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The efficacy of cognitive and behavior therapies for insomnia on daytime symptoms: A systematic review and network meta-analysis
Open accessAbstract
Insomnia disorder, defined by nocturnal and daytime symptoms, is highly prevalent worldwide and is associated with the onset of mental illness. Although daytime symptoms are often the reason insomnia patients seek help, it is not clear whether recommended treatment is effective on daytime symptoms. We aimed to investigate the efficacy of cognitive and behavior therapies for insomnia (CBT-I) on all daytime symptoms explored in the literature using both direct and indirect data. 86 studies (15,578 participants) met inclusion criteria. Results showed significant effects of CBT-I administered face-to-face individually, in group and different self-help settings on depressive symptoms, anxiety, daytime sleepiness, fatigue, quality of life, daytime and social functioning and mental state, with Cohen's d's ranging from -0.52 and 0.81. Our results suggest that CBT-I is effective in the treatment of daytime symptoms, albeit with predominantly small to moderate effects compared to far stronger effects on the core symptoms of insomnia. Effects may be biased for depressive and anxiety symptoms, since many included studies excluded patients with severe levels of these complaints. Further, small to moderate effects may reflect that CBT-I, by improving nighttime symptoms, has a positive effect on daytime symptoms, but it does not target the daytime symptoms directly. Future studies may benefit from adding therapeutic techniques that address daytime symptoms more directly.
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“yet little research has investigated the effect of other sleep interventions on anxiety symptoms.”
From Do non-pharmacological sleep interventions affect anxiety symptoms? A meta-analysis (2022) · cites this paper as Benz et al., 2020
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“Additionally, this meta-analysis comments that effects may be biased given many studies excluded participants with severe levels of anxiety.”
From Do non-pharmacological sleep interventions affect anxiety symptoms? A meta-analysis (2022) · cites this paper as Benz et al., 2020
Experimental — accuracy not yet measuredIn the citing paper
“In patients with insomnia without psychiatric comorbidity, CBT-I is highly effective for the improvement of self-rated insomnia severity and several other sleep parameters like for example sleep onset latency and wake time after sleep onset [9], including daytime symptoms [10].”
From Cognitive behavioral therapy for insomnia in patients with mental disorders and comorbid insomnia: A systematic review and meta-analysis (2022) · cites this paper as [10]
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BackgroundNetwork meta-analysis examining efficacy of components of cognitive behavioural therapy for insomnia
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Psychological treatments for excessive gaming: a systematic review and meta-analysis
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“…on individual daytime symptoms of fatigue, depressive symptoms, and daytime sleepiness as reported in a recent systematic review and meta-analysis (Benz et al., 2020) and our previous preliminary efficacy study and the study from which the current data were drawn (Redeker et al., 2015, 2022).”
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“However, previous research has found that CBT-i is not as effective for the treatment of daytime symptoms [62], so adding fatigue management to insomnia treatment can also potentially optimize treatment outcomes.”
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“A meta-analysis of cognitive behavioral therapy for insomnia found that it moderately improved worry and difficulty staying asleep 24,25 .”
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The Future of Insomnia Research—There's Still Work to Be Done
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“It has been convincingly demonstrated that CBT-I has positive effects on secondary outcomes that are related to psycho-pathology in general (e.g., depression or anxiety symptoms; Benz et al. 2020).”
Andersen, S. G., Sæterhagen, H., Pacheco, A. P., Pripp, A. H., Hrubos‐Strøm, H., Papageorgiou, C., Munkhaugen, J., & Dammen, T. (2025) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.11656 · Cited by 13
“19,23 There is also some evidence for the effectiveness of CBT-I in the treatment of comorbid insomnia in general.”
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“…associated with a wide range of impairments (Bélanger et al., 2004; Brenes et al., 2009; Glidewell et al., 2015), including impaired concentration and memory, decreased occupational functioning, increased absenteeism, and increased use of medical services (Benz et al., 2020; Harvey et al., 2009).”
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“The meta-analysis concluded that future studies may benefit from incorporating therapeutic techniques that more directly address daytime symptoms (Benz et al. 2020).”
