Anxiety Disorders Among Women: A Female Lifespan Approach
Open accessAbstract
Anxiety symptoms may present differently between women and men, and at different points in the female lifespan. The female lifespan includes distinct epochs of hormonal function, including puberty, the premenstruum, in some women pregnancy or postpartum, and the menopausal transition. These stages give rise to important treatment considerations when treating anxiety in women. When making assessments, the clinician should consider reproductive events and hormonal status, as well as sex differences in anxiety presentation. This review is structured to: 1) Define major epochs of the female lifespan, 2) Provide a brief summary of the major anxiety disorders, with a focus on prevalence and presentation in the context of sex differences and at points in the female lifespan, 3) Describe potential biopsychosocial underpinnings of anxiety disorders among women, 4) Provide guidelines for assessment and differential diagnosis, and 5) Describe treatment options with attention to reproductive events such as pregnancy.
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Rumination, neuroticism, behavioral inhibition, worry, anxiety sensitivity, trauma, and low self-esteem correlated positively with anxiety, with all variables being typical of the female stereotype.
“Such studies showed that rumination, neuroticism, behavioral inhibition, worry, anxiety sensitivity, trauma, and low self-esteem correlated positively with anxiety, with all variables being typical of the female stereotype.33,44,51,55,65,73”
From Factors associated with gender and sex differences in anxiety prevalence and comorbidity: A systematic review (2022) · cites this paper as [65]
The Biopsychosocial Underpinnings and Coping and Cognitive Styles sections link rumination, worry, anxiety sensitivity, and traumatic stress to anxiety symptoms or disorders in women and girls (page numbers unavailable). They do not establish positive correlations for every listed variable or describe all the variables as typical of a female stereotype; neuroticism, behavioral inhibition, and low self-esteem are not addressed in the relevant text. (LLM, conf=0.87)
Experimental — accuracy not yet measuredOf the 44 documents, 31 were empirical/quantitative studies and 13 were reviews.
“Of the 44 documents, 31 were empirical/quantitative studies30–60 and 13 were reviews.61–73”
From Factors associated with gender and sex differences in anxiety prevalence and comorbidity: A systematic review (2022) · cites this paper as [65]
Rumination is a salient risk factor for women observed from the review.
“some of the most salient risk factors for women observed from our review were rumination33,44,49,65,73 and anxiety sensitivity.51,55,57,65”
From Factors associated with gender and sex differences in anxiety prevalence and comorbidity: A systematic review (2022) · cites this paper as [65]
Anxiety sensitivity is a salient risk factor for women observed from the review.
“some of the most salient risk factors for women observed from our review were rumination33,44,49,65,73 and anxiety sensitivity.51,55,57,65”
From Factors associated with gender and sex differences in anxiety prevalence and comorbidity: A systematic review (2022) · cites this paper as [65]
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Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
Posttraumatic Stress Disorder in the National Comorbidity Survey
Kessler, R. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240066012 · Cited by 10,379 · see citing works
Prevalence and development of psychiatric disorders in childhood and adolescence
Costello, E. J., Mustillo, S., Erkanli, A., Keeler, G., & Angold, A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.837 · Cited by 4,035 · see citing works
McLean, C. P., Asnaani, A., Litz, B. T., & Hofmann, S. G. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.006 · Cited by 2,519 · see citing works
Epidemiology of anxiety disorders in the 21st century
Bandelow, B., & Michaelis, S. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/bbandelow · Cited by 2,079 · see citing works
Anxiety and its disorders : the nature and treatment of anxiety and panic
Barlow, D. (1988) · doi:10.1097/00005053-200306000-00023 · Cited by 2,059
Identifying the women at risk of antenatal anxiety and depression: a systematic review
Biaggi, A., Conroy, S., Pawlby, S., & Pariante, C. M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.014 · Cited by 1,657 · see citing works
Sex differences in anxiety and depression clinical perspectives
Altemus, M., Sarvaiya, N., & Neill Epperson, C. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.004 · Cited by 1,413 · see citing works
Self-citationEmotion Regulation and Psychopathology: The Role of Gender
Nolen–Hoeksema, S. (2012) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032511-143109 · Cited by 1,276 · see citing works
Comorbidity of anxiety and depression in children and adolescents: 20 years after
Cummings, C. M., Caporino, N. E., & Kendall, P. C. (2014) · Psychological Bulletin · doi:10.1037/a0034733 · Cited by 1,028 · see citing works
Sex Differences in Adolescent Depression: Stress Exposure and Reactivity Models
Hankin, B. L., Mermelstein, R., & Roesch, L. (2007) · Child Development · doi:10.1111/j.1467-8624.2007.00997.x · Cited by 810 · see citing works
Grigoriadis, S., VonderPorten, E. H., Mamisashvili, L., Tomlinson, G., Dennis, C.-L., Koren, G., Steiner, M., Mousmanis, P., Cheung, A., Radford, K., et al. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07968 · Cited by 797 · see citing works
Schmidt, P. J., Nieman, L. K., Danaceau, M. A., Adams, L. F., & Rubinow, D. R. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801223380401 · Cited by 765 · see citing works
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751 · see citing works
Self-citationComorbidity of anxiety and depression in children and adolescents
Brady, E. U., & Kendall, P. C. (1992) · Psychological Bulletin · doi:10.1037/0033-2909.111.2.244 · Cited by 748 · see citing works
Sex differences in stress-related psychiatric disorders: neurobiological perspectives
Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737 · see citing works
Soares, C. N., Almeida, O., Joffe, H., & Cohen, L. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.529 · Cited by 715 · see citing works
Michl, L. C., McLaughlin, K. A., Shepherd, K., & Nolen-Hoeksema, S. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0031994 · Cited by 694 · see citing works
Association of Hormonal Contraception With Depression
Skovlund, C. W., Mørch, L. S., Kessing, L. V., & Lidegaard, Ø. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2387 · Cited by 675 · see citing works
Craske, M. G., & Stein, M. B. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30381-6 · Cited by 640 · see citing works
Anxiety Disorders During Pregnancy and the Postpartum Period: A Systematic Review
Ross, L. E., & McLean, L. M. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0818 · Cited by 611 · see citing works
O'Connor, T., Heron, J., & Glover, V. (2002) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-200212000-00019 · Cited by 611 · see citing works
Grant, B. F., Hasin, D. S., Blanco, C., Stinson, F. S., Chou, S. P., Goldstein, R. B., Dawson, D. A., Smith, S., Saha, T. D., & Huang, B. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1102 · Cited by 601 · see citing works
Back to the future: The organizational-activational hypothesis adapted to puberty and adolescence
Schulz, K. M., Molenda-Figueira, H. A., & Sisk, C. L. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.010 · Cited by 587 · see citing works
Ding, X.-X., Wu, Y.-L., Xu, S.-J., Zhu, R.-P., Jia, X.-M., Zhang, S.-F., Huang, K., Zhu, P., Hao, J.-H., & Tao, F.-B. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.02.027 · Cited by 560 · see citing works
Prevalence, incidence and stability of premenstrual dysphoric disorder in the community
WITTCHEN, H.-U., BECKER, E., LIEB, R., & KRAUSE, P. (2002) · Psychological Medicine · doi:10.1017/s0033291701004925 · Cited by 554 · see citing works
Gender and age differences in the prevalence of specific fears and phobias
Fredrikson, M., Annas, P., Fischer, H., & Wik, G. (1996) · Behaviour Research and Therapy · doi:10.1016/0005-7967(95)00048-3 · Cited by 548 · see citing works
Gleason, C. E., Dowling, N. M., Wharton, W., Manson, J. E., Miller, V. M., Atwood, C., Brinton, E. A., Cedars, M. I., Løbo, R. A., Merriam, G. R., et al. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001833 · Cited by 495 · see citing works
Daily Record of Severity of Problems (DRSP): reliability and validity
Endicott, J., Nee, J., & Harrison, W. M. (2005) · Archives of Women s Mental Health · doi:10.1007/s00737-005-0103-y · Cited by 483 · see citing works
Phase III Evaluation of Fluoxetine for Treatment of Hot Flashes
Loprinzi, C. L., Sloan, J. A., Perez, E. A., Quella, S. K., Stella, P. J., Mailliard, J. A., Halyard, M. Y., Pruthi, S., Novotny, P. J., & Rummans, T. A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.6.1578 · Cited by 473 · see citing works
Yonkers, K. A., Wisner, K. L., Stewart, D. E., Oberlander, T. F., Dell, D. L., Stotland, N., Ramin, S., Chaudron, L., & Lockwood, C. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.04.003 · Cited by 469 · see citing works
Gorey, K., & Leslie, D. R. (1997) · International Journal of Child Abuse & Neglect · doi:10.1016/s0145-2134(96)00180-9 · Cited by 463 · see citing works
The persisting effect of maternal mood in pregnancy on childhood psychopathology
