The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

Mariathasan, S., & Monack, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1997 · Cited by 879

Keratinocytes as initiators of inflammation

Barker, J. N., Griffiths, C. E. M., Nickoloff, B. J., Mitra, R. S., Dixit, V. M., & Nickoloff, B. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)92168-2 · Cited by 766

Early molecular events in the induction phase of contact sensitivity.

Enk, A., & Katz, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1398 · Cited by 650

Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

Gurcel, L., Abrami, L., Girardin, S. E., Tschopp, J., & van der Goot, F. G. (2006) · Cell · doi:10.1016/j.cell.2006.07.033 · Cited by 508

Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea

Dinarello, C. A. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08307.x · Cited by 497

The Inflammasome: First Line of the Immune Response to Cell Stress

Ogura, Y., Sutterwala, F. S., & Flavell, R. A. (2006) · Cell · doi:10.1016/j.cell.2006.08.002 · Cited by 474

Identification and expressional analysis of NLRC5 inflammasome gene in smolting Atlantic salmon ( Salmo salar )

Pontigo, J. P., Agüero, M. J., Sánchez, P., Oyarzún, R., Vargas‐Lagos, C., Mancilla, J., Kossmann, H., Morera, F. J., Yáñez, A. J., & Vargas‐Chacoff, L. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.09.031 · Cited by 32

Activation mechanisms of inflammasomes by bacterial toxins

Jing, W., Pilato, J. L., Kay, C., & Man, S. M. (2021) · Cellular Microbiology · doi:10.1111/cmi.13309 · Cited by 32

Inflammasome activation and metabolic disease progression

Li, H., Jin, C., Chen, Y., & Flavell, R. A. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.020 · Cited by 32

Keratinocytes express functional CARD18, a negative regulator of inflammasome activation, and its altered expression in psoriasis may contribute to disease pathogenesis

Göblös, A., Danis, J., Vas, K., Bata‐Csörgõ, Z., Kemény, L. V., & Széll, M. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.03.009 · Cited by 32

NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)

Ciążyńska, M. A., Bednarski, I. A., Wódz, K., Narbutt, J., & Lesiak, A. (2020) · Oncology Letters · doi:10.3892/ol.2020.11284 · Cited by 33

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Korhonen, E., Bisevac, J., Hyttinen, J. M. T., Piippo, N., Hytti, M., Kaarniranta, K., Petrovski, G., & Kauppinen, A. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.4.7 · Cited by 31

Purinergic Signaling and Inflammasome Activation in Psoriasis Pathogenesis

Ferrari, D., Casciano, F., Secchiero, P., & Reali, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179449 · Cited by 31

Infection with Mycobacterium avium subsp. paratuberculosis Results in Rapid Interleukin-1β Release and Macrophage Transepithelial Migration

Lamont, E. A., O’Grady, S. M., Davis, W. C., Eckstein, T. M., & Sreevatsan, S. (2012) · Infection and Immunity · doi:10.1128/iai.06322-11 · Cited by 31

Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

Wei, Z., Zhan, X., Ding, K., Xu, G., Shi, W., Ren, L., Fang, Z., Liu, T., Hou, X., Zhao, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.750815 · Cited by 30

Selective Hyaluronan–CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation

Bourguignon, L., & Bikle, D. D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00224 · Cited by 30

Primary human keratinocytes efficiently induce IL‐1‐dependent IL‐17 in CCR6+ T cells

Muhr, P., Renne, J., Schaefer, V., Werfel, T., & Wittmann, M. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01134.x · Cited by 30

Collagen XVII ( BP 180) modulates keratinocyte expression of the proinflammatory chemokine, IL ‐8

den Bergh, F. V., Eliason, S. L., Burmeister, B. T., & Giudice, G. J. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01529.x · Cited by 30

Anakinra and related drugs targeting interleukin-1 in the treatment of cryopyrin- associated periodic syndromes

Chang, C. C., & Bachove, I. (2014) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s46017 · Cited by 30

TLR3 mediates release of IL-1β and cell death in keratinocytes in a caspase-4 dependent manner

Grimstad, Ø., Husebye, H., & Espevik, T. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.05.006 · Cited by 30

