The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes
Open accessAbstract
It has long been known that human keratinocytes are a potent source of the proinflammatory cytokines proIL-1alpha and -1beta[1], which are activated and released in response to UV irradiation [2]. However, the intracellular pathways, which regulate maturation and secretion of IL-1 in keratinocytes, are unknown. Here we show that the UVB-mediated enhancement of cytoplasmic Ca(2+) is required for activation of the IL-1beta-converting enzyme caspase-1 by the inflammasome, a multiprotein innate immune complex [3, 4]. Caspase-1 in turn activates proIL-1beta, and keratinocytes secrete the cytokine as well as inflammasome components. These results demonstrate the presence of a proIL-1beta-processing inflammasome in nonprofessional immune cells and the necessity of inflammasome components for the UVB-induced secretion of IL-1beta. This supports the concept that keratinocytes are important immuno-competent cells under physiological and pathological conditions [5].
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recent studies have implicated the inflammasome, a multiprotein complex of the innate immune system responsible for activation and release of IL-1β from several skin cell types, in the development of chronic wounds (31, 32).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [31]
In the citing paper
“We postulated that constitutive expression of pro-IL-1β by keratinocytes [20] as shown (Figure 2A) would prime them for activation of the inflammasome.”
From Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes (2012) · cites this paper as [20]
In the citing paper
“For example, both murine and human keratinocytes express inflammasome components NLRP-3, ASC, caspase-1, IL-1β, and IL-18 (43,44).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [43]
In the citing paper
“In addition, ultraviolet irradiation–induced IL-1β secretion from human keratinocytes in vitro appears to be mediated by the NLRP-3 inflammasome (43)”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [43]
Citations
Cites
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864
Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
Mariathasan, S., & Monack, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1997 · Cited by 879
Keratinocytes as initiators of inflammation
Barker, J. N., Griffiths, C. E. M., Nickoloff, B. J., Mitra, R. S., Dixit, V. M., & Nickoloff, B. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)92168-2 · Cited by 766
Early molecular events in the induction phase of contact sensitivity.
Enk, A., & Katz, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1398 · Cited by 650
Gurcel, L., Abrami, L., Girardin, S. E., Tschopp, J., & van der Goot, F. G. (2006) · Cell · doi:10.1016/j.cell.2006.07.033 · Cited by 508
Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea
Dinarello, C. A. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08307.x · Cited by 497
The Inflammasome: First Line of the Immune Response to Cell Stress
Ogura, Y., Sutterwala, F. S., & Flavell, R. A. (2006) · Cell · doi:10.1016/j.cell.2006.08.002 · Cited by 474
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–541 of 541
Saleh, M. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511976094.032
Inflammasome and Lung Pathologies
Ryffel, B., Togbe, D., & Couillin, I. (2011) · Springer eBooks · doi:10.1007/978-3-0348-0148-5_11
The role of mast cells in the immune response against bacterial infections
Zimmermann, C. (2016) · DepositOnce · doi:10.14279/depositonce-5528
Ion Flux Regulates Inflammasome Signaling
Yaron, J. R. (2015) · doi:10.13140/rg.2.2.32297.60007 · Cited by 1
Contribuição da genética do inflamassoma na predisposição a desenvolver melanoma maligno esporádico
da Silva, W. C. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2017.tde-09082017-113742
Cytokines, Growth Factors, and POMC Peptides
Böhm, M., Boniface, K., & Moretti, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-62960-5_29
Regulation of Endogenous Interleukin-36 Activity
Jaafar, A. (2019) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
IL-1 mediated autoinflammatory diseases
de Jesus, A. A., Ferguson, P. J., & Goldbach‐Mansky, R. T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816768-7.00028-4
Moore, C. D., Choi, S., Moon, G., Zhang, J. Y., Chen, Y., & Liedtke, W. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.09.426056
Fernandes, F. P. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2020.tde-01072021-115731
(2007) · Nature reviews. Immunology · doi:10.1038/nri2149
Mechanism of cytosolic nucleic acid induced IL-23 expression of human keratinocytes
Kelemen, E. (2022) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.11290
Epigenetic control of skin immunity
Shibata, S. (2023) · Immunological Medicine · doi:10.1080/25785826.2023.2170087