O'Donnell, K. J., Glover, V., Barker, E. D., & O'Connor, T. G. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000029 · Cited by 425 · see citing works
Pregnant women with posttraumatic stress disorder and risk of preterm birth
Yonkers, K. A., Smith, M. V., Forray, A., Epperson, C. N., Costello, D., Lin, H., & Belanger, K. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.558 · Cited by 331 · see citing works
Self-citationThe Perinatal Anxiety Screening Scale: Development and preliminary validation
Somerville, S., Dedman, K., Hagan, R., Oxnam, E., Wettinger, M., Byrne, S., Coo, S., Doherty, D., & Page, A. C. (2014) · Archives of Women's Mental Health · doi:10.1007/s00737-014-0425-8 · Cited by 302 · see citing works
O’Brien, P. M. S., Bäckström, T. C., Brown, C., Dennerstein, L., Endicott, J., Epperson, C. N., Eriksson, E., Freeman, E. W., Halbreich, U. M., ISMAIL, K. M. K., et al. (2011) · Archives of Women s Mental Health · doi:10.1007/s00737-010-0201-3 · Cited by 302 · see citing works
Self-citationLebrón‐Milad, K., & Milad, M. R. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-3 · Cited by 298 · see citing works
Bromberger, J. T., Kravitz, H. M., Chang, Y., Randolph, J. F., Avis, N. E., Gold, E. B., & Matthews, K. A. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182730599 · Cited by 296 · see citing works
Premenstrual Dysphoric Disorder: Epidemiology and Treatment
Hantsoo, L., & Epperson, C. N. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0628-3 · Cited by 278 · see citing works
Self-citationOral contraceptives containing drospirenone for premenstrual syndrome
Lopez, L. M., Kaptein, A. A., & Helmerhorst, F. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006586.pub4 · Cited by 275 · see citing works
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression
Schmidt, P. J., Dor, R. R. B., Martinez, P. E., Guerrieri, G. M., Harsh, V., Thompson, K., Koziol, D. E., Nieman, L. K., & Rubinow, D. R. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0111 · Cited by 265 · see citing works
Anxiety Disorders During Pregnancy: A Systematic Review
Goodman, J. H., Chenausky, K. L., & Freeman, M. P. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14r09035 · Cited by 258 · see citing works
Vesga-López, O., Schneier, F., Wang, S., Heimberg, R., Liu, S.-M., Hasin, D., & Blanco, C. (2008) · Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n1011 · Cited by 253 · see citing works
Gracia, C., Sammel, M., Freeman, E., Lin, H., Langan, E., Kapoor, S., & Nelson, D. B. (2005) · Menopause · doi:10.1097/00042192-200512020-00005 · Cited by 250 · see citing works
Rubinow, D. R., Hoban, M. C., Grover, G. N., Galloway, D. S., Roy-Byrne, P., Andersen, R., & Merriam, G. R. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90765-x · Cited by 235 · see citing works
Romeo, R. D. (2003) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2003.01106.x · Cited by 233 · see citing works
Räisänen, S., Lehto, S. M., Nielsen, H. S., Gissler, M., Kramer, M. R., & Heinonen, S. T. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-004883 · Cited by 222 · see citing works
Cesta, C. E., Månsson, M., Palm, C., Lichtenstein, P., Iliadou, A. N., & Landén, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.005 · Cited by 217 · see citing works
Allopregnanolone and mood disorders
Bäckström, T. C., Bixo, M., Johansson, M., Nyberg, S., Ossewaarde, L., Ragagnin, G., Savić, I., Strömberg, J., Timby, E., van Broekhoven, F., et al. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.07.005 · Cited by 212 · see citing works
Dokras, A., Clifton, S., Futterweit, W., & Wild, R. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.10.022 · Cited by 209 · see citing works
Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms
Kim, D. R., Bale, T. L., & Epperson, C. N. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-014-0546-9 · Cited by 203 · see citing works
Self-citationHankin, B. (2009) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374410902976288 · Cited by 203 · see citing works
A critical review of the empirical literature on the relation between anxiety and puberty
Reardon, L. E., Leen-Feldner, E. W., & Hayward, C. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2008.09.005 · Cited by 197 · see citing works
Joffe, H., Guthrie, K. A., LaCroix, A. Z., Reed, S. D., Ensrud, K. E., Manson, J. E., Newton, K. M., Freeman, E. W., Anderson, G. L., Larson, J. C., et al. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.1891 · Cited by 194 · see citing works
Mechanisms of estradiol in fear circuitry: implications for sex differences in psychopathology
Cover, K. K., Maeng, L. Y., Lebrón‐Milad, K., & Milad, M. R. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.67 · Cited by 193 · see citing works
Pregnancy anxiety: A systematic review of current scales
Brunton, R., Dryer, R., Saliba, A. J., & Kohlhoff, J. R. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.039 · Cited by 182 · see citing works
Selective serotonin reuptake inhibitors for premenstrual syndrome.
Marjoribanks, J., Brown, J., O'Brien, P., & Wyatt, K. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001396.pub3 · Cited by 180 · see citing works
Update on Research and Treatment of Premenstrual Dysphoric Disorder
Cunningham, J., Yonkers, K. A., O’Brien, S., & Eriksson, E. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902891836 · Cited by 180 · see citing works
Xu, Y., Schneier, F., Heimberg, R., Princisvalle, K., Liebowitz, M., Wang, S., & Blanco, C. (2012) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2011.08.006 · Cited by 172 · see citing works
The Postpartum Specific Anxiety Scale: development and preliminary validation
Fallon, V., Halford, J., Bennett, K., & Harrold, J. (2016) · Archives of Women's Mental Health · doi:10.1007/s00737-016-0658-9 · Cited by 171 · see citing works
Clinical management of perinatal anxiety disorders: A systematic review
Marchesi, C., Ossola, P., Amerio, A., Daniel, B. D., Tonna, M., & Panfilis, C. D. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.004 · Cited by 171 · see citing works
Menstrual-Related Problems and Psychological Distress among Women in the United States
Strine, T. W., Chapman, D. P., & Ahluwalia, I. B. (2005) · Journal of Women s Health · doi:10.1089/jwh.2005.14.316 · Cited by 168 · see citing works
Reed, V., & Wittchen, H. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00014-4 · Cited by 162 · see citing works
Dokras, A., Sarwer, D. B., Allison, K. C., Milman, L., Kris-Etherton, P. M., Kunselman, A. R., Stetter, C. M., Williams, N. I., Gnatuk, C. L., Estes, S. J., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1896 · Cited by 161 · see citing works
Gender differences in panic disorder: findings from the National Comorbidity Survey.
Sheikh, J., Leskin, G., & Klein, D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.55 · Cited by 152 · see citing works
Charney, D., Woods, S., Krystal, J., Nagy, L., & Heninger, G. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb03266.x · Cited by 148 · see citing works
Martinez, P. E., Rubinow, D. R., Nieman, L. K., Koziol, D. E., Morrow, A. L., Schiller, C. E., Cintrón-López, D., Thompson, K., Khine, K., & Schmidt, P. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.246 · Cited by 147 · see citing works
Childhood Abuse and Age at Menarche
Boynton‐Jarrett, R., Wright, R. J., Putnam, F. W., Hibert, E. N. L., Michels, K. B., Forman, M. R., & Rich-Edwards, J. W. (2012) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2012.06.006 · Cited by 145 · see citing works
Gingnell, M., Engman, J., Frick, A., Moby, L., Wikström, J., Fredrikson, M., & Poromaa, I. S. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.006 · Cited by 143 · see citing works
Perinatal Generalized Anxiety Disorder: Assessment and Treatment
Misri, S. K., Abizadeh, J., Sanders, S., & Swift, E. (2015) · Journal of Women s Health · doi:10.1089/jwh.2014.5150 · Cited by 143 · see citing works
Reduced benzodiazepine sensitivity in patients with premenstrual syndrome: a pilot study.
Sundström, I., Ashbrook, D., & Bäckström, T. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(96)00035-2 · Cited by 133 · see citing works
Soares, C. N., Arsenio, H., Joffe, H., Bankier, B., Cassano, P., Petrillo, L., & Cohen, L. (2006) · Menopause · doi:10.1097/01.gme.0000240633.46300.fa · Cited by 132 · see citing works
Shah, N., Jones, J. B., Aperi, J., Shemtov, R., Karne, A., & Borenstein, J. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31816fd73b · Cited by 130 · see citing works
Mood and anxiety disorders in women with PCOS.
Dokras, A. (2012) · Steroids · doi:10.1016/j.steroids.2011.12.008 · Cited by 128 · see citing works
Pubertal stage and panic attack history in sixth- and seventh-grade girls.
Hayward, C., Killen, J., Hammer, L. D., Litt, I., Wilson, D. M., Simmonds, B., & Taylor, C. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1239 · Cited by 128 · see citing works
Juang, K., Wang, S., Lu, S., Lee, S., & Fuh, J. (2005) · Maturitas · doi:10.1016/j.maturitas.2005.01.005 · Cited by 128 · see citing works
Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs.
Epperson, N., Czarkowski, K. A., Ward-O’Brien, D., Weiss, E. L., Gueorguieva, R., Jatlow, P., & Anderson, G. M. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1631 · Cited by 126 · see citing works
Generalized Anxiety Disorder: Course and Risk Factors in Pregnancy
Buist, A., Gotman, N., & Yonkers, K. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.01.003 · Cited by 118 · see citing works
Oral contraceptives and premenstrual symptoms: comparison of a 21/7 and extended regimen.
