Cell Signaling: Moving to a Wnt-Rap
Open accessAbstract
Non-canonical, beta-catenin-independent Wnt signaling regulates cell polarization and movements. A recent study reveals that casein kinase Iepsilon mediates an additional novel non-canonical Wnt pathway via the activation of the Rap1 GTPase during vertebrate gastrulation.
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During gastrulation, Wnt signaling via casein kinase inhibits the Rap1-GTPase leading to cytoskeletal modulation.
“During gastrulation, Wnt signaling via casein kinase inhibits the Rap1-GTPase leading to cytoskeletal modulation.106,107”
From Wnt signal transduction pathways (2008) · cites this paper as [106]
Cites
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LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
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Self-citationHabas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842 · see citing works
Self-citationCoactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
Habas, R., Dawid, I. B., & He, X. (2003) · Genes & Development · doi:10.1101/gad.1022203 · Cited by 603 · see citing works
Self-citationFrizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
Seifert, J. R. K., & Mlodzik, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2042 · Cited by 513 · see citing works
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509 · see citing works
Self-citationBos, J. L. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.009 · Cited by 481 · see citing works
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Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure
Ybot‐González, P., Savery, D., Gerrelli, D., Signore, M., Mitchell, C. E., Faux, C. H., Greene, N. D. E., & Copp, A. J. (2007) · Development · doi:10.1242/dev.000380 · Cited by 330 · see citing works
Wnt11 Functions in Gastrulation by Controlling Cell Cohesion through Rab5c and E-Cadherin
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CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signalingPreprint
Price, M. A. (2006) · Genes & Development · doi:10.1101/gad.1394306 · Cited by 257 · see citing works
Rap1 GTPase Regulation of Adherens Junction Positioning and Cell Adhesion
Knox, A. L., & Brown, N. H. (2002) · Science · doi:10.1126/science.1067549 · Cited by 238 · see citing works
Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled
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Gastrulation in zebrafish — all just about adhesion?
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Planar Polarity Is Positively Regulated by Casein Kinase Iɛ in Drosophila
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CKIɛ/discs overgrown Promotes Both Wnt-Fz/β-Catenin and Fz/PCP Signaling in Drosophila
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Rap1: A turnabout for the crosstalk between cadherins and integrins
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Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works
Self-citationWnt3A Induces GSK‐3β Phosphorylation and β‐Catenin Accumulation Through RhoA/ROCK
Kim, J., Kim, M., Choi, W. B., Moon, M., Kim, H., Lee, J., Kim, J., Kim, S., Kang, S. G., Seo, G., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25572 · Cited by 65 · see citing works
Are Small GTPases Signal Hubs in Sugar-Mediated Induction of Fructan Biosynthesis?
Ritsema, T., Brodmann, D., Diks, S. H., Bos, C. L., Nagaraj, V. J., Pieterse, C. M. J., Böller, T., Wiemken, A., & Peppelenbosch, M. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006605 · Cited by 38 · see citing works
Non-redundant roles for Profilin2 and Profilin1 during vertebrate gastrulation
Khadka, D., Liu, W., & Habas, R. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.06.008 · Cited by 37 · see citing works
Self-citationTideglusib enhances odontogenic differentiation in human dental pulp stem cellsin vitro
Kornsuthisopon, C., Tompkins, K. A., & Osathanon, T. (2022) · International Endodontic Journal · doi:10.1111/iej.13877 · Cited by 21 · see citing works
Potential of casein kinase I in digestive cancer screening
Modak, C. (2009) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v1.i1.26 · Cited by 11 · see citing works
Birnbaum, R., Ezer, S., Lotan, N. S., Eilat, A., Sternlicht, K., Benyamini, L., Reish, O., Zaccai, T. C. F., Ben-Gad, G., Rod, R., et al. (2023) · Journal of Medical Genetics · doi:10.1136/jmg-2023-109504 · Cited by 2 · see citing works
- Authors
- Habas, R., & He, X.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Habas, Raymond
- He, Xi
- ORCID
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 17
- Issue
- 12
- Pages
- R474-R477
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2032774843
- Cited by
- 7
- References
- 20
- Citations by year
- 2023: 1 · 2022: 1 · 2016: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2238 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM078172)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- non-canonical Wnt signaling, casein kinase I epsilon, Rap1 GTPase, cell polarization, cell migration
- MeSH terms
- Animals, Gastrula, Xenopus, Zebrafish, Signal Transduction, Gene Expression Regulation, Developmental, rap1 GTP-Binding Proteins, Xenopus Proteins, Zebrafish Proteins, Casein Kinase 1 epsilon, Wnt Proteins
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