Editor’s Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D. H., Amin, S., Glick, A. B., & Perdew, G. H. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx160 · Cited by 30

NLRP3 Inflammasome and Inflammatory Response in Aging Disorders: The Entanglement of Redox Modulation in Different Outcomes

Chhunchha, B., Kubo, E., Lehri, D., & Singh, D. P. (2025) · Cells · doi:10.3390/cells14130994 · Cited by 30

Critical roles of irradiance in the regulation of UVB-induced inflammasome activation and skin inflammation in human skin keratinocytes

Lee, T.-A., Huang, Y., Hsiao, P., Chiu, L., Chern, S., & Wu, N. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112373 · Cited by 29

miR‐200a Modulates the Expression of the DNA Repair Protein OGG1 Playing a Role in Aging of Primary Human Keratinocytes

Tinaburri, L., D’Errico, M., Sileno, S., Maurelli, R., Degan, P., Magenta, A., & Dellambra, E. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9147326 · Cited by 31

The NLRP1 Inflammasome Pathway Is Silenced in Cutaneous Squamous Cell Carcinoma

Sand, J., Fenini, G., Grossi, S., Hennig, P., Filippo, M. D., Levesque, M. P., Werner, S., French, L. E., & Beer, H. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.01.025 · Cited by 29

Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes

Cordier-Dirikoc, S., Pedretti, N., Garnier, J., Charreau, S., Ryffel, B., Morel, F., Bernard, F., de Almeida, V. H., Lecron, J., & Jégou, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984045 · Cited by 30

Silencing of ASC in Cutaneous Squamous Cell Carcinoma

Meier, K., Drexler, S. K., Eberle, F. C., Lefort, K., & Yazdi, A. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164742 · Cited by 28

Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier

Danis, J., & Mellett, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094677 · Cited by 28

The Inflammasome, an Innate Immunity Guardian, Participates in Skin Urticarial Reactions and Contact Hypersensitivity

Kambe, N., Nakamura, Y., Saito, M. K., & Nishikomori, R. (2010) · Allergology International · doi:10.2332/allergolint.09-rai-0160 · Cited by 27

Cytokine concentrations in basal cell carcinomas of different histological types and localization.

Elamin, I., Zečević, R. D., Vojvodić, D., Medenica, L., & Pavlović, M. D. (2008) · PubMed · Cited by 27

Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice

Kajitani, G. S., Quayle, C., Garcia, C. C. M., Fotoran, W. L., dos Santos, J. F. R., van der Horst, G. T. J., Hoeijmakers, J. H. J., & Menck, C. F. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.800606 · Cited by 26

Homo-oligomerization and Activation of AMP-activated Protein Kinase Are Mediated by the Kinase Domain αG-Helix

Scholz, R., Suter, M., Weimann, T., Polge, C., Konarev, P. V., Thali, R. F., Tuerk, R. D., Viollet, B., Wallimann, T., Schlattner, U., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047670 · Cited by 27

The gasdermins: a pore-forming protein family expressed in the epidermis

Slaufova, M., Karakaya, T., Filippo, M. D., Hennig, P., & Beer, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1254150 · Cited by 28

Inactivation of the Cytoprotective Major Vault Protein by Caspase-1 and -9 in Epithelial Cells during Apoptosis

Grossi, S., Fenini, G., Kockmann, T., Hennig, P., Filippo, M. D., & Beer, H. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.11.015 · Cited by 25

In vitro Evaluation of Programmed Cell Death in the Immune System of Pacific Oyster Crassostrea gigas by the Effect of Marine Toxins

Estrada, N., Núñez-Vázquez, E. J., Palacios, A., Ascencio, F., Guzmán-Villanueva, L. T., & Contreras, R. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.634497 · Cited by 24

Aberrant inflammasome activation as a driving force of human autoimmune skin disease

Fetter, T., de Graaf, D. M., Claus, I., & Wenzel, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1190388 · Cited by 25

Immunohistochemical localization of NALP 3 inflammasome in experimental periapical lesions

Liu, S., Li, Q., & Liu, Y. (2014) · International Endodontic Journal · doi:10.1111/iej.12240 · Cited by 24