Ramos, Y. Á. L., Pietrobon, A. J., Teixeira, F. M. E., Aoki, V., Sato, M. N., & Orfali, R. L. (2025) · Anais Brasileiros de Dermatologia (Versão em Português) · doi:10.1016/j.abdp.2025.501136
Luo, Z.-L., Zhang, Q.-X., Du, M., Wang, Q., Liu, Y., & Ren, J.-D. (2023) · Research Square · doi:10.21203/rs.3.rs-3166793/v1
Skin Immune System: Microanatomy
Ono, S., & Kabashima, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00504-4
酸化ストレスに対するビタミンD及びニコチンアミドモノヌクレオチドの保護作用とその分子機序の解明
仲條, 嵩. (2025) · Institutional Repositories DataBase (IRDB)
Tamargo, M. G. D. A. (2011) · theses.fr (ABES) · doi:10.70675/8febaec4z61f1z41f7z9621zf9a3ffc15ed7
Implication de l'inflammasome NLRP3 dans la sécrétion non conventionnelle de la protéine FADD
Mouasni, S. (2018) · theses.fr (ABES) · doi:10.70675/8623f190zbb94z44b7z8b70zd93fa9be484d
New roles of the Lyn tyrosine kinase in psoriasis development and cell death
Diaz, L. E. A. (2018) · theses.fr (ABES) · doi:10.70675/3deccde8zd3dez40abzbda2ze9b04bfdfd62
Les inflammasomes : de la régulation aux maladies auto-inflammatoires
Jamilloux, Y. (2017) · theses.fr (ABES) · doi:10.70675/9025bd52z314az4bbcz9837za63778a1ffd3
Rôle de l'oncostatine M et des interleukines 6 et 31 dans l'inflammation cutanée chez la souris
Pohin, M. (2017) · theses.fr (ABES) · doi:10.70675/6ee5de11z33c0z4d68z9887z2c7a7194291a
Mécanismes immunologiques impliqués dans la perte des mélanocytes au cours du vitiligo
Boukhedouni, N. (2018) · theses.fr (ABES) · doi:10.70675/90f54f42z8dcaz46fezbd50zc27acc2f8cb1
Assrawi, E. (2019) · theses.fr (ABES) · doi:10.70675/82f530d5z0154z474cz9746z470b6a42c9e0
Lymphocytes T mémoires et conséquences sur la réponse inflammatoire épidermique et la pigmentation
Martins, C. (2020) · theses.fr (ABES) · doi:10.70675/dbfdf5d8z2beez442dzb1a1z99b4860df70a
Parny, M. (2020) · theses.fr (ABES) · doi:10.70675/43001866z792bz4ef1z9593ze927a52316f6
Balasubramaniam, L. (2021) · theses.fr (ABES) · doi:10.70675/1099cf72zaa1bz4f7azbfc0z3067478b32d6
Louvrier, C. (2019) · theses.fr (ABES) · doi:10.70675/ee57af23z15cdz4ec8zafebz9f9ac9f08220
Propriétés immunitaires des kératinocytes humains et de leurs précurseurs
Mestrallet, G. (2021) · theses.fr (ABES) · doi:10.70675/99958530z8e43z417dz8f34z9ff9b3cb3ce5
Emergence of NLRP1 inflammasome as a sensor of microbial virulence in human epithelium
Pinilla, M. (2023) · theses.fr (ABES) · doi:10.70675/1209ef79zd7c9z4b14z8a56za9b7f12b4bd0
Rodrigues‐Braz, D. (2023) · theses.fr (ABES) · doi:10.70675/b5ea077fz3ec6z4238z8e5ez326aeef1629e
Chirayath, T. W. (2023) · theses.fr (ABES) · doi:10.70675/5dbfa9f5zf8d1z4e51zaf01z277a9548aeeb
Mast Cells Are a Reservoir of NLRP1 in Human Skin
Dobre, A., Fertig, T. E., Niculae, A. M., Cohn, A.-M., Curici, A., Andrei, R. T., Marta, D. S., Peteu, V. E., Popescu, R. G., Marinescu, G. C., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093775
An overview of human inflammasomes: Activation and regulation
Jäger, E. J., Ismaeel, S., Stehlik, C., & Dorfleutner, A. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag081 · Cited by 1
Aggarwal, D., Thyagarajan‐Sahu, A., Kemp, M. G., & Sahu, R. P. (2026) · Photochemistry and Photobiology · doi:10.1111/php.70145
The gasdermin family: from pyroptosis mechanisms to therapeutic targets
Xu, W., Liu, S., Yu, Z., Shi, J., Yang, Y., & Shi, F. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02867-2
The interplay between vitamin D3 and Nrf2 signaling: mechanistic insights and therapeutic potentials
Tajgardan, A., Tameh, A. A., Barati, S., Behdarvandy, M., & Vahidinia, Z. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05968-5
Unraveling the pyroptosis-mitophagy axis: from molecular mechanisms to therapeutic opportunities
Ban, J., 陈然兴, Ao, L., Zhao, H., Li, J., Wei, Y., & Huang, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1950578
Metadata
- Authors
- Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D.
- Affiliations
- ETH Zurich (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Beer, Hans-Dietmar
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 17
- Issue
- 13
- Pages
- 1140-1145
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1999276471
- Cited by
- 544
- References
- 25
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 19 · 2023: 22 · 2022: 23 · 2021: 32 · 2020: 29 · 2019: 30 · 2018: 30 · 2017: 38 · 2016: 34 · 2015: 35 · 2014: 40 · 2013: 30 · 2012: 41
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- inflammasome, UVB irradiation, IL-1β, keratinocytes, caspase-1, intracellular calcium, innate immunity, skin inflammation
- MeSH terms
- Animals, Calcium, Cytoplasm, Dermatitis, Humans, Interleukin-1, Protein Precursors, Ultraviolet Rays, Keratinocytes, Cytokines, Mice, Knockout, Inflammation Mediators, Caspase 1, Multiprotein Complexes, Mice, Interleukin-1beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review