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“have a positive effect on daytime symptoms indirectly.(46) Similarly, the SR-sleep-device group in this study has a significant effect on the level of daytime sleepiness, which means that the SR may improve insomnia patients’ daytime quality of life (such as energy/fatigue, bodily pain, and mental health).”
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“Furthermore, although CBT-I does not target daytime fatigue directly, several studies demonstrate improvements in fatigue following this intervention (Benz et al., 2020; Vedaa et al., 2020).”
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“In a meta-analysis by Benz et al. (2020), it was observed that CBT-I approaches (individual, group, and internet self-help treatment formats) have evidence of efficacy on daytime symptoms.”
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“30 31 Nevertheless, the therapeutic approach’s technical adapt-ability may diverge contingent on the educational attainment of the recipient, potentially influencing treatment efficacy.”
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Hypnotic Medications as an Adjunct Treatment to Cognitive Behavioral Therapy for Insomnia
Barkopoulos, P., & Cho, H. J. (2023) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.10.004 · Cited by 7
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Redefining insomnia: from neural dysregulation to personalized therapeutics
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“This discrepancy may be partly due to the use of general health measures not explicitly designed to capture insomnia-related daytime dysfunction [193,194].”
Fiori, V., Lombardo, C., & Ballesio, A. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.108735 · Cited by 6
Chan, K. L., Pau, N. H. Y., Poon, S. F. O., Lam, B. L. H., Lam, C. B., & Chan, K. K. S. (2025) · Applied Psychology Health and Well-Being · doi:10.1111/aphw.70047 · Cited by 5
“Finally, the intervention may help alleviate sleep-related impairments in social interactions and relationships (Benz et al., 2020).”
Trinca, E., Hertenstein, E., Wunderlin, M., Schneider, C. L., Züst, M. A., Fehér, K. D., Su, T., van Straten, A., Berger, T., Riemann, D. W., et al. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.05.311 · Cited by 5
Sleep and Daily Positive Emotions – Is Heart Rate Variability a Mediator?
Ballesio, A., Zagaria, A., Salaris, A., Terrasi, M., Lombardo, C., & Ottaviani, C. (2022) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000315 · Cited by 5
Kognitive Verhaltenstherapie bei Insomnie
Weinhold, S. L., & Göder, R. (2022) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-022-00341-z · Cited by 5
Vallim, J. R. D. S., Pires, G. N., Bonaldi, R. R., Zanini, M. A., Soster, L. A., Garbuio, S. A., & Sousa, K. M. M. (2023) · Sleep Epidemiology · doi:10.1016/j.sleepe.2023.100061 · Cited by 5
Mindfulness and Insomnia Disorder
Baglioni, C. (2022) · doi:10.1002/9781119891192.ch17 · Cited by 5
Efficacy of Multicomponent CBT‐I and Its Single Components
Maurer, L., & Kyle, S. D. (2022) · Wiley eBooks · doi:10.1002/9781119891192.ch3 · Cited by 7
Maurer, L., Aust, F., & Lorenz, N. (2025) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-025-00502-w · Cited by 4
Sit, H. F., Cheung, F. T. W., Li, X., Chan, N., Chan, J. W. Y., Wing, Y. K., & Li, S. X. (2025) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2025.100619 · Cited by 4
“Meanwhile, CBT-I has also been suggested as a promising intervention for improving fatigue among individuals with insomnia disorder (Benz et al., 2020).”
Pitfalls of insomnia management in the elderly: A narrative review
Rollo, E., Antonioni, A., & Lorenzo, F. D. (2026) · Neurological Sciences · doi:10.1007/s10072-025-08621-w · Cited by 4
Ewart, C., Egan, K. J., Henderson, M., McCrory, S., & Fleming, L. (2025) · Behavioral Sleep Medicine · doi:10.1080/15402002.2025.2529856 · Cited by 5
“Furthermore, CBT-I has been shown to improve markers of mental health including anxiety and depression (Benz et al., 2020; Hertenstein et al., 2022).”