Coffee, A. L., Kuehl, T., Willis, S., & Sulak, P. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.05.012 · Cited by 118 · see citing works
Carter, R., Silverman, W. K., & Jaccard, J. J. (2011) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2011.597082 · Cited by 111 · see citing works
Hunter, M. (2000) · Quality of Life Research · doi:10.1023/a:1008973822876 · Cited by 109 · see citing works
Premenstrual dysphoric disorder and psychiatric co-morbidity
Kim, D. R., Gyulai, L., Freeman, E. W., Morrison, M. F., Baldassano, C. F., & Dub�, B. (2004) · Archives of Women s Mental Health · doi:10.1007/s00737-003-0027-3 · Cited by 108 · see citing works
Panic Disorder, Phobias, and Generalized Anxiety Disorder
Craske, M. G., & Waters, A. M. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143857 · Cited by 106 · see citing works
Developmental sex differences in resting state functional connectivity of amygdala sub-regions
Alarcón, G., Cservenka, A., Rudolph, M. D., Fair, D. A., & Nagel, B. J. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.013 · Cited by 105 · see citing works
Salmela-Aro, K., Read, S., Rouhe, H., Halmesmäki, E., Toivanen, R., Tokola, M., & Saisto, T. (2012) · Journal of Health Psychology · doi:10.1177/1359105311421050 · Cited by 95 · see citing works
Ismaili, E., Walsh, S., O'Brien, P., Bäckström, T., Brown, C. S., Dennerstein, L., Eriksson, E., Freeman, E., Ismail, K., Panay, N., et al. (2016) · Archives of Women's Mental Health · doi:10.1007/s00737-016-0631-7 · Cited by 90 · see citing works
Self-citationNillni, Y., Toufexis, D., & Rohan, K. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.07.006 · Cited by 87 · see citing works
Detecting the severity of perinatal anxiety with the Perinatal Anxiety Screening Scale (PASS).
Somerville, S., Byrne, S. L., Dedman, K., Hagan, R., Coo, S., Oxnam, E., Doherty, D., Cunningham, N. K., & Page, A. C. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.07.012 · Cited by 83 · see citing works
Epperson, C., Jatlow, P., Czarkowski, K. A., & Anderson, G. (2003) · Pediatrics · doi:10.1542/peds.112.5.e425 · Cited by 80 · see citing works
Self-citationEFFICACY OF ESTRADIOL IN PERIMENOPAUSAL DEPRESSION: SO MUCH PROMISE AND SO FEW ANSWERS
Rubinow, D., Johnson, S., Schmidt, P. J., Girdler, S., & Gaynes, B. (2015) · Depression and Anxiety · doi:10.1002/da.22391 · Cited by 79 · see citing works
Hong, J., Park, S., Wang, H., Chang, S.-M., Sohn, J., Jeon, H., Lee, H., Cho, S.-J., Kim, B.-S., Bae, J., et al. (2012) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-012-0509-6 · Cited by 77 · see citing works
Safety of Selective Serotonin Reuptake Inhibitors in Pregnancy: A Review of Current Evidence
Alwan, S. S., Friedman, J. M., & Chambers, C. (2016) · CNS Drugs · doi:10.1007/s40263-016-0338-3 · Cited by 75 · see citing works
Sigmon, S. T., Dorhofer, D. M., Rohan, K., & Boulard, N. (2000) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(00)00054-2 · Cited by 71 · see citing works
Brief Scales to Detect Postpartum Depression and Anxiety Symptoms
O'Hara, M., Stuart, S., Watson, D., Dietz, P., Farr, S., & D'Angelo, D. V. (2012) · Journal of Women's Health · doi:10.1089/jwh.2012.3612 · Cited by 70 · see citing works
Premenstrual symptoms and premenstrual exacerbation in patients with psychiatric disorders
Hsiao, M.-C., Hsiao, C.-C., & Liu, C.-Y. (2004) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2003.01215.x · Cited by 70 · see citing works
Anxiety and the menstrual cycle in panic disorder.
Cook, B., Russell, N., Garvey, M., Beach, V., Sobotka, J., & Chaudhry, D. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90095-p · Cited by 68 · see citing works
Marshall, A. D. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.10.004 · Cited by 67 · see citing works
Social anxiety in childhood: Bridging developmental and clinical perspectives
Gazelle, H., & Rubin, K. H. (2010) · New Directions for Child and Adolescent Development · doi:10.1002/cd.259 · Cited by 64 · see citing works
Prenoveau, J., Craske, M., Counsell, N., West, V., Davies, B., Cooper, P., Rapa, E., & Stein, A. (2013) · Depression and Anxiety · doi:10.1002/da.22040 · Cited by 62 · see citing works
Elevated Social Anxiety among Early Maturing Girls
Blumenthal, H., Leen-Feldner, E. W., Babson, K., Gahr, J. L., Trainor, C. D., & Frala, J. L. (2011) · Developmental Psychology · doi:10.1037/a0024008 · Cited by 62 · see citing works
Yonkers, K., Kornstein, S., Gueorguieva, R., Merry, B., Steenburgh, K. V., & Altemus, M. (2015) · JAMA psychiatry · doi:10.1001/jamapsychiatry.2015.1472 · Cited by 60 · see citing works
Clinical features, prevalence and psychiatric complaints in subjects with fear of vomiting.
van Hout, W., & Bouman, T. (2012) · Clinical Psychology and Psychotherapy · doi:10.1002/cpp.761 · Cited by 60 · see citing works
Stein, M. B., Schmidt, P., Rubinow, D., & Uhde, T. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.10.1299 · Cited by 60 · see citing works
Segebladh, B., Borgström, A., Odlind, V., Bixo, M., & Sundström-Poromaa, I. (2009) · Contraception · doi:10.1016/j.contraception.2008.08.001 · Cited by 59 · see citing works
The Effects of Female Reproductive Hormones in Generalized Social Anxiety Disorder
van Veen, J. F., Jonker, B., van Vliet, I. V., & Zitman, F. G. (2009) · International Journal of Psychiatry in Medicine · doi:10.2190/pm.39.3.e · Cited by 57 · see citing works
Pagliaccio, D., Luby, J. L., Bogdan, R., Arpana Agrawal, A., Gaffrey, M. S., Belden, A. C., Botteron, K. N., Harms, M. P., & Barch, D. M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.017 · Cited by 55 · see citing works
Gender–age interaction in incidence rates of childhood emotional disorders
Wesselhoeft, R., Pedersen, C. B., Mortensen, P. B., Mors, O., & Bilenberg, N. (2015) · Psychological Medicine · doi:10.1017/s0033291714001901 · Cited by 52 · see citing works
Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder.
Brambilla, F., Mellado, C., Alciati, A., Pisu, M., Purdy, R., Zanone, S., Perini, G., Serra, M., & Biggio, G. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2005.08.001 · Cited by 50
Lavigne, J., Heckler, C., Mathews, J., Palesh, O., Kirshner, J., Lord, R. S., Jacobs, A., Amos, E., Morrow, G., & Mustian, K. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2251-x · Cited by 49 · see citing works
Computer-assisted cognitive behavioral therapy for pregnant women with major depressive disorder
Kim, D. R., Hantsoo, L., Thase, M. E., Sammel, M., & Epperson, C. N. (2014) · Journal of Women's Health · doi:10.1089/jwh.2014.4867 · Cited by 42 · see citing works
Self-citationAşık, M., Altınbaş, K., Eroğlu, M., Karaahmet, E., Erbag, G., Ertekin, H., & Şen, H. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.043 · Cited by 41 · see citing works
Pregnancy outcomes among women with panic disorder — Do panic attacks during pregnancy matter?
Chen, Y., Lin, H., & Lee, H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.025 · Cited by 41 · see citing works
The influence of gender on social anxiety spectrum symptoms in a sample of university students
Dell'Osso, L., Abelli, M., Pini, S., Carpita, B., Carlini, M., Mengali, F., Tognetti, R., Rivetti, F., & Massimetti, G. (2015) · Rivista di Psichiatria · doi:10.1708/2098.22688 · Cited by 40 · see citing works
Oral contraceptives and neuroactive steroids.
Rapkin, A., Biggio, G., & Concas, A. (2006) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2006.06.008 · Cited by 40 · see citing works
LaCroix, A., Freeman, E., Larson, J. C., Carpenter, J., Joffe, H., Reed, S., Newton, K., Seguin, R. A., Sternfeld, B., Cohen, L., et al. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.09.006 · Cited by 38 · see citing works
Diagnosis and Treatment of Anxiety in the Aging Woman
Siegel, A. M., & Mathews, S. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0636-3 · Cited by 34 · see citing works
Review: Puberty as a time of remodeling the adult response to ovarian hormones
Blaustein, J. D., Ismail, N., & Holder, M. K. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.05.007 · Cited by 30 · see citing works
Obstetric and perinatal outcomes among women with blood- and injection phobia during pregnancy.
Lilliecreutz, C., Sydsjö, G., & Josefsson, A. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.08.013 · Cited by 28 · see citing works
Pincus, S. M., Alam, S., Rubinow, D. R., Bhuvaneswar, C. G., & Schmidt, P. J. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.07.006 · Cited by 28 · see citing works
Gerber, M., King, M., Pineles, S., Stirman, S. W., Bean-Mayberry, B., Japuntich, S. J., & Haskell, S. (2015) · Journal of general internal medicine · doi:10.1007/s11606-014-3073-9 · Cited by 27 · see citing works
Risk factors for panic disorder in pregnancy: a cohort study.
Marchesi, C., Ampollini, P., Paraggio, C., Giaracuni, G., Ossola, P., Panfilis, C. D., Tonna, M., & Viviani, D. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.12.006 · Cited by 26 · see citing works
Is premenstrual dysphoria a variant of panic disorder? A review.
