Functional MRI evidence for LTP-induced neural network reorganization
Open accessAbstract
The hippocampal formation is a region of the forebrain that is important for memory and spatial navigation. On the basis of a vast amount of literature, the hippocampus is linked with long-term potentiation (LTP), the increased synaptic strength following repeated stimulation of the hippocampal neurons. LTP is considered to be the experimental demonstration of Hebb's postulate on synaptic strength and learning, and it is the dominant model of an experience-dependent modification of brain circuits. Yet, despite the importance of this phenomenon for brain physiology and behavior, little is known about how experimentally measured regional synaptic modifications alter the activity of global, widespread networks. Here, we use simultaneous fMRI, microstimulation, and electrophysiology to unveil global changes in brain activity due to local hippocampal plasticity. Our findings offer the first evidence of an LTP-induced network reorganization that includes increased interhemispheric communication and recruitment of limbic and neocortical circuits after changes in synaptic strength within the hippocampus.
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The observed differences in functional network associations with increasing frequency of IJA across 12-24 months may reflect changes in functional connectivity driven by social experience-dependent learning over the second year of life and the unfolding, later transition from nonverbal to verbal communication.
“These observed differences in functional network associations with increasing frequency of IJA across 12–24 months may reflect changes in fc driven by social experience-dependent learning that occurs over the second year of life (Tomasello et al. 2005; Canals et al. 2009; Lewis et al. 2009; Fransson et al. 2011) and the unfolding, later transition from nonverbal to verbal communication (Morales et”
From Joint attention and brain functional connectivity in infants and toddlers (2017) · cites this paper as Canals et al. 2009
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- Authors
- Canals, S., Beyerlein, M., Merkle, H., & Logothetis, N. K.
- Affiliations
- Max Planck Institute for Biological Cybernetics (DE)
- National Institutes of Health (US)
- University of Manchester (GB)
- Corresponding author
- Canals, Santiago
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 19
- Issue
- 5
- Pages
- 398-403
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2060419273
- Cited by
- 114
- References
- 32
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 12 · 2014: 4 · 2013: 12 · 2012: 4
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Max-Planck-Gesellschaft
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, hippocampus, neural network reorganization, Hebbian plasticity, interhemispheric communication, limbic circuits, neocortical circuits, synaptic plasticity, memory, spatial navigation, microstimulation
- MeSH terms
- Animals, Electric Stimulation, Electrophysiology, Hippocampus, Magnetic Resonance Imaging, Male, Nerve Net, Neuronal Plasticity, Neurons, Synapses, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Rats, Sprague-Dawley, Long-Term Potentiation, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Rats
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