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Respiratory sinus arrhythmia: a transdiagnostic biomarker of emotion dysregulation and psychopathology
Open accessAbstract
In the past two decades, respiratory sinus arrhythmia (RSA)-an index of parasympathetic nervous system (PNS)-mediated cardiac control-has emerged as a reliable peripheral biomarker of emotion regulation (ER). Reduced RSA and excessive RSA reactivity (i.e., withdrawal) to emotional challenge are observed consistently among individuals with poor ER capabilities, including those with various forms of internalizing and externalizing psychopathology, and those with specific psychopathological syndromes, including anxiety, phobias, attention problems, autism, callousness, conduct disorder, depression, non-suicidal self-injury, panic disorder, and trait hostility. Emerging evidence suggests that low RSA and excessive RSA reactivity index poor ER because they are downstream peripheral markers of prefrontal cortex (PFC) dysfunction. Poorly modulated inhibitory efferent pathways from the medial PFC to the PNS result in reduced RSA and excessive RSA reactivity. According to this perspective, RSA is a non-invasive proxy for poor executive control over behavior, which characterizes most forms of psychopathology.
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Cites
The expression of the emotions in man and animals.
Darwin, C. D. (1872) · J. Murray eBooks · doi:10.1037/10001-000 · Cited by 12,120
Emotion-regulation strategies across psychopathology: A meta-analytic review
Aldao, A., Nolen-Hoeksema, S., & Schweizer, S. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.11.004 · Cited by 6,686
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604
Large-scale brain networks and psychopathology: a unifying triple network model
Menon, V. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.003 · Cited by 4,168
Thayer, J. F., Åhs, F., Fredrikson, M., Sollers, J. J., & Wager, T. D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.11.009 · Cited by 3,224
Thayer, J. F., Hansen, A. L., Saus-Rose, E., & Johnsen, B. H. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9101-z · Cited by 1,872 · cited 3×
“Since most forms of psychopathology are characterized by PFC dysfunction [44,45 ], they are also characterized by low resting RSA and excessive RSA reactivity, peripheral biomarkers of poor executive control [41].”
BackgroundInfluentialPORGES, S. W. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb01213.x · Cited by 1,624
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547
BEAUCHAINE, T. (2001) · Development and Psychopathology · doi:10.1017/s0954579401002012 · Cited by 1,466 · cited 1×
“Doing so provides considerably more specificity in distinguishing among psychiatric disorders [10 ,48].”
BackgroundSelf-citationAnxiety and affective style: role of prefrontal cortex and amygdala
Davidson, R. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01328-2 · Cited by 1,170
Cognitive neuroscience of self-regulation failure
Heatherton, T. F., & Wagner, D. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.12.005 · Cited by 1,033
Reyes del Paso, G. A., Langewitz, W., Mulder, L. J. M., van Roon, A., & Duschek, S. (2013) · Psychophysiology · doi:10.1111/psyp.12027 · Cited by 954
Heart rate variability as a transdiagnostic biomarker of psychopathology
Beauchaine, T. P., & Thayer, J. F. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.08.004 · Cited by 870
Self-citationVagal influence on working memory and attention
Hansen, A. L., Johnsen, B. H., & Thayer, J. F. (2003) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(03)00073-4 · Cited by 759
Beauchaine, T. P., Gatzke-Kopp, L., & Mead, H. K. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2005.08.008 · Cited by 722
Self-citationNeural correlates of heart rate variability during emotion
Lane, R. D., Kateri Mcrae, A., Reiman, E. M., Chen, K., Ahern, G. L., & Thayer, J. F. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.056 · Cited by 687
Monk, C. S., Telzer, E. H., Mogg, K., Bradley, B. P., Mai, X., Louro, H. M. C., Chen, G., McClure-Tone, E. B., Ernst, M., & Pine, D. S. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.568 · Cited by 682
VAGAL TONE AND THE PHYSIOLOGICAL REGULATION OF EMOTION
Porges, S. W., Doussard-Roosevelt, J. A., & Maiti, A. K. (1994) · Monographs of the Society for Research in Child Development · doi:10.1111/j.1540-5834.1994.tb01283.x · Cited by 666
The development of emotion regulation : biological and behavioral considerations
Fox, N. A., & Campos, J. J. (1994) · University of Chicago Press eBooks · Cited by 557
Neuroscience of Self and Self-Regulation