Polyandric Acid A, a Clerodane Diterpenoid from the Australian Medicinal Plant Dodonaea polyandra, Attenuates Pro-inflammatory Cytokine Secretion in Vitro and in Vivo

Simpson, B. S., Luo, X., Costabile, M., Caughey, G. E., Wang, J., Claudie, D. J., McKinnon, R. A., & Semple, S. J. (2014) · Journal of Natural Products · doi:10.1021/np400704b · Cited by 24

Death by ribosome

Vind, A., Zhong, F. L., & Bekker‐Jensen, S. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.10.013 · Cited by 23

Secreted immunoregulatory proteins in the skin

Nöske, K. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.10.008 · Cited by 23

Walking down Skeletal Muscle Lane: From Inflammasome to Disease

Dubuisson, N., Versele, R., de Carrizosa, M. A. D., Selvais, C. M., Brichard, S. M., & Abou‐Samra, M. (2021) · Cells · doi:10.3390/cells10113023 · Cited by 23

ASC Speck Formation after Inflammasome Activation in Primary Human Keratinocytes

Smatlik, N., Drexler, S. K., Burian, M., Röcken, M., & Yazdi, A. S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7914829 · Cited by 23

UVB Radiation Illuminates the Role of TLR3 in the Epidermis

Borkowski, A. W., & Gallo, R. L. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.167 · Cited by 25

Asiatic Acid Glucosamine Salt Alleviates Ultraviolet B‐induced Photoaging of Human Dermal Fibroblasts and Nude Mouse Skin

Huang, J., Tu, T., Wang, W., Zhou, G., Zhang, W., Wu, X., & Liu, W. (2019) · Photochemistry and Photobiology · doi:10.1111/php.13160 · Cited by 23

Establishment of an in vitro photoallergy test using NCTC2544 cells and IL-18 production

Galbiati, V., Martínez, V., Bianchi, S. E., Mitjans, M., & Corsini, E. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.09.017 · Cited by 23

Interleukin-22 participates in the inflammatory process of vitiligo

Dong, J., An, X., Zhong, H., Wang, Y., Shang, J., & Zhou, J. (2017) · Oncotarget · doi:10.18632/oncotarget.22644 · Cited by 23

Requirement of MyD88 signaling in keratinocytes for Langerhans cell migration and initiation of atopic dermatitis‐like symptoms in mice

Didovic, S., Opitz, F. V., Holzmann, B., Förster, I., & Weighardt, H. (2015) · European Journal of Immunology · doi:10.1002/eji.201545710 · Cited by 22

Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other's activities in mice

Wang, J., Shen, T., Zhu, W., Dou, L., Gu, H., Zhang, L., Yang, Z., Chen, H., Zhou, Q., Sánchez, E. R., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004256 · Cited by 22

Photoaging: UV radiation-induced cGAS-STING signaling promotes the aging process in skin by remodeling the immune network

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2025) · Biogerontology · doi:10.1007/s10522-025-10268-1 · Cited by 21

The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing

Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s448693 · Cited by 22

In vitro expression of NLRP inflammasome-induced active Caspase-1 expression in normal human epidermal keratinocytes (NHEK) by various exogenous threats and subsequent inhibition by naturally derived ingredient blends

Gruber, J. V., & HOLTZ, R. W. (2019) · Journal of Inflammation Research · doi:10.2147/jir.s215776 · Cited by 21

Only IL‐1β release is inflammasome‐dependent upon ultraviolet B irradiation although IL‐18 is also secreted

Korhonen, E., Piippo, N., Hytti, M., Hyttinen, J. M. T., Kaarniranta, K., & Kauppinen, A. (2020) · The FASEB Journal · doi:10.1096/fj.201902355rr · Cited by 21

Activation of NLRP3 Inflammasome in the Skin of Patients with Systemic and Cutaneous Lupus Erythematosus

Mähönen, K., Hau, A., Bondet, V., Duffy, D., Eklund, K. K., Panelius, J., & Ranki, A. (2022) · Acta Dermato Venereologica · doi:10.2340/actadv.v102.2293 · Cited by 21

