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A critical review of the empirical literature on the relation between anxiety and puberty
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The current paper critically reviews the empirical literature focused on the association between puberty and anxiety. A detailed review of more than 45 empirical articles is provided. There is some evidence that among girls, but not boys, a more advanced pubertal status (controlling for age) is associated with higher reported anxiety symptoms. Also among girls, earlier pubertal timing is linked to higher anxiety scores. It is unclear whether early puberty may lead to increased anxiety or if high anxiety influences pubertal timing. With respect to hormones, there were relatively few significant associations for girls, although this literature is very small. Among boys, several studies reported positive associations between both gonadal and adrenal hormones and anxiety. The direction of effect for these finding is also unstudied. The primary limitation of the hormone-anxiety literature pertains to the absence of pubertal measures in samples of youth in which hormones are measured. The paper concludes with a comprehensive examination of the methodological strengths and weaknesses of the literature and recommendations for future work.
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“It is known that human adolescent development is associated with increased anxiety and depression (23).”
From Puberty Blocker, Leuprolide, Reduces Sex Differences in Rough-and-Tumble Play and Anxiety-like Behavior in Juvenile Rats (2024) · cites this paper as [23]
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Self-citation
Metadata
- Authors
- Reardon, L. E., Leen-Feldner, E. W., & Hayward, C.
- Affiliations
- University of Arkansas at Fayetteville (US)
- Stanford University (US)
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 29
- Issue
- 1
- Pages
- 1-23
- ISSN
- 0272-7358 (ISSN-L)
- PMC
- PMC2652567
- OpenAlex
- W1999235562
- Cited by
- 197
- References
- 202
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 15 · 2023: 11 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 14 · 2017: 19 · 2016: 8 · 2015: 12 · 2014: 16 · 2013: 9 · 2012: 13
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Psychology Review (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R03MH077692)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- puberty, anxiety, pubertal timing, precocious puberty, sex differences, gonadal hormones, adrenal hormones, anxiety symptoms, adolescent development
- MeSH terms
- Adolescent, Anxiety Disorders, Child, Depressive Disorder, Female, Humans, Interpersonal Relations, Male, Puberty, Panic Disorder
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