Heatherton, T. F. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131616 · Cited by 476
Future Directions in Emotion Dysregulation and Youth Psychopathology
Beauchaine, T. P. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2015.1038827 · Cited by 394
Self-citationCardiac vagal control in depression: A critical analysis
Rottenberg, J. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2005.08.010 · Cited by 376
Beauchaine, T. P., & McNulty, T. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000746 · Cited by 348
Self-citationThompson, R. A. (1988) · PubMed · Cited by 291
Beauchaine, T. P., Katkin, E. S., Strassberg, Z., & Snarr, J. (2001) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.110.4.610 · Cited by 288
Self-citationde Wied, M. A., Boxtel, A. V., Matthys, W., & Meeus, W. (2011) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-011-9557-8 · Cited by 251 · cited 1×
“First, abnormally low resting RSA and/or large reductions in RSA specifically during emotion evocation are associated with symptoms of both internalizing and externalizing psychopathology [29,30], and with numerous psychopathological syndromes, including anxiety [31], phobias [32], attention problems [33], autism [34]…”
BackgroundThe Oxford Handbook of Coercive Relationship Dynamics
Dishion, T. J. 1., & Snyder, J. 1.-2. (2015) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199324552.001.0001 · Cited by 245
Ventral medial prefrontal cortex and cardiovagal control in conscious humans
Wong, S. W., Massé, N., Kimmerly, D. S., Menon, R. S., & Shoemaker, J. K. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.027 · Cited by 233 · cited 1×
“Inhibitory efferent pathways from the medial PFC to the PNS have been characterized for some time [43].”
BackgroundPsychological, autonomic, and serotonergic correlates of parasuicide among adolescent girls
CROWELL, S. E., BEAUCHAINE, T. P., McCAULEY, E., SMITH, C. J., STEVENS, A. L., & SYLVERS, P. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050522 · Cited by 229
Self-citationVagal Tone and the Physiological Regulation of Emotion
Porges, S. W., Doussard-Roosevelt, J. A., & Maiti, A. K. (1994) · Monographs of the Society for Research in Child Development · doi:10.2307/1166144 · Cited by 216
Vasilev, C. A., Crowell, S. E., Beauchaine, T. P., Mead, H. K., & Gatzke‐Kopp, L. M. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02172.x · Cited by 213 · cited 1×
“First, abnormally low resting RSA and/or large reductions in RSA specifically during emotion evocation are associated with symptoms of both internalizing and externalizing psychopathology [29,30], and with numerous psychopathological syndromes, including anxiety [31], phobias [32], attention problems [33], autism [34]…”
BackgroundSelf-citationChild and Adolescent Psychopathology
Kovshoff, H., Grindle, C. F., & Hastings, R. P. (2012) · Routledge eBooks · doi:10.4324/9780203929629 · Cited by 186
Cardiac autonomic control and hostility in healthy subjects
Sloan, R. P., Shapiro, P. A., Bigger, J. T., Bagiella, E., Steinman, R. C., & Gorman, J. M. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90382-4 · Cited by 185 · cited 1×
“First, abnormally low resting RSA and/or large reductions in RSA specifically during emotion evocation are associated with symptoms of both internalizing and externalizing psychopathology [29,30], and with numerous psychopathological syndromes, including anxiety [31], phobias [32], attention problems [33], autism [34]…”
BackgroundHastings, P. D., Sullivan, C., McShane, K., Coplan, R. J., Utendale, W. T., & Vyncke, J. D. (2008) · Child Development · doi:10.1111/j.1467-8624.2007.01110.x · Cited by 173 · cited 1×
“First, abnormally low resting RSA and/or large reductions in RSA specifically during emotion evocation are associated with symptoms of both internalizing and externalizing psychopathology [29,30], and with numerous psychopathological syndromes, including anxiety [31], phobias [32], attention problems [33], autism [34]…”
BackgroundPHYSIOLOGICAL MARKERS OF EMOTION AND BEHAVIOR DYSREGULATION IN EXTERNALIZING PSYCHOPATHOLOGY
Beauchaine, T. P. (2012) · Monographs of the Society for Research in Child Development · doi:10.1111/j.1540-5834.2011.00665.x · Cited by 157 · cited 1×
“First, abnormally low resting RSA and/or large reductions in RSA specifically during emotion evocation are associated with symptoms of both internalizing and externalizing psychopathology [29,30], and with numerous psychopathological syndromes, including anxiety [31], phobias [32], attention problems [33], autism [34]…”
BackgroundSelf-citationInteractions between the prefrontal cortex and amygdala during delay discounting and reversal.