Anti-Apoptotic NF-κB and “Gain of Function” mutp53 in Concert Act Pro-Apoptotic in Response to UVB+IL-1 via Enhanced TNF Production

Müller, I., Beissert, S., & Kulms, D. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.481 · Cited by 20

Expression of CYP1A1, CYP1B1 and IL-1β in PBMCs and skin samples of PCB exposed individuals

Leijs, M. M., Esser, A., Amann, P. M., Schettgen, T., Heise, R., Fietkau, K., Gube, M., Merk, H. F., Kraus, T., & Baron, J. M. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.06.136 · Cited by 20

Enhanced Wound Healing- and Inflammasome-Associated Gene Expression in TNFAIP3-Interacting Protein 1- (TNIP1-) Deficient HaCaT Keratinocytes Parallels Reduced Reepithelialization

Shamilov, R., Ackley, T. W., & Aneskievich, B. J. (2020) · Mediators of Inflammation · doi:10.1155/2020/5919150 · Cited by 20

Innate immunity, inflammation activation and heat-shock protein in COVID-19 pathogenesis

Danladi, J., & Sabir, H. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577632 · Cited by 21

AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis

Uresti‐Rivera, E. E., & García-Hernández, M. H. (2022) · Autoimmunity · doi:10.1080/08916934.2022.2103802 · Cited by 21

Elevated Expression of NLRP1 and IPAF Are Related to Oral Pemphigus Vulgaris Pathogenesis

Shamsabadi, R. M., Basafa, S., Yarahmadi, R., Goorani, S., Khani, M., Kamarehei, M., & Kiani, A. H. (2014) · Inflammation · doi:10.1007/s10753-014-0023-y · Cited by 20

Innate immune response of human epidermal keratinocytes and dermal fibroblasts to in vitro incubation of Trichophyton benhamiae DSM 6916

Hesse, J., Morgner, B., Morgenstern, S., Grimm, M., Elsner, P. U., Hipler, U. ‐., & Wiegand, C. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15472 · Cited by 20

Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation

Douglas, T., & Saleh, M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011622 · Cited by 20

IL-1 Receptor–Knockout Mice Develop Epidermal Cysts and Show an Altered Innate Immune Response after Exposure to UVB Radiation

Kulkarni, N. N., Adase, C. A., Zhang, L., Borkowski, A. W., Li, F., Sanford, J. A., Coleman, D. J., Aguilera, C., Indra, A. K., & Gallo, R. L. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.07.814 · Cited by 20

Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α

Martin, P., Palmer, G., Rodriguez, E., Palomo, J., Lemeille, S., Goldstein, J., & Gabay, C. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901074 · Cited by 19

An overview of disease models for NLRP3 inflammasome over-activation

Zhang, H., Zahid, A., Ismail, H., Tang, Y., Jin, T., & Tao, J. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1844179 · Cited by 20

The Essential Role of Ca2+ Signals in UVB–Induced IL-1β Secretion in Keratinocytes

Park, K., Park, D., Kim, Y., Nam, T., Jang, K. Y., Chung, H., & Kim, U. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.12.005 · Cited by 19

Photoprotective Potential of Glycolic Acid by Reducing NLRC4 and AIM2 Inflammasome Complex Proteins in UVB Radiation-Induced Normal Human Epidermal Keratinocytes and Mice

Hung, S., Tang, S., Liao, P.-Y., Ge, J., Hsiao, Y., & Yang, J. (2017) · DNA and Cell Biology · doi:10.1089/dna.2016.3471 · Cited by 19

Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes

Hasegawa, T., Noguchi, S., Nakashima, M., Miyai, M., Goto, M., Matsumoto, Y. M., Torii, S., Honda, S., & Shimizu, S. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107173 · Cited by 18

Effect of 1-MHz ultrasound on the proinflammatory interleukin-6 secretion in human keratinocytes

Giantulli, S., Tortorella, E., Brasili, F., Scarpa, S., Cerroni, B., Paradossi, G., Bedini, A., Morrone, S., Silvestri, I., & Domenici, F. (2021) · Scientific Reports · doi:10.1038/s41598-021-98141-2 · Cited by 18