Vickers, K., & McNally, R. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.08.001 · Cited by 26 · see citing works
Pregnancy outcomes in women with severe needle phobia.
McAllister, N., Elshtewi, M., Badr, L., Russell, I., & Lindow, S. (2012) · European Journal of Obstetrics, Gynecology, and Reproductive Biology · doi:10.1016/j.ejogrb.2012.02.019 · Cited by 23
Psychotropic medications and other non-hormonal treatments for premenstrual disorders
Pearlstein, T. (2012) · Menopause International · doi:10.1258/mi.2012.012010 · Cited by 22 · see citing works
The development of worry throughout childhood: Avon Longitudinal Study of Parents and Children data
Caes, L., Fisher, E., Clinch, J., Tobias, J. H., & Eccleston, C. (2015) · British Journal of Health Psychology · doi:10.1111/bjhp.12174 · Cited by 21 · see citing works
Premenstrual Syndrome and Anxiety Disorders: A Psychobiological Link
Facchinetti, F., Tarabusi, M., & Nappi, G. (1998) · Psychotherapy and Psychosomatics · doi:10.1159/000012260 · Cited by 20 · see citing works
Gaysina, D., Richards, M., Kuh, D. J., & Hardy, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579414001448 · Cited by 19 · see citing works
Prevalence of blood and injection phobia among pregnant women
LILLIECREUTZ, C., & JOSEFSSON, A. (2008) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340802468324 · Cited by 16 · see citing works
Recurrence of Panic Disorder During Pregnancy: A 7-Year Naturalistic Follow-up Study
Dannon, P., Iancu, I., Lowengrub, K., Grunhaus, L., & Kotler, M. (2006) · Clinical neuropharmacology · doi:10.1097/01.wnf.0000220821.73017.14 · Cited by 15
The role of perceived control over anxiety in prospective symptom reports across the menstrual cycle
Mahon, J. N., Rohan, K., Nillni, Y., & Zvolensky, M. J. (2014) · Archives of Women's Mental Health · doi:10.1007/s00737-014-0456-1 · Cited by 14 · see citing works
Koyuncu, A., Ertekin, E., Deveci, E., Ertekin, B., Yüksel, Ç., Çelebi, F., Binbay, Z., Demir, E., & Tükel, R. (2015) · Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · doi:10.1177/104012371502700202 · Cited by 13 · see citing works
Course of panic disorder during the early postpartum period: a prospective analysis.
Guler, O., Köken, G., Emul, M., Ozbulut, O., Geçici, O., Uğuz, F., Gezginc, K., Zeytinci, I. E., Karatayli, S., & Askin, R. (2008) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2007.06.007 · Cited by 13 · see citing works
Current update of hormonal and psychotropic drug treatment of premenstrual dysphoric disorder
Freeman, E. W. (2002) · Current Psychiatry Reports · doi:10.1007/s11920-002-0071-0 · Cited by 10 · see citing works
Anxiety sensitivity: Changes with puberty and cardiovascular variables
Akça, Ö., Vural, T. A., Türkoğlu, S., & Kılıç, E. (2015) · Pediatrics International · doi:10.1111/ped.12443 · Cited by 7 · see citing works
Patel, R. R., & Hollins, K. (2015) · Journal of Psychosomatic Obstetrics and Gynaecology · doi:10.3109/0167482x.2014.993312 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 32
- [2]Craske MG Rauch SL Ursano R Prenoveau J Pine DS Zinbarg RE What is an anxiety disorder? Depress Anxiety 2009 26 1066 1085 19957279
- [3]Craske MG Stein MB Anxiety Lancet Lond Engl 2016 27349358
- [8]Huerta R Brizuela-Gamiño OL Interaction of pubertal status, mood and self-esteem in adolescent girls J Reprod Med 2002 47 217 225 11933687
- [18]Epperson CN Steiner M Hartlage SA Eriksson E Schmidt PJ Jones I Yonkers KA Premenstrual dysphoric disorder: evidence for a new category for DSM-5 Am J Psychiatry 2012 169 465 475 22764360 PMC3462360
- [31]Freeman EW Sammel MD Anxiety as a risk factor for menopausal hot flashes: evidence from the Penn Ovarian Aging cohort Menopause N Y 2016 PMC4993654 27433864
- [32]Hanisch LJ Hantsoo L Freeman EW Sullivan GM Coyne JC Hot flashes and panic attacks: A comparison of symptomatology, neurobiology, treatment, and a role for cognition Psychol Bull 2008 134 247 269 18298271
- [46]Leen-Feldner EW Reardon LE Zvolensky MJ Pubertal Status and Emotional Reactivity to a Voluntary Hyperventilation Challenge Predicting Panic Symptoms and Somatic Complaints A Laboratory-Based Multi-Informant Test Behav Modif 2007 31 8 31 17179529
- [52]Sholomskas DE Wickamaratne PJ Dogolo L O’Brien DW Leaf PJ Woods SW Postpartum onset of panic disorder: a coincidental event? J Clin Psychiatry 1993 54 476 480 8276738
- [58]Claudia P Andrea C Chiara C Stefano L Giuseppe M Vincenzo DL Felice P Paolo C Panic disorder in menopause: a case control study Maturitas 2004 48 147 154 15172089
- [60]Freedman RR Woodward S Sabharwal SC Alpha 2-adrenergic mechanism in menopausal hot flushes Obstet Gynecol 1990 76 573 578 2170883
- [62]Stinson FS Dawson DA Patricia Chou S Smith S Goldstein RB June Ruan W Grant BF The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions Psychol Med 2007 37 1047 1059 17335637
- [69]Sydsjö G Sydsjö A Gunnervik C Bladh M Josefsson A Obstetric outcome for women who received individualized treatment for fear of childbirth during pregnancy Acta Obstet Gynecol Scand 2012 91 44 49 21787365
- [78]Reynolds BM Juvonen J Pubertal timing fluctuations across middle school: implications for girls’ psychological health J Youth Adolesc 2012 41 677 690 21706259 PMC3217169
- [79]Deardorff J Hayward C Wilson KA Bryson S Hammer LD Agras S Puberty and gender interact to predict social anxiety symptoms in early adolescence J Adolesc Health Off Publ Soc Adolesc Med 2007 41 102 104 PMC2710300 17577541
- [98]Derry HM Padin AC Kuo JL Hughes S Kiecolt-Glaser JK Sex Differences in Depression: Does Inflammation Play a Role? Curr Psychiatry Rep 2015 17 78 26272539 PMC4869519
- [100]Gluck RL Lynn DA Dritschel B Brown GR Sex differences in interpretation bias in adolescents Br J Dev Psychol 2014 32 116 122 24417225
- [103]Taylor SE Klein LC Lewis BP Gruenewald TL Gurung RA Updegraff JA Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight Psychol Rev 2000 107 411 429 10941275
- [107]Blanton RE Cooney RE Joormann J Eugène F Glover GH Gotlib IH Pubertal stage and brain anatomy in girls Neuroscience 2012 217 105 112 22569152 PMC4584426
- [108]Smith SS The influence of stress at puberty on mood and learning: role of the α₄βδ GABAA receptor Neuroscience 2013 249 192 213 23079628 PMC3586385
- [111]Epperson CN Haga K Mason GF Sellers E Gueorguieva R Zhang W Weiss E Rothman DL Krystal JH Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study Arch Gen Psychiatry 2002 59 851 858 12215085
- [118]Eisenlohr-Moul TA Girdler SS Schmalenberger KM Dawson DN Surana P Johnson JL Rubinow DR Toward the Reliable Diagnosis of DSM-5 Premenstrual Dysphoric Disorder: The Carolina Premenstrual Assessment Scoring System (C-PASS) Am J Psychiatry 2016 appiajp201615121510 PMC5205545 27523500
- [126]Freeman EW Sammel MD Lin H Gracia CR Kapoor S Symptoms in the menopausal transition: hormone and behavioral correlates Obstet Gynecol 2008 111 127 136 18165401
- [130]Steinberg EM Cardoso GMP Martinez PE Rubinow DR Schmidt PJ Rapid response to fluoxetine in women with premenstrual dysphoric disorder Depress Anxiety 2012 29 531 540 22565858 PMC3442940
- [131]Yonkers KA Kornstein SG Gueorguieva R Merry B Van Steenburgh K Altemus M Symptom-Onset Dosing of Sertraline for the Treatment of Premenstrual Dysphoric Disorder: A Randomized Clinical Trial JAMA Psychiatry 2015 72 1037 1044 26351969 PMC4811029
- [132]Hantsoo L Czarkowski KA Child J Howes C Epperson CN Selective serotonin reuptake inhibitors and endothelial function in women J Womens Health 2002 2014 23 613 618 PMC4089019 24886268
- [141]Rapkin AJ YAZ in the treatment of premenstrual dysphoric disorder J Reprod Med 2008 53 729 741 18980045
- [144]Freeman EW Sondheimer SJ Rickels K Gonadotropin-releasing hormone agonist in the treatment of premenstrual symptoms with and without ongoing dysphoria: a controlled study Psychopharmacol Bull 1997 33 303 309 9230648
- [160]Nelson HD Vesco KK Haney E Fu R Nedrow A Miller J Nicolaidis C Walker M Humphrey L Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis JAMA 2006 295 2057 2071 16670414
- [161]Freeman EW Guthrie KA Caan B Sternfeld B Cohen LS Joffe H Carpenter JS Anderson GL Larson JC Ensrud KE Reed SD Newton KM Sherman S Sammel MD LaCroix AZ Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial JAMA 2011 305 267 274 21245182 PMC3129746
- [164]Orleans RJ Li L Kim M-J Guo J Sobhan M Soule L Joffe HV FDA approval of paroxetine for menopausal hot flushes N Engl J Med 2014 370 1777 1779 24806158
- [165]Hayes LP Carroll DG Kelley KW Use of gabapentin for the management of natural or surgical menopausal hot flashes Ann Pharmacother 2011 45 388 394 21343402
- [167]Coleman VH Carter MM Morgan MA Schulkin J Obstetrician-gynecologists’ screening patterns for anxiety during pregnancy Depress Anxiety 2008 25 114 123 17326098
Cited by
Sorted by citations
Farhane-Medina, N. Z., Luque, B., Tabernero, C., & Castillo-Mayén, R. (2022) · Science Progress · doi:10.1177/00368504221135469 · Cited by 409 · see citing works
“According to this statement, some of the most salient risk factors for women observed from our review were rumination(33,44,49,65,73) and anxiety sensitivity.(51,55,57,65) The results also suggest that gender socialization mediates the type of stimuli that are anxiogenic in women and men.”
