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The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes
Open accessAbstract
It has long been known that human keratinocytes are a potent source of the proinflammatory cytokines proIL-1alpha and -1beta[1], which are activated and released in response to UV irradiation [2]. However, the intracellular pathways, which regulate maturation and secretion of IL-1 in keratinocytes, are unknown. Here we show that the UVB-mediated enhancement of cytoplasmic Ca(2+) is required for activation of the IL-1beta-converting enzyme caspase-1 by the inflammasome, a multiprotein innate immune complex [3, 4]. Caspase-1 in turn activates proIL-1beta, and keratinocytes secrete the cytokine as well as inflammasome components. These results demonstrate the presence of a proIL-1beta-processing inflammasome in nonprofessional immune cells and the necessity of inflammasome components for the UVB-induced secretion of IL-1beta. This supports the concept that keratinocytes are important immuno-competent cells under physiological and pathological conditions [5].
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“Recent studies have implicated the inflammasome, a multiprotein complex of the innate immune system responsible for activation and release of IL-1β from several skin cell types, in the development of chronic wounds (31, 32).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [31]
In the citing paper
“We postulated that constitutive expression of pro-IL-1β by keratinocytes [20] as shown (Figure 2A) would prime them for activation of the inflammasome.”
From Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes (2012) · cites this paper as [20]
In the citing paper
“For example, both murine and human keratinocytes express inflammasome components NLRP-3, ASC, caspase-1, IL-1β, and IL-18 (43,44).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [43]
In the citing paper
“In addition, ultraviolet irradiation–induced IL-1β secretion from human keratinocytes in vitro appears to be mediated by the NLRP-3 inflammasome (43)”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [43]
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Cites
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864
Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
Mariathasan, S., & Monack, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1997 · Cited by 879
Keratinocytes as initiators of inflammation
Barker, J. N., Griffiths, C. E. M., Nickoloff, B. J., Mitra, R. S., Dixit, V. M., & Nickoloff, B. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)92168-2 · Cited by 766
Early molecular events in the induction phase of contact sensitivity.
Enk, A., & Katz, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1398 · Cited by 650
Gurcel, L., Abrami, L., Girardin, S. E., Tschopp, J., & van der Goot, F. G. (2006) · Cell · doi:10.1016/j.cell.2006.07.033 · Cited by 508
Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea
Dinarello, C. A. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08307.x · Cited by 497
The Inflammasome: First Line of the Immune Response to Cell Stress
Ogura, Y., Sutterwala, F. S., & Flavell, R. A. (2006) · Cell · doi:10.1016/j.cell.2006.08.002 · Cited by 474
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The gasdermin family: emerging therapeutic targets in diseases
Zhu, C., Xu, S., Jiang, R., Yu, Y., Bian, J., & Zou, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01801-8 · Cited by 149
Inflammasome biology, molecular pathology and therapeutic implications
Awad, F., Assrawi, E., Louvrier, C., Jumeau, C., Georgin‐Lavialle, S., Grateau, G., Amselem, S., Giurgea, I., & Karabina, S. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.011 · Cited by 138
Detection of immune danger signals by NALP3
Martinon, F. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607362 · Cited by 140
Sharma, A., Bode, B., Wenger, R. H., Lehmann, K., Sartori, A. A., Moch, H., Knuth, A. K., von Boehmer, L., & van den Broek, M. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028217 · Cited by 133
Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells
Stoecklein, V. M., Osuka, A., Ishikawa, S., Lederer, M. R., Wanke-Jellinek, L., & Lederer, J. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303051 · Cited by 137
HPV16 activates the AIM2 inflammasome in keratinocytes
Reinholz, M., Kawakami, Y., Salzer, S., Kreuter, A., Dombrowski, Y., Koglin, S., Kresse, S., Ruzicka, T., & Schauber, J. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1375-0 · Cited by 132
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Shrivastava, G., León‐Juárez, M., García‐Cordero, J., Meza-Sánchez, D. E., & Cedillo‐Barrón, L. (2016) · Immunologic Research · doi:10.1007/s12026-016-8873-z · Cited by 135
Sand, J., Haertel, E., Biedermann, T., Contassot, E., Ernst Reichmann, A., French, L. E., Werner, S., & Beer, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0009-4 · Cited by 132
