Cited by 280Sleep and Wakefulness ResearchNeurobiology and Insect Physiology ResearchCircadian rhythm and melatonin

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Unearthing the Phylogenetic Roots of Sleep

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Allada, Ravi, Siegel, Jerome M.·2008·Current Biology

DOI 10.1016/j.cub.2008.06.033PMC PMC2899675

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Abstract

Why we sleep remains one of the enduring unanswered questions in biology. At its core, sleep can be defined behaviorally as a homeostatically regulated state of reduced movement and sensory responsiveness. The cornerstone of sleep studies in terrestrial mammals, including humans, has been the measurement of coordinated changes in brain activity during sleep measured using the electroencephalogram (EEG). Yet among a diverse set of animals, these EEG sleep traits can vary widely and, in some cases, are absent, raising questions as to whether they define a universal, or even essential, feature of sleep. Over the past decade, behaviorally defined sleep-like states have been identified in a series of genetic model organisms, including fish, flies and worms. Genetic analyses in these systems are revealing a remarkable conservation in the underlying mechanisms controlling sleep behavior. Taken together, these studies suggest an ancient origin for sleep and raise the possibility that model organism genetics may reveal the molecular mechanisms that guide sleep and wake.

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Authors: Allada, R., & Siegel, J. M.
Affiliations: Northwestern University (US)
University of California, Los Angeles (US)
Corresponding author: Allada, Ravi
Siegel, Jerome M.
ORCID: Allada, Ravi
Siegel, Jerome M.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2008-08
Volume: 18
Issue: 15
Pages: R670-R679
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2008.06.033
PMC: PMC2899675
OpenAlex: W2021185182
Cited by: 280
References: 149
Citations by year: 2026: 13 · 2025: 21 · 2024: 22 · 2023: 15 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 18 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 14 · 2012: 13
FWCI: 0.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1847 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH064109, R01MH067870, R01MH64109)
National Institute of Neurological Disorders and Stroke (R01NS042947, R01NS052903, 1R01-NS42947, R01NS059042)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep evolution, sleep-like state, sleep homeostasis, sleep-wake regulation, genetic model organisms, fish, Drosophila, Caenorhabditis elegans
MeSH terms: Animals, Behavior, Animal, Circadian Rhythm, Homeostasis, Humans, Phylogeny, Sleep, Species Specificity, Time Factors, Signal Transduction, Models, Animal

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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Unearthing the Phylogenetic Roots of Sleep

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