BackgroundResultAoun, C., Nassar, L., Soumi, S., Osta, N. E., Papazian, T., & Khabbaz, L. R. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00204 · Cited by 96 · see citing works
“This finding confirms previously published results showing that females turn out to be more emotional eaters than males (Hantsoo and Epperson, 2017).”
ResultAssociation between Sexual Satisfaction and Depression and Anxiety in Adolescents and Young Adults
Carcedo, R. J., Fernández-Rouco, N., Fernández‐Fuertes, A. A., & Martínez, J. L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17030841 · Cited by 98 · see citing works
“This finding is supported by previous studies [30,31], although other research has suggested the opposite [56].”
ResultMedicinal herbs for the treatment of anxiety: a systematic review and network meta-analysis
Zhang, W., Yan, Y., Wu, Y., Yang, H., Zhu, P., Yan, F., Zhao, R., Tian, P., Wang, T., Fan, Q., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106204 · Cited by 75 · see citing works
The brain as a target of hormonal contraceptives: evidence from animal studies.
Porcu, P., Serra, M., & Concas, A. (2019) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2019.100799 · Cited by 57 · see citing works
Pestana, J., & Graham, B. (2024) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105789 · Cited by 56 · see citing works
“Sex differences in the prevalence of anxiety disorders typically emerge after puberty and cease after menopause (Faravelli et al., 2013; Hantsoo and Epperson, 2017; Paus et al., 2008), suggesting a possible role of the menstrual cycle, and ensuing fluctuations in ovarian sex hormones (mainly…”
Maternal stressors and the developmental origins of neuropsychiatric risk
Khambadkone, S. G., Cordner, Z. A., & Tamashiro, K. L. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100834 · Cited by 56 · see citing works
“This dovetails with the sexual dimorphism in neuropsychiatric presentation: among males, the prevalence rates of neurodevelopmental disorders such as ASDs, attention deficit hyperactivity disorder (ADHD), and earlier-onset schizophrenia tend to be higher, whereas females have an increased prevalence of affective disor…”
BackgroundNeuroendocrine pathways underlying risk and resilience to PTSD in women
Ravi, M., Stevens, J. S., & Michopoulos, V. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100790 · Cited by 55 · see citing works
“Some critical gaps in knowledge that currently exist regarding the influences of E2 and P4/ allopregnanolone on risk and resilience to PTSD stem from the lack of studies assessing these relationships throughout the lifespan, when dramatic changes in concentrations of these steroid hormones occur concomitantly with inc…”
BackgroundSuicidal ideation and suicide attempt among Indonesian adolescent students
Putra, I. E., Karin, P. A. E. S., & Ariastuti, N. L. P. (2019) · International Journal of Adolescent Medicine and Health · doi:10.1515/ijamh-2019-0035 · Cited by 45 · see citing works
Anxiety in Late Life: An Update on Pathomechanisms
Hellwig, S., & Domschke, K. (2019) · Gerontology · doi:10.1159/000500306 · Cited by 49 · see citing works
Alalalmeh, S. O., Hegazi, O. E., Shahwan, M., Hassan, N., Alnuaimi, G. R. H., Alaila, R. F., Jairoun, A., Hamdi, Y. T., Abdullah, M., Abdullah, R. M., et al. (2024) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2024.101987 · Cited by 42 · see citing works
Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze
Fabris, D., Carvalho, M. C., Brandão, M., Prado, W. A., Zuardi, A., Crippa, J., de Oliveira, A. D., Lovick, T., & Genaro, K. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221125440 · Cited by 38 · see citing works
“In view of the rising popularity of cannabis derivatives for medical purposes and the two-fold higher prevalence of anxiety-related disorders in women compared to men (Hantsoo and Epperson, 2017), an understanding of sex differences in responsiveness to CBD is overdue.”
BackgroundGender Differences between Multimorbidity and All-Cause Mortality among Older Adults
Lay, A. A. R., do Nascimento, C. F., Burgos, F. C., Huerta, A. D. C. L., René Rivera, Z., Silva, V. P., & Duarte, Y. A. D. O. (2020) · Current Gerontology and Geriatrics Research · doi:10.1155/2020/7816785 · Cited by 37 · see citing works
“Women had more prevalence of self-reported MD when compared to men, a similar result to those obtained by other studies showing that women had higher prevalence of mental illness such as depression [31] and anxiety [32].”
ResultA Retrospective Study to Identify Novel Factors Associated with Post-stroke Anxiety
Beauchamp, J. E. S., Montiel, T. C., Cai, C. C., Tallavajhula, S. S., Hinojosa, E., Okpala, M. N., Vahidy, F., Savitz, S. I., & Sharrief, A. Z. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.104582 · Cited by 34 · see citing works
Mei, D., Deng, Y., Li, Q., Lin, Z., Jiang, H., Zhang, J., Ming, W., Zhang, H., Sun, X., Yan, G., et al. (2022) · Nutrients · doi:10.3390/nu14132585 · Cited by 36 · see citing works
Depression, Anxiety, and Suicide Among Adolescents: Sex Differences and Future Perspectives
Toro, G., Arias, P., de la Torre-Luque, A., Singer, J. B., & Lagunas, N. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103446 · Cited by 30 · see citing works
Beyond Hot Flashes: The Role of Estrogen Receptors in Menopausal Mental Health and Cognitive Decline
Cho, J. M., Lee, J., Ahn, E., & Bae, J.-W. (2025) · Brain Sciences · doi:10.3390/brainsci15091003 · Cited by 29 · see citing works
“During menopause, the decline in estrogen levels can impair dopaminergic signaling, which may contribute to reduced motivation, feelings of anhedonia, and a general decline in cognitive flexibility [49–51].”
Poitras, M., Shearzad, F., Qureshi, A. F., Blackburn, C., & Plamondon, H. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105784 · Cited by 30 · see citing works
Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain
Morrison, K. E., Cole, A. B., Kane, P. J., Meadows, V. E., Thompson, S. M., & Bale, T. L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0634-y · Cited by 23 · see citing works
“It is of critical importance that drug development focus on inclusion of women’s health as a priority, as prior research has shown that women experience greater prevalence of affective disorders and often respond differently than men to therapeutic treatments [66, 67].”
BackgroundHantsoo, L. V., Golden, C. E. M., Kornfield, S. L., Grillon, C., & Epperson, C. N. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0906-y · Cited by 30 · see citing works
Self-citationKetamine effects on anxiety and fear-related behaviors: current literature evidence and new findings
Silote, G., de Oliveira, S. S., Ribeiro, D., Machado, M. S., Andreatini, R., Joca, S., & Beijamini, V. (2019) · bioRxiv · doi:10.1101/793398 · Cited by 27
“It is noteworthy that women are twice more likely than men to experience an anxiety disorder over their lifespan (Bandelow and Michaelis, 2015; Craske et al., 2017; Hantsoo and Epperson, 2017; Remes et al., 2016).”
Pharmacotherapeutic approaches to treating depression during the perimenopause
Garay, R. P., Charpeaud, T., Logan, S. J. S., Hannaert, P. A., Garay, R. G., Llorca, P., & Shorey, S. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1645122 · Cited by 28 · see citing works
Influence of estrous cycle stage on acquisition and expression of fear conditioning in female rats
de Carvalho, M. C., Genaro, K., Leite‐Panissi, C. R. A., & Lovick, T. A. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113372 · Cited by 25 · see citing works
The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies
Pisu, M., Concas, L., Siddi, C., Serra, M., & Porcu, P. (2022) · Biomolecules · doi:10.3390/biom12091262 · Cited by 22 · see citing works
“Indeed, an increased prevalence of these disorders is observed during hormonal variations occurring at puberty, the premenstrual period, pregnancy, postpartum and perimenopause [1,63,64].”
BackgroundNegative affect symptoms, anxiety sensitivity, and vasomotor symptoms during perimenopause
Jaeger, M. D. B., Miná, C. S., Alves, S. G., Schuh, G. J., Wender, M. C. O., & Manfro, G. G. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-0871 · Cited by 27 · see citing works
How hormonal contraceptives shape brain and behavior: A review of preclinical studies.
