Cited by 236Olfactory and Sensory Function StudiesIon Channels and ReceptorsBiochemical Analysis and Sensing Techniques

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Something in the Air? New Insights into Mammalian Pheromones

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Brennan, Peter A., Keverne, Eric B.·2004·Current Biology

DOI 10.1016/j.cub.2003.12.052

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Abstract

Olfaction is the dominant sensory modality for most animals and chemosensory communication is particularly well developed in many mammals. Our understanding of this form of communication has grown rapidly over the last ten years since the identification of the first olfactory receptor genes. The subsequent cloning of genes for rodent vomeronasal receptors, which are important in pheromone detection, has revealed an unexpected diversity of around 250 receptors belonging to two structurally different classes. This review will focus on the chemical nature of mammalian pheromones and the complementary roles of the main olfactory system and vomeronasal system in mediating pheromonal responses. Recent studies using genetically modified mice and electrophysiological recordings have highlighted the complexities of chemosensory communication via the vomeronasal system and the role of this system in handling information about sex and genetic identity. Although the vomeronasal organ is often regarded as only a pheromone detector, evidence is emerging that suggests it might respond to a much broader variety of chemosignals.

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“The AOB and the vomeronasal organ are responsible for pheromone sensing in mammals.(17) Pheromonal cues are detected within the vomeronasal organ at the base of the nasal cavity and carried via vomeronasal receptor neurons to the AOB, where this information is processed.”
Background
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Background
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“Consequently, both systems should be conceived as complementary rather than as separate pathways [87, 88].”
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Background
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“While volatile pheromonal signals are thought to bemediated by V1Rs in apical VNO neurons, evidence suggests that V2Rs located in the basal VNOmediate non-volatile signaling and are thus responsible for behaviors attributed to non-volatiles such as pregnancy block (failure of implantation caused by a non-congenic male…”
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“Starting from the late ‘60s, many studies have been carried out on chemical communication in mammals and extensive work has been made in the attempt to identify the semiochemicals involved (Albone and Shirley 1984; Johnston 2003; Brennan and Keverne 2004).”
Background
Olfactory and tissue markers of fear in mammals including humans.
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“Various articles have well-summarized the detailed molecular mechanisms responsible for decoding pheromonal communication (Zufall and Leinders-Zufall, 2007; Stowers and Marton, 2005; Dulac and Torello, 2003; Brennan and Keverne, 2004).”
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“Nevertheless, it has been shown that volatile compounds and their associations with major urinary proteins (MUPs), acting on the accessory olfactory system and vomeronasal organ (VNO) system (Brennan and Keverne, 2004) elicit physiological and behavioral changes (Johnston and Bronson, 1982; Sipos et al.”
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“Olfactory sense is critical for a range of mouse behaviors, including navigation, foraging, escape, object recognition, and behavioral elements (Doty, 1986; Schellinck et al., 1993; Brennan and Keverne, 2004; Keverne, 2004; Restrepo et al., 2004; Kavaliers et al., 2005).”
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“Releaser pheromones induce direct behavioural changes, while primer pheromones cause neuroendocrine changes (Karlson and Luscher 1959; Brennan and Keverne 2004).”
Background
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“Initially described in insects, subsequently they have been detected and investigated in mammals [2].”
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Accessory Olfactory System
Zufall, F., Leinders‐Zufall, T., & Puché, A. C. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00128-6 · Cited by 6
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“The term pheromones, first used by Karlson and Lüscher in 1959, refers to a chemicals capable of convey information, triggering endocrine, behavioral and developmental reactions amongst conspecifics, including mammals (Brennan & Keverne, 2004; Karlson & Luscher, 1959).”
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“Indeed, olfactory discrimination abilities are crucial to survival in most rodents [67, 68], and it is likely highly adaptable to exhibit preserved sensory function throughout the lifespan of a rodent.”
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“These receptors represent the first processing stage of the vomeronasal (or “accessory”) olfactory system, which is the major pheromone chemosensory system in small-brained mammals ( Brennan and Keverne 2004; Keverne 2002).”
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“Consequently, both systems should be conceived as complementary rather than as separate pathways (Brennan and Keverne, 2004; Keller et al., 2009).”
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“1) (Brennan & Keverne, 2004).”
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“These proteins belong to lipocalin family and called as pheromone binding / carrying protein (PBP/PCP) [5].”
Background
Phylogeny of Chemical Sensitivity
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“Without a functional VNO, these animals have lost the ability to acquire the biologically relevant information about conspecifics that is necessary for appropriate and adaptive social interaction (for a review of the effects of surgical and genetic VNO ablations see Brennan & Keverne, 2004).”
Background

Authors: Brennan, P. A., & Keverne, E. B.
Affiliations: University of Cambridge (GB)
ORCID: Brennan, Peter A.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2004-01
Volume: 14
Issue: 2
Pages: R81-R89
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2003.12.052
OpenAlex: W2110523906
Semantic Scholar: e0cc580358f9277e8f24797630d7e7ff00834142
Cited by: 236
References: 77
Citations by year: 2026: 2 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 11 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 19
FWCI: 2.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3485 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: vomeronasal system, vomeronasal receptors, olfactory receptors, chemosensory communication, vomeronasal organ, sex pheromone, genetic identity, chemosignals, olfactory system
MeSH terms: Afferent Pathways, Animals, Animal Communication, Chemoreceptor Cells, Mammals, Olfactory Bulb, Pheromones, Sex Factors, Smell, Vomeronasal Organ

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Something in the Air? New Insights into Mammalian Pheromones

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