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Something in the Air? New Insights into Mammalian Pheromones
Open accessAbstract
Olfaction is the dominant sensory modality for most animals and chemosensory communication is particularly well developed in many mammals. Our understanding of this form of communication has grown rapidly over the last ten years since the identification of the first olfactory receptor genes. The subsequent cloning of genes for rodent vomeronasal receptors, which are important in pheromone detection, has revealed an unexpected diversity of around 250 receptors belonging to two structurally different classes. This review will focus on the chemical nature of mammalian pheromones and the complementary roles of the main olfactory system and vomeronasal system in mediating pheromonal responses. Recent studies using genetically modified mice and electrophysiological recordings have highlighted the complexities of chemosensory communication via the vomeronasal system and the role of this system in handling information about sex and genetic identity. Although the vomeronasal organ is often regarded as only a pheromone detector, evidence is emerging that suggests it might respond to a much broader variety of chemosignals.
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“It is the first site where signals from the olfactory bulb and vomeronasal system converge, thus positioning the MeA to recognize, analyze, and categorize incoming chemosensory information 11 .”
From Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics (2016) · cites this paper as [11]
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BackgroundResultUkhanov, K., Leinders‐Zufall, T., & Zufall, F. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00642.2007 · Cited by 45
Comparative Analysis of Volatile Constituents from Mice and their Urine
Röck, F., Mueller, S., Weimar, U., Rammensee, H., & Overath, P. (2006) · Journal of Chemical Ecology · doi:10.1007/s10886-006-9091-2 · Cited by 44
“These compounds are perceived either through the main or the accessory olfactory organ (reviewed in Brennan and Keverne, 2004; Stowers and Marton, 2005).”
BackgroundAchiraman, S., & Archunan, G. (2006) · Theriogenology · doi:10.1016/j.theriogenology.2006.05.010 · Cited by 43
“Chemical olfaction is vital for inter-individual communication among the same species for several functions including reproductive behaviour, such as, sexual attraction [1–4], interference with puberty, estrus cycle and pregnancy [5,6], as well as social behaviour like territorial marking [7,8], individual identificat…”
BackgroundCladistic Analysis of Olfactory and Vomeronasal Systems
Úbeda‐Bañón, I., Pró-Sistiaga, P., Mohedano‐Moriano, A., Saiz‐Sánchez, D., de la Rosa‐Prieto, C., Gutiérrez‐Castellanos, N., Lanuza, E., Martínez‐Garciá, F., & Martı́nez-Marcos, A. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00003 · Cited by 42
“neurons to higher processing centers and, ultimately, to behavior (Buck, 1995, 1996, 2000, 2004; Mombaerts, 1996, 1999a,b, 2004; Mombaerts et al., 1996; Dulac, 1997, 2000; Dulac and Torello, 2003; Brennan and Keverne, 2004; Brennan and Zufall, 2006; Dulac and Wagner, 2006; Cleland, 2010).”
Meillour, P. N., Vercoutter‐Edouart, A., Hilliou, F., Danvic, C. L., & Lévy, F. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00202 · Cited by 45
“Contrary to OBP isoforms of short size, VEG isoforms of short size are never labeled by RL2, suggesting that the modification occurs on the N-terminal part that is missing in these forms (peptide [1–16]).”
BackgroundReisenman, C. E., Christensen, T. A., & Hildebrand, J. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1314-05.2005 · Cited by 41
“The second subsystem, analogous to the “accessory” OB of many vertebrates (for review, see Brennan and Keverne, 2004), comprises three sexually dimorphic glomeruli (Rospars and Hildebrand, 1992).”
BackgroundThe scent of wolves: pyrazine analogs induce avoidance and vigilance behaviors in prey
Osada, K., Miyazono, S., & Kashiwayanagi, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00363 · Cited by 39
“In addition to the primary olfactory system, most mammals have a vomeronasal system; this system contributes to the detection of certain conspecific pheromones, and it also perceives common volatile odorants (Trinh and Storm, 2003; Brennan and Keverne, 2004).”
BackgroundCo-evolution of a primordial peptide-presentation system and cellular immunity
Boehm, T. L. J. (2006) · Nature reviews. Immunology · doi:10.1038/nri1749 · Cited by 38
“Previous work had shown that the Bruce effect depends on an intact vomeronasal organ that forms part of the olfactory system in mic”
BackgroundThe Microevolution of V1r Vomeronasal Receptor Genes in Mice
Park, S. H., Podlaha, O., Grus, W. E., & Zhang, J. (2011) · Genome Biology and Evolution · doi:10.1093/gbe/evr039 · Cited by 37
“In the genome of the laboratory mouse, ª The Author(s) 2011.”
BackgroundZhang, H., Wang, P., Yu, H., Yu, K., Cao, Z., Xu, F., Yang, X., Song, M., & Li, Y. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.03.162 · Cited by 36
Shimazaki, R. (2006) · Chemical Senses · doi:10.1093/chemse/bjj047 · Cited by 37
“…in the brain (for reviews on the vomeronasal system see Døving and Trotier, 1998; Jacobson et al., 1998; Keverne, 2002; Zufall et al., 2002, 2005; Dulac and Torello, 2003; Halpern and Martinez-Marcos, 2003; Rodriguez, 2003, 2004; Brennan and Keverne, 2004; Luo and Katz, 2004; Bigiani et al., 2005).”
BackgroundBiomarkers of fitness and welfare in dairy animals: healthy living
de Almeida, A. D., Zachut, M., Hernández-Castellano, L., Šperanda, M., Gabai, G., & Mobasheri, A. (2019) · Journal of Dairy Research · doi:10.1017/s0022029919000803 · Cited by 29
Natural ligands of hamster aphrodisin.