Concas, A., Serra, M., & Porcu, P. (2022) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2022.101017 · Cited by 21 · see citing works
Bonifacino, T., Mingardi, J., Facchinetti, R., Sala, N., Frumento, G., Ndoj, E., Valenza, M., Paoli, C., Ieraci, A., Torazza, C., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02366-w · Cited by 18 · see citing works
Ryherd, G. L., Bunce, A. L., Edwards, H. A., Baumgartner, N. E., & Lucas, E. K. (2023) · bioRxiv · doi:10.1101/2023.09.23.559127 · Cited by 17
“Women are twice as likely as men to experience an anxiety disorder (Kessler et al., 2005; Kessler et al., 2006; Kessler et al., 1995), and epidemiological data further indicate that this increased susceptibility primarily occurs during years of reproductive viability (Hantsoo and Epperson, 2017).”
Neural correlates of emotional reactivity and regulation in youth with and without anxiety
Padgaonkar, N., Uy, J. P., DePasque, S., Galván, A., & Peris, T. (2020) · Depression and Anxiety · doi:10.1002/da.23154 · Cited by 17 · see citing works
“The greater proportion of females in this sample is consistent with disorder prevalence (Hantsoo & Epperson, 2017).”
Women in space: A review of known physiological adaptations and health perspectives
Hughes-Fulford, M., Carroll, D. J., Allaway, H., Dunbar, B., & Sawyer, A. (2024) · Experimental Physiology · doi:10.1113/ep091527 · Cited by 16 · see citing works
“Anxiety disorders are reportedly more prevalent in women (Hantsoo & Epperson, 2017).”
Sex and Time-of-Day Impact on Anxiety and Passive Avoidance Memory Strategies in Mice
Henarejos, A. B. M., Popovic, N., Bokonjić, D., Morales-Delgado, N., Alonso, A., Caballero-Bleda, M., & Popović, M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00068 · Cited by 16 · see citing works
“Although it is well known that women are about twice more likely to develop generalized anxiety disorders, panic disorders, and posttraumatic stress disorders (Hantsoo and Epperson, 2017), the influence of gender circadian typology on anxiety is not clear.”
BackgroundMental health aspect of quality of life in the menopausal transition
Dotlić, J., Radovanović, S., Rancic, B., Milošević, B., Nicević, S., Kurtagić, I., Marković, N., & Gazibara, T. (2020) · Journal of Psychosomatic Obstetrics and Gynaecology · doi:10.1080/0167482x.2020.1734789 · Cited by 15 · see citing works
Barbetti, M., Sgoifo, A., & Carnevali, L. (2024) · Physiology and Behavior · doi:10.1016/j.physbeh.2024.114702 · Cited by 14 · see citing works
“The association between stress exposure and disease vulnerability may be sex-biased, as evidenced by a higher lifetime prevalence of depression [3], anxiety [4], and other trauma-related disorders [5] in women compared to men.”
Pestana, J., Kershaw, K. A., & Graham, B. M. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02480-9 · Cited by 14 · see citing works
Alves, J. V. D. S., de Paula, W., Netto, P. R. R., Godman, B., Nascimento, R. C. R. M. D., & Coura-Vital, W. (2021) · Jornal Brasileiro de Psiquiatria · doi:10.1590/0047-2085000000322 · Cited by 14 · see citing works
“Anxiety has been shown to be greater in women than men 55 .”
BackgroundEverything changes but nothing changes: gender stereotypes in the Italian population
Silva, R. C., Vezzoli, M., Menesello, V., Meattini, M., Sartori, R., & Minelli, A. (2024) · Archives of Women's Mental Health · doi:10.1007/s00737-024-01437-1 · Cited by 13 · see citing works
“The female lifespan is characterized by several distinct stages, each with a unique hormonal environment and psychosocial context that significantly influences the susceptibility to psychiatric disorders (Hantsoo & Epperson 2017).”
BackgroundPutra, I. G. N. E., Pradnyani, P. E., Putra, G. W., Astiti, N. L. E. P., Derayanti, N. W., Artini, N. N. A., Astuti, P. A. S., Dendup, T., & Ratan, Z. A. (2022) · Journal of Biosocial Science · doi:10.1017/s0021932022000426 · Cited by 14 · see citing works
“…vulnerable to stress due to biological predispositions, such as experiencing hormonal fluctuations (e.g., menstruation), as well as, social factors (e.g., social expectations from gender roles) that can provoke psychological distress (Hantsoo & Epperson, 2017; Mayor, 2015; Parker & Brotchie, 2010).”
Helman, T., Headrick, J., Vider, J., Peart, J. N., & Stapelberg, N. J. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25115 · Cited by 13 · see citing works
“…risk of stress- dependent psychopathology differs markedly between the sexes, with women more than twice as likely to develop depression and anxiety disorders (Hantsoo & Epperson, 2017; Kessler, 1997; Olff, 2017; Verma et al., 2011), and displaying more severe symptoms (de Graaf et al., 2002).”
BackgroundMușat, M. I., Militaru, F., Udriștoiu, I., Mitran, S., & Cătălin, B. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13092723 · Cited by 12 · see citing works
“Although patients with alcoholism were excluded from this study, the increase in the levels of liver enzymes in some of the patients suggests that they may underestimate their alcohol consumption.”
BackgroundFuture Anxiety in Young Spanish Adults: Psychometric Properties of the Dark Future Scale
Torrado, M., García-Castro, F. J., & Blanca, M. (2024) · Anales de Psicología · doi:10.6018/analesps.549681 · Cited by 12 · see citing works
“…experience stressors and tend to use different coping strategies, and this, coupled with certain biological mechanisms, including hormonal fluctuation, may make them more vulnerable to anxiety disorders (Faravelli et al., 2013; Graves et al., 2021; Hantsoo & Epperson, 2017; Marques et al., 2016).”
BackgroundThe Differential Role of Cytokines on Stress Responses in a Menopause Rat Model
Park, H., Shim, H., & Shim, I. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.577561 · Cited by 12 · see citing works
Unsworth, D., Mathias, J., & Dorstyn, D. (2019) · Journal of Stroke & Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.03.014 · Cited by 12 · see citing works
Çol, B. K., Başaran, A. G., & Köse, B. G. (2025) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s513017 · Cited by 16 · see citing works
“100,101 At the same time, the literature suggests that in terms of psychosocial and cultural factors, women are encouraged to express emotions such as anxiety and fear and are more often directed towards dependency, cowardice and passivity.”
A Systematic Review of the Etiology and Neurobiology of Intermittent Explosive Disorder
Paliakkara, J., Ellenberg, S., Ursino, A., Smith, A., Evans, J., Strayhorn, J., Faraone, S., & Zhang-James, Y. (2024) · medRxiv · doi:10.1101/2024.09.12.24313573 · Cited by 10
Xiangshao granules can relieve emotional symptoms in menopausal women: a randomized controlled trial
Chen, R., Tang, R., Zhang, S., Wang, Y., Wang, R., Ouyang, Y., Xie, X., Liu, H., Lv, S., Shi, H., et al. (2020) · Climacteric · doi:10.1080/13697137.2020.1820476 · Cited by 12 · see citing works
Doornweerd, A. M., Baas, J. M. P., Montoya, E. R., van de Vijver, I., & Gerritsen, L. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107174 · Cited by 11 · see citing works
“This increased vulnerability to affective disorders is most pronounced during hormonal transitions, as seen in puberty, pregnancy, menopause, and the menstrual cycle (Faravelli et al., 2013; Hantsoo and Epperson, 2017; Paus et al., 2008).”
Trait Anxiety and Unhealthy Eating in Adult Women: The Mediating Role of Cognitive Instability
Mróz, M., Gross, J., & Brytek-Matera, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20010296 · Cited by 9 · see citing works
“These strategies are possible reasons for sex differences: women experience more anxiety than men [22].”
BackgroundAging and the neuropsychiatry of multiple sclerosis: a cross-sectional study
Freedman, D., Oh, J., Einstein, G., & Feinstein, A. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13116-x · Cited by 8 · see citing works
“Some have suggested that the age-associated reduction in anxiety may relate to decreased hormonal fluctuations across the lifespan (especially in women) [77, 78], but there is limited supporting evidence for the link between hormonal fluctuations and age differences in anxiety in pwMS.”
Evrard, M. R., Li, M., Shen, H., & Smith, S. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-99965-8 · Cited by 8 · see citing works
Mamed, G. E., Tefera, G. M., Bitew, M., & Yu, M. (2024) · International Journal of Social Psychiatry · doi:10.1177/00207640241299357 · Cited by 7 · see citing works
“Female IDPs are likely to have higher anxiety and sensitivity and could severely interpret traumatic events, and as a result, they may develop PTSD (Hantsoo & Epperson, 2017).”
Melitracen and flupentixol (deanxit) use disorder in Lebanon
Zahran, T. E., Hassan, S. A., Khalifeh, M., Aboukhater, D., Hammoud, L., Hariri, M. A., & Kazzi, Z. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15847 · Cited by 7
“Additionally, the Collaborative Psychiatric Epidemiology Studies revealed that women have higher lifetime diagnosis rates for almost all anxiety disorders in a sample of more than 20,000 people [5].”