Galectin-3 regulates UVB-induced inflammation in skin

Wang, J., Lu, P., Lin, W., Wei, Y.-H., Chiu, L., Chern, S., Hung, C., & Wu, N. (2020) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2020.03.007 · Cited by 18

Loss of Epidermal p38α Signaling Prevents UVR-Induced Inflammation via Acute and Chronic Mechanisms

Sano, Y., & Park, J. M. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.153 · Cited by 18

Novel Chemically Modified Curcumin (CMC) Analogs Exhibit Anti-Melanogenic Activity in Primary Human Melanocytes

Goenka, S., & Simon, S. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116043 · Cited by 17

The neutrophil inflammasome

Tyrkalska, S. D., Candel, S., & Mulero, V. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103874 · Cited by 18

Narrowband ultraviolet B inhibits innate cytosolic double-stranded RNA receptors in psoriatic skin and keratinocytes

Rácz, E., Prens, E. P., Kant, M., Florencia, E. F., Jaspers, N. G. J., Laman, J. D., de Ridder, D., & van der Fits, L. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10169.x · Cited by 17

Inflammasome activation by cell volume regulation and inflammation-associated hyponatremia: A vicious cycle

Kim, J. H., Park, J. H., Eisenhut, M., Yu, J., & Shin, J. I. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.05.018 · Cited by 18

Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies

Ma, Y., Meng, J., Sun, F., & Lei, M. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.09.006 · Cited by 17

Spleen tyrosine kinase regulates keratinocyte inflammasome activation and skin inflammation induced by UVB irradiation

Lu, P., Wang, J., Chiu, L., Huang, Y., Hung, C., & Wu, N. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.01.004 · Cited by 16

Targeting IL-1 controls refractory pityriasis rubra pilaris

Schmauch, E., Severin, Y., Xing, X., Mangold, A. R., Conrad, C., Johansen, P., Kahlenberg, J. M., Mellett, M., Navarini, A. A., Nobbe, S., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado2365 · Cited by 16

NCTC 2544 and IL-18 production: A tool for the in vitro identification of photoallergens

Galbiati, V., Bianchi, S. E., Martínez, V., Mitjans, M., & Corsini, E. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.06.008 · Cited by 16

Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC , by Inducing DNA Methylation in HaCaT Cells

Tang, S., Yeh, J., Hung, S., Hsiao, Y., Liu, F., & Yang, J. (2016) · DNA and Cell Biology · doi:10.1089/dna.2015.2993 · Cited by 16

Characterization of Inflammasome Components in Pig Intestine and Analysis of the Influence of ProbioticEnterococcus Faeciumduring anEscherichia ColiChallenge

Kern, M., Aschenbach, J. R., Tedin, K., Pieper, R., Loß, H., & Lodemann, U. (2017) · Immunological Investigations · doi:10.1080/08820139.2017.1360341 · Cited by 16

Inflammasome et interleukine 1

Jéru, I., & Amselem, S. (2010) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2010.02.013 · Cited by 17

Prevention of Photocarcinogenesis by Agonists of 5-HT1A and Antagonists of 5-HT2A Receptors

Menezes, A. C., Raposo, S., Simões, S., Ribeiro, H. M., Oliveira, H., & Ascenso, A. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-9068-z · Cited by 16

Linkage of bacterial colonization of skin and the urticaria-like rash of NLRP3-mediated autoinflammatory syndromes through mast cell-derived TNF-α

Nakamura, Y., & Kambe, N. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.04.009 · Cited by 16

MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes

Bugara, B., Konieczny, P., Wolnicka-Głubisz, A., Eckhart, L., Fischer, H., Skalniak, Ł., Borowczyk, J., Drukała, J., & Jura, J. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.03.013 · Cited by 16

Initial periodontal treatment affects nucleotide-binding domain leucine-rich repeat-containing protein 3 inflammasome priming in peripheral blood mononuclear cells

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Mansfield, K. P., & Naik, S. (2020) · PubMed · Cited by 17

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Jura, J., & Koj, A. (2011) · InTech eBooks · doi:10.5772/18207 · Cited by 13

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Kurata, R., Fujita, F., Oonishi, K., Kuriyama, K.-I., & Kawamata, S. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09850.x · Cited by 13

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