Churchwell, J. C., Morris, A. M., Heurtelou, N. M., & Kesner, R. P. (2009) · Behavioral Neuroscience · doi:10.1037/a0017734 · Cited by 148 · cited 1×
“Moreover, deficient top–down control of the amygdala by the PFC, and reduced functional connectivity between the amygdala and the PFC, are observed among those with deficient ER [25].”
BackgroundEmotion dysregulation as a risk factor for psychopathology.
Cole, P. M., & Hall, S. E. (2008) · Cited by 125
Beauchaine, T. P., & Gatzke‐Kopp, L. M. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000508 · Cited by 120
Self-citationNeuhaus, E., Bernier, R., & Beauchaine, T. P. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1923-7 · Cited by 119 · cited 1×
“First, abnormally low resting RSA and/or large reductions in RSA specifically during emotion evocation are associated with symptoms of both internalizing and externalizing psychopathology [29,30], and with numerous psychopathological syndromes, including anxiety [31], phobias [32], attention problems [33], autism [34]…”
BackgroundSelf-citationÅhs, F., Sollers, J. J., Furmark, T., Fredrikson, M. G., & Thayer, J. F. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.091 · Cited by 111 · cited 1×
“First, abnormally low resting RSA and/or large reductions in RSA specifically during emotion evocation are associated with symptoms of both internalizing and externalizing psychopathology [29,30], and with numerous psychopathological syndromes, including anxiety [31], phobias [32], attention problems [33], autism [34]…”
BackgroundDawson, G. (1994) · Monographs of the Society for Research in Child Development · doi:10.1111/j.1540-5834.1994.tb01281.x · Cited by 88
Psychophysiological Methods and Developmental Psychopathology
Zisner, A. R., & Beauchaine, T. P. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy222 · Cited by 84
Self-citationAsmundson, G. J. G., & Stein, M. B. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199405000-00002 · Cited by 82 · cited 1×
“First, abnormally low resting RSA and/or large reductions in RSA specifically during emotion evocation are associated with symptoms of both internalizing and externalizing psychopathology [29,30], and with numerous psychopathological syndromes, including anxiety [31], phobias [32], attention problems [33], autism [34]…”
BackgroundAttention-deficit hyperactivity disorder and cardiac vagal control: a systematic review
Rash, J. A., & Aguirre-Camacho, A. (2012) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-012-0087-1 · Cited by 72
Shahrestani, S., Stewart, E. M., Quintana, D. S., Hickie, I. B., & Guastella, A. J. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12226 · Cited by 65 · cited 1×
“Importantly, excessive RSA withdrawal among psychopathological groups is specific to emotion evocation, and is not observed in many other stimulus conditions [40].”