BackgroundASSOCIATION BETWEEN SLEEP DURATION, SLEEP QUALITY AND BODY MASS INDEX IN MEDICAL STUDENTS
Maharjan, N., Karki, P., Adhikari, B., Bhaila, A., & Shrestha, H. (2020) · Journal of Chitwan Medical College · doi:10.54530/jcmc.248 · Cited by 7 · see citing works
Demographic and clinical characterization of multiple sclerosis in Mexico: The REMEMBer study
Bertado-Cortés, B., Venzor-Mendoza, C., Rubio-Ordoñez, D., Pérez-Pérez, J. R., Novelo-Manzano, L. A., Villamil-Osorio, L. V., Jiménez-Ortega, M. D. J., Villalpando-Gueich, M. D. L. L., Sánchez-Rosales, N. A., & García-Talavera, V. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102575 · Cited by 11 · see citing works
Creativity on tap? The effect of creativity anxiety under evaluative pressure
Bullock Muir, A., Tribe, B., & Forster, S. (2025) · Creativity Research Journal · doi:10.1080/10400419.2024.2330800 · Cited by 6 · see citing works
“Notably, Daker, Cortes, Lyons, and Green (2020) observed that creativity anxiety is more common in women than men – as is the case for generalized anxiety disorder (Hantsoo & Epperson, 2017).”
Nelles, P., Singewald, N., Sperner‐Unterweger, B., & Hüfner, K. (2025) · Medical Hypotheses · doi:10.1016/j.mehy.2025.111580 · Cited by 8 · see citing works
Gejala Menopause pada Wanita Premenopause
Fruitasari, M. F. (2024) · Journal of Nursing Invention · doi:10.33859/jni.v5i1.507 · Cited by 6 · see citing works
Ortahisar, B. K., & Uslu, Y. (2023) · Intensive & Critical Care Nursing · doi:10.1016/j.iccn.2023.103464 · Cited by 6 · see citing works
Factors associated with psychic symptomatology in diabetics during the COVID-19 pandemic
Souza, G. F. D. A., Praciano, G. D. A. F., Neto, O. D. C. F., Paiva, M. C., de Jesus, R. P. F. S., Cordeiro, A. L. N., Souza, G. A., da Silva, J. R., & Souza, A. S. R. (2021) · Revista Brasileira de Saúde Materno Infantil · doi:10.1590/1806-9304202100s100009 · Cited by 15 · see citing works
“The subscale of anxiety has no signs and/or symptoms (0-7), mild (89), moderate (10-14), severe (15-19) and extreme (>19).”
BackgroundAnxiety as a risk factor in coronary artery disease among young women
Cho, S.-G., Kim, H. Y., & Bom, H. (2020) · Journal of Nuclear Cardiology · doi:10.1007/s12350-020-02101-8 · Cited by 6 · see citing works
“The ovarian steroids are thought to control sympathetic drive on the heart and their monthly fluctuations may characterize the sex differences in myocardial ischemia as well as anxiety.(16,17) Another explanation can be provided by the unique phenotypic features of CAD in women.”
BackgroundSex differences in the programming of stress resilience
Morrison, K. E., Epperson, C. N., & Bale, T. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00006-9 · Cited by 7 · see citing works
Self-citationBrouillard, A., Davignon, L., Vachon‐Presseau, É., Roy, M., & Marin, M. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16509 · Cited by 5 · see citing works
“This marked difference emerges in adolescence (Costello et al., 2003; Hantsoo & Epperson, 2017; Lewinsohn et al., 1998; Wesselhoeft et al., 2015), suggesting a pivotal timing for anxiety and stress susceptibility during this developmental stage.”
Alangari, A. S., Fatani, F., Binhowaimel, N., Kadri, H. A. A., Alshahrani, A., Khateeb, B. F. A., Aldubikhi, A., Amer, M. I. B., Alsaif, A., & El-Metwally, A. (2024) · Healthcare · doi:10.3390/healthcare12131298 · Cited by 5 · see citing works
Assessment and correlates of aloneliness among Indonesian adolescents
Abidin, F. A., Sunardy, G. N., Yudiana, W., Alverina, Y., & Coplan, R. J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28862 · Cited by 5 · see citing works
“Such gender differences in aloneliness and psychological distress may be attributed to a combination of biological predispositions and high social demands, such as social expectations based on gender roles [36,37].”
BackgroundPsychological factors among Appalachian women with abnormal Pap results
Adegboyega, A., Dignan, M., Sha, S.-Y., Nkwonta, C., & Williams, L. B. (2021) · Journal of Rural Health · doi:10.1111/jrh.12585 · Cited by 5
Mahran, Z., Khalifa, H., Makhlouf, N., Mostafa, D., Aboalam, H. S., Moustafa, E., & Ahmed, G. (2022) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-022-00585-4 · Cited by 4 · see citing works
Impact of Exposure to Environmental Enrichment on the Anxiety-Like Behavior of Ovariectomized Mice
Briones-Aranda, A., Castellanos-Pérez, M., Vega-Villa, V. M., & Picazo, O. (2020) · Iranian Journal of Psychiatry · doi:10.18502/ijps.v15i1.2443 · Cited by 4 · see citing works
Granata, L., Giubilato, S., Giuffrida, C., Pavan, D., Mojoli, M., Aspromonte, N., Fumarulo, I., Marchetta, M., Sbrigata, A., Pisano, C., et al. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13070301 · Cited by 3 · see citing works
“Similar to depression, anxiety disorders in women often precipitate or worsen during periods of hormonal fluctuation, including puberty, the premenstrual phase, pregnancy or postpartum, and the menopausal transition [81].”
InfluentialDating Violence, Emotional Dependence and Mental Health Problems in Ecuadorian College Students
Gonzáles, M. E. C., del Barco, B. L., Mendo-Lázaro, S., & Andrade, E. G. T. (2026) · Healthcare · doi:10.3390/healthcare14070834 · Cited by 4 · see citing works
“…previous research has primarily focused on female victims—given their historically higher risk of victimization and poorer mental health outcomes [35,38–42]—recent studies suggest that, in the context of dating violence, men and women may report comparable levels of victimization [16,33,34,43].”
Nabulsi, M., Ahmead, M., & Sharif, N. E. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1728734 · Cited by 4 · see citing works
“Research indicates that women exhibit a signi fi cantly higher prevalence of anxiety disorders and a higher level of anxiety sensitivity than men (32).”
Liao, T.-K., Huang, H.-Y., Lin, Y.-J., Ho, C., Wang, J.-J., Liang, F.-W., Chou, H.-H., & Lim, S.-W. (2025) · BMC Psychology · doi:10.1186/s40359-025-03762-1 · Cited by 3 · see citing works
“A large-scale epidemiological study in the United States found that the lifetime prevalence of anxiety disorders in women is approximately twice that in men [37, 38].”
Hammouda, E. A., Ashmawy, R., Hassan, M. A., & Ghazy, R. M. (2025) · BMC Public Health · doi:10.1186/s12889-025-23854-2 · Cited by 3 · see citing works
“Furthermore, females are more vulnerable to developing mental health disorders, including depression and anxiety, due to hormonal, genetic, and neurobiological influences [44].”
Astrocytic glucocorticoid receptors in the ventral hippocampus modulate anxiety-like behaviors
Lu, C., Ren, J., Wang, W., Chen, L.-Y., Lian, X.-Y., & Cao, X. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111518 · Cited by 3 · see citing works
Brooke, M., & Graham, B. M. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105789 · Cited by 4 · see citing works
“…during puberty, this suggests that the menstrual cycle, and accompanying fluctuations in ovarian hormones that occur with the onset of menarche, may contribute to the development and maintenance of anxiety disorders in women (Faravelli et al., 2013; Hantsoo and Epperson, 2017; Paus et al., 2008).”
Kerstis, B., Jönsson, P., Derwig, M., Nilsson, K. W., Hallström, I., & Lindeberg, S. (2025) · Child: Care, Health and Development · doi:10.1111/cch.70099 · Cited by 3 · see citing works
“Consistent with study results concerning levels of depressive symptoms and anxiety (Glasser and Lerner-Geva 2019; Hantsoo and Epperson 2017; Nguyen et al. 2023), studies demonstrate higher perinatal stress levels in mothers than in fathers (Challacombe et al. 2023; Hildingsson and Thomas 2014),…”
Prado, R. C. R., Oliveira, T. N., Saunders, B., Foster, R., Bella, Z. I. K. D. J. D., Kilpatrick, M. W., Asano, R. Y., Hackney, A. C., & Takito, M. Y. (2025) · Endocrines · doi:10.3390/endocrines6010014 · Cited by 3 · see citing works
“Depressive and anxiety spectrum disorders among women often precipitate or worsen during menses and/or in women under drastic hormonal alterations, such as puberty, the premenstrual period, postpartum, and at menopause and premenstrual syndrome (PMS) [1–4].”
