The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Antifungal therapy with an emphasis on biofilms
Open accessAbstract
Fungal infections are on the rise as advances in modern medicine prolong the lives of severely ill patients. Fungi are eukaryotic organisms and there are a limited number of targets for antifungal drug development; as a result the antifungal arsenal is exceedingly limited. Azoles, polyenes and echinocandins constitute the mainstay of antifungal therapy for patients with life-threatening mycoses. One of the main factors complicating antifungal therapy is the formation of fungal biofilms, microbial communities displaying resistance to most antifungal agents. A better understanding of fungal biofilms provides for new opportunities for the development of urgently needed novel antifungal agents and strategies.
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“sessile cells show high levels of tolerance to antifungal therapy as compared to their planktonic counterparts [21,22].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [21]
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Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study
Lara, H. H., Romero-Urbina, D. G., Pierce, C., Lopez-Ribot, J. L., Arellano-Jiménez, M. J., & Jose-Yacaman, M. (2015) · Journal of Nanobiotechnology · doi:10.1186/s12951-015-0147-8 · Cited by 323
“This is important as both filamentation and development of biofilms represent two of the main virulence factors of Candida species [11].”
BackgroundInfluentialSelf-citationCandida albicans biofilm growth and dispersal: contributions to pathogenesis
Wall, G., Montelongo-Jauregui, D., Vidal Bonifacio, B., Lopez-Ribot, J. L., & Uppuluri, P. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.04.001 · Cited by 263
“albicans cells within a biofilm display high-levels of resistance to azoles and polyenes[33,34], with biofilms formed under flow conditions exhibiting even higher resistance [18].”
BackgroundSelf-citationFreires, I. A., Murata, R. M., Furletti, V. F., Sartoratto, A., de Alencar, S. M., Figueira, G. M., Rodrigues, J. A. D. O., Duarte, M. C. T., & Rosalen, P. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099086 · Cited by 201
“This same mechanism accounts for the antifungal activity of polyenes such as nystatin and amphotericin B [42].”
BackgroundCurrent Antimycotics, New Prospects, and Future Approaches to Antifungal Therapy
Wall, G., & Lopez-Ribot, J. L. (2020) · Antibiotics · doi:10.3390/antibiotics9080445 · Cited by 183
“As a consequence, and in stark contrast with antibacterials, the current antifungal armamentarium is still very limited [8,9].”
ResultTargeting Candida albicans filamentation for antifungal drug development
Vila, T., Romo, J. A., Pierce, C. G., McHardy, S. F., Saville, S. P., & Lopez-Ribot, J. L. (2017) · Virulence · doi:10.1080/21505594.2016.1197444 · Cited by 174
“major classes of antifungal drugs: polyenes, azoles and echinocandins.(14,15) However, this arsenal is compromised by problems of selectivity, toxicity, and the development of resistance.”
BackgroundSelf-citation
Metadata
- Authors
- Pierce, C. G., Srinivasan, A., Uppuluri, P., Ramasubramanian, A. K., & López-Ribot, J. L.
- Affiliations
- The University of Texas at San Antonio (US)
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 13
- Issue
- 5
- Pages
- 726-730
- ISSN
- 1471-4892 (ISSN-L)
- PMC
- PMC3795934
- OpenAlex
- W2076025899
- Cited by
- 173
- References
- 64
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 7 · 2020: 19 · 2019: 18 · 2018: 14 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 9 · 2013: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R01DE023510)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- antifungal therapy, fungal biofilms, antifungal resistance, azoles, polyenes, echinocandins, fungal infection, antifungal drug development
- MeSH terms
- Animals, Antifungal Agents, Fungi, Humans, Mycoses, Biofilms, Drug Resistance, Fungal
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