Jernelöv, S., & Blom, K. (2025) · Journal of Sleep Research · doi:10.1111/jsr.70164 · Cited by 4
“While interventions like CBT-I produce robust and long-term effects on subjective sleep complaints and sleep parameters (Furukawa, Sakata, Furukawa, et al. 2024), their impact on daytime functioning tends to be smaller and more variable (Benz et al. 2020).”
InfluentialManagement of Sleep and Fatigue in Gastrointestinal Patients
Salwen‐Deremer, J. K., & Sun, M. (2022) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2022.07.007 · Cited by 4
Sleep Deficiency and Fatigue in Adults with Inflammatory Bowel Disease: A Systematic Review
Conley, S., Hwang, Y., Al-Saleh, S. A., Kamp, K., Cahalan, A., & Redeker, N. S. (2025) · Western Journal of Nursing Research · doi:10.1177/01939459251314941 · Cited by 4
“39,40 CBT-I is feasible and acceptable in people with IBD, 41 and a brief behavioral intervention based on CBT-I improves sleep quality and fatigue severity from baseline.”
Circadian and Sleep Modulation of Dreaming in Women with Major Depression
Birchler-Pedross, A., Frey, S., Cajochen, C., & Chellappa, S. L. (2022) · Clocks & Sleep · doi:10.3390/clockssleep4010012 · Cited by 4
“Meta-analyses show that insomnia symptoms can double the odds of developing depression [5,6], while cognitive behavioral therapy for insomnia can lower rates of depression recurrence [7,8].”
BackgroundMoulder, Z., Sweetman, A., Lovato, N., Micic, G., Lack, L. C., & Scott, H. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14142 · Cited by 6
“There are several individual components of CBTi, including sleep restriction, cognitive therapy, stimulus control therapy, sleep hygiene and psychoeducation, and relaxation (Benz et al., 2020).”
Jun, J., Park, C. G., Fritschi, C., Izci‐Balserak, B., Martyn-Nemeth, P. A., Kuna, S. T., & Kapella, M. C. (2023) · Heart & Lung · doi:10.1016/j.hrtlng.2023.11.001 · Cited by 3
Conley, S., Jeon, S., Wang, Z., Tocchi, C., Linsky, S., O’Connell, M., & Redeker, N. S. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14058 · Cited by 3
“Our results are consistent with a recent systematic review and meta-analysis that revealed that CBT-I improves individual daytime symptoms of depression, anxiety, fatigue, and daytime sleepiness in people with insomnia with and without medical conditions (Benz et al., 2020).”
Zhang, G., Wang, S., Ma, P., & Pan, J. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2311200 · Cited by 4
Khorzoghi, M. B., & Sajjadian, P. S. (2022) · Salmand · doi:10.32598/sija.2021.2111.3 · Cited by 3
Redeker, N. S. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101632 · Cited by 3
Dhaliwal, S. S., & Gehrman, P. (2023) · SLEEP · doi:10.1093/sleep/zsad192 · Cited by 3
Chen, S., Ivers, H., Dang‐Vu, T. T., Shapiro, C. M., Carney, C. E., Robillard, R., & Morin, C. M. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06878-1 · Cited by 2
“These patients often show elevated depressive and anxiety symptoms, increased worry about falling asleep and greater distress about daytime functioning (e.g., fatigue) [27, 33–35], which can be effectively addressed by CBT-I intervention [36, 37].”
Jiayuan, Z., Xiaoxi, L., Chen, D., & Yuqiu, Z. (2025) · Midwifery · doi:10.1016/j.midw.2025.104476 · Cited by 3
Lin, C., Cheng, C., Xia, Y., Wang, R., Zhang, L., Han, L., Hai, D., Dai, C., Dai, T.-E., Cao, L., et al. (2025) · Sleep Medicine: X · doi:10.1016/j.sleepx.2025.100157 · Cited by 2
“In patients with insomnia without psychiatric co-morbidities, CBT-I has demonstrated significant efficacy in improving subjective insomnia severity, shortening sleep latency, decreasing the time of awakening after sleep onset, and alleviating daytime symptoms [16 – 18].”
