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Unearthing the Phylogenetic Roots of Sleep
Open accessAbstract
Why we sleep remains one of the enduring unanswered questions in biology. At its core, sleep can be defined behaviorally as a homeostatically regulated state of reduced movement and sensory responsiveness. The cornerstone of sleep studies in terrestrial mammals, including humans, has been the measurement of coordinated changes in brain activity during sleep measured using the electroencephalogram (EEG). Yet among a diverse set of animals, these EEG sleep traits can vary widely and, in some cases, are absent, raising questions as to whether they define a universal, or even essential, feature of sleep. Over the past decade, behaviorally defined sleep-like states have been identified in a series of genetic model organisms, including fish, flies and worms. Genetic analyses in these systems are revealing a remarkable conservation in the underlying mechanisms controlling sleep behavior. Taken together, these studies suggest an ancient origin for sleep and raise the possibility that model organism genetics may reveal the molecular mechanisms that guide sleep and wake.
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“The observation of behaviorally and mechanistically conserved sleep-like states across the animal kingdom [6,7] strongly supports the possibility for an early rooted sleep state rather than many instances of convergent evolution.”
From The Jellyfish Cassiopea Exhibits a Sleep-like State (2017) · cites this paper as [6]
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Flagged first, then by citations
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Research works printed but not linked: 3
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Neural Circuitry of Wakefulness and Sleep
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Metadata
- Authors
- Allada, R., & Siegel, J. M.
- Affiliations
- Northwestern University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Allada, Ravi
- Siegel, Jerome M.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 18
- Issue
- 15
- Pages
- R670-R679
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC2899675
- OpenAlex
- W2021185182
- Cited by
- 280
- References
- 149
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 22 · 2023: 15 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 18 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 14 · 2012: 13
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1847 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH064109, R01MH067870, R01MH64109)
- National Institute of Neurological Disorders and Stroke (R01NS042947, R01NS052903, 1R01-NS42947, R01NS059042)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep evolution, sleep-like state, sleep homeostasis, sleep-wake regulation, genetic model organisms, fish, Drosophila, Caenorhabditis elegans
- MeSH terms
- Animals, Behavior, Animal, Circadian Rhythm, Homeostasis, Humans, Phylogeny, Sleep, Species Specificity, Time Factors, Signal Transduction, Models, Animal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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