Cited by 544Inflammasome and immune disordersImmune Response and InflammationSkin Protection and Aging

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The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

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Feldmeyer, Laurence, Keller, Martin, Niklaus, Gisela, Hohl, Daniel, Werner, Sabine, Beer, Hans-Dietmar·2007·Current Biology

DOI 10.1016/j.cub.2007.05.074

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Abstract

It has long been known that human keratinocytes are a potent source of the proinflammatory cytokines proIL-1alpha and -1beta[1], which are activated and released in response to UV irradiation [2]. However, the intracellular pathways, which regulate maturation and secretion of IL-1 in keratinocytes, are unknown. Here we show that the UVB-mediated enhancement of cytoplasmic Ca(2+) is required for activation of the IL-1beta-converting enzyme caspase-1 by the inflammasome, a multiprotein innate immune complex [3, 4]. Caspase-1 in turn activates proIL-1beta, and keratinocytes secrete the cytokine as well as inflammasome components. These results demonstrate the presence of a proIL-1beta-processing inflammasome in nonprofessional immune cells and the necessity of inflammasome components for the UVB-induced secretion of IL-1beta. This supports the concept that keratinocytes are important immuno-competent cells under physiological and pathological conditions [5].

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A ADMINISTRAÇÃO SISTÊMICA E TÓPICA DE VITAMINAS ANTIOXIDANTES ACELERA A CICATRIZAÇÃO DE FERIDAS CUTÂNEAS EM CAMUNDONGOS DIABÉTICOS
Paulo, S. (2014)

Authors: Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D.
Affiliations: ETH Zurich (CH)
Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author: Beer, Hans-Dietmar
ORCID: Feldmeyer, Laurence
Hohl, Daniel
Werner, Sabine
Beer, Hans-Dietmar
Venue: Current Biology
Publisher: Elsevier BV
Published: 2007-07
Volume: 17
Issue: 13
Pages: 1140-1145
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2007.05.074
OpenAlex: W1999276471
Cited by: 544
References: 25
Citations by year: 2026: 14 · 2025: 18 · 2024: 19 · 2023: 22 · 2022: 23 · 2021: 32 · 2020: 29 · 2019: 30 · 2018: 30 · 2017: 38 · 2016: 34 · 2015: 35 · 2014: 40 · 2013: 30 · 2012: 41
FWCI: 10.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2208 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords: inflammasome, UVB irradiation, IL-1β, keratinocytes, caspase-1, intracellular calcium, innate immunity, skin inflammation
MeSH terms: Animals, Calcium, Cytoplasm, Dermatitis, Humans, Interleukin-1, Protein Precursors, Ultraviolet Rays, Keratinocytes, Cytokines, Mice, Knockout, Inflammation Mediators, Caspase 1, Multiprotein Complexes, Mice, Interleukin-1beta

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The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

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