Self-citationInflammation: A key process in skin tumorigenesis (Review)
Neagu, M. T., Constantin, C., Căruntu, C., Dumitru, C., Surcel, M., & Zurac, S. (2018) · Oncology Letters · doi:10.3892/ol.2018.9735 · Cited by 129
Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases
Marzano, A. V., Ortega‐Loayza, A. G., Heath, M. S., Morse, D., Genovese, G., & Cugno, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01059 · Cited by 126
Fenini, G., Grossi, S., Contassot, E., Biedermann, T., Reichmann, E., French, L. E., & Beer, H.-D. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.07.016 · Cited by 125
Self-citationVaeth, M., Zee, I., Concepcion, A. R., Maus, M., Shaw, P. J., Portal‐Celhay, C., Zahra, A., Kozhaya, L., Weidinger, C., Philips, J. A., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403013 · Cited by 122
Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP
Liao, K., & Mogridge, J. (2012) · Infection and Immunity · doi:10.1128/iai.01003-12 · Cited by 120
Bryan, N. B., Dorfleutner, A., Kramer, S. J., Yun, C., Rojanasakul, Y., & Stehlik, C. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-23 · Cited by 123
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Dunn, J. H., Ellis, L. Z., & Fujita, M. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.10.001 · Cited by 117
Xu, Z., Dong, M., Yin, S., Dong, J., Zhang, M., Tian, R., Min, W., Zeng, L. J., Qiao, H., & Chen, J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114764 · Cited by 115
Vieyra-Garcia, P. A., & Wolf, P. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107784 · Cited by 114
Jenster, L., Lange, K.-E., Normann, S., Hemdt, A. V., Wuerth, J. D., Schiffelers, L. D. J., Tesfamariam, Y. M., Gohr, F. N., Klein, L., Kaltheuner, I. H., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220837 · Cited by 114
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Cataisson, C., Salcedo, R., Hakim, S., Moffitt, A. B., Wright, L. N., Yi, M., Stephens, R. M., Dai, R., Lyakh, L. A., Schenten, D., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20101355 · Cited by 112
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Altmeier, S., Toska, A., Sparber, F., Teijeira, A., Halin, C., & LeibundGut-Landmann, S. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005882 · Cited by 112
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Ratsimandresy, R. A., Dorfleutner, A., & Stehlik, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00440 · Cited by 114
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Thi, H. T. H., & Hong, S. (2017) · Journal of Cancer Prevention · doi:10.15430/jcp.2017.22.2.62 · Cited by 111
Angst, M. S., Clark, J. D., Carvalho, B., Tingle, M. S., Schmelz, M., & Yeomans, D. C. (2008) · Pain · doi:10.1016/j.pain.2008.02.028 · Cited by 109
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Hibma, M. H. (2012) · The Open Virology Journal · doi:10.2174/1874357901206010241 · Cited by 112
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Meier-Schiesser, B., Feldmeyer, L., Jankovic, D. L., Mellett, M., Satoh, T. K., Yerly, D., Navarini, A. A., Abe, R., Yawalkar, N., Chung, W., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.10.023 · Cited by 108
Self-citationInflammasomes in wound healing and fibrosis
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Tang, S., Liao, P.-Y., Hung, S., Ge, J., Chen, S.-M., Lai, J.-C., Hsiao, Y., & Yang, J. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.03.004 · Cited by 107
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Nasti, T. H., & Timares, L. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01182.x · Cited by 107
Jang, J., Kim, D.-H., Lim, J. M., Lee, J. W., Jeong, S. J., Kim, K. P., & Surh, Y. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2288 · Cited by 108
Lian, L., Milora, K. A., Manupipatpong, K. K., & Jensen, L. E. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.482 · Cited by 107
Xie, Q., SHEN, W.-W., Zhong, J., Huang, C., Zhang, L., & Li, J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1755 · Cited by 104
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Piippo, N., Korhonen, E., Hytti, M., Skottman, H., Kinnunen, K., Josifovska, N., Petrovski, G., Kaarniranta, K., & Kauppinen, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-25123-2 · Cited by 102
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Patra, V., Wagner, K., Arulampalam, V., & Wolf, P. (2019) · iScience · doi:10.1016/j.isci.2019.04.026 · Cited by 99
Cohen, I., Rider, P., Vornov, E., Tomas, M., Tudor, C., Wegner, M., Brondani, L., Freudenberg, M., Mittler, G., Ferrando-May, E., et al. (2015) · Scientific Reports · doi:10.1038/srep14756 · Cited by 98
Jiang, W., Lv, H., Wang, H., Wang, D., Sun, S., Jia, Q., Wang, P., Song, B., & Ni, L. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2118-7 · Cited by 98
Photoaging and skin cancer: Is the inflammasome the missing link?
