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Antifungal therapy with an emphasis on biofilms
Open accessAbstract
Fungal infections are on the rise as advances in modern medicine prolong the lives of severely ill patients. Fungi are eukaryotic organisms and there are a limited number of targets for antifungal drug development; as a result the antifungal arsenal is exceedingly limited. Azoles, polyenes and echinocandins constitute the mainstay of antifungal therapy for patients with life-threatening mycoses. One of the main factors complicating antifungal therapy is the formation of fungal biofilms, microbial communities displaying resistance to most antifungal agents. A better understanding of fungal biofilms provides for new opportunities for the development of urgently needed novel antifungal agents and strategies.
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“sessile cells show high levels of tolerance to antifungal therapy as compared to their planktonic counterparts [21,22].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [21]
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Metadata
- Authors
- Pierce, C. G., Srinivasan, A., Uppuluri, P., Ramasubramanian, A. K., & López-Ribot, J. L.
- Affiliations
- The University of Texas at San Antonio (US)
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 13
- Issue
- 5
- Pages
- 726-730
- ISSN
- 1471-4892 (ISSN-L)
- PMC
- PMC3795934
- OpenAlex
- W2076025899
- Cited by
- 173
- References
- 64
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 7 · 2020: 19 · 2019: 18 · 2018: 14 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 9 · 2013: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R01DE023510)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- antifungal therapy, fungal biofilms, antifungal resistance, azoles, polyenes, echinocandins, fungal infection, antifungal drug development
- MeSH terms
- Animals, Antifungal Agents, Fungi, Humans, Mycoses, Biofilms, Drug Resistance, Fungal
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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