosts: Recent Developments and Future Challenges

Braga, A., & Faria, N. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00096 · Cited by 39 · see citing works

A whiff of the future: functions of phenylalanine‐derived aroma compounds and advances in their industrial production

Skaliter, O., Livneh, Y., Agron, S., Shafir, S., & Vainstein, A. (2022) · Plant Biotechnology Journal · doi:10.1111/pbi.13863 · Cited by 39 · see citing works

Phenylalanine Biosynthesis in Escherichia coli K-12: Mutants Derepressed for Chorismate Mutase P-Prephenate Dehydratase

Im, S. W. K., & Pittard, J. (1971) · Journal of Bacteriology · doi:10.1128/jb.106.3.784-790.1971 · Cited by 37 · see citing works

A photoautotrophic platform for the sustainable production of valuable plant natural products from CO ₂

Ni, J., Tao, F., Wang, Y., Yao, F., & Xu, P. (2016) · Green Chemistry · doi:10.1039/c6gc00317f · Cited by 37 · see citing works

Helicase-AID: A novel molecular device for base editing at random genomic loci

Wang, J., Zhao, D., Li, J., Hu, M., Xin, X., Price, M. A., Li, Q., Liu, L., Li, S., Rosser, S. J., et al. (2021) · Metabolic Engineering · doi:10.1016/j.ymben.2021.08.005 · Cited by 36 · see citing works

Comprehensive Analyses of Cytochrome P450 Monooxygenases and Secondary Metabolite Biosynthetic Gene Clusters in Cyanobacteria

Khumalo, M. J., Nzuza, N., Padayachee, T., Chen, W., Yu, J., Nelson, D. R., & Syed, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020656 · Cited by 34 · see citing works

Study on the isoprene-producing co-culture system of Synechococcus elongates–Escherichia coli through omics analysis

Liu, H., Cao, Y., Guo, J., Xu, X., Long, Q., Song, L., & Xian, M. (2021) · Microbial Cell Factories · doi:10.1186/s12934-020-01498-8 · Cited by 34 · see citing works

Random Base Editing for Genome Evolution in Saccharomyces cerevisiae

Pan, Y., Xia, S., Dong, C., Pan, H., Cai, J., Huang, L., Xu, Z., & Lian, J. (2021) · ACS Synthetic Biology · doi:10.1021/acssynbio.1c00217 · Cited by 34 · see citing works

Photoautotrophic production of p-Coumaric acid using genetically engineered Synechocystis sp. Pasteur Culture Collection 6803

Gao, E., Kyere-Yeboah, K., Wu, J., & Qiu, H. (2021) · Algal Research · doi:10.1016/j.algal.2020.102180 · Cited by 31 · see citing works

Evolution of tryptophan biosynthetic pathway in microbial genomes: a comparative genetic study

Priya, V. K., Sarkar, S., & Sinha, S. (2013) · Systems and Synthetic Biology · doi:10.1007/s11693-013-9127-1 · Cited by 29 · see citing works

Combining Random Mutagenesis and Metabolic Engineering for Enhanced Tryptophan Production in Synechocystis sp. Strain PCC 6803

Deshpande, A., Vue, J., & Morgan, J. A. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.02816-19 · Cited by 29 · see citing works

A Highly Compatible Phototrophic Community for Carbon‐Negative Biosynthesis

Li, C., Wang, R., Wang, J., Liu, L., Li, H., Zheng, H., & Ni, J. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202215013 · Cited by 26 · see citing works

Responses of Synechocystis sp. PCC 6803 to heterologous biosynthetic pathways

Vavitsas, K., Rue, E. Ø., Stefánsdóttir, L. K., Gnanasekaran, T., Blennow, A., Crocoll, C., Guðmundsson, S., & Jensen, P. E. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0757-y · Cited by 25 · see citing works

CyanoOmicsDB: an integrated omics database for functional genomic analysis of cyanobacteria

Zhou, P., Wang, L., Liu, H., Li, C., Li, Z., Wang, J., & Tan, X. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab891 · Cited by 24 · see citing works

Expression of phenylalanine ammonia lyases in Synechocystis sp. PCC 6803 and subsequent improvements of sustainable production of phenylpropanoids

Kukil, K., & Lindberg, P. (2022) · Microbial Cell Factories · doi:10.1186/s12934-021-01735-8 · Cited by 22 · see citing works

Metabolic flux phenotyping of secondary metabolism in cyanobacteria

Babele, P. K., Srivastava, A., & Young, J. D. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.05.005 · Cited by 21 · see citing works