BackgroundShannon, K. E., Sauder, C. L., Beauchaine, T. P., & Gatzke‐Kopp, L. M. (2009) · Criminal Justice and Behavior · doi:10.1177/0093854809342856 · Cited by 57 · cited 1×
“connectivity in prefrontal–striatal connections than controls [24].”
Self-citationFox, N. A. (1994) · Monographs of the Society for Research in Child Development · doi:10.2307/1166140 · Cited by 38
Dawson, G. (1994) · Monographs of the Society for Research in Child Development · doi:10.2307/1166142 · Cited by 37
Mack, A. (2009) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/s0084-3970(08)79329-0 · Cited by 23
Coercive Family Processes in the Development of Externalizing Behavior
Beauchaine, T. P., Hinshaw, S. P., & Snyder, J. J. (2014) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199324675.013.009 · Cited by 2
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Sorted by citations
Heart rate variability as a transdiagnostic biomarker of psychopathology
Beauchaine, T. P., & Thayer, J. F. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.08.004 · Cited by 870
“…HF-HRV to assorted challenges—particularly emotion evocation—are associated with symptoms of both internalizing and externalizing psychopathology (see Beauchaine, 2001, 2012, 2015a, 2015b; Porges, 2007; Vasilev et al., 2009), andwith a wide range of psychopathological syndromes, including anxiety…”
InfluentialSelf-citationAldao, A., Gee, D. G., De Los Reyes, A., & Seager, I. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000638 · Cited by 636
“…such as the amygdala and ventral striatum, facilitate emotional reactivity and motivational processes that may be more automatic and tendency related, whereas top-down control mediated by prefrontal regions may be more involved in the volitional regulation of emotion (see Beauchaine, 2015a).”
BackgroundInfluentialEmotion dysregulation and non-suicidal self-injury: a systematic review and meta-analysis
Wolff, J. C., Thompson, E., Thomas, S. A., Nesi, J., Bettis, A. H., Ransford, B., Scopelliti, K., Frazier, E. A., & Liu, R. T. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2019.03.004 · Cited by 512
“begun to rely on objective, psychophysiological measures believed to index emotion regulatory capacity—such as respiratory sinus arrhythmia [87,88] and cardiac vagal tone measured through heart rate variability [89].”
BackgroundFuture Directions in Emotion Dysregulation and Youth Psychopathology
Beauchaine, T. P. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2015.1038827 · Cited by 394
“…index of emotion dysregulation is RSA—which quantifies, usually via spectral analysis of the electrocardiogram R-R time series, parasympathetically mediated ebbing and flowing of heart rate across successive respiratory cycles (see Beauchaine, 2001, 2015; Zisner & Beauchaine, in press-b).”
BackgroundSelf-citationCardiac vagal control as a marker of emotion regulation in healthy adults: a review
Balzarotti, S., Biassoni, F., Colombo, B., & Ciceri, M. R. (2017) · Biological Psychology · doi:10.1016/j.biopsycho.2017.10.008 · Cited by 306
“more in general−because they are peripheral markers of prefrontal cortex inhibitory activity (Beauchaine, 2015).”
Background
Metadata
- Authors
- Beauchaine, T. P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Beauchaine, Theodore P
- Venue
- Current Opinion in Psychology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 3
- Pages
- 43-47
- ISSN
- 2352-250X (ISSN-L)
- PMC
- PMC4389219
- OpenAlex
- W2008969489
- Cited by
- 529
- References
- 50
- Citations by year
- 2026: 52 · 2025: 51 · 2024: 47 · 2023: 53 · 2022: 47 · 2021: 79 · 2020: 63 · 2019: 47 · 2018: 36 · 2017: 28 · 2016: 17 · 2015: 8
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Psychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH063699)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- respiratory sinus arrhythmia, emotion regulation, parasympathetic nervous system, emotional dysregulation, psychopathology, internalizing disorders, externalizing disorders, anxiety, autism spectrum disorder, depression, non-suicidal self-injury, panic disorder, trait hostility, prefrontal cortex dysfunction, executive function, peripheral biomarkers
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