Awad, F., Assrawi, E., Louvrier, C., Jumeau, C., Giurgea, I., Amselem, S., & Karabina, S. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.003 · Cited by 101
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Self-citationDubey, S. R., Turnbull, C., Pandey, A., Zhao, A., Kurera, M., Al-Zidan, R. N., Shen, C. X., Gautam, M., Mahajan, S., Jadhav, P. S., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01354-y · Cited by 101
Li, S., Herrera, G. G., Tam, K. K., Lizarraga, J. S., Beedle, M., & Winuthayanon, W. (2018) · Scientific Reports · doi:10.1038/s41598-018-29423-5 · Cited by 95
Cerqueira, D. M., Gomes, M. T. R., Silva, A. L. N., Rungue, M., Assis, N. R. G., Guimarães, E. S., Morais, S. B., Brož, P., Zamboni, D. S., & Oliveira, S. C. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007519 · Cited by 98
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Weinheimer-Haus, E. M., Mirza, R. E., & Koh, T. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119106 · Cited by 95
Newman, Z. L., Printz, M. P., Liu, S., Crown, D., Breen, L., Miller-Randolph, S., Flodman, P. L., Leppla, S. H., & Moayeri, M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000906 · Cited by 97
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Gong, Y., Wang, X., Wang, J., Yang, Z., Li, S., Yang, J., Liu, L., Lei, X., & Shao, F. (2010) · Cell Research · doi:10.1038/cr.2010.135 · Cited by 96
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Marie, J., Kovacs, D., Pain, C., Jouary, T., Cota, C., Vergier, B., Picardo, M., Taı̈eb, A., Ezzedine, K., & Cario, M. (2014) · British Journal of Dermatology · doi:10.1111/bjd.12691 · Cited by 93
Mellett, M., Meier-Schiesser, B., Mohanan, D., Schairer, R., Cheng, P. F., Satoh, T. K., Kiefer, B., Ospelt, C., Nobbe, S., Thome, M., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.03.1525 · Cited by 93
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Innate immunity in the pathogenesis of psoriasis
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Jura, J., Skalniak, Ł., & Koj, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.06.029 · Cited by 90
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Faustin, B., Chen, Y., Zhai, D., Negrate, G. L., Lartigue, L., Satterthwait, A. C., & Reed, J. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809414106 · Cited by 86
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Han, S., Cai, W., Yang, X., Jia, Y., Zheng, Z., Wang, H., Li, J., Li, Y., Gao, J., Fan, L., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/720457 · Cited by 86
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Johnston, A. W. B., Gudjonsson, J. E., Aphale, A., Guzman, A. M., Stoll, S. W., & Elder, J. T. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.313 · Cited by 85
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Kurinna, S. M., Schäfer, M., Ostano, P., Karouzakis, E., Chiorino, G., Bloch, W., Bachmann, A., Gay, S., Garrod, D. R., Lefort, K., et al. (2014) · Nature Communications · doi:10.1038/ncomms6099 · Cited by 82
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Zhou, J., An, X., Dong, J., Wang, Y., Zhong, H., Duan, L., Ling, J., Ping, F., & Shang, J. (2018) · The FASEB Journal · doi:10.1096/fj.201701242rr · Cited by 80
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Stojadinovic, O., Minkiewicz, J., Sawaya, A., Bourne, J. W., Torzilli, P., de Rivero Vaccari, J. P., Dietrich, W. D., Keane, R. W., & Tomic-Canic, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069223 · Cited by 77
Chronic Inflammation in Skin Malignancies
Tang, L., & Wang, K. (2016) · Journal of Molecular Signaling · doi:10.5334/1750-2187-11-2 · Cited by 78
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Metadata
- Authors
- Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D.
- Affiliations
- ETH Zurich (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Beer, Hans-Dietmar
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 17
- Issue
- 13
- Pages
- 1140-1145
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1999276471
- Cited by
- 544
- References
- 25
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 19 · 2023: 22 · 2022: 23 · 2021: 32 · 2020: 29 · 2019: 30 · 2018: 30 · 2017: 38 · 2016: 34 · 2015: 35 · 2014: 40 · 2013: 30 · 2012: 41
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- inflammasome, UVB irradiation, IL-1β, keratinocytes, caspase-1, intracellular calcium, innate immunity, skin inflammation
- MeSH terms
- Animals, Calcium, Cytoplasm, Dermatitis, Humans, Interleukin-1, Protein Precursors, Ultraviolet Rays, Keratinocytes, Cytokines, Mice, Knockout, Inflammation Mediators, Caspase 1, Multiprotein Complexes, Mice, Interleukin-1beta
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