Problematic Media Use and Anxiety Symptoms in Adolescents: The Role of Age and Gender
Rodríguez‐Rojo, I. C., González, R. L., Peñacoba, C., García-Sastre, M., Espín‐Lorite, E. J., Cuesta‐Lozano, D., Esteve, Á. L. A., & Noriega, C. (2025) · Healthcare · doi:10.3390/healthcare13030281 · Cited by 3 · see citing works
Mother's little helper turned a foe: Alprazolam use, misuse, and abuse
Cardona-Acosta, A. M., Meisser, N., Vardeleon, N. I., Steiner, H., & Bolaños‐Guzmán, C. A. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111137 · Cited by 3 · see citing works
Guimarães, G., D'Angelo, F., Brouillette, K., Souza, L., da Silva, R. D., Mondin, T., Moreira, F., Kapczinski, F., Cardoso, T. D. A., & Jansen, K. (2022) · L'Encephale · doi:10.1016/j.encep.2022.08.012 · Cited by 3 · see citing works
ANXIETY AMONG THE URBAN WORKING WOMEN AND HOMEMAKERS: A QUESTIONNAIRE-BASED SURVEY
Jana, N., Nayaka, M., Devershetty, S., Gajjala, P. K., Kamdar, P., & Pal, C. (2022) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2022.v15i5.44308 · Cited by 3 · see citing works
Transtornos de Ansiedade em Idosos
Bellora, R. M., Sgnaolin, V., Engroff, P., Dannebrock, L. G., Diefenthaeler, E. C., & Cataldo, A. (2021) · PAJAR - Pan-American Journal of Aging Research · doi:10.15448/2357-9641.2021.1.40528 · Cited by 3 · see citing works
Segal, J., Smith, P. J., & Verma, A. (2020) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2020.06.036 · Cited by 3
Shah, B. M., & Kornstein, S. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816569-0.00008-5 · Cited by 6 · see citing works
Dating violence and mental health issues in Ecuadorian university students
Castillo-Gonzáles, M., & Terán-Andrade, E. (2026) · Frontiers in Sociology · doi:10.3389/fsoc.2026.1743049 · Cited by 2 · see citing works
“These results are consistent with studies that reported women experience more MH problems related to anxiety and depression (Burris et al., 2024; Hantsoo and Epperson, 2017).”
Why does FND mainly affect women? A consideration of gender imbalance in neuropsychiatric disease
Bradlow, R. C. J., Weid, L. V. D., Zwickl, S., Cheung, A. S., & Kanaan, R. (2026) · Psychological Medicine · doi:10.1017/s0033291726104085 · Cited by 2 · see citing works
“Like other mental illnesses, generalized anxiety disorder is influenced by the menstrual cycle, pregnancy, the postnatal and peri-menopausal periods, implying the possible influence of gonadal hormones (Hantsoo & Epperson, 2017; Jalnapurkar, Allen, & Pigott, 2018).”
Gendered Patterns in Anxiety and Subjective Well-Being
Pinho, M., & Varsori, E. (2026) · Sexuality & Culture · doi:10.1007/s12119-026-10535-4 · Cited by 2 · see citing works
“Gendered expectations and greater exposure to specific stressors, such as caregiving burdens or gender-based violence, may also contribute to heightened anxiety among women (Farhane-Medina et al., 2022 ; Hantsoo & Epperson, 2017 ; Riecher-Rössler, 2017 ).”
Clinical implementation of pre-emptive pharmacogenomics in patients with anxiety disorders
Pandi, M.-T., Skokou, M., Koufaki, M., Karamperis, K., Melograna, F., Mitropoulou, C., & Patrinos, G. (2025) · Nature Mental Health · doi:10.1038/s44220-025-00466-8 · Cited by 2 · see citing works
“In addition, in the Hantsoo and Epperson study it was shown that AD was twice as common among female individuals compared to male individuals 40 .”
Effects of mind-body exercise intervention on anxiety among women: a meta-analysis
Chen, P., Gu, Y., Mazalan, N. S., Koh, D., Du, W., & Luo, Y. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1652882 · Cited by 1 · see citing works
Alabdulkarem, K. B., Alshammari, G. M., Alyousef, A. A., MOHAMMED, M. A., Fattiny, S. Z. A., Alqahtani, I. Z., & Yahya, M. A. (2024) · Healthcare · doi:10.3390/healthcare12232419 · Cited by 2 · see citing works
Fruitasari, M. F., Romlah, I., Sari, A. P., Indaryati, S., & Hutabarat, M. (2024) · JMM (Jurnal Masyarakat Mandiri) · doi:10.31764/jmm.v8i5.24114 · Cited by 2
“…seperti: semburan panas yang menjalar dari leher ke wajah (hot flash), gangguan tidur dan cepat lelah dari sinilah mereka merasakan kecemasan (Hantsoo & Epperson, 2017), terutama perempuan usia di atas 40 tahun yang tidak terpapar terhadap informasi tentang apa yang akan dihadapi menjelang…”
Alemayehu, Y., Hussen, M. A., Abdu, Z., Dule, A., Hajure, M., Mulatu, G., Gezimu, W., Alemu, S. S., & Wedajo, L. F. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1437891 · Cited by 2 · see citing works
“The possible interpretation could be the hormonal fl uctuations in females related to puberty, the pre-menstrual period, pregnancy or postpartum, and the menopausal transition (33, 34).”
BackgroundProblematic Behaviors and Predicting Online Risk Behaviors in High School Students
Dowdell, E., Lamade, R. V., Lee, A. F. S., Schuler, A., & Prentky, R. (2022) · Journal of School Nursing · doi:10.1177/10598405221091481 · Cited by 2 · see citing works
“…and sex have been found to in fl uence brain maturation during adolescence, implying that speci fi c stages of brain development and maturation in males and females can differ as signi fi cant brain remodeling occurs in females (Bale, & Epperson, 2017; Ernst et al., 2019; Hantsoo, & Epperson, 2017).”
BackgroundBremer, E. (2021) · Each Woman’s Menopause: An Evidence Based Resource · doi:10.1007/978-3-030-85484-3_10 · Cited by 2 · see citing works
Essiben, F., Um, E., Ojong, S., Gimnwi, F., Olen, K., & Nana, P. (2018) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20182312 · Cited by 2 · see citing works
“The postpartum period is more likely to cause anxiety in women compared to the general population.(32) Using the GAD-7 questionnaire, we obtained a 79.”
BackgroundThe Impact of COVID-19 on Social Anxiety and Rejection Sensitivity
Powell, C. A. J., & Martin, K. (2023) · Medical Research Archives · doi:10.18103/mra.v11i7.1.4046 · Cited by 5 · see citing works
“In our study, the observed gender differences in anxiety and depression diagnoses are supported by the current body of research 45,46 .”
Weigl, K. (2020) · International Congress on Sport Sciences Research and Technology Support · doi:10.5220/0010135600830089 · Cited by 2
“These findings are in line with other previous studies which, however, did not focus on cycling (Bahrami and Yousefi, 2011; Hantsoo and Epperson, 2017; Howell et al., 2001; Kendler et al., 1992; McLean and Anderson, 2009; Pigott, 2003; Yonkers et al., 2003).”
ResultCano, M. T., Lindstrom, M. R., Perez, O. R. R., & Muñoz, R. F. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1735343 · Cited by 1 · see citing works
“This dierence is well documented in the literature in that women tend to report and experience higher rates of depression and anxiety (62, 63).”
Harrison, E. M., Maki, P. M., Chang, Y., Wu, M., Kamboh, M. I., Aizenstein, H. J., & Thurston, R. C. (2026) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2026.2647965 · Cited by 2 · see citing works
“Anxiety is particularly prevalent among women, who are twice as likely to be diagnosed with an anxiety disorder in their lifetime compared to men; this gender gap is evident across the life-span (Hantsoo & Epperson, 2017; McLean et al., 2011).”
Sivathasan, S., Crown, M. J., Rutenberg, E., Brammell, S., Thoma, B., Beck, K. B., Conner, C. M., Mazefsky, C. A., & Rofey, D. L. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1766767 · Cited by 1 · see citing works
“For example, people assigned female sex at birth (AFAB) are more likely to identify with LGBTQIA+ identities (31) and to receive psychiatric diagnoses, particularly anxiety, depression, and PTSD (32 – 34).”
InfluentialAdhikari, D., Giri, B., Mandal, S., & Mondal, S. (2026) · Engineering applications of artificial intelligence · doi:10.1016/j.engappai.2025.113420 · Cited by 1 · see citing works
Depression and Anxiety Among Women in Lesotho: A Multilevel Analysis of the 2023–2024 LSDHS
Endalew, H. L., Bazezew, A. M., Alemu, E. A., Mekonen, E., Mengistie, B. A., Zeleke, G., Ayele, D., Yirsaw, A. N., Aragaw, G. M., Abuhay, A. E., et al. (2026) · Depression and Anxiety · doi:10.1155/da/1572451 · Cited by 1 · see citing works
“Standard severity categories include minimal (0 – 4), mild [5 – 9], moderate [10 – 14], moderately severe [15 – 19], and severe [20 – 27] depressive symptoms.”
- Authors
- Hantsoo, L., & Epperson, C. N.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Focus
- Published
- 2017-04
- Volume
- 15
- Issue
- 2
- Pages
- 162-172
- ISSN
- 1541-4094 (ISSN-L)
- 1541-4108
- PMC
- PMC5613977
- OpenAlex
- W2606811217
- Cited by
- 183
- References
- 132
- Citations by year
- 2026: 25 · 2025: 27 · 2024: 28 · 2023: 11 · 2022: 19 · 2021: 43 · 2020: 15 · 2019: 11 · 2018: 2 · 2017: 2
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- FOCUS The Journal of Lifelong Learning in Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K23MH107831)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- anxiety disorders, women, female longevity, sex differences, puberty, premenstrual phase, pregnancy, postpartum anxiety, menopause, hormonal status, biopsychosocial model, differential diagnosis, assessment, treatment, reproductive events
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