Insomnia – An outlook for the future
Riemann, D. W., & Spiegelhalder, K. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14061 · Cited by 2
“Moreover, we believe that it is likely that an early and adequate insomnia treatment reduces the incidence and recurrence of depressive episodes and anxiety disorders (Benz et al., 2020; Boland et al., 2023; Leerssen et al., 2021) .”
BackgroundShi, Y., Ren, R., Zhang, Y., Vitiello, M. V., & Tang, X. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14077 · Cited by 2
“The durability of D-CBT-I suggests that the patients exhibit sustained clinical gains after the formal six or eight intervention is discontinued (Benz et al., 2020).”
Hartley, S., Dagneaux, S., Palethorpe, C., Londe, V., Liane, M.-T., Decalf, L., Aussert, F., Francs, C. C. D., Leymarie, R., & Royant‐Parola, S. (2025) · Médecine du Sommeil · doi:10.1016/j.msom.2025.02.001 · Cited by 2
Faccini, J., Bayard, S., Madiouni, C., & Del-Monte, J. (2025) · Journal of American College Health · doi:10.1080/07448481.2025.2479693 · Cited by 3
“On the other hand, a meta-analysis 11 revealed that cognitive-behavioral sleep therapy is more effective in treating nocturnal symptoms than daily ones.”
Murri, M. B., Garza, C. K., Grassi, L. G., & Muskin, P. R. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_113 · Cited by 1
Sochal, M., Feige, B., Spiegelhalder, K., & Ell, J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14093206 · Cited by 1
“Because of this, the following actigraphy-derived PA parameters (continuous variables) were calculated for each day: average PA as well as minutes of >10 mg PA (see [14]) one and two hours before and one and two hours after time in bed (TIB).”
Zhao, C., Chen, X., Zhang, A., Huo, N., Yu, S., Lai, L., & Liu, J. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1535349 · Cited by 1
Faccini, J., Joshi, V., & Jonathan, D.-M. (2025) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2025.152625 · Cited by 1
Rauwerda, N. L., Kuut, T. A., Braamse, A. M. J., Nieuwkerk, P. T., Boss, H., Knoop, H., & van Straten, A. (2025) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465825100945 · Cited by 1
“CBT-F can lead to improvements in subjective sleep quality in patients with ME/CFS (Russell et al ., 2017) and CBT-I to moderate improvements in fatigue (Benz et al ., 2020).”
Perseverative Thinking in Depression and Insomnia
Ballesio, A., Zagaria, A., & Goldschmied, J. (2025) · CBT: science into practice · doi:10.1007/978-3-031-92265-7_3 · Cited by 1
Lai, Y., Chen, D., Tian, C., Huang, Y., Gan, D., Liu, L., & Yang, J. (2025) · International Journal of Women s Health · doi:10.2147/ijwh.s553524 · Cited by 1
“10,11 However, their efficacy is often limited in patients with diminished ovarian reserve (DOR), owing to the complex and intertwined nature of the comorbid symptomatology.”
Metadata
- Authors
- Benz, F., Knoop, T., Ballesio, A., Bacaro, V., Johann, A. F., Rücker, G., Feige, B., Riemann, D., & Baglioni, C.
- Affiliations
- University of Freiburg (DE)
- Sapienza University of Rome (IT)
- Marconi University (IT)
- Corresponding author
- Benz, Fee
- ORCID
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 80
- Pages
- 101873
- ISSN
- 0272-7358 (ISSN-L)
- OpenAlex
- W3033016172
- Cited by
- 142
- References
- 61
- Citations by year
- 2026: 21 · 2025: 37 · 2024: 20 · 2023: 30 · 2022: 21 · 2021: 11 · 2020: 2
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Clinical Psychology Review (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by-nc-nd)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- Funders
- Bundesministerium für Bildung und Forschung (01KG1703)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- insomnia, cognitive behavioral therapy for insomnia, daytime symptoms, daytime sleepiness, fatigue, depressive symptoms, anxiety, quality of life, daytime functioning, social functioning, self-help intervention, group therapy, individual psychotherapy
- MeSH terms
- Network Meta-Analysis, Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Cognition, Depression, Fatigue, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Quality of Life, Cognitive Behavioral Therapy, Treatment Outcome, Young Adult
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