Psychological, autonomic, and serotonergic correlates of parasuicide among adolescent girls
Abstract
Although parasuicidal behavior in adolescence is poorly understood, evidence suggests that it may be a developmental precursor of borderline personality disorder (BPD). Current theories of both parasuicide and BPD suggest that emotion dysregulation is the primary precipitant of self-injury, which serves to dampen overwhelmingly negative affect. To date, however, no studies have assessed endophenotypic markers of emotional responding among parasuicidal adolescents. In the present study, we compare parasuicidal adolescent girls (n=23) with age-matched controls (n=23) on both psychological and physiological measures of emotion regulation and psychopathology. Adolescents, parents, and teachers completed questionnaires assessing internalizing and externalizing psychopathology, substance use, trait affectivity, and histories of parasuicide. Psychophysiological measures including electrodermal responding (EDR), respiratory sinus arrhythmia, and cardiac pre-ejection period (PEP) were collected at baseline, during negative mood induction, and during recovery. Compared with controls, parasuicidal adolescents exhibited reduced respiratory sinus arrhythmia (RSA) at baseline, greater RSA reactivity during negative mood induction, and attenuated peripheral serotonin levels. No between-group differences on measures of PEP or EDR were found. These results lend further support to theories of emotion dysregulation and impulsivity in parasuicidal teenage girls.
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In an early concurrent study, 23 adolescent females aged 14-18 with a history of suicidal behavior or NSSI, or both, showed lower resting RSA and excessive RSA withdrawal following evocative stimuli compared with controls.
“23 adolescent females aged 14 to 18 years with a history of suicidal behavior or NSSI, or both, evinced lower resting RSA and excessive RSA withdrawal (i.e., greater release of SNS suppression) following exposure to evocative stimuli compared with controls (N = 23, ages 14–18 years) (Crowell et al. 2005)”
From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Crowell et al. 2005
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- Authors
- CROWELL, S. E., BEAUCHAINE, T. P., McCAULEY, E., SMITH, C. J., STEVENS, A. L., & SYLVERS, P.
- Affiliations
- University of Washington (US)
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-12
- Volume
- 17
- Issue
- 4
- Pages
- 1105-1127
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- OpenAlex
- W2167504416
- Cited by
- 229
- References
- 13
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 12 · 2023: 19 · 2022: 11 · 2021: 11 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 16 · 2016: 18 · 2015: 18 · 2014: 17 · 2013: 11 · 2012: 10
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH063699)
- National Center for Research Resources (M01RR000037)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- parasuicide, adolescent girls, emotional dysregulation, self-harm, borderline personality disorder, serotonin, respiratory sinus arrhythmia, electrodermal activity, negative mood induction, impulsivity, internalizing psychopathology, endophenotypes
- MeSH terms
- Adolescent, Arousal, Autonomic Nervous System, Borderline Personality Disorder, Emotions, Female, Humans, Impulsive Behavior, Internal-External Control, Personality Assessment, Psychometrics, Reference Values, Risk Factors, Serotonin, Statistics as Topic, Suicide, Attempted, Comorbidity, Self-Injurious Behavior, Substance-Related Disorders
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