The DOI matches its Crossref record; 147 of the 149 references it cites were found in a registry or an index.
Unearthing the Phylogenetic Roots of Sleep
Open accessAbstract
Why we sleep remains one of the enduring unanswered questions in biology. At its core, sleep can be defined behaviorally as a homeostatically regulated state of reduced movement and sensory responsiveness. The cornerstone of sleep studies in terrestrial mammals, including humans, has been the measurement of coordinated changes in brain activity during sleep measured using the electroencephalogram (EEG). Yet among a diverse set of animals, these EEG sleep traits can vary widely and, in some cases, are absent, raising questions as to whether they define a universal, or even essential, feature of sleep. Over the past decade, behaviorally defined sleep-like states have been identified in a series of genetic model organisms, including fish, flies and worms. Genetic analyses in these systems are revealing a remarkable conservation in the underlying mechanisms controlling sleep behavior. Taken together, these studies suggest an ancient origin for sleep and raise the possibility that model organism genetics may reveal the molecular mechanisms that guide sleep and wake.
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“The observation of behaviorally and mechanistically conserved sleep-like states across the animal kingdom [6,7] strongly supports the possibility for an early rooted sleep state rather than many instances of convergent evolution.”
From The Jellyfish Cassiopea Exhibits a Sleep-like State (2017) · cites this paper as [6]
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Cites
The Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,902
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089
Self-citationHuber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854
Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776
Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698
Roffwarg, H. P., Muzio, J. N., & Dement, W. C. (1966) · Science · doi:10.1126/science.152.3722.604 · Cited by 1,559
Sleep Homeostasis and Models of Sleep Regulation
Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,546
Research works printed but not linked: 3
- Lyamin, 1996, Paradoxical sleep in northern fur seals in water and on land, J. Sleep Res., 5, 130
- Mukhametov, 1981, EEG investigation of sleep in porpoises (Phocoena phocoena), J. Higher Nervous Activity, 31, 333
- Mukhametov, L.M., Lyamin, O.I., Shpak, O.V., Manger, P., and Siegel, J.M., (2002). Swimming styles and their relationship to rest and activity states in captive Commerson's dolphins. Proceedings of the 14th Biennial Conference on the Biology of Marine Mammals, Vancouver, Nov.27-Dec.3, 152.
Cited by
Sorted by citations
Neural Circuitry of Wakefulness and Sleep
Scammell, T. E., Arrigoni, E., & Lipton, J. O. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.014 · Cited by 966
Fullagar, H. H. K., Skorski, S., Duffield, R., Hammes, D., Coutts, A. J., & Meyer, T. (2014) · Sports Medicine · doi:10.1007/s40279-014-0260-0 · Cited by 1,087
Circadian Organization of Behavior and Physiology in Drosophila
Allada, R., & Chung, B. Y. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135815 · Cited by 456
Self-citationGenetics of Sleep and Sleep Disorders
Sehgal, A., & Mignot, E. J.-M. (2011) · Cell · doi:10.1016/j.cell.2011.07.004 · Cited by 416
Functions and Mechanisms of Sleep
Zielinski, M. R., McKenna, J. T., & McCarley, R. W. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.1.67 · Cited by 392
Metadata
- Authors
- Allada, R., & Siegel, J. M.
- Affiliations
- Northwestern University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Allada, Ravi
- Siegel, Jerome M.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 18
- Issue
- 15
- Pages
- R670-R679
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC2899675
- OpenAlex
- W2021185182
- Cited by
- 280
- References
- 149
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 22 · 2023: 15 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 18 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 14 · 2012: 13
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1847 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH064109, R01MH067870, R01MH64109)
- National Institute of Neurological Disorders and Stroke (R01NS042947, R01NS052903, 1R01-NS42947, R01NS059042)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep evolution, sleep-like state, sleep homeostasis, sleep-wake regulation, genetic model organisms, fish, Drosophila, Caenorhabditis elegans
- MeSH terms
- Animals, Behavior, Animal, Circadian Rhythm, Homeostasis, Humans, Phylogeny, Sleep, Species Specificity, Time Factors, Signal Transduction, Models, Animal
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