Briand, L., Blon, F., Trotier, D., & Pernollet, J. (2004) · Chemical Sensors · doi:10.1093/chemse/bjh044 · Cited by 38
“In many species, in contrast with the large number of well-documented sex attractants in insects, mammal pheromones are still poorly identified chemical cues (Dulac and Torello, 2003; Schaal et al., 2003; Brennan and Keverne, 2004).”
BackgroundVolatile female odors activate the accessory olfactory system of male mice without physical contact
Muroi, Y., Ishii, T., Komori, S., Kitamura, N., & Nishimura, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.026 · Cited by 35
“proteins act as transporters and reservoirs of volatile pheromones ( Brennan and Keverne, 2004 ).”
BackgroundDhungel, S., Masaoka, M., Rai, D., Kondo, Y., & Sakuma, Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.051 · Cited by 32
“VNO and OE inputs may complement each other (Brennan and Keverne, 2004; Brennan and Zufall, 2006).”
Backgroundα1A‐Adrenergic regulation of inhibition in the olfactory bulb
Zimnik, N. C., Treadway, T., Smith, R. S., & Araneda, R. C. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.248591 · Cited by 35
“…a region involved in the processing of chemosignals that trigger aggressive and reproductive behaviours, noradrenaline (NA) is thought to promote synaptic changes that underlie a female mouse’s ability to learn a stud’s odour during mating, also known as the Bruce effect (Brennan & Keverne, 2004).”
BackgroundAsymmetrical cache pilfering between yellow pine chipmunks and golden-mantled ground squirrels
Wall, S. B. V., Enders, M. S., & Waitman, B. A. (2009) · Animal Behaviour · doi:10.1016/j.anbehav.2009.05.030 · Cited by 31
Chapter 8 Neurobiology of Maternal Behavior in Sheep
Lévy, F., & Keller, M. (2008) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)00008-9 · Cited by 31
The vomeronasal system in mice: From the nose to the hypothalamus- and back!
Boehm, U. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.04.013 · Cited by 31
Suárez, R., & Mpodozis, J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.009 · Cited by 31
Genomic Imprinting and the Evolution of Sex Differences in Mammalian Reproductive Strategies
Keverne, E. B. (2007) · Advances in genetics · doi:10.1016/s0065-2660(07)59008-5 · Cited by 29
Self-citationFactors That Can Influence Animal Research
Baker, D. G., & Lipman, N. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-409527-4.00033-x · Cited by 30
Thompson, R. N., McMillon, R., Napier, A., & Wekesa, K. S. (2007) · Journal of Experimental Biology · doi:10.1242/jeb.02753 · Cited by 29
“Clear phenotypic discrepancies have been observed between genetically modified mice and those with surgical VNO lesions (McCarthy and Auger, 2002; Brennan and Keverne, 2004; Pankevich et al., 2004).”
BackgroundKavaliers, M., Choleris, E., Ågmo, A., Muglia, L. J., Ogawa, S., & Pfaff, D. W. (2005) · Animal Behaviour · doi:10.1016/j.anbehav.2004.12.016 · Cited by 28
Induction of c-Fos Expression in Mouse Vomeronasal Neurons by Sex-specific Non-volatile Pheromone(s)
Kimoto, H. (2005) · Chemical Senses · doi:10.1093/chemse/bjh156 · Cited by 28
“Since numerous studies have described that urine or urine-derived compounds cause several pheromonal effects including male–male aggression, puberty acceleration and pregnancy block (Dulac and Torello, 2003; Brennan and Keverne, 2004), our observation that the stimulant(s) is non-volatile and not urine-originated is l…”
BackgroundDynamic evolution of V1R putative pheromone receptors between Mus musculus and Mus spretus
Kurzweil, V. C., Getman, M., Program, N. C. S., Green, E. D., & Lane, R. P. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-74 · Cited by 25
“The vomeronasal organ (VNO) of terrestrial vertebrates is responsible for pheromonal responses that evoke social and reproductive behaviors, including male territorial aggression, sexual preference, and sexual maturity (reviewed in [1]).”
BackgroundLiu, Y., Lieberwirth, C., Jia, X., Curtis, J. T., Meredith, M. J., & Wang, Z. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12531 · Cited by 25
“Although there are various definitions, pheromones are commonly defined as chemosensory stimuli conveying information among conspecifics (Dulac & Torello, 2003; Brennan & Keverne, 2004).”
BackgroundOdor Perception and the Variability in Natural Odor Scenes
Wright, G. A., & Thomson, M. G. A. (2005) · Recent advances in phytochemistry · doi:10.1016/s0079-9920(05)80009-7 · Cited by 25
“Pheromones are often produced in specific glandular tissues specialized for their production,(24,25) but they may also arise from other scent sources such as body tissues.(26) Volatile compounds, such as ethylene and methyl jasmonate, are produced by plants during herbivorous attack and have been shown to act as signa…”
Background
Metadata
- Authors
- Brennan, P. A., & Keverne, E. B.
- Affiliations
- University of Cambridge (GB)
- ORCID
- Brennan, Peter A.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 14
- Issue
- 2
- Pages
- R81-R89
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2110523906
- Semantic Scholar
- e0cc580358f9277e8f24797630d7e7ff00834142
- Cited by
- 236
- References
- 77
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 11 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 19
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3485 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- vomeronasal system, vomeronasal receptors, olfactory receptors, chemosensory communication, vomeronasal organ, sex pheromone, genetic identity, chemosignals, olfactory system
- MeSH terms
- Afferent Pathways, Animals, Animal Communication, Chemoreceptor Cells, Mammals, Olfactory Bulb, Pheromones, Sex Factors, Smell, Vomeronasal Organ
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