Laboratory evolution of Synechocystis sp. PCC 6803 for phenylpropanoid production

Kukil, K., Englund, E., Crang, N., Hudson, E. P., & Lindberg, P. (2023) · Metabolic Engineering · doi:10.1016/j.ymben.2023.06.014 · Cited by 21 · see citing works

Construction of an artificial consortium of Escherichia coli and cyanobacteria for clean indirect production of volatile platform hydrocarbons from CO2

Cui, Y., Rasul, F., Jiang, Y., Zhong, Y., Zhang, S., Boruta, T., Riaz, S., & Daroch, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.965968 · Cited by 20 · see citing works

Biocatalytic synthesis of flavones and hydroxyl-small molecules by recombinant Escherichia coli cells expressing the cyanobacterial CYP110E1 gene

Makino, T., Otomatsu, T., Shindo, K., Kitamura, E., Sandmann, G., Harada, H., & Misawa, N. (2012) · Microbial Cell Factories · doi:10.1186/1475-2859-11-95 · Cited by 19 · see citing works

Biotechnological production of specialty aromatic and aromatic-derivative compounds

Braga, A., & Faria, N. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03263-y · Cited by 19 · see citing works

Development of a lightweight multi-skin sheet photobioreactor for future cultivation of phototrophic biofilms on facades

Scherer, K., Stiefelmaier, J., Strieth, D., Wahl, M., & Ulber, R. (2020) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2020.06.004 · Cited by 18 · see citing works

Regulation of the aromatic pathway in the cyanobacterium Synechococcus sp. strain Pcc6301 (Anacystis nidulans)

Hall, G. C., Flick, M. B., & Jensen, R. A. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.423-428.1983 · Cited by 17 · see citing works

Potential of Producing Flavonoids Using Cyanobacteria as a Sustainable Chassis

Jin, H., Wang, Y., Zhao, P., Wang, L., Zhang, S., Meng, D., Yang, Q., Cheong, L.-Z., Bi, Y., & Fu, Y. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04632 · Cited by 17 · see citing works

Site-directed mutagenesis and over expression of aroG gene of Escherichia coli K-12

Lin, S., Meng, X., Jiang, J., Pang, D., Jones, G. S., Ouyang, H., & Ren, L. (2012) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.07.013 · Cited by 15 · see citing works

Metabolic sink engineering in cyanobacteria: Perspectives and applications

Bongirwar, R., & Shukla, P. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.128974 · Cited by 15 · see citing works

Metabolic engineering of Synechocystis sp. PCC 6803 for the improved production of phenylpropanoids

Kukil, K., & Lindberg, P. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02330-3 · Cited by 15 · see citing works

Combining metabolite doping and metabolic engineering to improve 2-phenylethanol production by engineered cyanobacteria

Usai, G., Cordara, A., Re, A., Polli, M. F., Mannino, G., Bertea, C. M., Fino, D., Pirri, C. F., & Menin, B. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1005960 · Cited by 14 · see citing works

Coupling dairy wastewaters for nutritional balancing and water recycling: sustainable heterologous 2-phenylethanol production by engineered cyanobacteria

Usai, G., Cordara, A., Mazzocchi, E., Re, A., Fino, D., Pirri, C. F., & Menin, B. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1359032 · Cited by 11 · see citing works

Co-substrate facilitated charge transfer for bioelectricity evolution in a toxic blue-green alga-fed microbial fuel cell technology

Ndayisenga, F., Yu, Z., Kabera, T., Wang, B., Liang, H., Phulpoto, I. A., Habiyakare, T., Ndayambaje, Y. K., & Yan, X. (2021) · Clean Technologies and Environmental Policy · doi:10.1007/s10098-021-02173-1 · Cited by 8 · see citing works

Synechocystis PCC 6803 cells heterologously expressing bacterial tyrosine ammonia lyase can use exogenous tyrosine for p-coumaric acid production

Tantong, S., Nuengchamnong, N., Kumphune, S., Incharoensakdi, A., Lindblad, P. C., & Sirikantaramas, S. (2017) · Journal of Plant Biochemistry and Biotechnology · doi:10.1007/s13562-017-0416-8 · Cited by 4 · see citing works

De-regulated assimilation and over-production of amino acids in analogue-resistant mutants of a cyanobacterium, Phormidium uncinatum

Rao, S. N., Shakila, T. M., & Bagchi, S. N. (1995) · World Journal of Microbiology and Biotechnology · doi:10.1007/bf00361013 · Cited by 3 · see citing works

Cyanobacterial Bioenergetics in Relation to Cellular Growth and Productivity

Burnap, R. L. (2023) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2022_215 · Cited by 3 · see citing works

Synthetic Light‐Driven Consortia for Carbon‐Negative Biosynthesis

Li, C.-F., Zheng, H., Li, H., Liu, L., Wang, J., & Ni, J. (2023) · ChemBioChem · doi:10.1002/cbic.202300122 · Cited by 3 · see citing works

Engineering metabolic flux for the microbial synthesis of aromatic compounds

Li, Z., Wang, X., Hu, G., Li, X., Song, W., Wei, W., Liu, L., & Gao, C. (2024) · Metabolic Engineering · doi:10.1016/j.ymben.2024.12.007 · Cited by 15 · see citing works

Extended Toolboxes Enable Efficient Biosynthesis of Multiple Products from CO₂ in Fast-Growing <i>Synechococcus</i> sp. PCC 11901

Zhang, T., Li, S., Chen, L., Zhang, W., & Sun, T. (2024) · ACS Sustainable Chemistry &amp; Engineering · doi:10.1021/acssuschemeng.4c04497 · Cited by 6 · see citing works

A modular artificial photosynthetic microbial consortium for the CO 2 -driven production of cis , cis -muconate

Ma, K., Wang, J., Ju, Y., Chen, L., Song, X., & Zhang, W. (2025) · Green Chemistry · doi:10.1039/d5gc04738b · Cited by 5 · see citing works

Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression

Walshe, J., & Saha, S. K. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48060638 · Cited by 1 · see citing works

Further enhanced acetate production by overexpressing selected CBB-cycle enzymes in an engineered Synechocystis PCC 6803 strain

Roussou, S., & Lindblad, P. C. (2026) · Algal Research · doi:10.1016/j.algal.2026.104714 · Cited by 1 · see citing works

Transforming nitrogen and phosphorus in cyanobacteria and municipal sludge via molecular sieve–catalyzed degradative solvent extraction

Fu, D., Chen, F., Duan, F., & Zhang, L. (2026) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2026.121558 · Cited by 1 · see citing works

Complete Epoxy Phosphonate Conversion to Dimethyl (1E)-3-Hydroxyprop-1-Enylphosphonate with Photobiocatalysts’ Assistance

Samson, S. O., Serafin‐Lewańczuk, M., Brzezińska‐Rodak, M., Klimek‐Ochab, M., & Żymańczyk–Duda, E. (2024) · Symmetry · doi:10.3390/sym16121676 · Cited by 1 · see citing works

Metabolic engineering of Synechocystis sp. PCC 6803 for olivetolic acid production

Gao, E., Ji, W., Yangjie, Z., & Wu, J. (2026) · Microbial Cell Factories · doi:10.1186/s12934-026-03058-y

Metabolic engineering strategies for sustainable production of high-value Gyrinops agarwood metabolites

Istiandari, P., Meitha, K., Pratama, F., Priharto, N., Putranto, R. A., Fukushima, E. O., & Faizal, A. (2026) · Current Plant Biology · doi:10.1016/j.cpb.2026.100663

[Synthetic biology for the synthesis of aromatic natural products: a review].

Liu, L., Li, C., Wang, J., Ni, J., & Xu, P. (2021) · PubMed · doi:10.13345/j.cjb.210074 · Cited by 4 · see citing works

Recent advances in microbial production of aromatic natural products and their derivatives

Wang, J., Shen, X., Rey, J. F., Yuan, Q., & Yan, Y. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8599-4 · Cited by 84 · see citing works

Expanding the repertoire of aromatic chemicals by microbial production

Wu, F., Cao, P., Song, G., Chen, W., & Wang, Q. (2018) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.5690 · Cited by 32 · see citing works

Microbial production of C 7 –C 9 aromatic building blocks for the production of natural products

Dai, Q., Xu, J., Wu, J., Li, X., Gao, C., Hu, G., & Liu, L. (2026) · Natural Product Reports · doi:10.1039/d5np00068h · Cited by 3 · see citing works

Recent Advances in Metabolically Engineered Microorganisms for the Production of Aromatic Chemicals Derived From Aromatic Amino Acids

Shen, Y., Niu, F.-X., Yan, Z.-B., Fong, L. S., Huang, Y., & Liu, J.-Z. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00407 · Cited by 63 · see citing works